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Differentiation potential and mRNA profiles of human dedifferentiated adipose cells and adipose‑derived stem cells from young donors

  • Authors:
    • Fangfei Nie
    • Hongsen Bi
    • Chen Zhang
    • Pengbing Ding
  • View Affiliations / Copyright

    Affiliations: Department of Plastic Surgery, Peking University Third Hospital, Beijing 100191, P.R. China
    Copyright: © Nie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 47
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    Published online on: November 12, 2020
       https://doi.org/10.3892/mmr.2020.11685
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Abstract

Dedifferentiated adipose cells (DAs) and adipose‑derived stem cells (ADSCs) are two of the primary types of stem cells derived from adipose tissue, which have been reported to possess similar characteristics, but also exhibit unique phenotypic and functional advantages. However, several reports have described inconsistent results regarding their differences in multilineage differentiation function. Moreover, to the best of our knowledge, there are no studies assessing their myogenic ability, or the differences in the transcriptome between the two cell types derived from lipoaspirates via tumescent liposuction from the same donors. The aim of the present study was to compare the properties and expression profiles of these cell types. Subcutaneous adipose tissue of three female patients (aged 23‑30 years) with a physiological BMI (19.1‑23.9 kg/m2) were obtained during tumescent liposuction of the abdomen or the thigh. The stromal vascular fraction and mature adipocytes were obtained via collagenase digestion, and ADSCs and DAs were cultured successively. To determine the differences between DAs and ADSCs after 6‑7 passages, cell proliferation assays, phenotypic assessment, differentiation assays and high‑throughput RNA sequencing (seq) were used. Similar cell morphologies, proliferation dynamics, surface markers and transcriptome expression profiles were observed between the DAs and ADSCs. Whilst there were notable individual differences in the osteogenic, lipogenic, chondrogenic and myogenic abilities of the DAs and ADSCs, it was difficult to determine their differentiation potential based only on the cell source. Interestingly, the myogenic ability was relatively stronger in cells with relatively weaker lipogenic ability. Only 186 differentially expressed genes between the two groups were identified using RNAseq. Several of these genes were involved in biological functions such as transcription regulation, protein translation regulation, cytokine interactions and energy metabolism regulation. The results of the present study suggested a similar functional potential of DAs and ADSCs from young donors undergoing tumescent liposuction operation in regeneration areas and the balance of the differentiative ability of the same cell populations. These data may provide a foundation for further clinical administration of stem cells derived from adipose tissues in therapy.
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View References

1 

Wu S, Coombs DM and Gurunian R: Liposuction: Concepts, safety, and techniques in body-contouring surgery. Cleve Clin J Med. 87:367–375. 2020. View Article : Google Scholar : PubMed/NCBI

2 

Svalgaard JD, Juul S, Vester-Glovinski PV, Haastrup EK, Ballesteros OR, Lynggaard CD, Jensen AK, Fischer-Nielsen A, Herly M and Munthe-Fog L: Lipoaspirate storage time and temperature: Effects on stromal vascular fraction quality and cell composition. Cells Tissues Organs. 209:54–63. 2020. View Article : Google Scholar : PubMed/NCBI

3 

Choudhery MS, Badowski M, Muise A, Pierce J and Harris DT: Donor age negatively impacts adipose tissue-derived mesenchymal stem cell expansion and differentiation. J Transl Med. 12:82014. View Article : Google Scholar : PubMed/NCBI

4 

Kornicka K, Marycz K, Tomaszewski KA, Marędziak M and Śmieszek A: The effect of age on osteogenic and adipogenic differentiation potential of human adipose derived stromal stem cells (hASCs) and the impact of stress factors in the course of the differentiation process. Oxid Med Cell Longev. 2015:3091692015. View Article : Google Scholar : PubMed/NCBI

5 

Nordberg RC, Zhang J, Griffith EH, Frank MW, Starly B and Loboa EG: Electrical cell-substrate impedance spectroscopy can monitor age-grouped human adipose stem cell variability during osteogenic differentiation. Stem Cells Transl Med. 6:502–511. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Zhu M, Kohan E, Bradley J, Hedrick M, Benhaim P and Zuk P: The effect of age on osteogenic, adipogenic and proliferative potential of female adipose-derived stem cells. J Tissue Eng Regen Med. 3:290–301. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Sasahara Y, Kubota Y, Kosaka K, Adachi N, Yamaji Y, Nagano H, Akita S, Kuroda M, Tanaka T, Bujo H, et al: Adipose-derived stem cells and ceiling culture-derived preadipocytes cultured from subcutaneous fat tissue differ in their epigenetic characteristics and osteogenic potential. Plast Reconstr Surg. 144:644–655. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, Mizuno H, Alfonso ZC, Fraser JK, Benhaim P and Hedrick MH: Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell. 13:4279–4295. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Kunze KN, Burnett RA, Wright-Chisem J, Frank RM and Chahla J: Adipose-derived mesenchymal stem cell treatments and available formulations. Curr Rev Musculoskelet Med. 13:264–280. 2020. View Article : Google Scholar : PubMed/NCBI

10 

Tsubosaka M, Matsumoto T, Sobajima S, Matsushita T, Iwaguro H and Kuroda R: The influence of adipose-derived stromal vascular fraction cells on the treatment of knee osteoarthritis. BMC Musculoskelet Disord. 21:2072020. View Article : Google Scholar : PubMed/NCBI

11 

Ramakrishnan VM and Boyd NL: The adipose stromal vascular fraction as a complex cellular source for tissue engineering applications. Tissue Eng Part B Rev. 24:289–299. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Heo JS, Choi Y, Kim HS and Kim HO: Comparison of molecular profiles of human mesenchymal stem cells derived from bone marrow, umbilical cord blood, placenta and adipose tissue. Int J Mol Med. 37:115–125. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Naderi N, Combellack EJ, Griffin M, Sedaghati T, Javed M, Findlay MW, Wallace CG, Mosahebi A, Butler PE, Seifalian AM, et al: The regenerative role of adipose-derived stem cells (ADSC) in plastic and reconstructive surgery. Int Wound J. 14:112–124. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Sugihara H, Yonemitsu N, Miyabara S and Yun K: Primary cultures of unilocular fat cells: Characteristics of growth in vitro and changes in differentiation properties. Differentiation. 31:42–49. 1986. View Article : Google Scholar : PubMed/NCBI

15 

Jumabay M and Boström KI: Dedifferentiated fat cells: A cell source for regenerative medicine. World J Stem Cells. 7:1202–1214. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Kishimoto N, Momota Y, Hashimoto Y, Tatsumi S, Ando K, Omasa T and Kotani J: The osteoblastic differentiation ability of human dedifferentiated fat cells is higher than that of adipose stem cells from the buccal fat pad. Clin Oral Investig. 18:1893–1901. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Watson JE, Patel NA, Carter G, Moor A, Patel R, Ghansah T, Mathur A, Murr MM, Bickford P, Gould LJ, et al: Comparison of markers and functional attributes of human adipose-derived stem cells and dedifferentiated adipocyte cells from subcutaneous fat of an obese diabetic donor. Adv Wound Care (New Rochelle). 3:219–228. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Saler M, Caliogna L, Botta L, Benazzo F, Riva F and Gastaldi G: hASC and DFAT, multipotent stem cells for regenerative medicine: A comparison of their potential differentiation in vitro. Int J Mol Sci. 18:182017. View Article : Google Scholar : PubMed/NCBI

19 

Reumann MK, Linnemann C, Aspera-Werz RH, Arnold S, Held M, Seeliger C, Nussler AK and Ehnert S: Donor site location is critical for proliferation, stem cell capacity, and osteogenic differentiation of adipose mesenchymal stem/stromal cells: Implications for bone tissue engineering. Int J Mol Sci. 19:18682018. View Article : Google Scholar : PubMed/NCBI

20 

Bi H, Li H, Zhang C, Mao Y, Nie F, Xing Y, Sha W, Wang X, Irwin DM and Tan H: Stromal vascular fraction promotes migration of fibroblasts and angiogenesis through regulation of extracellular matrix in the skin wound healing process. Stem Cell Res Ther. 10:3022019. View Article : Google Scholar : PubMed/NCBI

21 

Robinson MD, McCarthy DJ and Smyth GK: edgeR: A bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 26:139–140. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Tansriratanawong K, Tabei I, Ishikawa H, Ohyama A, Toyomura J and Sato S: Characterization and comparative DNA methylation profiling of four adipogenic genes in adipose-derived stem cells and dedifferentiated fat cells from aging subjects. Hum Cell. 33:974–989. 2020. View Article : Google Scholar : PubMed/NCBI

23 

Shukla L, Yuan Y, Shayan R, Greening DW and Karnezis T: Fat therapeutics: The clinical capacity of adipose-derived stem cells and exosomes for human disease and tissue regeneration. Front Pharmacol. 11:1582020. View Article : Google Scholar : PubMed/NCBI

24 

Baer PC: Adipose-derived mesenchymal stromal/stem cells: An update on their phenotype in vivo and in vitro. World J Stem Cells. 6:256–265. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Brooks AES, Iminitoff M, Williams E, Damani T, Jackson-Patel V, Fan V, James J, Dunbar PR, Feisst V and Sheppard HM: Ex vivo human adipose tissue derived mesenchymal stromal cells (ASC) are a heterogeneous population that demonstrate rapid culture-induced changes. Front Pharmacol. 10:16952020. View Article : Google Scholar : PubMed/NCBI

26 

Kilinc MO, Santidrian A, Minev I, Toth R, Draganov D, Nguyen D, Lander E, Berman M, Minev B and Szalay AA: The ratio of ADSCs to HSC-progenitors in adipose tissue derived SVF may provide the key to predict the outcome of stem-cell therapy. Clin Transl Med. 7:52018. View Article : Google Scholar : PubMed/NCBI

27 

Bourin P, Bunnell BA, Casteilla L, Dominici M, Katz AJ, March KL, Redl H, Rubin JP, Yoshimura K and Gimble JM: Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: A joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT). Cytotherapy. 15:641–648. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Maurizi G, Poloni A, Mattiucci D, Santi S, Maurizi A, Izzi V, Giuliani A, Mancini S, Zingaretti MC, Perugini J, et al: Human white adipocytes convert into ‘rainbow’ adipocytes in vitro. J Cell Physiol. 232:2887–2899. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Shen JF, Sugawara A, Yamashita J, Ogura H and Sato S: Dedifferentiated fat cells: An alternative source of adult multipotent cells from the adipose tissues. Int J Oral Sci. 3:117–124. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Bougaret L, Delort L, Billard H, Lequeux C, Goncalves-Mendes N, Mojallal A, Damour O, Vasson MP and Caldefie-Chezet F: Supernatants of adipocytes from obese versus normal weight women and breast cancer cells: In vitro impact on angiogenesis. J Cell Physiol. 232:1808–1816. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Torres-Torrillas M, Rubio M, Damia E, Cuervo B, Del Romero A, Peláez P, Chicharro D, Miguel L and Sopena JJ: Adipose-derived mesenchymal stem cells: A promising tool in the treatment of musculoskeletal diseases. Int J Mol Sci. 20:202019. View Article : Google Scholar : PubMed/NCBI

32 

Kazama T, Fujie M, Endo T and Kano K: Mature adipocyte-derived dedifferentiated fat cells can transdifferentiate into skeletal myocytes in vitro. Biochem Biophys Res Commun. 377:780–785. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Matsumoto T, Kano K, Kondo D, Fukuda N, Iribe Y, Tanaka N, Matsubara Y, Sakuma T, Satomi A, Otaki M, et al: Mature adipocyte-derived dedifferentiated fat cells exhibit multilineage potential. J Cell Physiol. 215:210–222. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Oki Y, Watanabe S, Endo T and Kano K: Mature adipocyte-derived dedifferentiated fat cells can trans-differentiate into osteoblasts in vitro and in vivo only by all-trans retinoic acid. Cell Struct Funct. 33:211–222. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Diekman BO, Estes BT and Guilak F: The effects of BMP6 overexpression on adipose stem cell chondrogenesis: Interactions with dexamethasone and exogenous growth factors. J Biomed Mater Res A. 93:994–1003. 2010.PubMed/NCBI

36 

Jeon HJ, Yoon KA, An ES, Kang TW, Sim YB, Ahn J, Choi EK, Lee S, Seo KW, Kim YB, et al: Therapeutic effects of human umbilical cord blood-derived mesenchymal stem cells combined with cartilage acellular matrix mediated via bone morphogenic protein 6 in a rabbit model of articular cruciate ligament transection. Stem Cell Rev Rep. 16:596–611. 2020. View Article : Google Scholar : PubMed/NCBI

37 

Sung SE, Hwang M, Kim AY, Lee EM, Lee EJ, Hwang SK, Kim SY, Kim HK and Jeong KS: MyoD overexpressed equine adipose-derived stem cells enhanced myogenic differentiation potential. Cell Transplant. 25:2017–2026. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Zhang X, Zuo X, Yang B, Li Z, Xue Y, Zhou Y, Huang J, Zhao X, Zhou J, Yan Y, et al: MicroRNA directly enhances mitochondrial translation during muscle differentiation. Cell. 158:607–619. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Perrini S, Ficarella R, Picardi E, Cignarelli A, Barbaro M, Nigro P, Peschechera A, Palumbo O, Carella M, De Fazio M, et al: Differences in gene expression and cytokine release profiles highlight the heterogeneity of distinct subsets of adipose tissue-derived stem cells in the subcutaneous and visceral adipose tissue in humans. PLoS One. 8:e578922013. View Article : Google Scholar : PubMed/NCBI

40 

Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Holko M, et al: NCBI GEO: Archive for functional genomics data sets-update. Nucleic Acids Res. 41(D1): D991–D995. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Conley SM, Hickson LJ, Kellogg TA, McKenzie T, Heimbach JK, Taner T, Tang H, Jordan KL, Saadiq IM, Woollard JR, et al: Human obesity induces dysfunction and early senescence in adipose tissue-derived mesenchymal stromal/stem cells. Front Cell Dev Biol. 8:1972020. View Article : Google Scholar : PubMed/NCBI

42 

Prieto González EA: Heterogeneity in adipose stem cells. Adv Exp Med Biol. 1123:119–150. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Nie F, Bi H, Zhang C and Ding P: Differentiation potential and mRNA profiles of human dedifferentiated adipose cells and adipose‑derived stem cells from young donors. Mol Med Rep 23: 47, 2021.
APA
Nie, F., Bi, H., Zhang, C., & Ding, P. (2021). Differentiation potential and mRNA profiles of human dedifferentiated adipose cells and adipose‑derived stem cells from young donors. Molecular Medicine Reports, 23, 47. https://doi.org/10.3892/mmr.2020.11685
MLA
Nie, F., Bi, H., Zhang, C., Ding, P."Differentiation potential and mRNA profiles of human dedifferentiated adipose cells and adipose‑derived stem cells from young donors". Molecular Medicine Reports 23.1 (2021): 47.
Chicago
Nie, F., Bi, H., Zhang, C., Ding, P."Differentiation potential and mRNA profiles of human dedifferentiated adipose cells and adipose‑derived stem cells from young donors". Molecular Medicine Reports 23, no. 1 (2021): 47. https://doi.org/10.3892/mmr.2020.11685
Copy and paste a formatted citation
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Spandidos Publications style
Nie F, Bi H, Zhang C and Ding P: Differentiation potential and mRNA profiles of human dedifferentiated adipose cells and adipose‑derived stem cells from young donors. Mol Med Rep 23: 47, 2021.
APA
Nie, F., Bi, H., Zhang, C., & Ding, P. (2021). Differentiation potential and mRNA profiles of human dedifferentiated adipose cells and adipose‑derived stem cells from young donors. Molecular Medicine Reports, 23, 47. https://doi.org/10.3892/mmr.2020.11685
MLA
Nie, F., Bi, H., Zhang, C., Ding, P."Differentiation potential and mRNA profiles of human dedifferentiated adipose cells and adipose‑derived stem cells from young donors". Molecular Medicine Reports 23.1 (2021): 47.
Chicago
Nie, F., Bi, H., Zhang, C., Ding, P."Differentiation potential and mRNA profiles of human dedifferentiated adipose cells and adipose‑derived stem cells from young donors". Molecular Medicine Reports 23, no. 1 (2021): 47. https://doi.org/10.3892/mmr.2020.11685
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