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Cardiac‑specific deletion of natriuretic peptide receptor A induces differential myocardial expression of circular RNA and mRNA molecules involved in metabolism in mice

  • Authors:
    • Baoying Chen
    • Pan Chang
    • Xi Shen
    • Xiaomeng Zhang
    • Jing Zhang
    • Xihui Wang
    • Jun Yu
  • View Affiliations / Copyright

    Affiliations: Imaging Diagnosis and Treatment Centre, Xi'an International Medical Centre Hospital, Xi'an, Shaanxi 710100, P.R. China, Department of Cardiology, The Second Affiliated Hospital, Xi'an Medical University, Xi'an, Shaanxi 710100, P.R. China, Clinical Experimental Centre, Xi'an International Medical Centre Hospital, Xi'an, Shaanxi 710100, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 50
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    Published online on: November 13, 2020
       https://doi.org/10.3892/mmr.2020.11688
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Abstract

Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are important biological markers and regulators of cardiac function. The natriuretic peptide receptor A (NPRA), also known as NPR1 or guanylyl cyclase A, binds ANP and BNP to initiate transmembrane signal transduction by elevating the intracellular levels of cyclic guanosine monophosphate. However, the effects and mechanisms downstream of NPRA are largely unknown. The aim of the present study was to evaluate the changes in the global pattern of mRNA and circular RNA (circRNA) expression in NPRA‑/‑ and NPRA+/+ myocardium. Differentially expressed mRNA molecules were characterised using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis and were found to be primarily related to metabolic processes. Moreover, circRNA expression was also examined, and a possible competing endogenous RNA network consisting of circRNA, microRNA (miRNA), and mRNA molecules was constructed. The results of this study indicated that NPRA may play a role in cardiac metabolism, which could be mediated by circRNA through endogenous competition mechanisms. These findings may provide insight into future characterisation of various ceRNA network pathways.
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View References

1 

Boerrigter G, Costello-Boerrigter LC and Burnett JC Jr: Natriuretic peptides in the diagnosis and management of chronic heart failure. Heart Fail Clin. 5:501–514. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Schipke J, Roloff K, Kuhn M and Mühlfeld C: Systemic, but not cardiomyocyte-specific, deletion of the natriuretic peptide receptor guanylyl cyclase A increases cardiomyocyte number in neonatal mice. Histochem Cell Biol. 144:365–375. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Cannone V, Cabassi A, Volpi R and Burnett JC Jr: Atrial natriuretic peptide: A molecular target of novel therapeutic approaches to cardio-metabolic disease. Int J Mol Sci. 20:32652019. View Article : Google Scholar : PubMed/NCBI

4 

Hsu MT and Coca-Prados M: Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cells. Nature. 280:339–340. 1979. View Article : Google Scholar : PubMed/NCBI

5 

Ren S, Xin Z, Xu Y, Xu J and Wang G: Construction and analysis of circular RNA molecular regulatory networks in liver cancer. Cell Cycle. 16:2204–2211. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Liu J, Marzluff WF and Sharpless NE: Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA. 19:141–157. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Hansen TB, Wiklund ED, Bramsen JB, Villadsen SB, Statham AL, Clark SJ and Kjems J: MiRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA. EMBO J. 30:4414–4422. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK and Kjems J: Natural RNA circles function as efficient microRNA sponges. Nature. 495:384–388. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, et al: Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 495:333–338. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Ashwal-Fluss R, Meyer M, Pamudurti NR, Ivanov A, Bartok O, Hanan M, Evantal N, Memczak S, Rajewsky N and Kadener S: circRNA biogenesis competes with pre-mRNA splicing. Mol Cell. 56:55–66. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Guo JU, Agarwal V, Guo H and Bartel DP: Expanded identification and characterization of mammalian circular RNAs. Genome Biol. 15:4092014. View Article : Google Scholar : PubMed/NCBI

12 

Huang S, Li X, Zheng H, Si X, Li B, Wei G, Li C, Chen Y, Chen Y, Liao W, et al: Loss of super-enhancer-regulated circRNA Nfix induces cardiac regeneration after myocardial infarction in adult mice. Circulation. 139:2857–2876. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Zhang F, Zhang R, Zhang X, Wu Y, Li X, Zhang S, Hou W, Ding Y, Tian J, Sun L and Kong X: Comprehensive analysis of circRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of atherosclerosis in rabbits. Aging (Albany NY). 10:2266–2283. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Yang F, Li A, Qin Y, Che H, Wang Y, Lv J, Li Y, Li H, Yue E, Ding X, et al: A novel Circular RNA mediates pyroptosis of diabetic cardiomyopathy by functioning as a competing endogenous RNA. Mol Ther Nucleic Acids. 17:636–643. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Zhou B and Yu JW: A novel identified circular RNA, circRNA_010567, promotes myocardial fibrosis via suppressing miR-141 by targeting TGF-β1. Biochem Biophys Res Commun. 487:769–775. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Altesha MA, Ni T, Khan A, Liu K and Zheng X: Circular RNA in cardiovascular disease. J Cell Physiol. 234:5588–5600. 2019. View Article : Google Scholar : PubMed/NCBI

17 

Bayoumi AS, Aonuma T, Teoh JP, Tang YL and Kim IM: Circular noncoding RNAs as potential therapies and circulating biomarkers for cardiovascular diseases. Acta Pharmacol Sin. 39:1100–1109. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Wang K, Long B, Liu F, Wang JX, Liu CY, Zhao B, Zhou LY, Sun T, Wang M, Yu T, et al: A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223. Eur Heart J. 37:2602–2611. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Yang H, Wang H, Shivalila CS, Cheng AW, Shi L and Jaenisch R: One-Step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-Mediated genome engineering. Cell. 154:1370–1379. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Feng GK, Ye JC, Zhang WG, Mei Y, Zhou C, Xiao YT, Li XL, Fan W, Wang F and Zeng MS: Integrin α6 targeted positron emission tomography imaging of hepatocellular carcinoma in mouse models. J Control Release. 310:11–21. 2019. View Article : Google Scholar : PubMed/NCBI

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Yu J, Bulk E, Ji P, Hascher A, Tang M, Metzger R, Marra A, Serve H, Berdel WE, Wiewroth R, et al: The EPHB6 receptor tyrosine kinase is a metastasis suppressor that is frequently silenced by promoter DNA hypermethylation in non-small cell lung cancer. Clin Cancer Res. 16:2275–2283. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Zhao HK, Chen BY, Chang R, Wang JB, Ni F, Yang L, Dong XC, Sun SH, Zhao G, Fang W, et al: Vasonatrin peptide, a novel protector of dopaminergic neurons against the injuries induced by n-methyl-4-phenylpyridiniums. Peptides. 49:117–122. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Lu Y, Xie L and Chen J: A novel procedure for absolute real-time quantification of gene expression patterns. Plant Methods. 8:92012. View Article : Google Scholar : PubMed/NCBI

25 

Wan QQ, Wu D and Ye QF: Candidate genes as biomarkers in Lipopolysaccharide-Induced acute respiratory distress syndrome based on mRNA expression profile by Next-Generation RNA-Seq analysis. Biomed Res Int. 2018:43847972018. View Article : Google Scholar : PubMed/NCBI

26 

Babraham Bioinformatics-FastQC A Quality Control tool for High Throughput Sequence Data. PubMed/NCBI

27 

Kim D, Langmead B and Salzberg SL: HISAT: A fast spliced aligner with low memory requirements. Nat Methods. 12:357–360. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Poole CJ, Lodh A, Choi JH and van Riggelen J: MYC deregulates TET1 and TET2 expression to control global DNA (hydroxy)methylation and gene expression to maintain a neoplastic phenotype in T-ALL. Epigenetics Chromatin. 12:412019. View Article : Google Scholar : PubMed/NCBI

29 

Benjamini Y and Hochberg Y: Controlling the false discovery rate: A practical and powerful approach to multiple testing. J R Stat Soc Ser B (Methodological). 57:289–300. 1995.

30 

Aebersold R and Mann M: Mass-spectrometric exploration of proteome structure and function. Nature. 537:347–355. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Kanehisa M, Furumichi M, Tanabe M, Sato Y and Morishima K: KEGG: New perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 45:D353–D361. 2017. View Article : Google Scholar : PubMed/NCBI

32 

He R, Liu P, Xie X, Zhou Y, Liao Q, Xiong W, Li X, Li G, Zeng Z and Tang H: circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a. J Exp Clin Cancer Res. 36:1452017. View Article : Google Scholar : PubMed/NCBI

33 

Lv C, Sun L, Guo Z, Li H, Kong D, Xu B, Lin L, Liu T, Guo D, Zhou J and Li Y: Circular RNA regulatory network reveals cell-cell crosstalk in acute myeloid leukemia extramedullary infiltration. J Transl Med. 16:3612018. View Article : Google Scholar : PubMed/NCBI

34 

Lin SP, Ye S, Long Y, Fan Y, Mao HF, Chen MT and Ma QJ: Circular RNA expression alterations are involved in OGD/R-induced neuron injury. Biochem Biophys Res Commun. 471:52–56. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Zhou J, Xiong Q, Chen H, Yang C and Fan Y: Identification of the spinal expression profile of non-coding rnas involved in neuropathic pain following spared nerve injury by sequence analysis. Front Mol Neurosci. 10:912017. View Article : Google Scholar : PubMed/NCBI

36 

Li JH, Liu S, Zhou H, Qu LH and Yang JH: StarBase v2.0: Decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res. 42:D92–D97. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Team R: R Core Team. R A Language and Environment for Statistical Computing 2014. R Foundation for Statistical Computing. 2008.

38 

Li M, Duan L, Li Y and Liu B: Long noncoding RNA/circular noncoding RNA-miRNA-mRNA axes in cardiovascular diseases. Life Sci. 233:1164402019. View Article : Google Scholar : PubMed/NCBI

39 

Schlueter N, de Sterke A, Willmes DM, Spranger J, Jordan J and Birkenfeld AL: Metabolic actions of natriuretic peptides and therapeutic potential in the metabolic syndrome. Pharmacol Ther. 144:12–27. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Wu W, Shi F, Liu D, Ceddia RP, Gaffin R, Wei W, Fang H, Lewandowski ED and Collins S: Enhancing natriuretic peptide signaling in adipose tissue, but not in muscle, protects against diet-induced obesity and insulin resistance. Sci Signal. 10:eaam68702017. View Article : Google Scholar : PubMed/NCBI

41 

Zois NE, Bartels ED, Hunter I, Kousholt BS, Olsen LH and Goetze JP: Natriuretic peptides in cardiometabolic regulation and disease. Nat Rev Cardiol. 11:403–412. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Verboven K, Hansen D, Jocken JWE and Blaak EE: Natriuretic peptides in the control of lipid metabolism and insulin sensitivity. Obes Rev. 18:1243–1259. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Ding B, Lou W, Xu L and Fan W: Non-coding RNA in drug resistance of hepatocellular carcinoma. Biosci Rep. 38:BSR201809152018. View Article : Google Scholar : PubMed/NCBI

44 

Xuan L, Qu L, Zhou H, Wang P, Yu H, Wu T, Wang X, Li Q, Tian L, Liu M and Sun Y: Circular RNA: A novel biomarker for progressive laryngeal cancer. Am J Transl Res. 8:932–939. 2016.PubMed/NCBI

45 

Fernández-Cao JC and Doepking C: Role of ethnicity and environment on lifestyle and cardiometabolic profile in the Native American Mapuche population: Protocol for a systematic review and meta-analysis. Medicine (Baltimore). 97:e133542018. View Article : Google Scholar : PubMed/NCBI

46 

Salmena L, Poliseno L, Tay Y, Kats L and Pandolfi PP: A ceRNA hypothesis: The Rosetta Stone of a hidden RNA language? Cell. 146:353–358. 2011. View Article : Google Scholar : PubMed/NCBI

47 

Wilusz JE: A 360° view of circular RNAs: From biogenesis to functions. Wiley Interdiscip Rev RNA. 9:e14782018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen B, Chang P, Shen X, Zhang X, Zhang J, Wang X and Yu J: Cardiac‑specific deletion of natriuretic peptide receptor A induces differential myocardial expression of circular RNA and mRNA molecules involved in metabolism in mice. Mol Med Rep 23: 50, 2021.
APA
Chen, B., Chang, P., Shen, X., Zhang, X., Zhang, J., Wang, X., & Yu, J. (2021). Cardiac‑specific deletion of natriuretic peptide receptor A induces differential myocardial expression of circular RNA and mRNA molecules involved in metabolism in mice. Molecular Medicine Reports, 23, 50. https://doi.org/10.3892/mmr.2020.11688
MLA
Chen, B., Chang, P., Shen, X., Zhang, X., Zhang, J., Wang, X., Yu, J."Cardiac‑specific deletion of natriuretic peptide receptor A induces differential myocardial expression of circular RNA and mRNA molecules involved in metabolism in mice". Molecular Medicine Reports 23.1 (2021): 50.
Chicago
Chen, B., Chang, P., Shen, X., Zhang, X., Zhang, J., Wang, X., Yu, J."Cardiac‑specific deletion of natriuretic peptide receptor A induces differential myocardial expression of circular RNA and mRNA molecules involved in metabolism in mice". Molecular Medicine Reports 23, no. 1 (2021): 50. https://doi.org/10.3892/mmr.2020.11688
Copy and paste a formatted citation
x
Spandidos Publications style
Chen B, Chang P, Shen X, Zhang X, Zhang J, Wang X and Yu J: Cardiac‑specific deletion of natriuretic peptide receptor A induces differential myocardial expression of circular RNA and mRNA molecules involved in metabolism in mice. Mol Med Rep 23: 50, 2021.
APA
Chen, B., Chang, P., Shen, X., Zhang, X., Zhang, J., Wang, X., & Yu, J. (2021). Cardiac‑specific deletion of natriuretic peptide receptor A induces differential myocardial expression of circular RNA and mRNA molecules involved in metabolism in mice. Molecular Medicine Reports, 23, 50. https://doi.org/10.3892/mmr.2020.11688
MLA
Chen, B., Chang, P., Shen, X., Zhang, X., Zhang, J., Wang, X., Yu, J."Cardiac‑specific deletion of natriuretic peptide receptor A induces differential myocardial expression of circular RNA and mRNA molecules involved in metabolism in mice". Molecular Medicine Reports 23.1 (2021): 50.
Chicago
Chen, B., Chang, P., Shen, X., Zhang, X., Zhang, J., Wang, X., Yu, J."Cardiac‑specific deletion of natriuretic peptide receptor A induces differential myocardial expression of circular RNA and mRNA molecules involved in metabolism in mice". Molecular Medicine Reports 23, no. 1 (2021): 50. https://doi.org/10.3892/mmr.2020.11688
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