Open Access

Cardiac‑specific deletion of natriuretic peptide receptor A induces differential myocardial expression of circular RNA and mRNA molecules involved in metabolism in mice

  • Authors:
    • Baoying Chen
    • Pan Chang
    • Xi Shen
    • Xiaomeng Zhang
    • Jing Zhang
    • Xihui Wang
    • Jun Yu
  • View Affiliations

  • Published online on: November 13, 2020     https://doi.org/10.3892/mmr.2020.11688
  • Article Number: 50
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are important biological markers and regulators of cardiac function. The natriuretic peptide receptor A (NPRA), also known as NPR1 or guanylyl cyclase A, binds ANP and BNP to initiate transmembrane signal transduction by elevating the intracellular levels of cyclic guanosine monophosphate. However, the effects and mechanisms downstream of NPRA are largely unknown. The aim of the present study was to evaluate the changes in the global pattern of mRNA and circular RNA (circRNA) expression in NPRA‑/‑ and NPRA+/+ myocardium. Differentially expressed mRNA molecules were characterised using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis and were found to be primarily related to metabolic processes. Moreover, circRNA expression was also examined, and a possible competing endogenous RNA network consisting of circRNA, microRNA (miRNA), and mRNA molecules was constructed. The results of this study indicated that NPRA may play a role in cardiac metabolism, which could be mediated by circRNA through endogenous competition mechanisms. These findings may provide insight into future characterisation of various ceRNA network pathways.
View Figures
View References

Related Articles

Journal Cover

January-2021
Volume 23 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Chen B, Chang P, Shen X, Zhang X, Zhang J, Wang X and Yu J: Cardiac‑specific deletion of natriuretic peptide receptor A induces differential myocardial expression of circular RNA and mRNA molecules involved in metabolism in mice. Mol Med Rep 23: 50, 2021
APA
Chen, B., Chang, P., Shen, X., Zhang, X., Zhang, J., Wang, X., & Yu, J. (2021). Cardiac‑specific deletion of natriuretic peptide receptor A induces differential myocardial expression of circular RNA and mRNA molecules involved in metabolism in mice. Molecular Medicine Reports, 23, 50. https://doi.org/10.3892/mmr.2020.11688
MLA
Chen, B., Chang, P., Shen, X., Zhang, X., Zhang, J., Wang, X., Yu, J."Cardiac‑specific deletion of natriuretic peptide receptor A induces differential myocardial expression of circular RNA and mRNA molecules involved in metabolism in mice". Molecular Medicine Reports 23.1 (2021): 50.
Chicago
Chen, B., Chang, P., Shen, X., Zhang, X., Zhang, J., Wang, X., Yu, J."Cardiac‑specific deletion of natriuretic peptide receptor A induces differential myocardial expression of circular RNA and mRNA molecules involved in metabolism in mice". Molecular Medicine Reports 23, no. 1 (2021): 50. https://doi.org/10.3892/mmr.2020.11688