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Hyperoxia sensitizes hypoxic HeLa cells to ionizing radiation by downregulating HIF‑1α and VEGF expression

  • Authors:
    • Dan Dong
    • Yan Fu
    • Feng Chen
    • Jing Zhang
    • Haiyan Jia
    • Jia Li
    • Huailin Wang
    • Jihong Wen
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
    Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 62
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    Published online on: November 18, 2020
       https://doi.org/10.3892/mmr.2020.11700
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Abstract

The current study investigated whether hyperoxia may reverse hypoxia‑induced radioresistance (RR) in cervical cancer. Human HeLa cells exposed to hypoxic, normoxic or hyperoxic conditions were irradiated using X‑rays. Cell proliferation and apoptosis were analyzed using MTT assays and flow cytometry. The expression levels of hypoxia‑inducible factor‑1α (HIF‑1α), VEGF165, VEGFRs, Akt and ERK were measured via western blotting and/or ELISA. The results demonstrated that hypoxia stimulated HIF‑1α and VEGF expression, and induced RR in HeLa cells. The administration of recombinant VEGF or the forced expression of VEGF promoted RR, whereas inactivating HIF‑1α or blocking the VEGF‑VEGFR interaction abrogated hypoxia‑induced RR. Notably, hyperoxia decreased the level of hypoxia‑stimulated HIF‑1α and VEGF, and enhanced radiosensitivity in hypoxic HeLa cells. The results demonstrated that hyperoxia suppressed the hypoxia‑activated Akt and ERK signaling pathways in HeLa cells. Therefore, a high O2 concentration may be considered as a radiotherapeutic sensitizer for hypoxic HeLa cells.
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1 

Wu WJ, Shen Y, Sui J, Li CY, Yang S, Xu SY, Zhang M, Yin LH, Pu YP and Liang GY: Integrated analysis of long noncoding RNA competing interactions revealed potential biomarkers in cervical cancer: Based on a public database. Mol Med Rep. 17:7845–7858. 2018.PubMed/NCBI

2 

Cohen PA, Jhingran A, Oaknin A and Denny L: Cervical cancer. Lancet. 393:169–182. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Lin CL, Lee CH, Chen CM, Cheng CW, Chen PN, Ying TH and Hsieh YH: Protodioscin induces apoptosis through ROS-mediated endoplasmic reticulum stress via the JNK/p38 activation pathways in human cervical cancer cells. Cell Physiol Biochem. 46:322–334. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Pranatharthi A, Thomas P, Udayashankar AH, Bhavani C, Suresh SB, Krishna S, Thatte J, Srikantia N, Ross CR and Srivastava S: RhoC regulates radioresistance via crosstalk of ROCK2 with the DNA repair machinery in cervical cancer. J Exp Clin Cancer Res. 38:3922019. View Article : Google Scholar : PubMed/NCBI

5 

Liu C, Lin Q and Yun Z: Cellular and molecular mechanisms underlying oxygen-dependent radiosensitivity. Radiat Res. 183:487–496. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Hennessey D, Martin LM, Atzberger A, Lynch TH, Hollywood D and Marignol L: Exposure to hypoxia following irradiation increases radioresistance in prostate cancer cells. Urol Oncol. 31:1106–1116. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Hong BJ, Kim J, Jeong H, Bok S, Kim YE and Ahn GO: Tumor hypoxia and reoxygenation: The yin and yang for radiotherapy. Radiat Oncol J. 34:239–249. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Candelaria M, Garcia-Arias A, Cetina L and Duenas-Gonzalez A: Radiosensitizers in cervical cancer. Cisplatin and beyond. Radiat Oncol. 1:152006. View Article : Google Scholar : PubMed/NCBI

9 

Tamari K, Sano K, Li Z, Seo Y, Otani K, Tatekawa S, Toratani M, Takaoka Y, Takahashi Y, Minami K, et al: Ro 90–7501 is a novel radiosensitizer for cervical cancer cells that inhibits ATM phosphorylation. Anticancer Res. 39:4805–4810. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Mabuchi S and Kimura T: Nedaplatin: A radiosensitizing agent for patients with cervical cancer. Chemother Res Pract. 2011:9631592011.PubMed/NCBI

11 

Javvadi P, Segan AT, Tuttle SW and Koumenis C: The chemopreventive agent curcumin is a potent radiosensitizer of human cervical tumor cells via increased reactive oxygen species production and overactivation of the mitogen-activated protein kinase pathway. Mol Pharmacol. 73:1491–1501. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Vaupel P: Oxygenation of human tumors. Strahlenther Onkol. 166:377–386. 1990.PubMed/NCBI

13 

Mayer R, Hamilton-Farrell MR, van der Kleij AJ, Schmutz J, Granström G, Sicko Z, Melamed Y, Carl UM, Hartmann KA, Jansen EC, et al: Hyperbaric oxygen and radiotherapy. Strahlenther Onkol. 181:113–123. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Becker A, Kuhnt T, Liedtke H, Krivokuca A, Bloching M and Dunst J: Oxygenation measurements in head and neck cancers during hyperbaric oxygenation. Strahlenther Onkol. 178:105–108. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Brizel DM, Hage WD, Dodge RK, Munley MT, Piantadosi CA and Dewhirst MW: Hyperbaric oxygen improves tumor radiation response significantly more than carbogen/nicotinamide. Radiat Res. 147:715–720. 1997. View Article : Google Scholar : PubMed/NCBI

16 

Hartmann KA, van der Kleij AJ, Carl UM, Hulshof MC, Willers R and Sminia P: Effects of hyperbaric oxygen and normobaric carbogen on the radiation response of the rat rhabdomyosarcoma R1H. Int J Radiat Oncol Biol Phys. 51:1037–1044. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Nordsmark M, Maxwell RJ, Horsman MR, Bentzen SM and Overgaard J: The effect of hypoxia and hyperoxia on nucleoside triphosphate/inorganic phosphate, pO2 and radiation response in an experimental tumour model. Br J Cancer. 76:1432–1439. 1997. View Article : Google Scholar : PubMed/NCBI

18 

Pietrofesa RA, Velalopoulou A, Lehman SL, Arguiri E, Solomides P, Koch CJ, Mishra OP, Koumenis C, Goodwin TJ and Christofidou-Solomidou M: Novel double-hit model of radiation and hyperoxia-induced oxidative cell damage relevant to space travel. Int J Mol Sci. 17:9532016. View Article : Google Scholar : PubMed/NCBI

19 

Hofer T, Desbaillets I, Hopfl G, Wenger RH and Gassmann M: Characterization of HIF-1 alpha overexpressing HeLa cells and implications for gene therapy. Comp Biochem Physiol C Toxicol Pharmacol. 133:475–481. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Masoud GN and Li W: HIF-1α pathway: Role, regulation and intervention for cancer therapy. Acta Pharm Sin B. 5:378–389. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Park JH, Yoon J and Park B: Pomolic acid suppresses HIF1α/VEGF-mediated angiogenesis by targeting p38-MAPK and mTOR signaling cascades. Phytomedicine. 23:1716–1726. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Chen JY, Gu ZJ, Wu MX, Yang Y, Zhang JH, Ou JS, Zuo ZY, Wang JF and Chen YX: C-reactive protein can upregulate VEGF expression to promote ADSC-induced angiogenesis by activating HIF-1α via CD64/PI3k/Akt and MAPK/ERK signaling pathways. Stem Cell Res Ther. 7:1142016. View Article : Google Scholar : PubMed/NCBI

23 

Miyasaka A, Oda K, Ikeda Y, Sone K, Fukuda T, Inaba K, Makii C, Enomoto A, Hosoya N, Tanikawa M, et al: PI3K/mTOR pathway inhibition overcomes radioresistance via suppression of the HIF1-α/VEGF pathway in endometrial cancer. Gynecol Oncol. 138:174–180. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Fechner G, Dederichs F, Schmidt D, Muller S, Vaupel P and Albers P: Hyperoxia-induced improvement of the in vitro response to gemcitabine in transitional cell carcinoma. Anticancer Res. 25:3413–3418. 2005.PubMed/NCBI

25 

Liu Q, He X, Liu Y, Du B, Wang X, Zhang W, Jia P, Dong J, Ma J, Wang X, et al: NADPH oxidase-mediated generation of reactive oxygen species: A new mechanism for X-ray-induced HeLa cell death. Biochem Biophys Res Commun. 377:775–779. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Lu J, Suzuki T, Lu S and Suzuki N: Involvement of glyceraldehyde-3-phosphate dehydrogenase in the X-Ray resistance of HeLa cells. Biosci Biotechnol Biochem. 72:2432–2435. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Lake AC, Vassy R, Di Benedetto M, Lavigne D, Visage CL, Perret GY and Letourneur D: Low molecular weight fucoidan increases VEGF165-induced endothelial cell migration by enhancing VEGF165 binding to VEGFR-2 and NRP1. J Biol Chem. 281:37844–37852. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Wu XJ, Zhu JW, Jing J, Xue D, Liu H, Zheng M and Lu ZF: VEGF165 modulates proliferation, adhesion, migration and differentiation of cultured human outer root sheath cells from central hair follicle epithelium through VEGFR-2 activation in vitro. J Dermatol Sci. 73:152–160. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Zhang H, Han Y, Tao J, Liu S, Yan C and Li S: Cellular repressor of E1A-stimulated genes regulates vascular endothelial cell migration by the ILK/AKT/mTOR/VEGF(165) signaling pathway. Exp Cell Res. 317:2904–2913. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Tsuzuki T, Okada H, Shindoh H, Shimoi K, Nishigaki A and Kanzaki H: Effects of the hypoxia-inducible factor-1 inhibitor echinomycin on vascular endothelial growth factor production and apoptosis in human ectopic endometriotic stromal cells. Gynecol Endocrinol. 32:323–328. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Walsh CM, Chvanov M, Haynes LP, Petersen OH, Tepikin AV and Burgoyne RD: Role of phosphoinositides in STIM1 dynamics and store-operated calcium entry. Biochem J. 425:159–168. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Ma S, Musa T and Bag J: Reduced stability of mitogen-activated protein kinase kinase-2 mRNA and phosphorylation of poly(A)-binding protein (PABP) in cells overexpressing PABP. J Biol Chem. 281:3145–3156. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Lin C, McGough R, Aswad B, Block JA and Terek R: Hypoxia induces HIF-1alpha and VEGF expression in chondrosarcoma cells and chondrocytes. J Orthop Res. 22:1175–1181. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Fu Z, Chen D, Cheng H and Wang F: Hypoxia-inducible factor-1α protects cervical carcinoma cells from apoptosis induced by radiation via modulation of vascular endothelial growth factor and p53 under hypoxia. Med Sci Monitor. 21:318–325. 2015. View Article : Google Scholar

35 

Shibuya M: VEGF-VEGFR system as a target for suppressing inflammation and other diseases. Endocr Metab Immune Disord Drug Targets. 15:135–144. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Gupta AK, Bakanauskas VJ, Cerniglia GJ, Cheng Y, Bernhard EJ, Muschel RJ and McKenna WG: The Ras radiation resistance pathway. Cancer Res. 61:4278–4282. 2001.PubMed/NCBI

37 

McKenna WG, Muschel RJ, Gupta AK, Hahn SM and Bernhard EJ: The RAS signal transduction pathway and its role in radiation sensitivity. Oncogene. 22:5866–5875. 2003. View Article : Google Scholar : PubMed/NCBI

38 

Shimura T, Kakuda S, Ochiai Y, Kuwahara Y, Takai Y and Fukumoto M: Targeting the AKT/GSK3beta/cyclin D1/Cdk4 survival signaling pathway for eradication of tumor radioresistance acquired by fractionated radiotherapy. Int J Radiat Oncol Biol Phys. 80:540–548. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Vaupel P and Mayer A: Hypoxia in cancer: Significance and impact on clinical outcome. Cancer Metastasis Rev. 26:225–239. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Liao D and Johnson RS: Hypoxia: A key regulator of angiogenesis in cancer. Cancer Metastasis Rev. 26:281–290. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Thomlinson RH and Gray LH: The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer. 9:539–549. 1955. View Article : Google Scholar : PubMed/NCBI

42 

Bennett MH, Feldmeier J, Smee R and Milross C: Hyperbaric oxygenation for tumour sensitisation to radiotherapy. Cochrane Database Syst Rev. 4:CD0050072018.PubMed/NCBI

43 

Gorski DH, Beckett MA, Jaskowiak NT, Calvin DP, Mauceri HJ, Salloum RM, Seetharam S, Koons A, Hari DM, Kufe DW and Weichselbaum RR: Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Res. 59:3374–3378. 1999.PubMed/NCBI

44 

Ferrara N, Gerber HP and LeCouter J: The biology of VEGF and its receptors. Nat Med. 9:669–676. 2003. View Article : Google Scholar : PubMed/NCBI

45 

Hiratsuka S, Minowa O, Kuno J, Noda T and Shibuya M: Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc Natl Acad Sci USA. 95:9349–9354. 1998. View Article : Google Scholar : PubMed/NCBI

46 

Selvaraj D, Gangadharan V, Michalski CW, Kurejova M, Stösser S, Srivastava K, Schweizerhof M, Waltenberger J, Ferrara N, Heppenstall P, et al: A functional role for VEGFR1 expressed in peripheral sensory neurons in cancer pain. Cancer Cell. 27:780–796. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Ding ZY, Huang YJ, Tang JD, Li G, Jiang PQ and Wu HT: Silencing of hypoxia-inducible factor-1α promotes thyroid cancer cell apoptosis and inhibits invasion by downregulating WWP2, WWP9, VEGF and VEGFR2. Exp Ther Med. 12:3735–3741. 2016. View Article : Google Scholar : PubMed/NCBI

48 

Gupta VK, Jaskowiak NT, Beckett MA, Mauceri HJ, Grunstein J, Johnson RS, Calvin DA, Nodzenski E, Pejovic M, Kufe DW, et al: Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance. Cancer J. 8:47–54. 2002. View Article : Google Scholar : PubMed/NCBI

49 

Chen YA, Tzeng DTW, Huang YP, Lin CJ, Lo UG, Wu CL, Lin H, Hsieh JT, Tang CH and Lai CH: Antrocin sensitizes prostate cancer cells to radiotherapy through inhibiting PI3K/AKT and MAPK signaling pathways. Cancers (Basel). 11:342018. View Article : Google Scholar : PubMed/NCBI

50 

Mazzatti DJ, Lee YJ, Helt CE, O'Reilly MA and Keng PC: p53 modulates radiation sensitivity independent of p21 transcriptional activation. Am J Clin Oncol. 28:43–50. 2005. View Article : Google Scholar : PubMed/NCBI

51 

Lee KB, Kim KR, Huh TL and Lee YM: Proton induces apoptosis of hypoxic tumor cells by the p53-dependent and p38/JNK MAPK signaling pathways. Int J Oncol. 33:1247–1256. 2008.PubMed/NCBI

52 

Yoon TM, Kim SA, Lee DH, Lee JK, Park YL, Lee KH, Chung IJ, Joo YE and Lim SC: EGR1 regulates radiation-induced apoptosis in head and neck squamous cell carcinoma. Oncol Rep. 33:1717–1722. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Dong D, Fu Y, Chen F, Zhang J, Jia H, Li J, Wang H and Wen J: Hyperoxia sensitizes hypoxic HeLa cells to ionizing radiation by downregulating HIF‑1α and VEGF expression. Mol Med Rep 23: 62, 2021.
APA
Dong, D., Fu, Y., Chen, F., Zhang, J., Jia, H., Li, J. ... Wen, J. (2021). Hyperoxia sensitizes hypoxic HeLa cells to ionizing radiation by downregulating HIF‑1α and VEGF expression. Molecular Medicine Reports, 23, 62. https://doi.org/10.3892/mmr.2020.11700
MLA
Dong, D., Fu, Y., Chen, F., Zhang, J., Jia, H., Li, J., Wang, H., Wen, J."Hyperoxia sensitizes hypoxic HeLa cells to ionizing radiation by downregulating HIF‑1α and VEGF expression". Molecular Medicine Reports 23.1 (2021): 62.
Chicago
Dong, D., Fu, Y., Chen, F., Zhang, J., Jia, H., Li, J., Wang, H., Wen, J."Hyperoxia sensitizes hypoxic HeLa cells to ionizing radiation by downregulating HIF‑1α and VEGF expression". Molecular Medicine Reports 23, no. 1 (2021): 62. https://doi.org/10.3892/mmr.2020.11700
Copy and paste a formatted citation
x
Spandidos Publications style
Dong D, Fu Y, Chen F, Zhang J, Jia H, Li J, Wang H and Wen J: Hyperoxia sensitizes hypoxic HeLa cells to ionizing radiation by downregulating HIF‑1α and VEGF expression. Mol Med Rep 23: 62, 2021.
APA
Dong, D., Fu, Y., Chen, F., Zhang, J., Jia, H., Li, J. ... Wen, J. (2021). Hyperoxia sensitizes hypoxic HeLa cells to ionizing radiation by downregulating HIF‑1α and VEGF expression. Molecular Medicine Reports, 23, 62. https://doi.org/10.3892/mmr.2020.11700
MLA
Dong, D., Fu, Y., Chen, F., Zhang, J., Jia, H., Li, J., Wang, H., Wen, J."Hyperoxia sensitizes hypoxic HeLa cells to ionizing radiation by downregulating HIF‑1α and VEGF expression". Molecular Medicine Reports 23.1 (2021): 62.
Chicago
Dong, D., Fu, Y., Chen, F., Zhang, J., Jia, H., Li, J., Wang, H., Wen, J."Hyperoxia sensitizes hypoxic HeLa cells to ionizing radiation by downregulating HIF‑1α and VEGF expression". Molecular Medicine Reports 23, no. 1 (2021): 62. https://doi.org/10.3892/mmr.2020.11700
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