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Resveratrol alleviates oxygen/glucose deprivation/reoxygenation‑induced neuronal damage through induction of mitophagy

  • Authors:
    • Ming Ye
    • Hui Wu
    • Shuguo Li
  • View Affiliations / Copyright

    Affiliations: Department of Geriatrics, Yichang Central People's Hospital, Yichang, Hubei 443003, P.R. China, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei 443003, P.R. China
    Copyright: © Ye et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 73
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    Published online on: November 20, 2020
       https://doi.org/10.3892/mmr.2020.11711
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Abstract

Resveratrol confers neuroprotective effects in cerebral ischemia; however, the involvement of mitophagy in the neuroprotective function of resveratrol remains unclear. The aim of the present study was to investigate whether resveratrol exerts neuroprotective effects on primary cortical neurons subjected to oxygen/glucose deprivation/reoxygenation (OGD/R) via modulating mitophagy. The data demonstrated that resveratrol at 1‑10 µM during reoxygenation improved cell viability and suppressed apoptosis following OGD/R in a concentration‑dependent manner. Moreover, resveratrol alleviated OGD/R‑induced loss of mitochondrial membrane potential and excessive oxidative stress. Confocal imaging of LC3 and TOM20 antibody‑labeled mitochondria, as well as western blot analysis, demonstrated that mitophagy was further enhanced following resveratrol treatment. In addition, resveratrol was revealed to stimulate the phosphatase and tensin homolog‑induced kinase 1/Parkin pathway. Mitophagy inhibition then inhibited the protective effects of resveratrol. These results indicated that resveratrol exerts its protective effects against OGD/R damage, at least in part, by promoting mitophagy.
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Copy and paste a formatted citation
Spandidos Publications style
Ye M, Wu H and Li S: Resveratrol alleviates oxygen/glucose deprivation/reoxygenation‑induced neuronal damage through induction of mitophagy. Mol Med Rep 23: 73, 2021.
APA
Ye, M., Wu, H., & Li, S. (2021). Resveratrol alleviates oxygen/glucose deprivation/reoxygenation‑induced neuronal damage through induction of mitophagy. Molecular Medicine Reports, 23, 73. https://doi.org/10.3892/mmr.2020.11711
MLA
Ye, M., Wu, H., Li, S."Resveratrol alleviates oxygen/glucose deprivation/reoxygenation‑induced neuronal damage through induction of mitophagy". Molecular Medicine Reports 23.1 (2021): 73.
Chicago
Ye, M., Wu, H., Li, S."Resveratrol alleviates oxygen/glucose deprivation/reoxygenation‑induced neuronal damage through induction of mitophagy". Molecular Medicine Reports 23, no. 1 (2021): 73. https://doi.org/10.3892/mmr.2020.11711
Copy and paste a formatted citation
x
Spandidos Publications style
Ye M, Wu H and Li S: Resveratrol alleviates oxygen/glucose deprivation/reoxygenation‑induced neuronal damage through induction of mitophagy. Mol Med Rep 23: 73, 2021.
APA
Ye, M., Wu, H., & Li, S. (2021). Resveratrol alleviates oxygen/glucose deprivation/reoxygenation‑induced neuronal damage through induction of mitophagy. Molecular Medicine Reports, 23, 73. https://doi.org/10.3892/mmr.2020.11711
MLA
Ye, M., Wu, H., Li, S."Resveratrol alleviates oxygen/glucose deprivation/reoxygenation‑induced neuronal damage through induction of mitophagy". Molecular Medicine Reports 23.1 (2021): 73.
Chicago
Ye, M., Wu, H., Li, S."Resveratrol alleviates oxygen/glucose deprivation/reoxygenation‑induced neuronal damage through induction of mitophagy". Molecular Medicine Reports 23, no. 1 (2021): 73. https://doi.org/10.3892/mmr.2020.11711
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