Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
January-2021 Volume 23 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2021 Volume 23 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Oncogenic potential of macrophage‑capping protein in clear cell renal cell carcinoma

  • Authors:
    • Zhuang-Fei Chen
    • Ze-Hai Huang
    • Shi-Jun Chen
    • Yao-Dong Jiang
    • Zi-Ke Qin
    • Shao-Bin Zheng
    • Tong Chen
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Urology, Cancer Center, Sun Yat‑Sen University and State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong 510060, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 80
    |
    Published online on: November 23, 2020
       https://doi.org/10.3892/mmr.2020.11718
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Macrophage‑capping protein (CapG) is a newly characterized oncogene involved in several types of cancer. However, the expression patterns and biological mechanisms of CapG in clear cell renal cell carcinoma (ccRCC) are unclear. The present study aimed to investigate the roles of CapG in the prognosis, proliferation and metastasis of ccRCC. In the present study, the expression of CapG was analyzed by western blotting in 24 paired ccRCC and adjacent normal tissue samples. Another 152 tissue samples from 152 patients with ccRCC were examined by immunohistochemistry. Compared with normal tissue, CapG expression was significantly increased in ccRCC tissue, and high CapG expression was associated with advanced tumor stage, histological grade, lymph node metastasis, and poor overall survival. Moreover, CapG was an independent predictor of survival. Lentivirus‑mediated CapG knockdown significantly inhibited 786‑O cell proliferation, migration, and invasion, induced cell cycle arrest at the G2/M phase, and increased apoptosis in vitro. Microarray analysis indicated that RAC, CDC42 and ERK/MAPK signaling were disrupted by CapG knockdown in 786‑O cells. In conclusion, the present findings indicate that CapG plays an oncogenic role in ccRCC and may represent a potential therapeutic target for this disease.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J and Ficarra V: Renal cell carcinoma. Nat Rev Dis Primers. 3:170092017. View Article : Google Scholar : PubMed/NCBI

2 

Ross K and Jones RJ: Immune checkpoint inhibitors in renal cell carcinoma. Clin Sci (Lond). 131:2627–2642. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Dabestani S, Thorstenson A, Lindblad P, Harmenberg U, Ljungberg B and Lundstam S: Renal cell carcinoma recurrences and metastases in primary non-metastatic patients: A population-based study. World J Urol. 34:1081–1086. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Motzer RJ, Escudier B, McDermott DF, George S, Hammers HJ, Srinivas S, Tykodi SS, Sosman JA, Procopio G, Plimack ER, et al CheckMate 025 Investigators, : Nivolumab versus everolimus in advanced renal-cell carcinoma. N Engl J Med. 373:1803–1813. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Lei C, Lv S, Wang H, Liu C, Zhai Q, Wang S, Cai G, Lu D, Sun Z and Wei Q: Leukemia inhibitory factor receptor suppresses the metastasis of clear cell renal cell carcinoma through negative regulation of the yes-associated protein. DNA Cell Biol. 37:659–669. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Chen ZF, Xiao YJ, Huang ZH, Chen T, Zhao SC, Jiang YD, Wu P and Zheng SB: Quantitative and comparative proteomics analysis in clear cell renal cell carcinoma and adjacent noncancerous tissues by 2-D DIGE. Nan Fang Yi Ke Da Xue Xue Bao. 37:1517–1522. 2017.(In Chinese). PubMed/NCBI

7 

Silacci P, Mazzolai L, Gauci C, Stergiopulos N, Yin HL and Hayoz D: Gelsolin superfamily proteins: Key regulators of cellular functions. Cell Mol Life Sci. 61:2614–2623. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Yu FX, Johnston PA, Südhof TC and Yin HL: gCap39, a calcium ion- and polyphosphoinositide-regulated actin capping protein. Science. 250:1413–1415. 1990. View Article : Google Scholar : PubMed/NCBI

9 

Thompson CC, Ashcroft FJ, Patel S, Saraga G, Vimalachandran D, Prime W, Campbell F, Dodson A, Jenkins RE, Lemoine NR, et al: Pancreatic cancer cells overexpress gelsolin family-capping proteins, which contribute to their cell motility. Gut. 56:95–106. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Renz M, Betz B, Niederacher D, Bender HG and Langowski J: Invasive breast cancer cells exhibit increased mobility of the actin-binding protein CapG. Int J Cancer. 122:1476–1482. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Ichikawa H, Kanda T, Kosugi S, Kawachi Y, Sasaki H, Wakai T and Kondo T: Laser microdissection and two-dimensional difference gel electrophoresis reveal the role of a novel macrophage-capping protein in lymph node metastasis in gastric cancer. J Proteome Res. 12:3780–3791. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Chen Z, Xiao K, Chen S, Huang Z, Ye Y and Chen T: Circular RNA hsa_circ_001895 serves as a sponge of microRNA-296-5p to promote clear cell renal cell carcinoma progression by regulating SOX12. Cancer Sci. 111:713–726. 2020. View Article : Google Scholar : PubMed/NCBI

14 

Kitamura H, Takahashi A, Takei F, Hotta H, Miyao N, Shindo T, Igarashi M, Tachiki H, Kunishima Y, Muranaka T, et al Sapporo Medical University Urologic Oncology Consortium, : Molecular-targeted therapy and surgery may prolong survival of renal cell carcinoma patients with bone metastasis: a multi-institutional retrospective study in Japan. Anticancer Res. 36:5531–5536. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Partheen K, Levan K, Osterberg L, Claesson I, Fallenius G, Sundfeldt K and Horvath G: Four potential biomarkers as prognostic factors in stage III serous ovarian adenocarcinomas. Int J Cancer. 123:2130–2137. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Li T, Hong X, Zhao J, Teng Y, Zheng J, Chen H, Chen H and Li H: Gelsolin-like actin-capping protein is associated with patient prognosis, cellular apoptosis and proliferation in prostate cancer. Biomarkers Med. 10:1251–1260. 2016. View Article : Google Scholar

17 

Yun DP, Wang YQ, Meng DL, Ji YY, Chen JX, Chen HY and Lu DR: Actin-capping protein CapG is associated with prognosis, proliferation and metastasis in human glioma. Oncol Rep. 39:1011–1022. 2018.PubMed/NCBI

18 

De Corte V, Van Impe K, Bruyneel E, Boucherie C, Mareel M, Vandekerckhove J and Gettemans J: Increased importin-beta-dependent nuclear import of the actin modulating protein CapG promotes cell invasion. J Cell Sci. 117:5283–5292. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Lu PJ, Hsu AL, Wang DS, Yan HY, Yin HL and Chen CS: Phosphoinositide 3-kinase in rat liver nuclei. Biochemistry. 37:5738–5745. 1998. View Article : Google Scholar : PubMed/NCBI

20 

Steger DJ, Haswell ES, Miller AL, Wente SR and O'Shea EK: Regulation of chromatin remodeling by inositol polyphosphates. Science. 299:114–116. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Pellieux C, Desgeorges A, Pigeon CH, Chambaz C, Yin H, Hayoz D and Silacci P: Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress. J Biol Chem. 278:29136–29144. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Huang S, Chi Y, Qin Y, Wang Z, Xiu B, Su Y, Guo R, Guo L, Sun H, Zeng C, et al: CAPG enhances breast cancer metastasis by competing with PRMT5 to modulate STC-1 transcription. Theranostics. 8:2549–2564. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Kim HL, Seligson D, Liu X, Janzen N, Bui MHT, Yu H, Shi T, Figlin RA, Horvath S and Belldegrun AS: Using protein expressions to predict survival in clear cell renal carcinoma. Clin Cancer Res. 10:5464–5471. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Visapää H, Bui M, Huang Y, Seligson D, Tsai H, Pantuck A, Figlin R, Rao JY, Belldegrun A, Horvath S, et al: Correlation of Ki-67 and gelsolin expression to clinical outcome in renal clear cell carcinoma. Urology. 61:845–850. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Zhu X, Cai L, Meng Q and Jin X: Gelsolin inhibits the proliferation and invasion of the 786-0 clear cell renal cell carcinoma cell line in vitro. Mol Med Rep. 12:6887–6894. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Kankaya D, Kiremitci S, Tulunay O and Baltaci S: Gelsolin, NF-κB, and p53 expression in clear cell renal cell carcinoma: Impact on outcome. Pathol Res Pract. 211:505–512. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chen Z, Huang Z, Chen S, Jiang Y, Qin Z, Zheng S and Chen T: Oncogenic potential of macrophage‑capping protein in clear cell renal cell carcinoma. Mol Med Rep 23: 80, 2021.
APA
Chen, Z., Huang, Z., Chen, S., Jiang, Y., Qin, Z., Zheng, S., & Chen, T. (2021). Oncogenic potential of macrophage‑capping protein in clear cell renal cell carcinoma. Molecular Medicine Reports, 23, 80. https://doi.org/10.3892/mmr.2020.11718
MLA
Chen, Z., Huang, Z., Chen, S., Jiang, Y., Qin, Z., Zheng, S., Chen, T."Oncogenic potential of macrophage‑capping protein in clear cell renal cell carcinoma". Molecular Medicine Reports 23.1 (2021): 80.
Chicago
Chen, Z., Huang, Z., Chen, S., Jiang, Y., Qin, Z., Zheng, S., Chen, T."Oncogenic potential of macrophage‑capping protein in clear cell renal cell carcinoma". Molecular Medicine Reports 23, no. 1 (2021): 80. https://doi.org/10.3892/mmr.2020.11718
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Z, Huang Z, Chen S, Jiang Y, Qin Z, Zheng S and Chen T: Oncogenic potential of macrophage‑capping protein in clear cell renal cell carcinoma. Mol Med Rep 23: 80, 2021.
APA
Chen, Z., Huang, Z., Chen, S., Jiang, Y., Qin, Z., Zheng, S., & Chen, T. (2021). Oncogenic potential of macrophage‑capping protein in clear cell renal cell carcinoma. Molecular Medicine Reports, 23, 80. https://doi.org/10.3892/mmr.2020.11718
MLA
Chen, Z., Huang, Z., Chen, S., Jiang, Y., Qin, Z., Zheng, S., Chen, T."Oncogenic potential of macrophage‑capping protein in clear cell renal cell carcinoma". Molecular Medicine Reports 23.1 (2021): 80.
Chicago
Chen, Z., Huang, Z., Chen, S., Jiang, Y., Qin, Z., Zheng, S., Chen, T."Oncogenic potential of macrophage‑capping protein in clear cell renal cell carcinoma". Molecular Medicine Reports 23, no. 1 (2021): 80. https://doi.org/10.3892/mmr.2020.11718
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team