miR‑576‑3p overexpression enhances cisplatin sensitivity of ovarian cancer cells by dysregulating PD‑L1 and cyclin D1

  • Authors:
    • Ying Zuo
    • Wei Zheng
    • Qing Tang
    • Jing Liu
    • Shanshan Wang
    • Chunxia Xin
  • View Affiliations

  • Published online on: November 23, 2020     https://doi.org/10.3892/mmr.2020.11719
  • Article Number: 81
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Abstract

Cisplatin (DDP) resistance is a major obstacle in the chemotherapeutic efficacy of ovarian cancer. The present study aimed to explore the role of miR‑576‑3p in DDP sensitivity of ovarian cancer cells. Ovarian cancer cell lines SKOV3 and A2780 and DDP‑resistant ovarian cancer cell lines SKOV3/DDP and A2780/DDP were used in the present study. In vitro studies demonstrated that microRNA (miR)‑576‑3p overexpression increased the DDP sensitivity of DDP‑resistant ovarian cancer cells. A dual‑luciferase assay verified that both programmed death‑ligand 1 (PD‑L1) and cyclin D1 were targets of miR‑276‑3p and were reversely associated with the expression of miR‑576‑3p. Moreover, in vivo studies indicated that tumorigenesis was inhibited by DDP, which was enhanced by further miR‑576‑3p overexpression in tumor tissues. Taken together, the results suggested that miR‑576‑3p overexpression increased DDP chemosensitivity of ovarian cancer cells via decreasing PD‑L1 and cyclin D1, indicating that miR‑576‑3p may serve as a promising therapeutic target for ovarian cancer.
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January-2021
Volume 23 Issue 1

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Online ISSN:1791-3004

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Spandidos Publications style
Zuo Y, Zheng W, Tang Q, Liu J, Wang S and Xin C: miR‑576‑3p overexpression enhances cisplatin sensitivity of ovarian cancer cells by dysregulating PD‑L1 and cyclin D1. Mol Med Rep 23: 81, 2021
APA
Zuo, Y., Zheng, W., Tang, Q., Liu, J., Wang, S., & Xin, C. (2021). miR‑576‑3p overexpression enhances cisplatin sensitivity of ovarian cancer cells by dysregulating PD‑L1 and cyclin D1. Molecular Medicine Reports, 23, 81. https://doi.org/10.3892/mmr.2020.11719
MLA
Zuo, Y., Zheng, W., Tang, Q., Liu, J., Wang, S., Xin, C."miR‑576‑3p overexpression enhances cisplatin sensitivity of ovarian cancer cells by dysregulating PD‑L1 and cyclin D1". Molecular Medicine Reports 23.1 (2021): 81.
Chicago
Zuo, Y., Zheng, W., Tang, Q., Liu, J., Wang, S., Xin, C."miR‑576‑3p overexpression enhances cisplatin sensitivity of ovarian cancer cells by dysregulating PD‑L1 and cyclin D1". Molecular Medicine Reports 23, no. 1 (2021): 81. https://doi.org/10.3892/mmr.2020.11719