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Article

miR‑576‑3p overexpression enhances cisplatin sensitivity of ovarian cancer cells by dysregulating PD‑L1 and cyclin D1

  • Authors:
    • Ying Zuo
    • Wei Zheng
    • Qing Tang
    • Jing Liu
    • Shanshan Wang
    • Chunxia Xin
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, Affiliated Yantai Yuhuangding Hospital, Medical College of Qingdao University, Yantai, Shandong 264000, P.R. China, Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Medical College of Qingdao University, Yantai, Shandong 264000, P.R. China, Department of Medical Oncology, Affiliated Yantai Yuhuangding Hospital, Medical College of Qingdao University, Yantai, Shandong 264000, P.R. China
  • Article Number: 81
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    Published online on: November 23, 2020
       https://doi.org/10.3892/mmr.2020.11719
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Abstract

Cisplatin (DDP) resistance is a major obstacle in the chemotherapeutic efficacy of ovarian cancer. The present study aimed to explore the role of miR‑576‑3p in DDP sensitivity of ovarian cancer cells. Ovarian cancer cell lines SKOV3 and A2780 and DDP‑resistant ovarian cancer cell lines SKOV3/DDP and A2780/DDP were used in the present study. In vitro studies demonstrated that microRNA (miR)‑576‑3p overexpression increased the DDP sensitivity of DDP‑resistant ovarian cancer cells. A dual‑luciferase assay verified that both programmed death‑ligand 1 (PD‑L1) and cyclin D1 were targets of miR‑276‑3p and were reversely associated with the expression of miR‑576‑3p. Moreover, in vivo studies indicated that tumorigenesis was inhibited by DDP, which was enhanced by further miR‑576‑3p overexpression in tumor tissues. Taken together, the results suggested that miR‑576‑3p overexpression increased DDP chemosensitivity of ovarian cancer cells via decreasing PD‑L1 and cyclin D1, indicating that miR‑576‑3p may serve as a promising therapeutic target for ovarian cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zuo Y, Zheng W, Tang Q, Liu J, Wang S and Xin C: miR‑576‑3p overexpression enhances cisplatin sensitivity of ovarian cancer cells by dysregulating PD‑L1 and cyclin D1. Mol Med Rep 23: 81, 2021.
APA
Zuo, Y., Zheng, W., Tang, Q., Liu, J., Wang, S., & Xin, C. (2021). miR‑576‑3p overexpression enhances cisplatin sensitivity of ovarian cancer cells by dysregulating PD‑L1 and cyclin D1. Molecular Medicine Reports, 23, 81. https://doi.org/10.3892/mmr.2020.11719
MLA
Zuo, Y., Zheng, W., Tang, Q., Liu, J., Wang, S., Xin, C."miR‑576‑3p overexpression enhances cisplatin sensitivity of ovarian cancer cells by dysregulating PD‑L1 and cyclin D1". Molecular Medicine Reports 23.1 (2021): 81.
Chicago
Zuo, Y., Zheng, W., Tang, Q., Liu, J., Wang, S., Xin, C."miR‑576‑3p overexpression enhances cisplatin sensitivity of ovarian cancer cells by dysregulating PD‑L1 and cyclin D1". Molecular Medicine Reports 23, no. 1 (2021): 81. https://doi.org/10.3892/mmr.2020.11719
Copy and paste a formatted citation
x
Spandidos Publications style
Zuo Y, Zheng W, Tang Q, Liu J, Wang S and Xin C: miR‑576‑3p overexpression enhances cisplatin sensitivity of ovarian cancer cells by dysregulating PD‑L1 and cyclin D1. Mol Med Rep 23: 81, 2021.
APA
Zuo, Y., Zheng, W., Tang, Q., Liu, J., Wang, S., & Xin, C. (2021). miR‑576‑3p overexpression enhances cisplatin sensitivity of ovarian cancer cells by dysregulating PD‑L1 and cyclin D1. Molecular Medicine Reports, 23, 81. https://doi.org/10.3892/mmr.2020.11719
MLA
Zuo, Y., Zheng, W., Tang, Q., Liu, J., Wang, S., Xin, C."miR‑576‑3p overexpression enhances cisplatin sensitivity of ovarian cancer cells by dysregulating PD‑L1 and cyclin D1". Molecular Medicine Reports 23.1 (2021): 81.
Chicago
Zuo, Y., Zheng, W., Tang, Q., Liu, J., Wang, S., Xin, C."miR‑576‑3p overexpression enhances cisplatin sensitivity of ovarian cancer cells by dysregulating PD‑L1 and cyclin D1". Molecular Medicine Reports 23, no. 1 (2021): 81. https://doi.org/10.3892/mmr.2020.11719
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