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Effect of EZH2 on pulmonary artery smooth muscle cell migration in pulmonary hypertension

  • Authors:
    • Ying Wang
    • Xiao-Xi Huang
    • Dong Leng
    • Ji-Feng Li
    • Yan Liang
    • Tao Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Beijing Chao‑Yang Hospital, Capital Medical University, Beijing 100020, P.R. China, Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Institute of Respiratory Medicine, Beijing 100020, P.R. China, Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 129
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    Published online on: December 10, 2020
       https://doi.org/10.3892/mmr.2020.11768
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Abstract

Pulmonary hypertension (PH) is a life‑threatening disease that often involves vascular remodeling. Although pulmonary arterial smooth muscle cells (PASMCs) are the primary participants in vascular remodeling, their biological role is not entirely clear. The present study analyzed the role of enhancer of zeste homolog 2 (EZH2) in vascular remodeling of PH by investigating the behavior of PASMCs. The expression levels of EZH2 in PASMCs in chronic thromboembolic pulmonary hypertension (CTEPH), a type of PH, were detected. The role of EZH2 in PASMC migration was investigated by wound‑healing assay following overexpression and knockdown. Functional enrichment analysis of the whole‑genome expression profiles of PASMCs with EZH2 overexpression was performed using an mRNA Human Gene Expression Microarray. Quantitative (q)PCR was performed to confirm the results of the microarray. EZH2 expression levels increased in CTEPH cell models. The overexpression of EZH2 enhanced PASMC migration compared with control conditions. Functional enrichment analysis of the differentially expressed genes following EZH2 overexpression indicated a strong link between EZH2 and the immune inflammatory response and oxidoreductase activity in PASMCs. mRNA expression levels of superoxide dismutase 3 were verified by qPCR. The results suggested that EZH2 was involved in the migration of PASMCs in PH, and may serve as a potential target for the treatment of PH.
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1 

Simonneau G, Gatzoulis MA, Adatia I, Celermajer D, Denton C, Ghofrani A, Gomez Sanchez MA, Krishna Kumar R, Landzberg M, Machado RF, et al: Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol. 62 (25 Suppl):D34–D41. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Xiong PY, Potus F, Chan W and Archer SL: Models and molecular mechanisms of world health organization group 2 to 4 pulmonary hypertension. Hypertension. 71:34–55. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Shi N and Chen SY: Mechanisms simultaneously regulate smooth muscle proliferation and differentiation. J Biomed Res. 28:40–46. 2014.PubMed/NCBI

4 

Masudo K, Suganuma N, Nakayama H, Oshima T, Rino Y, Iwasaki H, Matsuzu K, Sugino K, Ito K, Kondo T, et al: EZH2 overexpression as a useful prognostic marker for aggressive behaviour in thyroid cancer. In Vivo. 32:25–31. 2018.PubMed/NCBI

5 

Simon JA and Lange CA: Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutat Res. 647:21–29. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Chang CJ and Hung MC: The role of EZH2 in tumour progression. Br J Cancer. 106:243–247. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Rao ZY, Cai MY, Yang GF, He LR, Mai SJ, Hua WF, Liao YJ, Deng HX, Chen YC, Guan XY, et al: EZH2 supports ovarian carcinoma cell invasion and/or metastasis via regulation of TGF-beta1 and is a predictor of outcome in ovarian carcinoma patients. Carcinogenesis. 31:1576–1583. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Nephew KP and Huang TH: Epigenetic gene silencing in cancer initiation and progression. Cancer Lett. 190:125–133. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Archer SL, Marsboom G, Kim GH, Zhang HJ, Toth PT, Svensson EC, Dyck JR, Gomberg-Maitland M, Thébaud B, Husain AN, et al: Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: A basis for excessive cell proliferation and a new therapeutic target. Circulation. 121:2661–2671. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Philibert RA, Sears RA, Powers LS, Nash E, Bair T, Gerke AK, Hassan I, Thomas CP, Gross TJ and Monick MM: Coordinated DNA methylation and gene expression changes in smoker alveolar macrophages: Specific effects on VEGF receptor 1 expression. J Leukoc Biol. 92:621–631. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Aljubran SA, Cox R Jr, Tamarapu Parthasarathy P, Kollongod Ramanathan G, Rajanbabu V, Bao H, Mohapatra SS, Lockey R and Kolliputi N: Enhancer of zeste homolog 2 induces pulmonary artery smooth muscle cell proliferation. PLoS One. 7:e377122012. View Article : Google Scholar : PubMed/NCBI

12 

Stenmark KR, Fagan KA and Frid MG: Hypoxia-induced pulmonary vascular remodeling: Cellular and molecular mechanisms. Circ Res. 99:675–691. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Groves BM, Reeves JT, Sutton JR, Wagner PD, Cymerman A, Malconian MK, Rock PB, Young PM and Houston CS: Operation everest II: Elevated high-altitude pulmonary resistance unresponsive to oxygen. J Appl Physiol (1985). 63:521–530. 1987. View Article : Google Scholar : PubMed/NCBI

14 

Galiè N and Kim NH: Pulmonary microvascular disease in chronic thromboembolic pulmonary hypertension. Proc Am Thorac Soc. 3:571–576. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Barst RJ, McGoon M, Torbicki A, Sitbon O, Krowka MJ, Olschewski H and Gaine S: Diagnosis and differential assessment of pulmonary arterial hypertension. J Am Coll Cardiol. 43 (12 Suppl S):40S–47S. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Wang Y, Huang X, Leng D, Li J, Wang L, Liang Y, Wang J, Miao R and Jiang T: DNA methylation signatures of pulmonary arterial smooth muscle cells in chronic thromboembolic pulmonary hypertension. Physiol Genomics. 50:313–322. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Ogawa A, Firth AL, Yao W, Madani MM, Kerr KM, Auger WR, Jamieson SW, Thistlethwaite PA and Yuan JX: Inhibition of mTOR attenuates store-operated Ca2+ entry in cells from endarterectomized tissues of patients with chronic thromboembolic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 297:L666–L676. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Rouillard AD, Gundersen GW, Fernandez NF, Wang Z, Monteiro CD, McDermott MG and Ma'ayan A: The harmonizome: A collection of processed datasets gathered to serve and mine knowledge about genes and proteins. Database (Oxford). 2016:baw1002016. View Article : Google Scholar : PubMed/NCBI

20 

Jassal B, Matthews L, Viteri G, Gong C, Lorente P, Fabregat A, Sidiropoulos K, Cook J, Gillespie M, Haw R, et al: The reactome pathway knowledgebase. Nucleic Acids Res. 48(D1): D498–D503. 2020.PubMed/NCBI

21 

Xie C, Mao X, Huang J, Ding Y, Wu J, Dong S, Kong L, Gao G, Li CY and Wei L: KOBAS 2.0: A web server for annotation and identification of enriched pathways and diseases. Nucleic Acids Res. 39((Web Server Issue)): W316–W322. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Humbert M: Pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: Pathophysiology. Eur Respir Rev. 19:59–63. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Czermin B, Melfi R, McCabe D, Seitz V, Imhof A and Pirrotta V: Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell. 111:185–196. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Bracken AP, Pasini D, Capra M, Prosperini E, Colli E and Helin K: EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J. 22:5323–5335. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Zhang YX, Li JF, Yang YH, Zhai ZG, Gu S, Liu Y, Miao R, Zhong PP, Wang Y, Huang XX, et al: Renin-angiotensin system regulates pulmonary arterial smooth muscle cell migration in chronic thromboembolic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 314:L276–L286. 2018.PubMed/NCBI

26 

Wang L, Liu J, Wang W, Qi X, Wang Y, Tian B, Dai H, Wang J, Ning W, Yang T and Wang C: Targeting IL-17 attenuates hypoxia-induced pulmonary hypertension through downregulation of β-catenin. Thorax. 74:564–578. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Varambally S, Cao Q, Mani RS, Shankar S, Wang X, Ateeq B, Laxman B, Cao X, Jing X, Ramnarayanan K, et al: Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science. 322:1695–1699. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Frid MG, Moiseeva EP and Stenmark KR: Multiple phenotypically distinct smooth muscle cell populations exist in the adult and developing bovine pulmonary arterial media in vivo. Circ Res. 75:669–681. 1994. View Article : Google Scholar : PubMed/NCBI

29 

Pugliese SC, Poth JM, Fini MA, Olschewski A, El Kasmi KC and Stenmark KR: The role of inflammation in hypoxic pulmonary hypertension: From cellular mechanisms to clinical phenotypes. Am J Physiol Lung Cell Mol Physiol. 308:L229–L252. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Rose-John S: Interleukin-6 family cytokines. Cold Spring Harb Perspect Biol. 10:a0284152018. View Article : Google Scholar : PubMed/NCBI

31 

Karan D, Tawfik O and Dubey S: Expression analysis of inflammasome sensors and implication of NLRP12 inflammasome in prostate cancer. Sci Rep. 7:43782017. View Article : Google Scholar : PubMed/NCBI

32 

Allen IC: Non-inflammasome forming NLRs in inflammation and tumorigenesis. Front Immunol. 5:1692014. View Article : Google Scholar : PubMed/NCBI

33 

Hermanns HM: Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology. Cytokine Growth Factor Rev. 26:545–558. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Miyata M, Ito M, Sasajima T, Ohira H and Kasukawa R: Effect of a serotonin receptor antagonist on interleukin-6-induced pulmonary hypertension in rats. Chest. 119:554–561. 2001. View Article : Google Scholar : PubMed/NCBI

35 

Unver N and McAllister F: IL-6 family cytokines: Key inflammatory mediators as biomarkers and potential therapeutic targets. Cytokine Growth Factor Rev. 41:10–17. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Ye RD and Sun L: Emerging functions of serum amyloid A in inflammation. J Leukoc Biol. 98:923–929. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Helgadottir A, Manolescu A, Thorleifsson G, Gretarsdottir S, Jonsdottir H, Thorsteinsdottir U, Samani NJ, Gudmundsson G, Grant SF, Thorgeirsson G, et al: The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat Genet. 36:233–239. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Malle E, Sodin-Semrl S and Kovacevic A: Serum amyloid A: An acute-phase protein involved in tumour pathogenesis. Cell Mol Life Sci. 66:9–26. 2009. View Article : Google Scholar : PubMed/NCBI

39 

De Buck M, Gouwy M, Wang JM, Van Snick J, Opdenakker G, Struyf S and Van Damme J: Structure and expression of different serum amyloid a (SAA) variants and their concentration-dependent functions during host insults. Curr Med Chem. 23:1725–1755. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Jumeau C, Awad F, Assrawi E, Cobret L, Duquesnoy P, Giurgea I, Valeyre D, Grateau G, Amselem S, Bernaudin JF and Karabina SA: Expression of SAA1, SAA2 and SAA4 genes in human primary monocytes and monocyte-derived macrophages. PLoS One. 14:e02170052019. View Article : Google Scholar : PubMed/NCBI

41 

Wang Y, Barbacioru C, Hyland F, Xiao W, Hunkapiller KL, Blake J, Chan F, Gonzalez C, Zhang L and Samaha RR: Large scale real-time PCR validation on gene expression measurements from two commercial long-oligonucleotide microarrays. BMC Genomics. 7:592006. View Article : Google Scholar : PubMed/NCBI

42 

Soon E, Crosby A, Southwood M, Yang P, Tajsic T, Toshner M, Appleby S, Shanahan CM, Bloch KD, Pepke-Zaba J, et al: Bone morphogenetic protein receptor type II deficiency and increased inflammatory cytokine production. A gateway to pulmonary arterial hypertension. Am J Respir Crit Care Med. 192:859–872. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Humbert M, Monti G, Brenot F, Sitbon O, Portier A, Grangeot-Keros L, Duroux P, Galanaud P, Simonneau G and Emilie D: Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension. Am J Respir Crit Care Med. 151:1628–1631. 1995. View Article : Google Scholar : PubMed/NCBI

44 

Furuya Y, Satoh T and Kuwana M: Interleukin-6 as a potential therapeutic target for pulmonary arterial hypertension. Int J Rheumatol. 2010:7203052010. View Article : Google Scholar : PubMed/NCBI

45 

Yang X, Coriolan D, Murthy V, Schultz K, Golenbock DT and Beasley D: Proinflammatory phenotype of vascular smooth muscle cells: Role of efficient Toll-like receptor 4 signaling. Am J Physiol Heart Circ Physiol. 289:H1069–H1076. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Bonnet S, Michelakis ED, Porter CJ, Andrade-Navarro MA, Thébaud B, Bonnet S, Haromy A, Harry G, Moudgil R, McMurtry MS, et al: An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: Similarities to human pulmonary arterial hypertension. Circulation. 113:2630–2641. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Sutendra G and Michelakis ED: The metabolic basis of pulmonary arterial hypertension. Cell Metab. 19:558–573. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Bonnet S, Archer SL, Allalunis-Turner J, Haromy A, Beaulieu C, Thompson R, Lee CT, Lopaschuk GD, Puttagunta L, Bonnet S, et al: A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell. 11:37–51. 2007. View Article : Google Scholar : PubMed/NCBI

49 

Archer SL, Gomberg-Maitland M, Maitland ML, Rich S, Garcia JG and Weir EK: Mitochondrial metabolism, redox signaling, and fusion: A mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer. Am J Physiol Heart Circ Physiol. 294:H570–H578. 2008. View Article : Google Scholar : PubMed/NCBI

50 

Cho KA, Suh JW, Lee KH, Kang JL and Woo SY: IL-17 and IL-22 enhance skin inflammation by stimulating the secretion of IL-1β by keratinocytes via the ROS-NLRP3-caspase-1 pathway. Int Immunol. 24:147–158. 2012. View Article : Google Scholar : PubMed/NCBI

51 

Sutendra G, Dromparis P, Bonnet S, Haromy A, McMurtry MS, Bleackley RC and Michelakis ED: Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFα contributes to the pathogenesis of pulmonary arterial hypertension. J Mol Med (Berl). 89:771–783. 2011. View Article : Google Scholar : PubMed/NCBI

52 

Yasui K and Baba A: Therapeutic potential of superoxide dismutase (SOD) for resolution of inflammation. Inflamm Res. 55:359–363. 2006. View Article : Google Scholar : PubMed/NCBI

53 

Rabinovitch M, Guignabert C, Humbert M and Nicolls MR: Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension. Circ Res. 115:165–175. 2014. View Article : Google Scholar : PubMed/NCBI

54 

Bauer EM, Zheng H, Comhair S, Erzurum S, Billiar TR and Bauer PM: Complement C3 deficiency attenuates chronic hypoxia-induced pulmonary hypertension in mice. PLoS One. 6:e285782011. View Article : Google Scholar : PubMed/NCBI

55 

Zhang J, Zhang Y, Li N, Liu Z, Xiong C, Ni X, Pu Y, Hui R, He J and Pu J: Potential diagnostic biomarkers in serum of idiopathic pulmonary arterial hypertension. Respir Med. 103:1801–1806. 2009. View Article : Google Scholar : PubMed/NCBI

56 

Langer F, Schramm R, Bauer M, Tscholl D, Kunihara T and Schäfers HJ: Cytokine response to pulmonary thromboendarterectomy. Chest. 126:135–141. 2004. View Article : Google Scholar : PubMed/NCBI

57 

von Haehling S, von Bardeleben RS, Kramm T, Thiermann Y, Niethammer M, Doehner W, Anker SD, Munzel T, Mayer E and Genth-Zotz S: Inflammation in right ventricular dysfunction due to thromboembolic pulmonary hypertension. Int J Cardiol. 144:206–211. 2010. View Article : Google Scholar : PubMed/NCBI

58 

Gu S, Su P, Yan J, Zhang X, An X, Gao J, Xin R and Liu Y: Comparison of gene expression profiles and related pathways in chronic thromboembolic pulmonary hypertension. Int J Mol Med. 33:277–300. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Huang X, Leng D, Li J, Liang Y and Jiang T: Effect of EZH2 on pulmonary artery smooth muscle cell migration in pulmonary hypertension. Mol Med Rep 23: 129, 2021.
APA
Wang, Y., Huang, X., Leng, D., Li, J., Liang, Y., & Jiang, T. (2021). Effect of EZH2 on pulmonary artery smooth muscle cell migration in pulmonary hypertension. Molecular Medicine Reports, 23, 129. https://doi.org/10.3892/mmr.2020.11768
MLA
Wang, Y., Huang, X., Leng, D., Li, J., Liang, Y., Jiang, T."Effect of EZH2 on pulmonary artery smooth muscle cell migration in pulmonary hypertension". Molecular Medicine Reports 23.2 (2021): 129.
Chicago
Wang, Y., Huang, X., Leng, D., Li, J., Liang, Y., Jiang, T."Effect of EZH2 on pulmonary artery smooth muscle cell migration in pulmonary hypertension". Molecular Medicine Reports 23, no. 2 (2021): 129. https://doi.org/10.3892/mmr.2020.11768
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Huang X, Leng D, Li J, Liang Y and Jiang T: Effect of EZH2 on pulmonary artery smooth muscle cell migration in pulmonary hypertension. Mol Med Rep 23: 129, 2021.
APA
Wang, Y., Huang, X., Leng, D., Li, J., Liang, Y., & Jiang, T. (2021). Effect of EZH2 on pulmonary artery smooth muscle cell migration in pulmonary hypertension. Molecular Medicine Reports, 23, 129. https://doi.org/10.3892/mmr.2020.11768
MLA
Wang, Y., Huang, X., Leng, D., Li, J., Liang, Y., Jiang, T."Effect of EZH2 on pulmonary artery smooth muscle cell migration in pulmonary hypertension". Molecular Medicine Reports 23.2 (2021): 129.
Chicago
Wang, Y., Huang, X., Leng, D., Li, J., Liang, Y., Jiang, T."Effect of EZH2 on pulmonary artery smooth muscle cell migration in pulmonary hypertension". Molecular Medicine Reports 23, no. 2 (2021): 129. https://doi.org/10.3892/mmr.2020.11768
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