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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February-2021 Volume 23 Issue 2

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Co‑expression of tissue kallikrein 1 and tissue inhibitor of matrix metalloproteinase 1 improves myocardial ischemia‑reperfusion injury by promoting angiogenesis and inhibiting oxidative stress

Shujie Huang, Meixian Chen, Huizhen Yu, Kaiyang Lin, Yansong Guo, Pengli Zhu
Article Number: 166
Published online on: 22 December 2020

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Article Open Access

miR‑126 overexpression attenuates oxygen‑glucose deprivation/reperfusion injury by inhibiting oxidative stress and inflammatory response via the activation of SIRT1/Nrf2 signaling pathway in human umbilical vein endothelial cells Corrigendum in /10.3892/mmr.2021.12158

Jixin Li, Caili Yang, Yan Wang
Article Number: 165
Published online on: 22 December 2020

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Article Open Access

S100A16 suppresses the proliferation, migration and invasion of colorectal cancer cells in part via the JNK/p38 MAPK pathway

Shiyu Ou, Yan Liao, Jie Shi, Jing Tang, Yanqing Ye, Fengfei Wu, Weidong Wang, Jieying Fei, Fang Xie, Lan Bai
Article Number: 164
Published online on: 22 December 2020

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Article

Effects of KAI gene expression on ferroptosis in pancreatic cancer cells

Xu Liu, Xiaozhong Guo, Hongyu Li, Jiang Chen, Hao Han
Article Number: 163
Published online on: 22 December 2020

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Article Open Access

Induction of notochordal differentiation of bone marrow mesenchymal‑derived stem cells via the stimulation of notochordal cell‑rich nucleus pulposus tissue

Defang Li, Qingmin Zeng, Zengxin Jiang, Lei Ding, Wei Lu, Mengxuan Bian, Jingping Wu
Article Number: 162
Published online on: 22 December 2020

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Article Open Access

Mitochondrial proteomics alterations in rat hearts following ischemia/reperfusion and diazoxide post‑conditioning

Yunchao Pan, Yuan Wang, Wenyan Shi, Yun Liu, Song Cao, Tian Yu
Article Number: 161
Published online on: 22 December 2020

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Article Open Access

Age affects the paracrine activity and differentiation potential of human adipose‑derived stem cells

Jeong Seop Park, Gabee Park, Hyun Sook Hong
Article Number: 160
Published online on: 22 December 2020

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Review

Role of peroxisome proliferator-activated receptors in osteoarthritis (Review)

Gang Huang, Wei Jiang, Weiyong Xie, Wei Lu, Weimin Zhu, Zhenhan Deng
Article Number: 159
Published online on: 22 December 2020

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Article

Neochlorogenic acid enhances the antitumor effects of pingyangmycin via regulating TOP2A

Jianhuan Che, Tongxia Zhao, Wen Liu, Shi Chen, Guangyu Yang, Xinyan Li, Dongling Liu
Article Number: 158
Published online on: 22 December 2020

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Article Open Access

Luteolin attenuates angiotensin II‑induced renal damage in apolipoprotein E‑deficient mice

Ying-Shu Liu, Qin Yang, Shen Li, Lan Luo, Hong-Yang Liu, Xin-Yu Li, Zheng-Nan Gao
Article Number: 157
Published online on: 22 December 2020

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Review

Estrogen receptor-associated receptor α and peroxisome proliferator-activated receptor γ in metabolism and disease (Review)

Wei-Yi Huang, Peng-Ming Sun
Article Number: 156
Published online on: 22 December 2020

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Article Open Access

Isoflurane reduces septic neuron injury by HO‑1‑mediated abatement of inflammation and apoptosis

Lina Zhang, Xuece Zhang, Ting Wu, Xu Pan, Zhi Wang
Article Number: 155
Published online on: 22 December 2020

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Article Open Access

MicroRNA‑223‑induced inhibition of the FBXW7 gene affects the proliferation and apoptosis of colorectal cancer cells via the Notch and Akt/mTOR pathways

Zhixin Liu, Teng Ma, Jufeng Duan, Xiaofei Liu, Long Liu
Article Number: 154
Published online on: 20 December 2020

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Article Open Access

lncRNA LIFR‑AS1 inhibits gastric carcinoma cell proliferation, migration and invasion by sponging miR‑4698

Jiangqiao Zhao, Xiaoning Li, Liping Fu, Na Zhang, Jiaping Yang, Jianhui Cai
Article Number: 153
Published online on: 20 December 2020

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Article Open Access

PMCA4 gene expression is regulated by the androgen receptor in the mouse testis during spermatogenesis

Rui Sun, Hui Liang, Huan Guo, Zhu Wang, Qiong Deng
Article Number: 152
Published online on: 20 December 2020

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Article Open Access

Matrix metalloproteinase 3 regulates angiotensin II‑induced myocardial fibrosis cell viability, migration and apoptosis

Jin Shu, Yiwen Gu, Li Jin, Haiya Wang
Article Number: 151
Published online on: 20 December 2020

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Article Open Access

JNK‑IN‑8 treatment alleviates lipopolysaccharide‑induced acute lung injury via suppression of inflammation and oxidative stress regulated by JNK/NF‑κB signaling

Jingxian Du, Gaojian Wang, Huanyu Luo, Na Liu, Junran Xie
Article Number: 150
Published online on: 20 December 2020

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Article Open Access

PRDM14 mediates chemosensitivity and glycolysis in drug‑resistant A549/cisplatin cells and their progenitor A549 human lung adenocarcinoma cells

Saifei He, Xiaokun Ma, Ni Zheng, Guoyu Wang, Menghan Wang, Wei Xia, Donghai Yu
Article Number: 149
Published online on: 17 December 2020

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Article Open Access

OxLDL/β2GPI/anti‑β2GPI Ab complex induces inflammatory activation via the TLR4/NF‑κB pathway in HUVECs

Guiting Zhang, Qianqian Cai, Hong Zhou, Chao He, Yudan Chen, Peng Zhang, Ting Wang, Liangjie Xu, Jinchuan Yan
Article Number: 148
Published online on: 17 December 2020

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Article Open Access

Liraglutide protects palmitate-induced INS-1 cell injury by enhancing autophagy mediated via FoxO1

Xiu-Dan Li, Shan-Shan He, Ting-Ting Wan, Yan-Bo Li
Article Number: 147
Published online on: 17 December 2020

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Article Open Access

Knockdown of long non‑coding RNA ANRIL inhibits the proliferation and promotes the apoptosis of Burkitt lymphoma cells through the TGF‑β1 signaling pathway

Shudan Mao, Jieping Jin, Zhe Li, Wenqi Yang
Article Number: 146
Published online on: 15 December 2020

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Article Open Access

Knockdown of lncRNA ANRIL suppresses the production of inflammatory cytokines and mucin 5AC in nasal epithelial cells via the miR-15a-5p/JAK2 axis

Huo-Wang Liu, Zhong-Liang Hu, Hao Li, Qi-Feng Tan, Jing Tong, Yong-Quan Zhang
Article Number: 145
Published online on: 15 December 2020

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Article Open Access

Atezolizumab alleviates the immunosuppression induced by PD‑L1‑positive neutrophils and improves the survival of mice during sepsis

Jianxin Chen, Ruiyuan Chen, Shaoxiong Huang, Bin Zu, Sen Zhang
Article Number: 144
Published online on: 15 December 2020

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Correction Open Access

[Corrigendum] Vorinostat protects against calcium oxalate‑induced kidney injury in mice

Li Wang, Wei Chen, Zhongjiang Peng, Changcheng Liu, Caihong Zhang, Zhiyong Guo
Article Number: 143
Published online on: 14 December 2020

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Article

Bioinformatics analysis indicates that microRNA‑628‑5p overexpression may alleviate Alzheimer's disease by targeting TYROBP

Miao Liu, Shuling Li, Chun Ma, Xinna Wang, Yu Shuang, Haining Lin, Zhiying Guan, Lihua Yang
Article Number: 142
Published online on: 13 December 2020

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Article Open Access

circARRDC3 contributes to interleukin‑13‑induced inflammatory cytokine and mucus production in nasal epithelial cells via the miR‑375/KLF4 axis

Tao Wang, Peihua Wang, Dong Chen, Zhou Xu, Liyun Yang
Article Number: 141
Published online on: 13 December 2020

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Article Open Access

Sericin inhibits MDA‑MB‑468 cell proliferation via the PI3K/Akt pathway in triple‑negative breast cancer

Lin Niu, Songhe Yang, Xueying Zhao, Xiaochao Liu, Lina Si, Meng Wei, Lei Liu, Luyang Cheng, Yuebing Qiao, Zhihong Chen
Article Number: 140
Published online on: 13 December 2020

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Article Open Access

lncRNA FLVCR1‑AS1 drives colorectal cancer progression via modulation of the miR‑381/RAP2A axis

Yi Han, Xiaoyan Wang, Enqiang Mao, Boyong Shen, Liang Huang
Article Number: 139
Published online on: 13 December 2020

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Article Open Access

Inhibition of SNCG suppresses the proliferation of lung cancer cells induced by high glucose

Jing Fei, Chi Xiao, Meiying Yang, Xue Zhou, Ping Gong
Article Number: 138
Published online on: 13 December 2020

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Article Open Access

CBX2 depletion inhibits the proliferation, invasion and migration of gastric cancer cells by inactivating the YAP/β-catenin pathway

Miaomiao Zeng, Bangxue Li, Lei Yang, Quanlin Guan
Article Number: 137
Published online on: 13 December 2020

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Article Open Access

MicroRNA‑338‑3p regulates age‑associated osteoporosis via targeting PCSK5

Jie Tong, Min Zhang, Xia Li, Guohai Ren
Article Number: 136
Published online on: 13 December 2020

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Article Open Access

GAS5 regulates diabetic cardiomyopathy via miR‑221‑3p/p27 axis‑associated autophagy

Dezhi Chen, Min Zhang
Article Number: 135
Published online on: 13 December 2020

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Article Open Access

Upregulation of microRNA‑140‑3p mediates dachshund family transcription factor 1 expression in immunoglobulin A nephropathy through cell cycle‑dependent mechanisms

Xiaobin Zhou, Yao Lu, Pengfei Guo, Chenglin Zhou
Article Number: 134
Published online on: 13 December 2020

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Article

Shikonin ameliorates lipoteichoic acid‑induced acute lung injury via promotion of neutrophil apoptosis

Yong Zhang, Haibo Zhang, Muqun Wang, Shan Gao, Lei Hong, Tingting Hou, Yaoyao Zhang, Yuling Zhu, Feng Qian
Article Number: 133
Published online on: 13 December 2020

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Article Open Access

Analysis of differential expression of long non‑coding RNAs in exosomes derived from mature and immature dendritic cells

Jiachang Wu, Renli Zhao, Jingxing Dai, Guohua Lai, Asmat Ullah Khan, Xiao Yu, Sha Wu, Jun Ouyang, Hongxun Sang
Article Number: 132
Published online on: 10 December 2020

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Article

Long non‑coding RNA H19 inhibition ameliorates oxygen‑glucose deprivation‑induced cell apoptosis and inflammatory cytokine expression by regulating the microRNA‑29b/SIRT1/PGC‑1α axis

Jing Xu, Chunyang Wang, Fanjie Meng, Pengjuan Xu
Article Number: 131
Published online on: 10 December 2020

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Article Open Access

miR‑182‑5p contributes to radioresistance in nasopharyngeal carcinoma by regulating BNIP3 expression Corrigendum in /10.3892/mmr.2021.11935

Wei He, Hongyan Jin, Qian Liu, Quanxin Sun
Article Number: 130
Published online on: 10 December 2020

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Article Open Access

Effect of EZH2 on pulmonary artery smooth muscle cell migration in pulmonary hypertension

Ying Wang, Xiao-Xi Huang, Dong Leng, Ji-Feng Li, Yan Liang, Tao Jiang
Article Number: 129
Published online on: 10 December 2020

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Article Open Access

Gli affects the stemness and prognosis of epithelial ovarian cancer via homeobox protein NANOG

Huan Zhao, Na Li, Yicun Pang, Jun Zhao, Xiaohua Wu
Article Number: 128
Published online on: 10 December 2020

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Article Open Access

Anti‑inflammatory effect of salusin‑β knockdown on LPS‑activated alveolar macrophages via NF‑κB inhibition and HO‑1 activation

Sheng Chen, Yunnan Hu, Jiaxin Zhang, Pengyu Zhang
Article Number: 127
Published online on: 08 December 2020

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Article

Analysis of the intestinal IgA response in mice exposed to chronic stress and treated with bovine lactoferrin

Teresita Rocío Cruz‑Ηernández, Daniel Cuauhtémoc Gómez‑Jiménez, Rafael Campos‑Rodríguez, Marycarmen Godínez‑Victoria, Maria Elisa Drago‑Serrano
Article Number: 126
Published online on: 08 December 2020

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Article Open Access

BMP2 induces hMSC osteogenesis and matrix remodeling

Hantao Cai, Ji Zou, Wei Wang, Aofei Yang
Article Number: 125
Published online on: 08 December 2020

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Article Open Access

miR‑654‑3p suppresses cell viability and promotes apoptosis by targeting RASAL2 in non‑small‑cell lung cancer

Jie Xiong, Shigang Xing, Zheng Dong, Lei Niu, Qinghua Xu, Yusheng Li, Pingyi Liu, Peixia Yang
Article Number: 124
Published online on: 08 December 2020

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Article

Identification of galectin‑10 as a biomarker for periodontitis based on proteomic analysis of gingival crevicular fluid

Jun Su Kim, Il-Hoon Cho, Kyung-Hee Kim, Young Sun Hwang
Article Number: 123
Published online on: 07 December 2020

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Article Open Access

Dickkopf‑1/cysteine‑rich angiogenic inducer 61 axis mediates palmitic acid‑induced inflammation and apoptosis of vascular endothelial cells

Yi-Rong Gan, Ling Wei, Yan-Zhen Wang, Zong-Ke Kou, Tian-Xiang Liang, Guan-Waner Ding, Yan-Hong Ding, Ding-Xiong Xie
Article Number: 122
Published online on: 07 December 2020

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Article Open Access

Induction of mesenchymal stem cell‑like transformation in rat primary glial cells using hypoxia, mild hypothermia and growth factors

Huiping Wei, Wenyun Zhou, Guozhu Hu, Chunhua Shi
Article Number: 121
Published online on: 07 December 2020

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Article Open Access

miR‑34c‑5p targets Notch1 and suppresses the metastasis and invasion of cervical cancer

Huali Wei, Xiaolan Wang, Xiumin Niu, Ruili Jiao, Xiaojuan Li, Sumei Wang
Article Number: 120
Published online on: 07 December 2020

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Retraction Open Access

[Retracted] MicroRNA‑21 increases cell viability and suppresses cellular apoptosis in non‑small cell lung cancer by regulating the PI3K/Akt signaling pathway

Tao Wang, Zhenyu Cai, Guolin Hong, Gangsen Zheng, Yu Huang, Shun Zhang, Jinhua Dai
Article Number: 119
Published online on: 04 December 2020

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Article Open Access

Effects of inhibiting PDK‑1 expression in bone marrow mesenchymal stem cells on osteoblast differentiation in vitro

Yiguang Bai, Qiong Zhang, Quan Zhou, Yanan Zhang, Haibin Nong, Mingfu Liu, Zhuohua Shi, Gaofeng Zeng, Shaohui Zong
Article Number: 118
Published online on: 04 December 2020

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Article Open Access

lncRNA SNHG16 promotes the occurrence of osteoarthritis by sponging miR‑373‑3p

Haiyan Fan, Liangjia Ding, Yun Yang
Article Number: 117
Published online on: 04 December 2020

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Article Open Access

Overexpression of lncRNA Dancr inhibits apoptosis and enhances autophagy to protect cardiomyocytes from endoplasmic reticulum stress injury via sponging microRNA-6324

Jiong Li, Jing Xie, Yan-Zhen Wang, Yi-Rong Gan, Ling Wei, Guan-Waner Ding, Yan-Hong Ding, Ding-Xiong Xie
Article Number: 116
Published online on: 03 December 2020

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Article

WWOX promotes apoptosis and inhibits autophagy in paclitaxel‑treated ovarian carcinoma cells

Yan Zhao, Wen Wang, Wenying Pan, Yunhai Yu, Wenqian Huang, Jiangang Gao, Ying Zhang, Shiqian Zhang
Article Number: 115
Published online on: 03 December 2020

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Correction Open Access

[Erratum] Oxidative stress, autophagy and pyroptosis in the neovascularization of oxygen‑induced retinopathy in mice

Shuai Wang, Li-Yang Ji, Li Li, Jing-Min Li
Article Number: 114
Published online on: 03 December 2020

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Article Open Access

The mRNA expression of Il6 and Pdcd1 are predictive and protective factors for doxorubicin‑induced cardiotoxicity

Syu-Ichi Kanno, Akiyoshi Hara
Article Number: 113
Published online on: 03 December 2020

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Article Open Access

Long non‑coding RNA ANRIL is a potential indicator of disease progression and poor prognosis in acute myeloid leukemia

Zhenqing Tan, Kaibo Zhu, Yafei Yin, Zimian Luo
Article Number: 112
Published online on: 03 December 2020

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Article Open Access

NORAD regulates epithelial‑mesenchymal transition of non‑small cell lung cancer cells via miR‑422a Corrigendum in /10.3892/mmr.2021.12178

Zhikun Chen, Qin Che, Chunxue Xie
Article Number: 111
Published online on: 03 December 2020

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Article Open Access

Prostaglandin E1 attenuates post‑cardiac arrest myocardial dysfunction through inhibition of mitochondria‑mediated cardiomyocyte apoptosis

Chenglei Su, Xinhui Fan, Feng Xu, Jiali Wang, Yuguo Chen
Article Number: 110
Published online on: 02 December 2020

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Article Open Access

hCINAP serves a critical role in hypoxia‑induced cardiomyocyte apoptosis via modulating lactate production and mitochondrial‑mediated apoptosis signaling

Hebing Xie, Gang Xu, Yuqi Gao, Zhibin Yuan
Article Number: 109
Published online on: 02 December 2020

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Article Open Access

Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice Corrigendum in /10.3892/mmr.2023.12994

Zhiping Li, Hui Bi, Hongbo Jiang, Jingjing Song, Qingfan Meng, Yizhi Zhang, Xiaofang Fei
Article Number: 108
Published online on: 02 December 2020

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Article Open Access

Intermedin protects thapsigargin‑induced endoplasmic reticulum stress in cardiomyocytes by modulating protein kinase A and sarco/endoplasmic reticulum Ca2+‑ATPase

Zhidong Li, Jia Guo, Yunfei Bian, Mingsheng Zhang
Article Number: 107
Published online on: 01 December 2020

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Article Open Access

Molecular mechanism underlying miR‑130b‑Sp1 transcriptional regulation in LPS‑induced upregulation of MUC5AC in the bile duct epithelium

Xiaodong Wu, Chenhui Yao, Jing Kong, Yu Tian, Ying  Fan, Zhen Zhang, Jinyan Han, Shuodong Wu
Article Number: 106
Published online on: 01 December 2020

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Review Open Access

Wnt/β‑catenin signaling: Causes and treatment targets of drug resistance in colorectal cancer (Review)

Gui-Xian Zhu, Dian Gao, Zhao-Zhao Shao, Li Chen, Wen-Jie Ding, Qiong-Fang Yu
Article Number: 105
Published online on: 01 December 2020

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Article Open Access

miR‑139‑5p enhances cisplatin sensitivity in non‑small cell lung cancer cells by inhibiting cell proliferation and promoting apoptosis via the targeting of Homeobox protein Hox‑B2

Hailian Du, Ya'nan Bao, Chunying Liu, Anqiao Zhong, Yikai Niu, Xingping Tang
Article Number: 104
Published online on: 01 December 2020

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Article

YY1 promotes SOCS3 expression to inhibit STAT3‑mediated neuroinflammation and neuropathic pain

Manyi Sun, Yue Sun, Jinfeng Ma, Kezhong Li
Article Number: 103
Published online on: 01 December 2020

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Article Open Access

miR‑125/CDK2 axis in cochlear progenitor cell proliferation

Tao Peng, Jing-Jing Peng, Gang-Yong Miao, Zhi-Qiang Tan, Bin Liu, En Zhou
Article Number: 102
Published online on: 01 December 2020

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Article

Inflammasome components and ADAMTS4 in premature rupture of membranes

Jinming Zhu, Chunling Ma, Xiaomei Luan, Juan Li, Fengyun Peng, Lei Huang
Article Number: 101
Published online on: 01 December 2020

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Penehyclidine hydrochloride alleviates lipopolysaccharide‑induced acute respiratory distress syndrome in cells via regulating autophagy‑related pathway

Xiaopeng Wang, Fen Liu, Min Xu, Liangxia Wu
Article Number: 100
Published online on: 01 December 2020

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Human galectin‑3: Molecular switch of gene expression in dermal fibroblasts in vitro and of skin collagen organization in open wounds and tensile strength in incisions in vivo

Peter Gál, Tomáš Vasilenko, Ivan Kováč, Matúš Čoma, Ján Jakubčo, Martina Jakubčová, Vlasta Peržeľová, Lukáš Urban, Michal Kolář, František Sabol, Ján Luczy, Martin Novotný, Jaroslav Majerník, Hans-Joachim Gabius, Karel Jr Smetana
Article Number: 99
Published online on: 27 November 2020

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Long non‑coding RNA ZFPM2‑AS1 promotes colorectal cancer progression by sponging miR‑137 to regulate TRIM24

Meihua Xiao, Zhi Liang, Zhihui Yin
Article Number: 98
Published online on: 27 November 2020

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Relationship between the pyroptosis of fibroblast‑like synoviocytes and HMGB1 secretion in knee osteoarthritis

Yancheng Xiao, Liang Ding, Songjiang Yin, Zhengquan Huang, Li  Zhang, Wei Mei, Peng Wu, Peimin Wang, Ke Pan
Article Number: 97
Published online on: 27 November 2020

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Roles of telomeres and telomerase in age‑related renal diseases (Review)

Haili Li, Boyuan Wang, Daoqun Li, Jinyuan Li, Ying Luo, Juhua Dan
Article Number: 96
Published online on: 27 November 2020

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let7f‑5p attenuates inflammatory injury in in vitro pneumonia models by targeting MAPK6

Lin Xu, Qingying Song, Zhanghong Ouyang, Xiangyan Zhang, Cheng Zhang
Article Number: 95
Published online on: 25 November 2020

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miR‑576‑5p promotes epithelial‑to‑mesenchymal transition in colorectal cancer by targeting the Wnt5a‑mediated Wnt/β‑catenin signaling pathway

Jialin Luo, Luying Liu, Jinwen Shen, Ning Zhou, Yanru Feng, Na Zhang, Quanquan Sun, Yuan Zhu
Article Number: 94
Published online on: 25 November 2020

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Nasopharyngeal carcinoma‑associated gene 6 inhibits cell viability, migration, invasion and induces apoptosis in osteosarcoma cells by inactivating the Wnt/β‑catenin signaling pathway

Lun Liu, Ruijing Wang, Zian Zhang, Xiangda Wang
Article Number: 93
Published online on: 25 November 2020

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Development and characterization of TrMab‑6, a novel anti‑TROP2 monoclonal antibody for antigen detection in breast cancer

Yusuke Sayama, Mika K. Kaneko, Yukinari Kato
Article Number: 92
Published online on: 25 November 2020

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FOXK1 plays an oncogenic role in the progression of hilar cholangiocarcinoma

Yujie Feng, Zhigang Bai, Jianning Song, Zhongtao Zhang
Article Number: 91
Published online on: 25 November 2020

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Long non‑coding RNA SNHG14 affects the proliferation and apoptosis of childhood acute myeloid leukaemia cells by modulating the miR‑193b‑3p/MCL1 axis

Xiaoliang Wang, Wenrong Li, Yanhong Chen, Lijuan Zhou
Article Number: 90
Published online on: 25 November 2020

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January-2026 Volume 33 Issue 1

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Non‑coding RNAs in epithelial‑mesenchymal transition of renal cell carcinoma (Review)

Ziqiao Liu, Hanshen Zhou, Junxiao Shen, Yiming Qi, Xuke Gong, Cheng Zhang
Article Number: 51
Published online on: 24 November 2025

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FOXJ3 drives mesenchymal stem cell osteogenic differentiation via the Wnt/β‑catenin pathway: A novel regulator implicated in osteoporosis

Hongwei Xiao, Jianfeng Li, Wei Huang, Yi Qin
Article Number: 50
Published online on: 21 November 2025

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NEDD4 regulates VEGF signaling and mTOR to promote angiogenesis and the cell cycle in steroid‑induced osteonecrosis of the femoral head

Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
Article Number: 49
Published online on: 21 November 2025

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Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway

Chih-Hsuan Hsia, Chun-Ming Yang, Chao-Chien Chang, Ting-Lin Yen, Arief Gunawan Darmanto, Chi-Chang Huang, Joen-Rong Sheu
Article Number: 48
Published online on: 21 November 2025

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Research progress on molecular therapy for glaucoma (Review)

Weiwei Wang, Gangwei Cheng, Qi Zhou, Sheng Wang, Linyi Zhang
Article Number: 47
Published online on: 21 November 2025

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Natural compounds for the treatment of rheumatoid arthritis based on the ‘gut‑joint axis’ (Review)

Wenjie Hu, Rui Li, Zhongming Zhang
Article Number: 46
Published online on: 20 November 2025

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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

Pan Guo, Mengke Sun, Jingyu Zhang, Qianshu Yuan, Hong Cui, Junkai Huang, Jing Luo, Qianyu Zhu, Bingxin Zhang, Lizhi Hu
Article Number: 45
Published online on: 20 November 2025

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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

Banghao Sun, Zhenyu Zhao, Qingyu Meng, Luya Pu, Xingyu Jiang, Shuai Li, Fadi Cao, Fan Li
Article Number: 44
Published online on: 20 November 2025

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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
Published online on: 18 November 2025

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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
Published online on: 17 November 2025

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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
Article Number: 41
Published online on: 12 November 2025

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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
Article Number: 40
Published online on: 12 November 2025

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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
Published online on: 12 November 2025

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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
Published online on: 10 November 2025

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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
Article Number: 35
Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
Published online on: 10 November 2025

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Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
Article Number: 22
Published online on: 31 October 2025

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Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review)

Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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Review

RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Article

Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 33 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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