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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February-2021 Volume 23 Issue 2

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Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Co‑expression of tissue kallikrein 1 and tissue inhibitor of matrix metalloproteinase 1 improves myocardial ischemia‑reperfusion injury by promoting angiogenesis and inhibiting oxidative stress

Shujie Huang, Meixian Chen, Huizhen Yu, Kaiyang Lin, Yansong Guo, Pengli Zhu
Article Number: 166
Published online on: 22 December 2020

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Article Open Access

miR‑126 overexpression attenuates oxygen‑glucose deprivation/reperfusion injury by inhibiting oxidative stress and inflammatory response via the activation of SIRT1/Nrf2 signaling pathway in human umbilical vein endothelial cells Corrigendum in /10.3892/mmr.2021.12158

Jixin Li, Caili Yang, Yan Wang
Article Number: 165
Published online on: 22 December 2020

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Article Open Access

S100A16 suppresses the proliferation, migration and invasion of colorectal cancer cells in part via the JNK/p38 MAPK pathway

Shiyu Ou, Yan Liao, Jie Shi, Jing Tang, Yanqing Ye, Fengfei Wu, Weidong Wang, Jieying Fei, Fang Xie, Lan Bai
Article Number: 164
Published online on: 22 December 2020

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Article

Effects of KAI gene expression on ferroptosis in pancreatic cancer cells

Xu Liu, Xiaozhong Guo, Hongyu Li, Jiang Chen, Hao Han
Article Number: 163
Published online on: 22 December 2020

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Article Open Access

Induction of notochordal differentiation of bone marrow mesenchymal‑derived stem cells via the stimulation of notochordal cell‑rich nucleus pulposus tissue

Defang Li, Qingmin Zeng, Zengxin Jiang, Lei Ding, Wei Lu, Mengxuan Bian, Jingping Wu
Article Number: 162
Published online on: 22 December 2020

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Article Open Access

Mitochondrial proteomics alterations in rat hearts following ischemia/reperfusion and diazoxide post‑conditioning

Yunchao Pan, Yuan Wang, Wenyan Shi, Yun Liu, Song Cao, Tian Yu
Article Number: 161
Published online on: 22 December 2020

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Article Open Access

Age affects the paracrine activity and differentiation potential of human adipose‑derived stem cells

Jeong Seop Park, Gabee Park, Hyun Sook Hong
Article Number: 160
Published online on: 22 December 2020

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Review

Role of peroxisome proliferator-activated receptors in osteoarthritis (Review)

Gang Huang, Wei Jiang, Weiyong Xie, Wei Lu, Weimin Zhu, Zhenhan Deng
Article Number: 159
Published online on: 22 December 2020

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Article

Neochlorogenic acid enhances the antitumor effects of pingyangmycin via regulating TOP2A

Jianhuan Che, Tongxia Zhao, Wen Liu, Shi Chen, Guangyu Yang, Xinyan Li, Dongling Liu
Article Number: 158
Published online on: 22 December 2020

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Article Open Access

Luteolin attenuates angiotensin II‑induced renal damage in apolipoprotein E‑deficient mice

Ying-Shu Liu, Qin Yang, Shen Li, Lan Luo, Hong-Yang Liu, Xin-Yu Li, Zheng-Nan Gao
Article Number: 157
Published online on: 22 December 2020

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Review

Estrogen receptor-associated receptor α and peroxisome proliferator-activated receptor γ in metabolism and disease (Review)

Wei-Yi Huang, Peng-Ming Sun
Article Number: 156
Published online on: 22 December 2020

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Article Open Access

Isoflurane reduces septic neuron injury by HO‑1‑mediated abatement of inflammation and apoptosis

Lina Zhang, Xuece Zhang, Ting Wu, Xu Pan, Zhi Wang
Article Number: 155
Published online on: 22 December 2020

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Article Open Access

MicroRNA‑223‑induced inhibition of the FBXW7 gene affects the proliferation and apoptosis of colorectal cancer cells via the Notch and Akt/mTOR pathways

Zhixin Liu, Teng Ma, Jufeng Duan, Xiaofei Liu, Long Liu
Article Number: 154
Published online on: 20 December 2020

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Article Open Access

lncRNA LIFR‑AS1 inhibits gastric carcinoma cell proliferation, migration and invasion by sponging miR‑4698

Jiangqiao Zhao, Xiaoning Li, Liping Fu, Na Zhang, Jiaping Yang, Jianhui Cai
Article Number: 153
Published online on: 20 December 2020

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Article Open Access

PMCA4 gene expression is regulated by the androgen receptor in the mouse testis during spermatogenesis

Rui Sun, Hui Liang, Huan Guo, Zhu Wang, Qiong Deng
Article Number: 152
Published online on: 20 December 2020

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Article Open Access

Matrix metalloproteinase 3 regulates angiotensin II‑induced myocardial fibrosis cell viability, migration and apoptosis

Jin Shu, Yiwen Gu, Li Jin, Haiya Wang
Article Number: 151
Published online on: 20 December 2020

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Article Open Access

JNK‑IN‑8 treatment alleviates lipopolysaccharide‑induced acute lung injury via suppression of inflammation and oxidative stress regulated by JNK/NF‑κB signaling

Jingxian Du, Gaojian Wang, Huanyu Luo, Na Liu, Junran Xie
Article Number: 150
Published online on: 20 December 2020

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Article Open Access

PRDM14 mediates chemosensitivity and glycolysis in drug‑resistant A549/cisplatin cells and their progenitor A549 human lung adenocarcinoma cells

Saifei He, Xiaokun Ma, Ni Zheng, Guoyu Wang, Menghan Wang, Wei Xia, Donghai Yu
Article Number: 149
Published online on: 17 December 2020

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Article Open Access

OxLDL/β2GPI/anti‑β2GPI Ab complex induces inflammatory activation via the TLR4/NF‑κB pathway in HUVECs

Guiting Zhang, Qianqian Cai, Hong Zhou, Chao He, Yudan Chen, Peng Zhang, Ting Wang, Liangjie Xu, Jinchuan Yan
Article Number: 148
Published online on: 17 December 2020

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Article Open Access

Liraglutide protects palmitate-induced INS-1 cell injury by enhancing autophagy mediated via FoxO1

Xiu-Dan Li, Shan-Shan He, Ting-Ting Wan, Yan-Bo Li
Article Number: 147
Published online on: 17 December 2020

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Article Open Access

Knockdown of long non‑coding RNA ANRIL inhibits the proliferation and promotes the apoptosis of Burkitt lymphoma cells through the TGF‑β1 signaling pathway

Shudan Mao, Jieping Jin, Zhe Li, Wenqi Yang
Article Number: 146
Published online on: 15 December 2020

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Article Open Access

Knockdown of lncRNA ANRIL suppresses the production of inflammatory cytokines and mucin 5AC in nasal epithelial cells via the miR-15a-5p/JAK2 axis

Huo-Wang Liu, Zhong-Liang Hu, Hao Li, Qi-Feng Tan, Jing Tong, Yong-Quan Zhang
Article Number: 145
Published online on: 15 December 2020

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Article Open Access

Atezolizumab alleviates the immunosuppression induced by PD‑L1‑positive neutrophils and improves the survival of mice during sepsis

Jianxin Chen, Ruiyuan Chen, Shaoxiong Huang, Bin Zu, Sen Zhang
Article Number: 144
Published online on: 15 December 2020

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Correction Open Access

[Corrigendum] Vorinostat protects against calcium oxalate‑induced kidney injury in mice

Li Wang, Wei Chen, Zhongjiang Peng, Changcheng Liu, Caihong Zhang, Zhiyong Guo
Article Number: 143
Published online on: 14 December 2020

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Article

Bioinformatics analysis indicates that microRNA‑628‑5p overexpression may alleviate Alzheimer's disease by targeting TYROBP

Miao Liu, Shuling Li, Chun Ma, Xinna Wang, Yu Shuang, Haining Lin, Zhiying Guan, Lihua Yang
Article Number: 142
Published online on: 13 December 2020

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Article Open Access

circARRDC3 contributes to interleukin‑13‑induced inflammatory cytokine and mucus production in nasal epithelial cells via the miR‑375/KLF4 axis

Tao Wang, Peihua Wang, Dong Chen, Zhou Xu, Liyun Yang
Article Number: 141
Published online on: 13 December 2020

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Article Open Access

Sericin inhibits MDA‑MB‑468 cell proliferation via the PI3K/Akt pathway in triple‑negative breast cancer

Lin Niu, Songhe Yang, Xueying Zhao, Xiaochao Liu, Lina Si, Meng Wei, Lei Liu, Luyang Cheng, Yuebing Qiao, Zhihong Chen
Article Number: 140
Published online on: 13 December 2020

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Article Open Access

lncRNA FLVCR1‑AS1 drives colorectal cancer progression via modulation of the miR‑381/RAP2A axis Expression of Concern in /10.3892/mmr.2025.13774

Yi Han, Xiaoyan Wang, Enqiang Mao, Boyong Shen, Liang Huang
Article Number: 139
Published online on: 13 December 2020

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Article Open Access

Inhibition of SNCG suppresses the proliferation of lung cancer cells induced by high glucose

Jing Fei, Chi Xiao, Meiying Yang, Xue Zhou, Ping Gong
Article Number: 138
Published online on: 13 December 2020

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Article Open Access

CBX2 depletion inhibits the proliferation, invasion and migration of gastric cancer cells by inactivating the YAP/β-catenin pathway

Miaomiao Zeng, Bangxue Li, Lei Yang, Quanlin Guan
Article Number: 137
Published online on: 13 December 2020

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Article Open Access

MicroRNA‑338‑3p regulates age‑associated osteoporosis via targeting PCSK5

Jie Tong, Min Zhang, Xia Li, Guohai Ren
Article Number: 136
Published online on: 13 December 2020

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Article Open Access

GAS5 regulates diabetic cardiomyopathy via miR‑221‑3p/p27 axis‑associated autophagy

Dezhi Chen, Min Zhang
Article Number: 135
Published online on: 13 December 2020

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Article Open Access

Upregulation of microRNA‑140‑3p mediates dachshund family transcription factor 1 expression in immunoglobulin A nephropathy through cell cycle‑dependent mechanisms

Xiaobin Zhou, Yao Lu, Pengfei Guo, Chenglin Zhou
Article Number: 134
Published online on: 13 December 2020

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Article

Shikonin ameliorates lipoteichoic acid‑induced acute lung injury via promotion of neutrophil apoptosis

Yong Zhang, Haibo Zhang, Muqun Wang, Shan Gao, Lei Hong, Tingting Hou, Yaoyao Zhang, Yuling Zhu, Feng Qian
Article Number: 133
Published online on: 13 December 2020

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Article Open Access

Analysis of differential expression of long non‑coding RNAs in exosomes derived from mature and immature dendritic cells

Jiachang Wu, Renli Zhao, Jingxing Dai, Guohua Lai, Asmat Ullah Khan, Xiao Yu, Sha Wu, Jun Ouyang, Hongxun Sang
Article Number: 132
Published online on: 10 December 2020

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Article

Long non‑coding RNA H19 inhibition ameliorates oxygen‑glucose deprivation‑induced cell apoptosis and inflammatory cytokine expression by regulating the microRNA‑29b/SIRT1/PGC‑1α axis

Jing Xu, Chunyang Wang, Fanjie Meng, Pengjuan Xu
Article Number: 131
Published online on: 10 December 2020

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Article Open Access

miR‑182‑5p contributes to radioresistance in nasopharyngeal carcinoma by regulating BNIP3 expression Corrigendum in /10.3892/mmr.2021.11935

Wei He, Hongyan Jin, Qian Liu, Quanxin Sun
Article Number: 130
Published online on: 10 December 2020

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Article Open Access

Effect of EZH2 on pulmonary artery smooth muscle cell migration in pulmonary hypertension

Ying Wang, Xiao-Xi Huang, Dong Leng, Ji-Feng Li, Yan Liang, Tao Jiang
Article Number: 129
Published online on: 10 December 2020

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Article Open Access

Gli affects the stemness and prognosis of epithelial ovarian cancer via homeobox protein NANOG

Huan Zhao, Na Li, Yicun Pang, Jun Zhao, Xiaohua Wu
Article Number: 128
Published online on: 10 December 2020

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Article Open Access

Anti‑inflammatory effect of salusin‑β knockdown on LPS‑activated alveolar macrophages via NF‑κB inhibition and HO‑1 activation

Sheng Chen, Yunnan Hu, Jiaxin Zhang, Pengyu Zhang
Article Number: 127
Published online on: 08 December 2020

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Article

Analysis of the intestinal IgA response in mice exposed to chronic stress and treated with bovine lactoferrin

Teresita Rocío Cruz‑Ηernández, Daniel Cuauhtémoc Gómez‑Jiménez, Rafael Campos‑Rodríguez, Marycarmen Godínez‑Victoria, Maria Elisa Drago‑Serrano
Article Number: 126
Published online on: 08 December 2020

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Article Open Access

BMP2 induces hMSC osteogenesis and matrix remodeling

Hantao Cai, Ji Zou, Wei Wang, Aofei Yang
Article Number: 125
Published online on: 08 December 2020

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Article Open Access

miR‑654‑3p suppresses cell viability and promotes apoptosis by targeting RASAL2 in non‑small‑cell lung cancer

Jie Xiong, Shigang Xing, Zheng Dong, Lei Niu, Qinghua Xu, Yusheng Li, Pingyi Liu, Peixia Yang
Article Number: 124
Published online on: 08 December 2020

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Article

Identification of galectin‑10 as a biomarker for periodontitis based on proteomic analysis of gingival crevicular fluid

Jun Su Kim, Il-Hoon Cho, Kyung-Hee Kim, Young Sun Hwang
Article Number: 123
Published online on: 07 December 2020

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Article Open Access

Dickkopf‑1/cysteine‑rich angiogenic inducer 61 axis mediates palmitic acid‑induced inflammation and apoptosis of vascular endothelial cells

Yi-Rong Gan, Ling Wei, Yan-Zhen Wang, Zong-Ke Kou, Tian-Xiang Liang, Guan-Waner Ding, Yan-Hong Ding, Ding-Xiong Xie
Article Number: 122
Published online on: 07 December 2020

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Article Open Access

Induction of mesenchymal stem cell‑like transformation in rat primary glial cells using hypoxia, mild hypothermia and growth factors

Huiping Wei, Wenyun Zhou, Guozhu Hu, Chunhua Shi
Article Number: 121
Published online on: 07 December 2020

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Article Open Access

miR‑34c‑5p targets Notch1 and suppresses the metastasis and invasion of cervical cancer

Huali Wei, Xiaolan Wang, Xiumin Niu, Ruili Jiao, Xiaojuan Li, Sumei Wang
Article Number: 120
Published online on: 07 December 2020

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Retraction Open Access

[Retracted] MicroRNA‑21 increases cell viability and suppresses cellular apoptosis in non‑small cell lung cancer by regulating the PI3K/Akt signaling pathway

Tao Wang, Zhenyu Cai, Guolin Hong, Gangsen Zheng, Yu Huang, Shun Zhang, Jinhua Dai
Article Number: 119
Published online on: 04 December 2020

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Article Open Access

Effects of inhibiting PDK‑1 expression in bone marrow mesenchymal stem cells on osteoblast differentiation in vitro

Yiguang Bai, Qiong Zhang, Quan Zhou, Yanan Zhang, Haibin Nong, Mingfu Liu, Zhuohua Shi, Gaofeng Zeng, Shaohui Zong
Article Number: 118
Published online on: 04 December 2020

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Article Open Access

lncRNA SNHG16 promotes the occurrence of osteoarthritis by sponging miR‑373‑3p

Haiyan Fan, Liangjia Ding, Yun Yang
Article Number: 117
Published online on: 04 December 2020

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Article Open Access

Overexpression of lncRNA Dancr inhibits apoptosis and enhances autophagy to protect cardiomyocytes from endoplasmic reticulum stress injury via sponging microRNA-6324

Jiong Li, Jing Xie, Yan-Zhen Wang, Yi-Rong Gan, Ling Wei, Guan-Waner Ding, Yan-Hong Ding, Ding-Xiong Xie
Article Number: 116
Published online on: 03 December 2020

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Article

WWOX promotes apoptosis and inhibits autophagy in paclitaxel‑treated ovarian carcinoma cells

Yan Zhao, Wen Wang, Wenying Pan, Yunhai Yu, Wenqian Huang, Jiangang Gao, Ying Zhang, Shiqian Zhang
Article Number: 115
Published online on: 03 December 2020

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Correction Open Access

[Erratum] Oxidative stress, autophagy and pyroptosis in the neovascularization of oxygen‑induced retinopathy in mice

Shuai Wang, Li-Yang Ji, Li Li, Jing-Min Li
Article Number: 114
Published online on: 03 December 2020

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Article Open Access

The mRNA expression of Il6 and Pdcd1 are predictive and protective factors for doxorubicin‑induced cardiotoxicity

Syu-Ichi Kanno, Akiyoshi Hara
Article Number: 113
Published online on: 03 December 2020

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Article Open Access

Long non‑coding RNA ANRIL is a potential indicator of disease progression and poor prognosis in acute myeloid leukemia

Zhenqing Tan, Kaibo Zhu, Yafei Yin, Zimian Luo
Article Number: 112
Published online on: 03 December 2020

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Article Open Access

NORAD regulates epithelial‑mesenchymal transition of non‑small cell lung cancer cells via miR‑422a Corrigendum in /10.3892/mmr.2021.12178

Zhikun Chen, Qin Che, Chunxue Xie
Article Number: 111
Published online on: 03 December 2020

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Article Open Access

Prostaglandin E1 attenuates post‑cardiac arrest myocardial dysfunction through inhibition of mitochondria‑mediated cardiomyocyte apoptosis

Chenglei Su, Xinhui Fan, Feng Xu, Jiali Wang, Yuguo Chen
Article Number: 110
Published online on: 02 December 2020

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Article Open Access

hCINAP serves a critical role in hypoxia‑induced cardiomyocyte apoptosis via modulating lactate production and mitochondrial‑mediated apoptosis signaling

Hebing Xie, Gang Xu, Yuqi Gao, Zhibin Yuan
Article Number: 109
Published online on: 02 December 2020

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Article Open Access

Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice Corrigendum in /10.3892/mmr.2023.12994

Zhiping Li, Hui Bi, Hongbo Jiang, Jingjing Song, Qingfan Meng, Yizhi Zhang, Xiaofang Fei
Article Number: 108
Published online on: 02 December 2020

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Article Open Access

Intermedin protects thapsigargin‑induced endoplasmic reticulum stress in cardiomyocytes by modulating protein kinase A and sarco/endoplasmic reticulum Ca2+‑ATPase

Zhidong Li, Jia Guo, Yunfei Bian, Mingsheng Zhang
Article Number: 107
Published online on: 01 December 2020

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Article Open Access

Molecular mechanism underlying miR‑130b‑Sp1 transcriptional regulation in LPS‑induced upregulation of MUC5AC in the bile duct epithelium

Xiaodong Wu, Chenhui Yao, Jing Kong, Yu Tian, Ying  Fan, Zhen Zhang, Jinyan Han, Shuodong Wu
Article Number: 106
Published online on: 01 December 2020

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Review Open Access

Wnt/β‑catenin signaling: Causes and treatment targets of drug resistance in colorectal cancer (Review)

Gui-Xian Zhu, Dian Gao, Zhao-Zhao Shao, Li Chen, Wen-Jie Ding, Qiong-Fang Yu
Article Number: 105
Published online on: 01 December 2020

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Article Open Access

miR‑139‑5p enhances cisplatin sensitivity in non‑small cell lung cancer cells by inhibiting cell proliferation and promoting apoptosis via the targeting of Homeobox protein Hox‑B2

Hailian Du, Ya'nan Bao, Chunying Liu, Anqiao Zhong, Yikai Niu, Xingping Tang
Article Number: 104
Published online on: 01 December 2020

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Article

YY1 promotes SOCS3 expression to inhibit STAT3‑mediated neuroinflammation and neuropathic pain

Manyi Sun, Yue Sun, Jinfeng Ma, Kezhong Li
Article Number: 103
Published online on: 01 December 2020

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Article Open Access

miR‑125/CDK2 axis in cochlear progenitor cell proliferation

Tao Peng, Jing-Jing Peng, Gang-Yong Miao, Zhi-Qiang Tan, Bin Liu, En Zhou
Article Number: 102
Published online on: 01 December 2020

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Article

Inflammasome components and ADAMTS4 in premature rupture of membranes

Jinming Zhu, Chunling Ma, Xiaomei Luan, Juan Li, Fengyun Peng, Lei Huang
Article Number: 101
Published online on: 01 December 2020

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Penehyclidine hydrochloride alleviates lipopolysaccharide‑induced acute respiratory distress syndrome in cells via regulating autophagy‑related pathway

Xiaopeng Wang, Fen Liu, Min Xu, Liangxia Wu
Article Number: 100
Published online on: 01 December 2020

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Human galectin‑3: Molecular switch of gene expression in dermal fibroblasts in vitro and of skin collagen organization in open wounds and tensile strength in incisions in vivo

Peter Gál, Tomáš Vasilenko, Ivan Kováč, Matúš Čoma, Ján Jakubčo, Martina Jakubčová, Vlasta Peržeľová, Lukáš Urban, Michal Kolář, František Sabol, Ján Luczy, Martin Novotný, Jaroslav Majerník, Hans-Joachim Gabius, Karel Jr Smetana
Article Number: 99
Published online on: 27 November 2020

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Long non‑coding RNA ZFPM2‑AS1 promotes colorectal cancer progression by sponging miR‑137 to regulate TRIM24

Meihua Xiao, Zhi Liang, Zhihui Yin
Article Number: 98
Published online on: 27 November 2020

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Relationship between the pyroptosis of fibroblast‑like synoviocytes and HMGB1 secretion in knee osteoarthritis

Yancheng Xiao, Liang Ding, Songjiang Yin, Zhengquan Huang, Li  Zhang, Wei Mei, Peng Wu, Peimin Wang, Ke Pan
Article Number: 97
Published online on: 27 November 2020

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Roles of telomeres and telomerase in age‑related renal diseases (Review)

Haili Li, Boyuan Wang, Daoqun Li, Jinyuan Li, Ying Luo, Juhua Dan
Article Number: 96
Published online on: 27 November 2020

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let7f‑5p attenuates inflammatory injury in in vitro pneumonia models by targeting MAPK6

Lin Xu, Qingying Song, Zhanghong Ouyang, Xiangyan Zhang, Cheng Zhang
Article Number: 95
Published online on: 25 November 2020

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miR‑576‑5p promotes epithelial‑to‑mesenchymal transition in colorectal cancer by targeting the Wnt5a‑mediated Wnt/β‑catenin signaling pathway

Jialin Luo, Luying Liu, Jinwen Shen, Ning Zhou, Yanru Feng, Na Zhang, Quanquan Sun, Yuan Zhu
Article Number: 94
Published online on: 25 November 2020

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Nasopharyngeal carcinoma‑associated gene 6 inhibits cell viability, migration, invasion and induces apoptosis in osteosarcoma cells by inactivating the Wnt/β‑catenin signaling pathway

Lun Liu, Ruijing Wang, Zian Zhang, Xiangda Wang
Article Number: 93
Published online on: 25 November 2020

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Development and characterization of TrMab‑6, a novel anti‑TROP2 monoclonal antibody for antigen detection in breast cancer

Yusuke Sayama, Mika K. Kaneko, Yukinari Kato
Article Number: 92
Published online on: 25 November 2020

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FOXK1 plays an oncogenic role in the progression of hilar cholangiocarcinoma

Yujie Feng, Zhigang Bai, Jianning Song, Zhongtao Zhang
Article Number: 91
Published online on: 25 November 2020

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Long non‑coding RNA SNHG14 affects the proliferation and apoptosis of childhood acute myeloid leukaemia cells by modulating the miR‑193b‑3p/MCL1 axis

Xiaoliang Wang, Wenrong Li, Yanhong Chen, Lijuan Zhou
Article Number: 90
Published online on: 25 November 2020

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Journal Cover
August-2026 Volume 34 Issue 2

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Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Regulatory function of ten‑eleven translocation‑2 in transcriptional mechanisms of demethylated myeloma cells

Lenka Slavickova, Michaela Nemcova, Dominika Svehlova, Veronika Frybortova, Jirina Manakova, Eva Kriegova, Jiri Minarik, Katerina Smesny Trtkova
Article Number: 237
Published online on: 25 June 2026

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Mulberroside A attenuates H2O2‑induced oxidative stress and barrier dysfunction in Caco‑2 cells through Nrf2/HO‑1‑associated antioxidant signaling

Jianxin Chen, Xiufeng Huang, Xi Chen, Wenhai Jin, Dawei Lin
Article Number: 236
Published online on: 25 June 2026

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[Retracted] Puerarin promotes DUSP1 expression by regulating miR‑133a‑3p in breast cancer

Zhifeng Li, Weiwei Xu, Xiaoyan Ren, Jinhua Xu, Jianxin Chen
Article Number: 235
Published online on: 23 June 2026

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Sulforaphane attenuates cisplatin‑induced acute kidney injury by inhibiting oxidative stress, inflammation and apoptosis via regulation of NRF2

Zeyu Wu, Mengting Lu, Lei Xu, Ming Luo, Limei Shan, Hongxia Xing, Wenwen Li, Junling Qian
Article Number: 234
Published online on: 19 June 2026

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Effects of β‑hydroxybutyrate on restoring autophagic flux and mitochondrial function in macrophages exposed to oxidized low‑density lipoprotein

Weiguang Luo, Mei He, Huiling Wang
Article Number: 233
Published online on: 19 June 2026

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Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review)

Xiaokang Wang, Qiwen Tan, Jingcheng Xu, Yunlin Yang, Haoyue Huang, Xiaomei Teng, Weihua Wu
Article Number: 232
Published online on: 18 June 2026

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Degraded sulfated galactan derived from Gracilaria fisheri induces immunogenic cell death in MDA‑MB‑231 cells

Tawut Rudtanatip, Yada Polsan, Waraporn Sakaew, Somsuda Somintara, Jenjiralai Phanphak, Jamal El‑Abid, Kanokpan Wongprasert, Choowadee Pariwatthanakun
Article Number: 231
Published online on: 17 June 2026

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Article

Irbesartan ameliorates high‑glucose‑induced epithelial‑mesenchymal transition by downregulating the expression of NLRP3 in HK‑2 cells

Qing Deng, Xiujuan Liu, Dan Wen, Yuhua Cheng, Qing Zhao, Yu Wang, Yu Xiang, Qinkai Chen, Jinlei Lv
Article Number: 230
Published online on: 17 June 2026

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A β‑1,3‑1,6‑glucan from Aureobasidium pullulans enhances apoptotic and autophagic pathways in colorectal cancer cells

Ji-Won Park, Gyeong Mim Mun, Tae Min Jo, Ji A Shin, Takao Kuge, Hisashi Kimoto, Jin-Kyung Kim
Article Number: 229
Published online on: 16 June 2026

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Growth pattern and molecular biological analysis of primary meningioma cell cultures under different conditions

Stefan Linsler, Anna-Lena Moroldo, Walter Schulz‑Schaeffer, Ralf Ketter, Joachim Oertel, Steffi Urbschat
Article Number: 228
Published online on: 12 June 2026

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Melatonin alleviates mitochondrial damage by regulating SIRT3‑mediated mitochondrial dynamics in granulosa cells under PCOS‑like conditions

Congcong Xie, Zehao Liu, Tong Chen, Hui Lu, Xiujia Zhang, Wenbo Yu, Jiaxin Zhang, Dandan Shang, Xueying Wang
Article Number: 227
Published online on: 11 June 2026

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Strontium‑based metal‑organic framework/alendronate‑silk fibroin hydrogels promote tendon‑bone interface healing

Tao Yang, Hanji Zhang, Mingjun Li, Yiming Ren, Yunbo Sun, Weiyu Hou, Mengqiang Tian
Article Number: 226
Published online on: 11 June 2026

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Retraction Open Access

[Retracted] Tripterygium glycoside suppresses epithelial‑to‑­­ mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway

Mei Tao, Danna Zheng, Xudong Liang, Diandian Wu, Kang Hu, Juan Jin, Qiang He
Article Number: 225
Published online on: 08 June 2026

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Gut microbiota‑derived metabolites in cardiovascular disease: Focus on trimethylamine N‑oxide, short‑chain fatty acids and bile acids (Review)

Meizhu Gao, Zhenming Hao, Yiling Li, Weixue Liu, Fubao Zhang
Article Number: 224
Published online on: 08 June 2026

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Fucoxanthin alleviates chondrocyte inflammation and osteoarthritis by modulating the JAK2/STAT3 signaling pathway

Miradj Siddick Adam, Huangming Zhuang, Xunshan Ren, Yuelong Zhang, Panghu Zhou
Article Number: 223
Published online on: 08 June 2026

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Prediction of molecular targets for zedoary turmeric oil in inhibiting proliferation and inducing apoptosis in non‑small cell lung cancer

Huaiyong Li, Lili Liu, Qingzhu Yang, Yao Li, Yongli Song, Jing Jiang, Zhenzhong Wu, Weiwei Zhang, Baisong Lou
Article Number: 222
Published online on: 08 June 2026

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Molecular mechanisms of iron metabolism and ferroptosis in cardiovascular diseases and intervention strategies targeting natural products (Review)

Liangqing Ge, Tianqing Zhang, Jiangbiao Yu, Sijie Xiao, Yu Zhou, Li Luo
Article Number: 221
Published online on: 05 June 2026

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Correction Open Access

[Corrigendum] Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis

Ruiqiao Guan, Zhihao Li, Xiaohong Dai, Wei Zou, Xueping Yu, Hao Liu, Qiuxin Chen, Wei Teng, Peng Liu, Xiaoying Liu, Shanshan Dong
Article Number: 220
Published online on: 03 June 2026

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LINC01117 promotes the malignant proliferation of lung adenocarcinoma by increasing HOXD8 mRNA stability

Lizhong Zeng, Jie Shi, Cai Zhang, Yujiao Dong, Yang Chen, Qiuhong Zhang, Long Zhang, Shuanying Yang
Article Number: 219
Published online on: 03 June 2026

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Targeting regulatory T cells in the prostate cancer microenvironment: From mechanisms to therapeutics (Review)

Hua Luo
Article Number: 218
Published online on: 03 June 2026

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Dapagliflozin alleviates heart failure with preserved ejection fraction potentially by regulating the AIM2/caspase‑1/GSDMD pathway and attenuating pyroptosis

Sailiang Ding, Hao Yang, Ting Lu, Yibin Luo, Liang Xu, Xianghui Zeng
Article Number: 217
Published online on: 03 June 2026

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[Retracted] Carnosic acid alleviates brain injury through NF‑κB‑regulated inflammation and Caspase‑3‑associated apoptosis in high fat‑induced mouse models

Yong Liu, Yan Zhang, Ming Hu, Yu-Hu Li, Xing-Hua Cao
Article Number: 216
Published online on: 02 June 2026

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SIRT1/AMPK/PGC1α pathway in ischemic stroke: Elucidating neuroprotective strategies (Review)

Irum Naz Abbasi, Nashwa Amin, Qiaolu Xu, Azhar Badry Hussain, Fei Wu, Xia Yuan, Yang Yang, Suhong Ye, Marong Fang, Yihua Jiang
Article Number: 215
Published online on: 02 June 2026

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Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review)

Yinhuan Wang, Jiefang Guan
Article Number: 214
Published online on: 29 May 2026

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Journal Cover
September-2026 Volume 34 Issue 3

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article

Leonurine inhibits the proliferation and metastasis of liver cancer cells by regulating the PI3K/AKT signaling pathway via epithelial‑mesenchymal transition

Bowen Hu, Maher Al Hussan, Jiakai Zhang, Peihao Wen, Changjun Huang, Yang Chen, Huanfei Ding
Article Number: 251
Published online on: 08 July 2026

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[Corrigendum] Resistin aggravates the expression of proinflammatory cytokines in cerulein‑stimulated AR42J pancreatic acinar cells

Chong-Yi Jiang, Wei Wang
Article Number: 250
Published online on: 08 July 2026

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A‑Raf: A serine/threonine protein kinase with important biological functions (Review)

Muhan Yang, Mengying Chen, Jinmei Wei, Yanling Li, Chen Long, Yan Lei, Yanhong Zhou
Article Number: 249
Published online on: 07 July 2026

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Gut dysbiosis‑derived butyrate loss predicts feeding intolerance: Multiomics evidence guiding nurse‑driven microbiota‑supportive interventions (Review)

Ling Wei, Xiaohua Kong, Yuying Li, Huixia Wu, Yirong Gan, Fang Sun
Article Number: 248
Published online on: 07 July 2026

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[Retracted] Network pharmacology combined with experimental validation to investigate the effect of Rongjin Niantong Fang on chondrocyte apoptosis in knee osteoarthritis

Jun Chen, Ting Zhang, Qingqing Luo, Ruyi Wang, Yuting Dai, Zhenyuan Chen, Chutian Zhang, Xuzheng Chen, Guangwen Wu
Article Number: 247
Published online on: 06 July 2026

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Laggera alata attenuates LPS‑induced systemic inflammation and hepatic‑pulmonary injury by regulating PINK1/Parkin-associated mitophagy and macrophage polarization

Jiangcun Wei, Wen Zhong, Guangyun Zhou, Mingtao Huang, Xiaodong Huang, Jing Liang
Article Number: 246
Published online on: 02 July 2026

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Proteolysis‑targeting chimeras in oral squamous cell carcinoma: Current evidence, translational challenges and future directions (Review)

Yun Bai, Danhua Ma, Xi Yang, Min Wang
Article Number: 245
Published online on: 02 July 2026

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Evolving role of biomarkers beyond prostate‑specific antigen in refining prostate cancer screening: From blood‑based tests to urinary and genetic markers (Review)

Luxi Li, Linyue Zhang, Zehong Li, Keqiang Chai, Weidong Ren
Article Number: 244
Published online on: 02 July 2026

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Nanocurcumin attenuates brain injury in rats with desert dry‑heat‑induced exertional heat stroke by suppressing TLR4/MyD88/NF‑κB signaling

Lisong Su, Jinquan Qu, Jiajia Li, Wenhui Shi, Laiyang Song, Feixing Liang, Jiangwei Liu
Article Number: 243
Published online on: 02 July 2026

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TREM2 in glioma: Reprogramming the immune microenvironment from mechanistic understanding to clinical translation (Review)

Junqi Fan, Hongyan Shen, Dan Liu, Songbai Luo, Qingqing Huang, Yi Wen, Libang Yuan
Article Number: 242
Published online on: 02 July 2026

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Human parvovirus B19 VP1u‑induced osteoclastogenesis is enhanced by RANKL in RAW264.7 macrophage cells

Chun-Yu Lin, Bor-Show Tzang, Yi-Hsuan Lin, Chih-Chen Tzang, Tsai-Ching Hsu
Article Number: 241
Published online on: 30 June 2026

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[Retracted] Anti‑tumor peptide AP25 decreases cyclin D1 expression and inhibits MGC‑803 proliferation via phospho­extracellular signal‑regulated kinase‑, Src‑, c‑Jun N‑terminal kinase‑ and phosphoinositide 3­-kinase‑associated pathways  

Jialiang Hu, Tao Cheng, Lijun Zhang, Beicheng Sun, Lei Deng, Hanmei Xu
Article Number: 240
Published online on: 29 June 2026

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Aspirin prevents postoperative peritoneal adhesions by inhibiting the TGF‑β1/Smad signaling pathway in rats

Siqi Yan, Yuan Ren, Bingyan Liu, Pai Xiong, Yimin Sun
Article Number: 239
Published online on: 29 June 2026

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Morinda officinalis oligosaccharides ameliorate corticosterone‑induced depression‑like behaviour in mice by modulating the BDNF signalling pathway and gut microbiota

Mengjie He, Zixuan Liu, Yuxin Chen, Xiaoru Wu, Xueling Dai, Qian Liu, Shuo Wang, Zeping Zuo, Yaxuan Sun
Article Number: 238
Published online on: 29 June 2026

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