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Sericin inhibits MDA‑MB‑468 cell proliferation via the PI3K/Akt pathway in triple‑negative breast cancer

  • Authors:
    • Lin Niu
    • Songhe Yang
    • Xueying Zhao
    • Xiaochao Liu
    • Lina Si
    • Meng Wei
    • Lei Liu
    • Luyang Cheng
    • Yuebing Qiao
    • Zhihong Chen
  • View Affiliations / Copyright

    Affiliations: Department of Human Anatomy, Chengde Medical University, Chengde, Hebei 067000, P.R. China, Department of Immunology, Chengde Medical University, Chengde, Hebei 067000, P.R. China
    Copyright: © Niu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 140
    |
    Published online on: December 13, 2020
       https://doi.org/10.3892/mmr.2020.11779
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Abstract

Triple negative breast cancer (TNBC) is a subtype of breast cancer characterized by an aggressive histology and poor prognosis, with limited treatment options in the clinic. In the present study, the effect of sericin, as an anti‑cancer drug, on TNBC cell proliferation was investigated using a MTT assay, a colony formation assay and immunocytochemistry staining of Ki67. Results from the flow cytometry demonstrated that sericin induced G0/G1 cell cycle arrest and promoted cellular apoptosis. Cell cycle and apoptosis‑related proteins were detected via western blot analysis. Immunocytochemistry staining identified that P21 was translocated into the nucleus. Additionally, several pathways were significantly enriched in TNBC based on the Gene Expression Omnibus database, with the most prominent pathway being the PI3K/Akt signaling pathway. In TNBC MDA‑MB‑468 cells, sericin suppressed the PI3K/Akt pathway. All these findings suggested that sericin served a critical role in suppressing TNBC cell proliferation, inducing cell cycle arrest and promoting cellular apoptosis. The results indicated that the underlying molecular mechanism was, at least partially, via the downregulation of the PI3K/Akt signaling pathway.
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1 

Kumar P and Aggarwal R: An overview of triple-negative breast cancer. Arch Gynecol Obstet. 293:247–269. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Kim A, Jang MH, Lee SJ and Bae YK: Mutations of the epidermal growth factor receptor gene in triple-negative breast cancer. J Breast Cancer. 20:150–159. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Zhao Z, Li L, Du P, Ma L, Zhang W, Zheng L, Lan B, Zhang B, Ma F, Xu B, et al: Transcriptional downregulation of miR-4306 serves as a new therapeutic target for triple negative breast cancer. Theranostics. 9:1401–1416. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Abramson VG and Mayer IA: Molecular heterogeneity of triple negative breast cancer. Curr Breast Cancer Rep. 6:154–158. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Abramson VG, Lehmann BD, Ballinger TJ and Pietenpol JA: Subtyping of triple-negative breast cancer: Implications for therapy. Cancer. 121:8–16. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Pandey MK, Gupta SC, Nabavizadeh A and Aggarwal BB: Regulation of cell signaling pathways by dietary agents for cancer prevention and treatment. Semin Cancer Biol. 46:158–181. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Cao TT and Zhang YQ: Processing and characterization of silk sericin from bombyx mori and its application in biomaterials and biomedicines. Mater Sci Eng C Mater Biol Appl. 61:940–952. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Zhang YQ, Tao ML, Shen WD, Zhou YZ, Ding Y, Ma Y and Zhou WL: Immobilization of L-asparaginase on the microparticles of the natural silk sericin protein and its characters. Biomaterials. 25:3751–3759. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Yasmin C, Otoi T, Setiadi MA and Karja NW: Maturation and fertilisation of sheep oocytes cultured in serum-free medium containing silk protein sericin. Acta Vet Hung. 63:110–117. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Okazaki Y, Kakehi S, Xu Y, Tsujimoto K, Sasaki M, Ogawa H and Kato N: Consumption of sericin reduces serum lipids, ameliorates glucose tolerance and elevates serum adiponectin in rats fed a high-fat diet. Biosci Biotechnol Biochem. 74:1534–1538. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Suktham K, Koobkokkruad T, Wutikhun T and Surassmo S: Efficiency of resveratrol-loaded sericin nanoparticles: Promising bionanocarriers for drug delivery. Int J Pharm. 537:48–56. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Song CJ, Fu XM, Li J and Chen ZH: Effects of sericine on TGF-beta1/Smad3 signal pathway of diabetic mephropathy rats kidney. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 27:102–105. 2011.(In Chinese). PubMed/NCBI

13 

Chen Z, He Y, Song C, Dong Z, Su Z and Xue J: Sericin can reduce hippocampal neuronal apoptosis by activating the Akt signal transduction pathway in a rat model of diabetes mellitus. Neural Regen Res. 7:197–201. 2012.PubMed/NCBI

14 

Song CJ, Yang ZJ, Tang QF and Chen ZH: Effects of sericin on the testicular growth hormone/insulin-like growth factor-1 axis in a rat model of type 2 diabetes. Int J Clin Exp Med. 8:10411–10419. 2015.PubMed/NCBI

15 

Guo WH, Chen ZY, Chen H, Lin T, Zhao ML, Liu H, Yu J, Hu YF and Li GX: Sericin regulates proliferation of human gastric cancer MKN45 cells through autophagic pathway. Nan Fang Yi Ke Da Xue Xue Bao. 38:148–154. 2018.(In Chinese). PubMed/NCBI

16 

Kaewkorn W, Limpeanchob N, Tiyaboonchai W, Pongcharoen S and Sutheerawattananonda M: Effects of silk sericin on the proliferation and apoptosis of colon cancer cells. Biol Res. 45:45–50. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Sasaki M, Kato N, Watanabe H and Yamada H: Silk protein, sericin, suppresses colon carcinogenesis induced by 1,2-dimethylhydrazine in mice. Oncol Rep. 7:1049–1052. 2000.PubMed/NCBI

18 

Zhaorigetu S, Sasaki M, Watanabe H and Kato N: Supplemental silk protein, sericin, suppresses colon tumorigenesis in 1,2-dimethylhydrazine-treated mice by reducing oxidative stress and cell proliferation. Biosci Biotechnol Biochem. 65:2181–2186. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Zhaorigetu S, Yanaka N, Sasaki M, Watanabe H and Kato N: Inhibitory effects of silk protein, sericin on UVB-induced acute damage and tumor promotion by reducing oxidative stress in the skin of hairless mouse. J Photochem Photobiol B. 71:11–17. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Zhaorigetu S, Yanaka N, Sasaki M, Watanabe H and Kato N: Silk protein, sericin, suppresses DMBA-TPA-induced mouse skin tumorigenesis by reducing oxidative stress, inflammatory responses and endogenous tumor promoter TNF-alpha. Oncol Rep. 10:537–543. 2003.PubMed/NCBI

21 

Kumar JP and Mandal BB: Silk sericin induced pro-oxidative stress leads to apoptosis in human cancer cells. Food Chem Toxicol. 123:275–287. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Santucci-Pereira J, Zeleniuch-Jacquotte A, Afanasyeva Y, Zhong H, Slifker M, Peri S, Ross EA, López de Cicco R, Zhai Y, Nguyen T, et al: Genomic signature of parity in the breast of premenopausal women. Breast Cancer Res. 21:462019. View Article : Google Scholar : PubMed/NCBI

23 

Burstein MD, Tsimelzon A, Poage GM, Covington KR, Contreras A, Fuqua SA, Savage MI, Osborne CK, Hilsenbeck SG, Chang JC, et al: Comprehensive genomic analysis identifies novel subtypes and targets of triple-negative breast cancer. Clin Cancer Res. 21:1688–1698. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Edgar R, Domrachev M and Lash AE: Gene expression omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 30:207–210. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Kanehisa M: Toward understanding the origin and evolution of cellular organisms. Protein Sci. 28:1947–1951. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Nagy Á, Lánczky A, Menyhárt O and Győrffy B: Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets. Sci Rep. 8:92272018. View Article : Google Scholar : PubMed/NCBI

27 

Kunz RI, Brancalhão RM, Ribeiro LF and Natali MR: Silkworm sericin: Properties and biomedical applications. Biomed Res Int. 2016:81757012016. View Article : Google Scholar : PubMed/NCBI

28 

Jena K, Pandey JP, Kumari R, Sinha AK, Gupta VP and Singh GP: Tasar silk fiber waste sericin: New source for anti-elastase, anti-tyrosinase and anti-oxidant compounds. Int J Biol Macromol. 114:1102–1108. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Aramwit P, Kanokpanont S, De-Eknamkul W and Srichana T: Monitoring of inflammatory mediators induced by silk sericin. J Biosci Bioeng. 107:556–561. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Purdy A, Uyetake L, Cordeiro MG and Su TT: Regulation of mitosis in response to damaged or incompletely replicated DNA require different levels of Grapes (Drosophila Chk1). J Cell Sci. 118:3305–3315. 2005. View Article : Google Scholar : PubMed/NCBI

32 

John RR, Malathi N, Ravindran C and Anandan S: Mini review: Multifaceted role played by cyclin D1 in tumor behavior. Indian J Dent Res. 28:187–192. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Lim S and Kaldis P: Cdks, cyclins and CKIs: Roles beyond cell cycle regulation. Development. 140:3079–3093. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Besson A, Dowdy SF and Roberts JM: CDK inhibitors: Cell cycle regulators and beyond. Dev Cell. 14:159–169. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Roninson IB: Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): Association with cell senescence and tumour-promoting activities of stromal fibroblasts. Cancer Lett. 179:1–14. 2002. View Article : Google Scholar : PubMed/NCBI

36 

Suzuki A, Tsutomi Y, Miura M and Akahane K: Caspase 3 inactivation to suppress Fas-mediated apoptosis: Identification of binding domain with p21 and ILP and inactivation machinery by p21. Oncogene. 18:1239–1244. 1999. View Article : Google Scholar : PubMed/NCBI

37 

Zagorac I, Fernandez-Gaitero S, Penning R, Post H, Bueno MJ, Mouron S, Manso L, Morente MM, Alonso S, Serra V, et al: In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer. Nat Commun. 9:35012018. View Article : Google Scholar : PubMed/NCBI

38 

Zhang C, Han Y, Huang H, Min L, Qu L and Shou C: Integrated analysis of expression profiling data identifies three genes in correlation with poor prognosis of triple-negative breast cancer. Int J Oncol. 44:2025–2033. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Bao C, Lu Y, Chen J, Chen D, Lou W, Ding B, Xu L and Fan W: Exploring specific prognostic biomarkers in triple-negative breast cancer. Cell Death Dis. 10:8072019. View Article : Google Scholar : PubMed/NCBI

40 

den Hollander P, Rawls K, Tsimelzon A, Shepherd J, Mazumdar A, Hill J, Fuqua SA, Chang JC, Osborne CK, Hilsenbeck SG, et al: Phosphatase PTP4A3 promotes triple-negative breast cancer growth and predicts poor patient survival. Cancer Res. 76:1942–1953. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Neckers L and Workman P: Hsp90 molecular chaperone inhibitors: Are we there yet? Clin Cancer Res. 18:64–76. 2012. View Article : Google Scholar : PubMed/NCBI

42 

He Y, Peng S, Wang J, Chen H, Cong X, Chen A, Hu M, Qin M, Wu H, Gao S, et al: Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer. Nat Commun. 7:131222016. View Article : Google Scholar : PubMed/NCBI

43 

Mangé A, Coyaud E, Desmetz C, Laurent E, Béganton B, Coopman P, Raught B and Solassol J: FKBP4 connects mTORC2 and PI3K to activate the PDK1/Akt-dependent cell proliferation signaling in breast cancer. Theranostics. 9:7003–7015. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Niu L, Yang S, Zhao X, Liu X, Si L, Wei M, Liu L, Cheng L, Qiao Y, Chen Z, Chen Z, et al: Sericin inhibits MDA‑MB‑468 cell proliferation via the PI3K/Akt pathway in triple‑negative breast cancer. Mol Med Rep 23: 140, 2021.
APA
Niu, L., Yang, S., Zhao, X., Liu, X., Si, L., Wei, M. ... Chen, Z. (2021). Sericin inhibits MDA‑MB‑468 cell proliferation via the PI3K/Akt pathway in triple‑negative breast cancer. Molecular Medicine Reports, 23, 140. https://doi.org/10.3892/mmr.2020.11779
MLA
Niu, L., Yang, S., Zhao, X., Liu, X., Si, L., Wei, M., Liu, L., Cheng, L., Qiao, Y., Chen, Z."Sericin inhibits MDA‑MB‑468 cell proliferation via the PI3K/Akt pathway in triple‑negative breast cancer". Molecular Medicine Reports 23.2 (2021): 140.
Chicago
Niu, L., Yang, S., Zhao, X., Liu, X., Si, L., Wei, M., Liu, L., Cheng, L., Qiao, Y., Chen, Z."Sericin inhibits MDA‑MB‑468 cell proliferation via the PI3K/Akt pathway in triple‑negative breast cancer". Molecular Medicine Reports 23, no. 2 (2021): 140. https://doi.org/10.3892/mmr.2020.11779
Copy and paste a formatted citation
x
Spandidos Publications style
Niu L, Yang S, Zhao X, Liu X, Si L, Wei M, Liu L, Cheng L, Qiao Y, Chen Z, Chen Z, et al: Sericin inhibits MDA‑MB‑468 cell proliferation via the PI3K/Akt pathway in triple‑negative breast cancer. Mol Med Rep 23: 140, 2021.
APA
Niu, L., Yang, S., Zhao, X., Liu, X., Si, L., Wei, M. ... Chen, Z. (2021). Sericin inhibits MDA‑MB‑468 cell proliferation via the PI3K/Akt pathway in triple‑negative breast cancer. Molecular Medicine Reports, 23, 140. https://doi.org/10.3892/mmr.2020.11779
MLA
Niu, L., Yang, S., Zhao, X., Liu, X., Si, L., Wei, M., Liu, L., Cheng, L., Qiao, Y., Chen, Z."Sericin inhibits MDA‑MB‑468 cell proliferation via the PI3K/Akt pathway in triple‑negative breast cancer". Molecular Medicine Reports 23.2 (2021): 140.
Chicago
Niu, L., Yang, S., Zhao, X., Liu, X., Si, L., Wei, M., Liu, L., Cheng, L., Qiao, Y., Chen, Z."Sericin inhibits MDA‑MB‑468 cell proliferation via the PI3K/Akt pathway in triple‑negative breast cancer". Molecular Medicine Reports 23, no. 2 (2021): 140. https://doi.org/10.3892/mmr.2020.11779
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