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Isoflurane reduces septic neuron injury by HO‑1‑mediated abatement of inflammation and apoptosis

  • Authors:
    • Lina Zhang
    • Xuece Zhang
    • Ting Wu
    • Xu Pan
    • Zhi Wang
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China, Digestive Department, The Second Affiliated Hospital, Xi'an Medical University, Xi'an, Shaanxi 710038, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 155
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    Published online on: December 22, 2020
       https://doi.org/10.3892/mmr.2020.11794
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Abstract

Sepsis‑associated encephalopathy (SAE) frequently occurs in critically ill patients with severe systemic infections. Subanesthetic isoflurane (0.7% ISO) possesses anti‑inflammatory, antioxidant and anti‑apoptotic properties against a number of human diseases, including brain injury. The activation of heme oxygenase‑1 (HO‑1) impedes inflammation, oxidation and apoptosis, thus alleviating sepsis‑induced brain damage. However, whether 0.7% ISO affords protection against septic neuronal injury involving HO‑1 activation is unclear. The present study aimed to investigate the neuroprotective effects of 0.7% ISO and its potential underlying mechanisms in SAE using a mouse model established by cecal ligation and puncture (CLP). The results indicated that the expression and activity of HO‑1 in the mouse hippocampus were increased by CLP, and further enhanced by ISO. ISO reduced the death rate, brain water content and blood‑brain barrier disruption, but improved the learning and memory functions of CLP‑treated mice. ISO significantly decreased the production of pro‑inflammatory cytokines and the levels of oxidative indictors in the serum and hippocampus, as well as the number of apoptotic neurons and the expression of pro‑apoptotic proteins in the hippocampus. Inversely, anti‑inflammatory factors, antioxidative enzymes and anti‑apoptotic proteins were markedly increased by ISO administration. However, the neuroprotective effects of ISO were abolished by a HO‑1 inhibitor. Overall, these findings suggested that 0.7% ISO alleviated SAE via its anti‑inflammatory, antioxidative and anti‑apoptotic properties, which involved the activated form of HO‑1.
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View References

1 

Delano MJ and Ward PA: Sepsis-induced immune dysfunction: Can immune therapies reduce mortality? J Clin Invest. 126:23–31. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, et al: Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 41:580–637. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Gong Y, Lan H, Yu Z, Wang M, Wang S, Chen Y, Rao H, Li J, Sheng Z and Shao J: Blockage of glycolysis by targeting PFKFB3 alleviates sepsis-related acute lung injury via suppressing inflammation and apoptosis of alveolar epithelial cells. Biochem Biophys Res Commun. 491:522–529. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Alobaidi R, Basu RK, Goldstein SL and Bagshaw SM: Sepsis-associated acute kidney injury. Semin Nephrol. 35:2–11. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Martin L, Derwall M, Al Zoubi S, Zechendorf E, A Reuter D, Thiemermann C and Schuerholz T: The septic heart: Current understanding of molecular mechanisms and clinical implications. Chest. 155:427–437. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Yan J and Li S and Li S: The role of the liver in sepsis. Int Rev Immunol. 33:498–510. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Zhu Y, Wang K, Ma Z, Liu D, Yang Y, Sun M, Wen A, Hao Y, Ma S, Ren F, et al: SIRT1 activation by butein attenuates sepsis-induced brain injury in mice subjected to cecal ligation and puncture via alleviating inflammatory and oxidative stress. Toxicol Appl Pharmacol. 363:34–46. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Gofton TE and Young GB: Sepsis-associated encephalopathy. Nat Rev Neurol. 8:557–566. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Zhang LN, Wang XT, Ai YH, Guo QL, Huang L, Liu ZY and Yao B: Epidemiological features and risk factors of sepsis-associated encephalopathy in intensive care unit patients: 2008–2011. Chin Med J (Engl). 125:828–831. 2012.PubMed/NCBI

10 

Iwashyna TJ, Ely EW, Smith DM and Langa KM: Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA. 304:1787–1794. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Barichello T, Martins MR, Reinke A, Feier G, Ritter C, Quevedo J and Dal-Pizzol F: Cognitive impairment in sepsis survivors from cecal ligation and perforation. Crit Care Med. 33:221–223, 262-223. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Semmler A, Frisch C, Debeir T, Ramanathan M, Okulla T, Klockgether T and Heneka MT: Long-term cognitive impairment, neuronal loss and reduced cortical cholinergic innervation after recovery from sepsis in a rodent model. Exp Neurol. 204:733–740. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Schwalm MT, Pasquali M, Miguel SP, JPAD Santos, Vuolo F, Comim CM, Petronilho F, Quevedo J, Gelain DP, Moreira JCF, et al: Acute brain inflammation and oxidative damage are related to long-term cognitive deficits and markers of neurodegeneration in sepsis-survivor rats. Mol Neurobiol. 49:380–385. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Comim CM, Barichello T, Grandgirard D, Dal-Pizzol F, Quevedo J and Leib SL: Caspase-3 mediates in part hippocampal apoptosis in sepsis. Mol Neurobiol. 47:394–398. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Heine H, Rietschel ET and Ulmer AJ: The biology of endotoxin. Mol Biotechnol. 19:279–296. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Vaure C and Liu Y: A comparative review of toll-like receptor 4 expression and functionality in different animal species. Front Immunol. 5:3162014. View Article : Google Scholar : PubMed/NCBI

17 

Shukla P, Rao GM, Pandey G, Sharma S, Mittapelly N, Shegokar R and Mishra PR: Therapeutic interventions in sepsis: Current and anticipated pharmacological agents. Br J Pharmacol. 171:5011–5031. 2014.PubMed/NCBI

18 

Sonneville R, Verdonk F, Rauturier C, Klein IF, Wolff M, Annane D, Chretien F and Sharshar T: Understanding brain dysfunction in sepsis. Ann Intensive Care. 3:152013. View Article : Google Scholar : PubMed/NCBI

19 

Danielski LG, Giustina AD, Badawy M, Barichello T, Quevedo J, Dal-Pizzol F and Petronilho F: Brain barrier breakdown as a cause and consequence of neuroinflammation in sepsis. Mol Neurobiol. 55:1045–1053. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Abramowitz J and Birnbaumer L: Physiology and pathophysiology of canonical transient receptor potential channels. FASEB J. 23:297–328. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Fleming I, Fisslthaler B and Busse R: Calcium signaling in endothelial cells involves activation of tyrosine kinases and leads to activation of mitogen-activated protein kinases. Circ Res. 76:522–529. 1995. View Article : Google Scholar : PubMed/NCBI

22 

Barichello T, Fortunato JJ, Vitali AM, Feier G, Reinke A, Moreira JCF, Quevedo J and Dal-Pizzol F: Oxidative variables in the rat brain after sepsis induced by cecal ligation and perforation. Crit Care Med. 34:886–889. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Dal-Pizzol F, Ritter C, Cassol OJ Jr, Rezin GT, Petronilho F, Zugno AI, Quevedo J and Streck EL: Oxidative mechanisms of brain dysfunction during sepsis. Neurochem Res. 35:1–12. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Hoetzel A and Schmidt R: Regulatory role of anesthetics on heme oxygenase-1. Curr Drug Targets. 11:1495–1503. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Alcaraz MJ, Fernandez P and Guillen MI: Anti-inflammatory actions of the heme oxygenase-1 pathway. Curr Pharm Des. 9:2541–2551. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Chen K, Gunter K and Maines MD: Neurons overexpressing heme oxygenase-1 resist oxidative stress-mediated cell death. J Neurochem. 75:304–313. 2000. View Article : Google Scholar : PubMed/NCBI

27 

Dong X, Hu R, Sun Y, Li Q and Jiang H: Isoflurane post-treatment improves pulmonary vascular permeability via upregulation of heme oxygenase-1. Exp Lung Res. 39:295–303. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Yu JB, Zhou F, Yao SL, Tang ZH, Wang M and Chen HR: Effect of heme oxygenase-1 on the kidney during septic shock in rats. Transl Res. 153:283–287. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Park JS, Choi HS, Yim SY and Lee SM: Heme oxygenase-1 protects the liver from septic injury by modulating TLR4-mediated mitochondrial quality control in mice. Shock. 50:209–218. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Liu L, Xie K, Chen H, Dong X, Li Y and Yu Y, Wang G and Yu Y: Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress and neuronal apoptosis. Brain Res. 1589:78–92. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Flondor M, Hofstetter C, Boost KA, Betz C, Homann M and Zwissler B: Isoflurane inhalation after induction of endotoxemia in rats attenuates the systemic cytokine response. Eur Surg Res. 40:1–6. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Jamnicki-Abegg M, Weihrauch D, Pagel PS, Kersten JR, Bosnjak ZJ, Warltier DC and Bienengraeber MW: Isoflurane inhibits cardiac myocyte apoptosis during oxidative and inflammatory stress by activating Akt and enhancing Bcl-2 expression. Anesthesiology. 103:1006–1014. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Head BP and Patel P: Anesthetics and brain protection. Curr Opin Anaesthesiol. 20:395–399. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Sakai H, Sheng H, Yates RB, Ishida K, Pearlstein RD and Warner DS: Isoflurane provides long-term protection against focal cerebral ischemia in the rat. Anesthesiology. 106:92–99; discussion 98–10. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Li QF, Zhu YS, Jiang H, Xu H and Sun Y: Heme oxygenase-1 mediates the anti-inflammatory effect of isoflurane preconditioning in LPS-stimulated macrophages. Acta Pharmacol Sin. 30:228–234. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Li Q, Zhu Y, Jiang H, Xu H and Liu H: Up-regulation of heme oxygenase-1 by isoflurane preconditioning during tolerance against neuronal injury induced by oxygen glucose deprivation. Acta Biochim Biophys Sin (Shanghai). 40:803–810. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Sackey PV, Martling CR, Carlswärd C, Sundin O and Radell PJ: Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam-a pilot study. Crit Care Med. 36:801–806. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Li JT, Wang H, Li W, Wang LF, Hou LC, Mu JL, Liu X, Chen HJ, Xie KL, Li NL and Gao CF: Anesthetic isoflurane posttreatment attenuates experimental lung injury by inhibiting inflammation and apoptosis. Mediators Inflamm. 2013:1089282013. View Article : Google Scholar : PubMed/NCBI

39 

Wang H, Fan J, Li NL, Li JT, Yuan SF, Yi J, Wang L, Chen JH, Lv YG, Yao Q, et al: A subanesthetic dose of isoflurane during postconditioning ameliorates zymosan-induced neutrophil inflammation lung injury and mortality in mice. Mediators Inflamm. 2013:4796282013. View Article : Google Scholar : PubMed/NCBI

40 

Wang H, Wang L, Li NL, Li JT, Yu F, Zhao YL, Wang L, Yi J, Wang L, Bian JF, et al: Subanesthetic isoflurane reduces zymosan-induced inflammation in murine Kupffer cells by inhibiting ROS-activated p38 MAPK/NF-κB signaling. Oxid Med Cell Longev. 2014:8516922014. View Article : Google Scholar : PubMed/NCBI

41 

Kilkenny C, Browne W, Cuthill IC, Emerson M and Altman DG; National Centre for the Replacement, Refinement and Reduction of Amimals in Research, : Animal research: Reporting in vivo experiments-the ARRIVE guidelines. J Cereb Blood Flow Metab. 31:991–993. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Toscano MG, Ganea D and Gamero AM: Cecal ligation puncture procedure. J Vis Exp. 7:28602011.

43 

Mu J, Xie K, Hou L, Peng D, Shang L, Ji G, Li J, Lu Y and Xiong L: Subanesthetic dose of isoflurane protects against zymosan-induced generalized inflammation and its associated acute lung injury in mice. Shock. 34:183–189. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Sui DM, Xie Q, Yi WJ, Gupta S, Yu XY, Li JB, Wang J, Wang JF and Deng XM: Resveratrol protects against sepsis-associated encephalopathy and inhibits the NLRP3/IL-1β axis in microglia. Mediators Inflamm. 2016:10456572016. View Article : Google Scholar : PubMed/NCBI

45 

Hatashita S, Hoff JT and Salamat SM: Ischemic brain edema and the osmotic gradient between blood and brain. J Cereb Blood Flow Metab. 8:552–559. 1988. View Article : Google Scholar : PubMed/NCBI

46 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

47 

Jiang M, Sun L, Feng DX, Yu ZQ, Gao R, Sun YZ and Chen G: Neuroprotection provided by isoflurane pre-conditioning and post-conditioning. Med Gas Res. 7:48–55. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Wang S, Yin J, Ge M, Dai Z, Li Y, Si J, Ma K, Li L and Yao S: Transforming growth-beta 1 contributes to isoflurane postconditioning against cerebral ischemia-reperfusion injury by regulating the c-Jun N-terminal kinase signaling pathway. Biomed Pharmacother. 78:280–290. 2016. View Article : Google Scholar : PubMed/NCBI

49 

Xu Y, Xue H, Zhao P, Yang Y, Ji G, Yu W, Han G, Ding M and Wang F: Isoflurane postconditioning induces concentration- and timing-dependent neuroprotection partly mediated by the GluR2 AMPA receptor in neonatal rats after brain hypoxia-ischemia. J Anesth. 30:427–436. 2016. View Article : Google Scholar : PubMed/NCBI

50 

Zhao DA, Bi LY, Huang Q, Zhang FM and Han ZM: Isoflurane provides neuroprotection in neonatal hypoxic ischemic brain injury by suppressing apoptosis. Braz J Anesthesiol. 66:613–621. 2016. View Article : Google Scholar : PubMed/NCBI

51 

Matsuda A, Jacob A, Wu R, Aziz M, Yang WL, Matsutani T, Suzuki H, Furukawa K, Uchida E and Wang P: Novel therapeutic targets for sepsis: Regulation of exaggerated inflammatory responses. J Nippon Med Sch. 79:4–18. 2012. View Article : Google Scholar : PubMed/NCBI

52 

Calabresi P, Castrioto A, Di Filippo M and Picconi B: New experimental and clinical links between the hippocampus and the dopaminergic system in Parkinson's disease. Lancet Neurol. 12:811–821. 2013. View Article : Google Scholar : PubMed/NCBI

53 

Alexander JJ, Jacob A, Cunningham P, Hensley L and Quigg RJ: TNF is a key mediator of septic encephalopathy acting through its receptor, TNF receptor-1. Neurochem Int. 52:447–456. 2008. View Article : Google Scholar : PubMed/NCBI

54 

Rothwell NJ and Hopkins SJ: Cytokines and the nervous system II: Actions and mechanisms of action. Trends Neurosci. 18:130–136. 1995. View Article : Google Scholar : PubMed/NCBI

55 

Sharief MK and Thompson EJ: In vivo relationship of tumor necrosis factor-alpha to blood-brain barrier damage in patients with active multiple sclerosis. J Neuroimmunol. 38:27–33. 1992. View Article : Google Scholar : PubMed/NCBI

56 

Williams LM, Ricchetti G, Sarma U, Smallie T and Foxwell BM: Interleukin-10 suppression of myeloid cell activation-a continuing puzzle. Immunology. 113:281–292. 2004. View Article : Google Scholar : PubMed/NCBI

57 

Altay O, Suzuki H, Hasegawa Y, Ostrowski RP, Tang J and Zhang JH: Isoflurane on brain inflammation. Neurobiol Dis. 62:365–371. 2014. View Article : Google Scholar : PubMed/NCBI

58 

Li QF, Wang XR, Yang YW and Su DS: Up-regulation of hypoxia inducible factor 1alpha by isoflurane in Hep3B cells. Anesthesiology. 105:1211–1219. 2006. View Article : Google Scholar : PubMed/NCBI

59 

Schmidt R, Tritschler E, Hoetzel A, Loop T, Humar M, Halverscheid L, Geiger KK and Pannen BH: Heme oxygenase-1 induction by the clinically used anesthetic isoflurane protects rat livers from ischemia/reperfusion injury. Ann Surg. 245:931–942. 2007. View Article : Google Scholar : PubMed/NCBI

60 

Hopkins RO: Sepsis, oxidative stress, and brain injury. Crit Care Med. 35:2233–2234. 2007. View Article : Google Scholar : PubMed/NCBI

61 

Chandra J, Samali A and Orrenius S: Triggering and modulation of apoptosis by oxidative stress. Free Radic Biol Med. 29:323–333. 2000. View Article : Google Scholar : PubMed/NCBI

62 

Requena JR, Fu MX, Ahmed MU, Jenkins AJ, Lyons TJ and Thorpe SR: Lipoxidation products as biomarkers of oxidative damage to proteins during lipid peroxidation reactions. Nephrol Dial Transplant. 11 (Suppl 5):48–53. 1996. View Article : Google Scholar : PubMed/NCBI

63 

Yang T, Sun Y and Zhang F: Anti-oxidative aspect of inhaled anesthetic gases against acute brain injury. Med Gas Res. 6:223–226. 2016. View Article : Google Scholar : PubMed/NCBI

64 

Yu J, Wang Y, Li Z, Dong S, Wang D, Gong L, Shi J, Zhang Y, Liu D and Mu R: Effect of heme oxygenase-1 on mitofusin-1 protein in LPS-induced ALI/ARDS in rats. Sci Rep. 6:365302016. View Article : Google Scholar : PubMed/NCBI

65 

Semmler A, Okulla T, Sastre M, Dumitrescu-Ozimek L and Heneka MT: Systemic inflammation induces apoptosis with variable vulnerability of different brain regions. J Chem Neuroanat. 30:144–157. 2005. View Article : Google Scholar : PubMed/NCBI

66 

Yao XL, Liu J, Lee E, Ling GS and McCabe JT: Progesterone differentially regulates pro- and anti-apoptotic gene expression in cerebral cortex following traumatic brain injury in rats. J Neurotrauma. 22:656–668. 2005. View Article : Google Scholar : PubMed/NCBI

67 

Renault TT, Teijido O, Antonsson B, Dejean LM and Manon S: Regulation of Bax mitochondrial localization by Bcl-2 and Bcl-x(L): Keep your friends close but your enemies closer. Int J Biochem Cell Biol. 45:64–67. 2013. View Article : Google Scholar : PubMed/NCBI

68 

Li L, Peng L and Zuo Z: Isoflurane preconditioning increases B-cell lymphoma-2 expression and reduces cytochrome c release from the mitochondria in the ischemic penumbra of rat brain. Eur J Pharmacol. 586:106–113. 2008. View Article : Google Scholar : PubMed/NCBI

69 

Bedirli N, Bagriacik EU, Emmez H, Yilmaz G, Unal Y and Ozkose Z: Sevoflurane and isoflurane preconditioning provides neuroprotection by inhibition of apoptosis-related mRNA expression in a rat model of focal cerebral ischemia. J Neurosurg Anesthesiol. 24:336–344. 2012. View Article : Google Scholar : PubMed/NCBI

70 

Wang L, Zhao YL, Liu NN, Zhu XS, Liu QQ, Mei HY, Wang LF, Yang AG, Gao CF and Li JT: Epithelial HO-1/STAT3 affords the protection of subanesthetic isoflurane against zymosan-induced lung injury in mice. Oncotarget. 8:54889–54903. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang L, Zhang X, Wu T, Pan X and Wang Z: Isoflurane reduces septic neuron injury by HO‑1‑mediated abatement of inflammation and apoptosis. Mol Med Rep 23: 155, 2021.
APA
Zhang, L., Zhang, X., Wu, T., Pan, X., & Wang, Z. (2021). Isoflurane reduces septic neuron injury by HO‑1‑mediated abatement of inflammation and apoptosis. Molecular Medicine Reports, 23, 155. https://doi.org/10.3892/mmr.2020.11794
MLA
Zhang, L., Zhang, X., Wu, T., Pan, X., Wang, Z."Isoflurane reduces septic neuron injury by HO‑1‑mediated abatement of inflammation and apoptosis". Molecular Medicine Reports 23.2 (2021): 155.
Chicago
Zhang, L., Zhang, X., Wu, T., Pan, X., Wang, Z."Isoflurane reduces septic neuron injury by HO‑1‑mediated abatement of inflammation and apoptosis". Molecular Medicine Reports 23, no. 2 (2021): 155. https://doi.org/10.3892/mmr.2020.11794
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Zhang X, Wu T, Pan X and Wang Z: Isoflurane reduces septic neuron injury by HO‑1‑mediated abatement of inflammation and apoptosis. Mol Med Rep 23: 155, 2021.
APA
Zhang, L., Zhang, X., Wu, T., Pan, X., & Wang, Z. (2021). Isoflurane reduces septic neuron injury by HO‑1‑mediated abatement of inflammation and apoptosis. Molecular Medicine Reports, 23, 155. https://doi.org/10.3892/mmr.2020.11794
MLA
Zhang, L., Zhang, X., Wu, T., Pan, X., Wang, Z."Isoflurane reduces septic neuron injury by HO‑1‑mediated abatement of inflammation and apoptosis". Molecular Medicine Reports 23.2 (2021): 155.
Chicago
Zhang, L., Zhang, X., Wu, T., Pan, X., Wang, Z."Isoflurane reduces septic neuron injury by HO‑1‑mediated abatement of inflammation and apoptosis". Molecular Medicine Reports 23, no. 2 (2021): 155. https://doi.org/10.3892/mmr.2020.11794
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