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Luteolin attenuates angiotensin II‑induced renal damage in apolipoprotein E‑deficient mice

  • Authors:
    • Ying-Shu Liu
    • Qin Yang
    • Shen Li
    • Lan Luo
    • Hong-Yang Liu
    • Xin-Yu Li
    • Zheng-Nan Gao
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian, Liaodong 116011, P.R. China, Department of Internal Medicine, The Affiliated Zhong Shan Hospital of Dalian University, Dalian, Liaodong 116011, P.R. China, Department of Heart Intensive Care Unit, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaodong 116011, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 157
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    Published online on: December 22, 2020
       https://doi.org/10.3892/mmr.2020.11796
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Abstract

Renal damage is a common and severe condition encountered in the clinic. Luteolin (Lut) exhibits anti‑inflammatory, anti‑fibrotic and anti‑apoptotic effects. Thus, the present study aimed to investigate the pharmacological effects of Lut on angiotensin II (AngII)‑induced renal damage in apolipoprotein E‑deficient (ApoE‑/‑) mice. Male ApoE‑/‑ mice (age, 8 weeks) were randomly divided into the following three groups: i) Control group (n=6); ii) AngII group (n=6); and iii) AngII + Lut group (n=6). Lut was administered by gavage (100 mg/kg/d). ApoE‑/‑ mice were implanted with Alzet osmotic minipumps, filled with either saline vehicle or AngII solution for a maximum period of 4 weeks. After 4 weeks, metabolic characteristics were measured and the histopathological alterations in the kidney tissue were observed. The metabolic characteristics of blood creatinine (CRE) levels were lower in the AngII + Lut group compared with in the AngII group. The expression levels of collagen I and III were lower in the kidney tissues of the AngII + Lut group compared with the corresponding tissues of the AngII group. The gene expression levels of IL‑1β, IL‑6, TNF‑α and IL‑10 were also suppressed in the kidney tissues of the AngII + Lut group compared with those in the corresponding tissues of the AngII group. Furthermore, the AngII + Lut group exhibited markedly increased LC3 protein expression and notably decreased p62 protein expression in the kidney tissues compared with the expression levels in the AngII group. The data demonstrated that Lut attenuated AngII‑induced collagen deposition and inflammation, while inducing autophagy. Collectively, the results suggested that Lut treatment exhibited a exerted effect on AngII‑induced renal injury in ApoE‑/‑ mice.
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View References

1 

Umanath K and Lewis JB: Update on diabetic nephropathy: Core curriculum 2018. Am J Kidney Dis. 71:884–895. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Skov J, Christiansen JS and Poulsen PL: Hypertension and diabetic nephropathy. Endocr Dev. 31:97–107. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Sharma N, Malek V, Mulay SR and Gaikwad AB: Angiotensin II type 2 receptor and angiotensin-converting enzyme 2 mediate ischemic renal injury in diabetic and non-diabetic rats. Life Sci. 235:1167962019. View Article : Google Scholar : PubMed/NCBI

4 

Urushihara M and Kagami S: Role of the intrarenal renin-angiotensin system in the progression of renal disease. Pediatr Nephrol. 32:1471–1479. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Kaliappan G, Nagarajan P, Moorthy R, Kalai Gana Selvi S, Avinash Raj T and Mahesh Kumar J: Ang II induce kidney damage by recruiting inflammatory cells and up regulates PPAR gamma and Renin 1 gene: Effect of β carotene on chronic renal damage. J Thromb Thrombolysis. 36:277–285. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Kelly TN, Raj D, Rahman M, Kretzler M, Kallem RR, Ricardo AC, Rosas SE, Tao K, Xie D, Hamm LL, et al CRIC Study Investigators, : The role of renin-angiotensin-aldosterone system genes in the progression of chronic kidney disease: Findings from the Chronic Renal Insufficiency Cohort (CRIC) study. Nephrol Dial Transplant. 30:1711–1718. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Kuksal N, Chalker J and Mailloux RJ: Progress in understanding the molecular oxygen paradox - function of mitochondrial reactive oxygen species in cell signaling. Biol Chem. 398:1209–1227. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Liu Y, Shi B, Li Y and Zhang H: Protective Effect of Luteolin Against renal ischemia/reperfusion injury via modulation of pro-inflammatory cytokines, oxidative stress and apoptosis for possible benefit in kidney transplant. Med Sci Monit. 23:5720–5727. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Tanida I: Autophagy basics. Microbiol Immunol. 55:1–11. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Guan X, Qian Y, Shen Y, Zhang L, Du Y, Dai H, Qian J and Yan Y: Autophagy protects renal tubular cells against ischemia/reperfusion injury in a time-dependent manner. Cell Physiol Biochem. 36:285–298. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Imran M, Rauf A, Abu-Izneid T, Nadeem M, Shariati MA, Khan IA, Imran A, Erdogan Orhan I, Rizwan M, Atif M, et al: Corrigendum to ‘Luteolin, a flavonoid, as an anticancer agent: A review’ [Biomed. Pharmacother. 112 (2019) 108612]. Biomed Pharmacother. 116:1090842019. View Article : Google Scholar : PubMed/NCBI

12 

Luo Y, Shang P and Li D: Luteolin: A flavonoid that has multiple cardio-protective effects and its molecular mechanisms. Front Pharmacol. 8:6922017. View Article : Google Scholar : PubMed/NCBI

13 

Hong X, Zhao X, Wang G, Zhang Z, Pei H and Liu Z: Luteolin treatment protects against renal ischemia-reperfusion injury in rats. Mediators Inflamm. 2017:97838932017. View Article : Google Scholar : PubMed/NCBI

14 

Xin SB, Yan H, Ma J, Sun Q and Shen L: Protective effects of luteolin on lipopolysaccharide-induced acute renal injury in mice. Med Sci Monit. 22:5173–5180. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Sung J and Lee J: Anti-inflammatory activity of Butein and Luteolin through suppression of NFκB activation and induction of heme oxygenase-1. J Med Food. 18:557–564. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Choi JS, Islam MN, Ali MY, Kim YM, Park HJ, Sohn HS and Jung HA: The effects of C-glycosylation of luteolin on its antioxidant, anti-Alzheimer's disease, anti-diabetic, and anti-inflammatory activities. Arch Pharm Res. 37:1354–1363. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Seelinger G, Merfort I, Wölfle U and Schempp CM: Anti-carcinogenic effects of the flavonoid luteolin. Molecules. 13:2628–2651. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Domitrović R, Cvijanović O, Pugel EP, Zagorac GB, Mahmutefendić H and Škoda M: Luteolin ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of platinum accumulation, inflammation and apoptosis in the kidney. Toxicology. 310:115–123. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Kang KP, Park SK, Kim DH, Sung MJ, Jung YJ, Lee AS, Lee JE, Ramkumar KM, Lee S, Park MH, et al: Luteolin ameliorates cisplatin-induced acute kidney injury in mice by regulation of p53-dependent renal tubular apoptosis. Nephrol Dial Transplant. 26:814–822. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Honjo T, Chyu KY, Dimayuga PC, Lio WM, Yano J, Trinidad P, Zhao X, Zhou J, Cercek B and Shah PK: Immunization with an ApoB-100 related peptide vaccine attenuates angiotensin-II induced hypertension and renal fibrosis in mice. PLoS One. 10:e01317312015. View Article : Google Scholar : PubMed/NCBI

21 

Cha J, Ivanov V, Ivanova S, Kalinovsky T, Rath M and Niedzwiecki A: Evolution of angiotensin II-mediated atherosclerosis in ApoE KO mice. Mol Med Rep. 3:565–570. 2010.PubMed/NCBI

22 

Xu Y, Zhang J, Liu J, Sai Li, Cheng Li, Wang W, Ma R and Liu Y: Luteolin attenuate the D-galactose-induced renal damage by attenuation of oxidative stress and inflammation. Nat Prod Res. 29:1078–1082. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Zhang W, Wang W, Yu H, Zhang Y, Dai Y, Ning C, Tao L, Sun H, Kellems RE, Blackburn MR, et al: Interleukin 6 underlies angiotensin II-induced hypertension and chronic renal damage. Hypertension. 59:136–144. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Zhong J, Guo D, Chen CB, Wang W, Schuster M, Loibner H, Penninger JM, Scholey JW, Kassiri Z and Oudit GY: Prevention of angiotensin II-mediated renal oxidative stress, inflammation, and fibrosis by angiotensin-converting enzyme 2. Hypertension. 57:314–322. 2011. View Article : Google Scholar : PubMed/NCBI

25 

National Research Council (US): Committee for the Update of the Guide for the Care and Use of Laboratory Animals. 8th edition. National Academies Press; Washington, DC: 2011

26 

Shingu C, Koga H, Hagiwara S, Matsumoto S, Goto K, Yokoi I and Noguchi T: Hydrogen-rich saline solution attenuates renal ischemia-reperfusion injury. J Anesth. 24:569–574. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Domitrović R, Jakovac H, Tomac J and Sain I: Liver fibrosis in mice induced by carbon tetrachloride and its reversion by luteolin. Toxicol Appl Pharmacol. 241:311–321. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Chen CY, Peng WH, Wu LC, Wu CC and Hsu SL: Luteolin ameliorates experimental lung fibrosis both in vivo and in vitro: Implications for therapy of lung fibrosis. J Agric Food Chem. 58:11653–11661. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Chen J, Shetty S, Zhang P, Gao R, Hu Y, Wang S, Li Z and Fu J: Aspirin-triggered resolvin D1 down-regulates inflammatory responses and protects againstendotoxin-induced acute kidney injury. Toxicol Appl Pharmacol. 277:118–123. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Seelinger G, Merfort I and Schempp CM: Anti-oxidant, anti-inflammatory and anti-allergic activities of luteolin. Planta Med. 74:1667–1677. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Okusa MD: The inflammatory cascade in acute ischemic renal failure. Nephron. 90:133–138. 2002. View Article : Google Scholar : PubMed/NCBI

33 

Hashmat S, Rudemiller N, Lund H, Abais-Battad JM, Van Why S and Mattson DL: Interleukin-6 inhibition attenuates hypertension and associated renal damage in Dahl salt-sensitive rats. Am J Physiol Renal Physiol. 311:F555–F561. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Levine B and Kroemer G: Autophagy in the pathogenesis of disease. Cell. 132:27–42. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Corrochano S, Renna M, Tomas-Zapico C, Brown SD, Lucas JJ, Rubinsztein DC and Acevedo-Arozena A: α-synuclein levels affect autophagosome numbers in vivo and modulate Huntington disease pathology. Autophagy. 8:431–432. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Eskelinen EL and Saftig P: Autophagy: A lysosomal degradation pathway with a central role in health and disease. Biochim Biophys Acta. 1793:664–673. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Virgin HW and Levine B: Autophagy genes in immunity. Nat Immunol. 10:461–470. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Luciani A, Villella VR, Esposito S, Brunetti-Pierri N, Medina D, Settembre C, Gavina M, Pulze L, Giardino I, Pettoello-Mantovani M, et al: Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition. Nat Cell Biol. 12:863–875. 2010. View Article : Google Scholar : PubMed/NCBI

39 

He L, Livingston MJ and Dong Z: Autophagy in acute kidney injury and repair. Nephron Clin Pract. 127:56–60. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Schmitz KJ, Ademi C, Bertram S, Schmid KW and Baba HA: Prognostic relevance of autophagy-related markers LC3, p62/sequestosome 1, Beclin-1 and ULK1 in colorectal cancer patients with respect to KRAS mutational status. World J Surg Oncol. 14:1892016. View Article : Google Scholar : PubMed/NCBI

41 

Lee YK, Jun YW, Choi HE, Huh YH, Kaang BK, Jang DJ and Lee JA: Development of LC3/GABARAP sensors containing a LIR and a hydrophobic domain to monitor autophagy. EMBO J. 36:1100–1116. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Schläfli AM, Berezowska S, Adams O, Langer R and Tschan MP: Reliable LC3 and p62 autophagy marker detection in formalin fixed paraffin embedded human tissue by immunohistochemistry. Eur J Histochem. 59:24812015. View Article : Google Scholar : PubMed/NCBI

43 

Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y and Yoshimori T: LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19:5720–5728. 2000. View Article : Google Scholar : PubMed/NCBI

44 

Jin Z, Li Y, Pitti R, Lawrence D, Pham VC, Lill JR and Ashkenazi A: Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell. 137:721–735. 2009. View Article : Google Scholar : PubMed/NCBI

45 

Schläfli AM, Adams O, Galván JA, Gugger M, Savic S, Bubendorf L, Schmid RA, Becker KF, Tschan MP, Langer R, et al: Prognostic value of the autophagy markers LC3 and p62/SQSTM1 in early-stage non-small cell lung cancer. Oncotarget. 7:39544–39555. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Yang Q, Li S, Luo L, Liu H, Li X and Gao Z: Luteolin attenuates angiotensin II‑induced renal damage in apolipoprotein E‑deficient mice. Mol Med Rep 23: 157, 2021.
APA
Liu, Y., Yang, Q., Li, S., Luo, L., Liu, H., Li, X., & Gao, Z. (2021). Luteolin attenuates angiotensin II‑induced renal damage in apolipoprotein E‑deficient mice. Molecular Medicine Reports, 23, 157. https://doi.org/10.3892/mmr.2020.11796
MLA
Liu, Y., Yang, Q., Li, S., Luo, L., Liu, H., Li, X., Gao, Z."Luteolin attenuates angiotensin II‑induced renal damage in apolipoprotein E‑deficient mice". Molecular Medicine Reports 23.2 (2021): 157.
Chicago
Liu, Y., Yang, Q., Li, S., Luo, L., Liu, H., Li, X., Gao, Z."Luteolin attenuates angiotensin II‑induced renal damage in apolipoprotein E‑deficient mice". Molecular Medicine Reports 23, no. 2 (2021): 157. https://doi.org/10.3892/mmr.2020.11796
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Yang Q, Li S, Luo L, Liu H, Li X and Gao Z: Luteolin attenuates angiotensin II‑induced renal damage in apolipoprotein E‑deficient mice. Mol Med Rep 23: 157, 2021.
APA
Liu, Y., Yang, Q., Li, S., Luo, L., Liu, H., Li, X., & Gao, Z. (2021). Luteolin attenuates angiotensin II‑induced renal damage in apolipoprotein E‑deficient mice. Molecular Medicine Reports, 23, 157. https://doi.org/10.3892/mmr.2020.11796
MLA
Liu, Y., Yang, Q., Li, S., Luo, L., Liu, H., Li, X., Gao, Z."Luteolin attenuates angiotensin II‑induced renal damage in apolipoprotein E‑deficient mice". Molecular Medicine Reports 23.2 (2021): 157.
Chicago
Liu, Y., Yang, Q., Li, S., Luo, L., Liu, H., Li, X., Gao, Z."Luteolin attenuates angiotensin II‑induced renal damage in apolipoprotein E‑deficient mice". Molecular Medicine Reports 23, no. 2 (2021): 157. https://doi.org/10.3892/mmr.2020.11796
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