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Review Open Access

Research progress of the transcription factor Brn4 (Review)

  • Authors:
    • Yuying Wu
    • Xunrui Zhang
    • Jue Wang
    • Guohua Jin
    • Xinhua Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Anatomy, Co-Innovation Center of Neuroregeneration, Medical School, Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Clinical Medicine, Faculty of Medicine, Xinglin College, Nantong University, Nantong, Jiangsu 226008, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 179
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    Published online on: December 31, 2020
       https://doi.org/10.3892/mmr.2020.11818
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Abstract

Brain 4 (Brn4) is a transcription factor belonging to the POU3 family, and it is important for the embryonic development of the neural tube, inner ear and pancreas. In addition, it serves a crucial role in neural stem cell differentiation and reprogramming. The present review aimed to summarize the chromosomal location, species homology, protein molecular structure and tissue distribution of Brn4, in addition to its biological processes, with the aim of providing a reference of its structure and function for further studies, and its potential use as a gene therapy target.
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Spandidos Publications style
Wu Y, Zhang X, Wang J, Jin G and Zhang X: Research progress of the transcription factor Brn4 (Review). Mol Med Rep 23: 179, 2021.
APA
Wu, Y., Zhang, X., Wang, J., Jin, G., & Zhang, X. (2021). Research progress of the transcription factor Brn4 (Review). Molecular Medicine Reports, 23, 179. https://doi.org/10.3892/mmr.2020.11818
MLA
Wu, Y., Zhang, X., Wang, J., Jin, G., Zhang, X."Research progress of the transcription factor Brn4 (Review)". Molecular Medicine Reports 23.3 (2021): 179.
Chicago
Wu, Y., Zhang, X., Wang, J., Jin, G., Zhang, X."Research progress of the transcription factor Brn4 (Review)". Molecular Medicine Reports 23, no. 3 (2021): 179. https://doi.org/10.3892/mmr.2020.11818
Copy and paste a formatted citation
x
Spandidos Publications style
Wu Y, Zhang X, Wang J, Jin G and Zhang X: Research progress of the transcription factor Brn4 (Review). Mol Med Rep 23: 179, 2021.
APA
Wu, Y., Zhang, X., Wang, J., Jin, G., & Zhang, X. (2021). Research progress of the transcription factor Brn4 (Review). Molecular Medicine Reports, 23, 179. https://doi.org/10.3892/mmr.2020.11818
MLA
Wu, Y., Zhang, X., Wang, J., Jin, G., Zhang, X."Research progress of the transcription factor Brn4 (Review)". Molecular Medicine Reports 23.3 (2021): 179.
Chicago
Wu, Y., Zhang, X., Wang, J., Jin, G., Zhang, X."Research progress of the transcription factor Brn4 (Review)". Molecular Medicine Reports 23, no. 3 (2021): 179. https://doi.org/10.3892/mmr.2020.11818
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