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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
March-2021 Volume 23 Issue 3

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

IL-32 exacerbates adenoid hypertrophy via activating NLRP3-mediated cell pyroptosis, which promotes inflammation

Junmei Zhang, Xuyuan Sun, Lingling Zhong, Bei Shen
Article Number: 226
Published online on: 24 January 2021

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Review

Ferroptosis in hepatic ischemia‑reperfusion injury: Regulatory mechanisms and new methods for therapy (Review)

Linfeng Luo, Guoheng Mo, Deqiang Huang
Article Number: 225
Published online on: 24 January 2021

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Article Open Access

Coniferaldehyde prevents articular cartilage destruction in a murine model via Nrf2/HO‑1 pathway

Dawei Cai, Jieling Wang, Sichun Chen, Longhai Jiang, Jinwei Chen, Ji Wu, Jian Qin
Article Number: 224
Published online on: 24 January 2021

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Article Open Access

Simiaosan alleviates the symptoms of gouty arthritis via the NALP3/IL‑1β pathway

Xianzhen Zhang, Huideng Ding, Gang Hu, Ying Lu
Article Number: 223
Published online on: 24 January 2021

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Article Open Access

H(+)/Cl(‑) exchange transporter 7 promotes lysosomal acidification‑mediated autophagy in mouse cardiomyocytes

Jiezhi Lin, Jinyu Wei, Yanling Lv, Xingyue Zhang, Ruo Fan Yi, Chen Dai, Qiong Zhang, Jiezhi Jia, Dongxia Zhang, Yuesheng Huang
Article Number: 222
Published online on: 21 January 2021

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Article

Nrf2‑Keap1‑ARE‑NQO1 signaling attenuates hyperoxia‑induced lung cell injury by inhibiting apoptosis

Bowen Weng, Xiaoyue Zhang, Xiaoyun Chu, Xiaohui Gong, Cheng Cai
Article Number: 221
Published online on: 21 January 2021

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Article

Effect of Notch1 on neural tube defects and neural stem cell differentiation induced by all‑trans retinoic acid

Na Chen, Jiaming Xu, Xinying Zhang, Shuwei Li, Weiwei Zhu, Haibin Cui, Yu Sun, Bo Han, Aihua Ma
Article Number: 220
Published online on: 21 January 2021

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Article Open Access

Shengxian decoction decreases doxorubicin‑induced cardiac apoptosis by regulating the TREM1/NF‑κB signaling pathway Retraction in /10.3892/mmr.2024.13159

Lei Yao, Mingtai Gui, Jianhua Li, Bo Lu, Jing Wang, Xunjie Zhou, Deyu Fu
Article Number: 219
Published online on: 20 January 2021

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Article Open Access

Long non‑coding RNA NEAT1 promotes pulmonary fibrosis by regulating the microRNA‑455‑3p/SMAD3 axis

Yuan Liu, Fu-Ai Lu, Le Wang, Yong-Fu Wang, Chun-Feng Wu
Article Number: 218
Published online on: 20 January 2021

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Article Open Access

β‑Lapachone ameliorates L‑DOPA‑induced dyskinesia in a 6‑OHDA‑induced mouse model of Parkinson's disease

Young-Kyoung Ryu, Hye-Yeon Park, Jun Go, In-Bok Lee, Young-Keun Choi, Chul-Ho Lee, Kyoung-Shim Kim
Article Number: 217
Published online on: 20 January 2021

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Article

Potassium bromate-induced cell model of age-related macular degeneration in vitro

Shu-Chun Kuo, Yingxiao Li, Kai-Chun Cheng, Chia-Chen Hsu, Juei-Tang Cheng, Hui-Hsuan Lau
Article Number: 216
Published online on: 20 January 2021

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Article Open Access

Allisartan isoproxil attenuates oxidative stress and inflammation through the SIRT1/Nrf2/NF‑κB signalling pathway in diabetic cardiomyopathy rats

Qinyang Jin, Qin Zhu, Kai Wang, Mengli Chen, Xinli Li
Article Number: 215
Published online on: 20 January 2021

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Article Open Access

Recombinant high‑mobility group box 1 induces cardiomyocyte hypertrophy by regulating the 14‑3‑3η, PI3K and nuclear factor of activated T cells signaling pathways

Feifei Su, Miaoqian Shi, Jian Zhang, Yan Li, Jianwei Tian
Article Number: 214
Published online on: 20 January 2021

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Article Open Access

miR-140-5p regulates vascular smooth muscle cell viability, migration and apoptosis by targeting ROBO4 gene expression in atherosclerosis

Yi Luo, Yangmin Li, Hong Peng, Yu Zhao
Article Number: 213
Published online on: 19 January 2021

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Article Open Access

Long non‑coding RNA PITPNA‑AS1 silencing suppresses proliferation, metastasis and epithelial‑mesenchymal transition in non‑small cell lung cancer cells by targeting microRNA‑32‑5p Corrigendum in /10.3892/mmr.2021.11911

Gang Chen, Zhifeng Zheng, Junsheng Li, Peigang Zhang, Zhenjun Wang, Shiping Guo, Jun Ma, Jian Shen, Huixin Li
Article Number: 212
Published online on: 18 January 2021

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Article Open Access

lncRNA LINC00963 downregulation regulates colorectal cancer tumorigenesis and progression via the miR‑10b/FGF13 axis

Yujin Wu, Longling Cong, Wenjian Chen, Xuechuan Wang, Fanghua Qiu
Article Number: 211
Published online on: 18 January 2021

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Article Open Access

Effects of renalase deficiency on liver fibrosis markers in a nonalcoholic steatohepatitis mouse model

Katsuyuki Tokinoya, Nanami Sekine, Kai Aoki, Seiko Ono, Tomoaki Kuji, Takehito Sugasawa, Yasuko Yoshida, Kazuhiro Takekoshi
Article Number: 210
Published online on: 18 January 2021

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Article

1,7‑Bis(4‑hydroxy‑3‑methoxyphenyl)‑1,4,6‑heptatrien‑3‑one alleviates lipopolysaccharide‑induced inflammation by targeting NF‑κB translocation in murine macrophages and it interacts with MD2 in silico

Chutima Jansakun, Wanatsanan Chulrik, Waraluck Chaichompoo, Pathumwadee Yotmanee, Kanokporn Lehboon, Wilanee Chunglok, Apsorn Sattayakhom, Poonsit Hiransai, Kornyok Kamdee, Tanyarath Utaipan, Apichart Suksamrarn, Warangkana Chunglok
Article Number: 209
Published online on: 18 January 2021

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Article Open Access

Cytotoxic effect of CLL‑1 CAR‑T cell immunotherapy with PD‑1 silencing on relapsed/refractory acute myeloid leukemia

Guoqiang Lin, Yanming Zhang, Lei Yu, Depei Wu
Article Number: 208
Published online on: 18 January 2021

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Article Open Access

P21‑activated kinase 1 mediates angiotensin II‑induced differentiation of human atrial fibroblasts via the JNK/c‑Jun pathway

Yafei Zhou, Ying Xie, Tao Li, Peng Zhang, Tangting Chen, Zhongcai Fan, Xiaoqiu Tan
Article Number: 207
Published online on: 18 January 2021

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Article Open Access

Gryllus bimaculatus extract protects against lipopolysaccharide and palmitate-induced production of proinflammatory cytokines and inflammasome formation

Woo-Jae Park, Jung-Soon Han
Article Number: 206
Published online on: 14 January 2021

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Article Open Access

Effects of Qing Hua Chang Yin on lipopolysaccharide‑induced intestinal epithelial tight junction injury in Caco‑2 cells

Wenyi Fang, Peilin Zhao, Aling Shen, Liya Liu, Hongwei Chen, Youqin Chen, Jun Peng, Thomas J. Sferra, Senthilkumar Sankararaman, Yunfeng Luo, Xiao Ke
Article Number: 205
Published online on: 14 January 2021

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Article Open Access

Knockdown of FAM225B inhibits the progression of the hypertrophic scar following glaucoma surgery by inhibiting autophagy

Xianpeng Ma, Lili Liu
Article Number: 204
Published online on: 14 January 2021

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Article

Discovery of natural adenosine monophosphate‑activated protein kinase activators through virtual screening and activity verification studies

Jia Hao, Zhen Yang, Jian Li, Lifeng Han, Yi Zhang, Tao Wang
Article Number: 203
Published online on: 13 January 2021

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Article Open Access

SCARA5 suppresses the proliferation and migration, and promotes the apoptosis of human retinoblastoma cells by inhibiting the PI3K/AKT pathway

Jinwei Wang, Sha Wang, Lu Chen, Jia Tan
Article Number: 202
Published online on: 13 January 2021

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Article Open Access

N‑acetylcysteine inhibits atherosclerosis by correcting glutathione‑dependent methylglyoxal elimination and dicarbonyl/oxidative stress in the aorta of diabetic mice

Xin Fang, Lihua Liu, Shaoqiong Zhou, Mengen Zhu, Bin Wang
Article Number: 201
Published online on: 13 January 2021

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Article Open Access

miR‑653‑5p suppresses the growth and migration of breast cancer cells by targeting MAPK6

Mei Zhang, Hongwei Wang, Xiaomei Zhang, Fengping Liu
Article Number: 200
Published online on: 12 January 2021

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Article

miR‑583 inhibits the proliferation and invasion of prostate cancer cells by targeting JAK1

Zhongyi Li, Jianheng Chen
Article Number: 199
Published online on: 12 January 2021

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Review Open Access

Role of Munc18-1 in the biological functions and pathogenesis of neurological disorders (Review)

Fajuan Tang, Dongqiong Xiao, Lin Chen, Hu Gao, Xihong Li
Article Number: 198
Published online on: 12 January 2021

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Correction Open Access

[Corrigendum] Ouabain suppresses the growth and migration abilities of glioma U‑87MG cells through inhibiting the Akt/mTOR signaling pathway and downregulating the expression of HIF‑1α

Xiao-Sa Yang, Zhong-Wei Xu, Tai-Long Yi, Rui-Cheng Xu, Jie Li, Wen-Bin Zhang, Sai Zhang, Hong-Tao Sun, Ze-Qi Yu, Hao-Xiang Xu, Yue Tu, Shi-Xiang Cheng
Article Number: 197
Published online on: 11 January 2021

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Article Open Access

Effect of long non‑coding RNA AK021443 on promoting hepatic fibrosis in vitro

Yuxin Yang, Zongsu Min
Article Number: 196
Published online on: 11 January 2021

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Article Open Access

Combination of curcumin and ginkgolide B inhibits cystogenesis by regulating multiple signaling pathways

Yousong Li, Jinsheng Gao, Xi Yang, Tao Li, Baoxue Yang, Aixingzi Aili
Article Number: 195
Published online on: 11 January 2021

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Article Open Access

MicroRNA‑153 attenuates hypoxia‑induced excessive proliferation and migration of pulmonary arterial smooth muscle cells by targeting ROCK1 and NFATc3 Corrigendum in /10.3892/mmr.2022.12848

Minjie Zhao, Wei Wang, Ya Lu, Nan Wang, Delei Kong, Lina Shan
Article Number: 194
Published online on: 07 January 2021

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Article Open Access

Bioinformatics analysis identifies biomarkers associated with poor prognosis in diffuse‑type gastric cancer

Sheng Li, Chao Yu, Yuanguang Cheng, Fangchao Du, Gang Wen
Article Number: 193
Published online on: 07 January 2021

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Article Open Access

Genistein alleviates chronic vascular inflammatory response via the miR‑21/NF‑κB p65 axis in lipopolysaccharide‑treated mice

Xiaolin Xie, Li Cong, Sujuan Liu, Liping Xiang, Xiaohua Fu
Article Number: 192
Published online on: 07 January 2021

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Article Open Access

Long non‑coding RNA MEG3 inhibits cell migration and invasion of non‑small cell lung cancer cells by regulating the miR‑21‑5p/PTEN axis

Dongjin Lv, Qing Bi, Yunxia Li, Jie Deng, Na Wu, Shu Hao, Mingli Zhao
Article Number: 191
Published online on: 06 January 2021

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Article

Downregulation of miR‑409‑3p suppresses LPS‑induced inflammation in human bronchial epithelial cells through SOCS3/JAK1/STAT3 signaling: The implication for bronchopneumonia

Li He, Lang Tian
Article Number: 190
Published online on: 06 January 2021

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Article Open Access

miR‑212 promotes renal interstitial fibrosis by inhibiting hypoxia‑inducible factor 1‑α inhibitor

Yun Zhang, Guo-Xin Zhang, Li-Shuang Che, Shu-Han Shi, Yue-Ting Li
Article Number: 189
Published online on: 06 January 2021

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Article Open Access

Nogo‑66 promotes β‑amyloid protein secretion via NgR/ROCK‑dependent BACE1 activation

Qing-Qing Xie, Xiao Feng, Yi-Υun Huang, Nian Fang, Hua Yi, Zi-Jian Wang, Qiao-Υu Cao, Guo-Feng Lou, Jun-Ping Pan, Yang Hu, Fang-Cheng Li, Qing Zheng, Fei Xiao
Article Number: 188
Published online on: 05 January 2021

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Article Open Access

Melatonin inhibits proliferation and viability and promotes apoptosis in colorectal cancer cells via upregulation of the microRNA-34a/449a cluster

Guangyu Ji, Wenjuan Zhou, Xian Li, Jingyi Du, Xinyue Li, Hongbo Hao
Article Number: 187
Published online on: 05 January 2021

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Article Open Access

Vascular endothelial ERp72 is involved in the inflammatory response in a rat model of skeletal muscle injury

Noureddine Ben Khalaf, Dalal Al‑Μehatab, Dahmani M. Fathallah
Article Number: 186
Published online on: 04 January 2021

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Article Open Access

Comprehensive RNA expression profile of therapeutic adipose‑derived mesenchymal stem cells co‑cultured with degenerative nucleus pulposus cells

Zhihua Han, Qiugen Wang, Xiaoming Wu, Jiandong Wang, Liang Gao, Ruipeng Guo, Jianhong Wu
Article Number: 185
Published online on: 04 January 2021

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Article

Elevation of hypertonicity‑induced protein NFAT5 promotes apoptosis of human umbilical vein endothelial cells through the NF‑κB pathway

Xupin Xie, Changpin Huang, Dong Xu, Yongchang Liu, Mengxiao Hu, Jianyun Long, Xin Fang
Article Number: 184
Published online on: 04 January 2021

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Article Open Access

Oxymatrine exerts a protective effect in myocardial ischemia/reperfusion‑induced acute lung injury by inhibiting autophagy in diabetic rats

Zhen Xiong, Jiali Xu, Xin Liu
Article Number: 183
Published online on: 04 January 2021

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Article Open Access

miR‑375 affects the hedgehog signaling pathway by downregulating RAC1 to inhibit hepatic stellate cell viability and epithelial‑mesenchymal transition

Zhiwei Liang, Jian Li, Longshuan Zhao, Yilei Deng
Article Number: 182
Published online on: 31 December 2020

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Article Open Access

9‑Hydroxy‑isoegomaketone inhibits LPS‑induced NO and inflammatory cytokine production in RAW264.7 cells

Hyun Mi Kim, Bomi Nam, Sunil Babu Paudel, Joo-Won Nam, Ah-Reum Han, Hye Gwang Jeong, Chang Hyun Jin
Article Number: 181
Published online on: 31 December 2020

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Article Open Access

Intestinal dysbacteriosis leads to kidney stone disease

Enyang Zhao, Wenfu Zhang, Bo Geng, Bosen You, Wanhui Wang, Xuedong Li
Article Number: 180
Published online on: 31 December 2020

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Review Open Access

Research progress of the transcription factor Brn4 (Review)

Yuying Wu, Xunrui Zhang, Jue Wang, Guohua Jin, Xinhua Zhang
Article Number: 179
Published online on: 31 December 2020

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Article

miR-613 inhibits the proliferation of human ovarian granulosa cells by arresting cell cycle progression via the targeting of IGF-1

Junhui Wan, Sisun Liu
Article Number: 178
Published online on: 30 December 2020

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Article

circFOXO3 protects cardiomyocytes against radiation‑induced cardiotoxicity

Yiming Qiu, Xianping Xie, Luhua Lin
Article Number: 177
Published online on: 30 December 2020

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Article Open Access

Propofol ameliorates endotoxin‑induced myocardial cell injury by inhibiting inflammation and apoptosis via the PPARγ/HMGB1/NLRP3 axis

Hui Zhao, Ying Gu, Hai Chen
Article Number: 176
Published online on: 30 December 2020

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Article Open Access

Electroacupuncture effects on the P2X4R pathway in microglia regulating the excitability of neurons in the substantia gelatinosa region of rats with spinal nerve ligation

Yuyin Zheng, Chengqian Jia, Xia Jiang, Jie Chen, Xiao-Long  Chen, Xinwang Ying, Jiayu Wu, Mingchen Jiang, Guanhu Yang, Wenzhan Tu, Kecheng Zhou, Songhe Jiang
Article Number: 175
Published online on: 30 December 2020

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Correction Open Access

[Corrigendum] Anticancer effect of quinacrine on diffuse large B‑cell lymphoma via inhibition of MSI2‑NUMB signaling pathway

Shujun Yang, Lixia Sheng, Kaihong Xu, Yi Wang, Huiling Zhu, Ping Zhang, Qitian Mu, Guifang Ouyang
Article Number: 174
Published online on: 29 December 2020

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Article Open Access

Genetic response to low‑intensity ultrasound on mouse ST2 bone marrow stromal cells

Yoshiaki Tabuchi, Hideyuki Hasegawa, Nobuo Suzuki, Yukihiro Furusawa, Tetsushi  Hirano, Ryo Nagaoka, Jun Hirayama, Nobuhiko Hoshi, Takashi Mochizuki
Article Number: 173
Published online on: 23 December 2020

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Article Open Access

MicroRNA‑149‑3p inhibits cell proliferation by targeting AKT2 in oral squamous cell carcinoma

Qin Shen, Hong Zhu, Qiaoling Lei, Luyuan Chen, Dajiang Yang, Wen Sui
Article Number: 172
Published online on: 23 December 2020

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Article Open Access

Zenglv Fumai Granule protects cardiomyocytes against hypoxia/reoxygenation-induced apoptosis via inhibiting TRIM28 expression

Xiao-Hua Zhang, Hong-Yu Zhao, Yu Wang, Lin Di, Xin-Yu Liu, Feng Qian, Shu-Rong Liu
Article Number: 171
Published online on: 23 December 2020

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Article

Resveratrol induces human colorectal cancer cell apoptosis by activating the mitochondrial pathway via increasing reactive oxygen species

Yun Fu, Yuedian Ye, Guifang Zhu, Yangwei Xu, Jingbo Sun, Hongmei Wu, Feiyan Feng, Zhihui Wen, Shanshan Jiang, Yanyan Li, Qingling Zhang
Article Number: 170
Published online on: 23 December 2020

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Article Open Access

Investigating the effect of lncRNA HOTAIR on apoptosis induced by myocardial ischemia-reperfusion injury

Jijing Fang, Weihong Zheng, Pengfei Hu, Jiale Wu
Article Number: 169
Published online on: 23 December 2020

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Article Open Access

Silencing of long non‑coding RNA NEAT1 inhibits hepatocellular carcinoma progression by downregulating SMO by sponging microRNA‑503

Chuihua Sun, Ting Xiao, Ying Xiao, Yunbao Li
Article Number: 168
Published online on: 23 December 2020

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Review Open Access

Role of Wnt5a in periodontal tissue development, maintenance, and periodontitis: Implications for periodontal regeneration (Review)

Xiuqun Wei, Qian Liu, Shujuan Guo, Yafei Wu
Article Number: 167
Published online on: 23 December 2020

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Journal Cover
January-2026 Volume 33 Issue 1

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Non‑coding RNAs in epithelial‑mesenchymal transition of renal cell carcinoma (Review)

Ziqiao Liu, Hanshen Zhou, Junxiao Shen, Yiming Qi, Xuke Gong, Cheng Zhang
Article Number: 51
Published online on: 24 November 2025

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Article Open Access

FOXJ3 drives mesenchymal stem cell osteogenic differentiation via the Wnt/β‑catenin pathway: A novel regulator implicated in osteoporosis

Hongwei Xiao, Jianfeng Li, Wei Huang, Yi Qin
Article Number: 50
Published online on: 21 November 2025

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NEDD4 regulates VEGF signaling and mTOR to promote angiogenesis and the cell cycle in steroid‑induced osteonecrosis of the femoral head

Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
Article Number: 49
Published online on: 21 November 2025

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Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway

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Published online on: 21 November 2025

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Article Number: 47
Published online on: 21 November 2025

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Natural compounds for the treatment of rheumatoid arthritis based on the ‘gut‑joint axis’ (Review)

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Article Number: 46
Published online on: 20 November 2025

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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

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Published online on: 20 November 2025

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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

Banghao Sun, Zhenyu Zhao, Qingyu Meng, Luya Pu, Xingyu Jiang, Shuai Li, Fadi Cao, Fan Li
Article Number: 44
Published online on: 20 November 2025

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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
Published online on: 18 November 2025

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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
Published online on: 17 November 2025

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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
Article Number: 41
Published online on: 12 November 2025

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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
Article Number: 40
Published online on: 12 November 2025

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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
Published online on: 12 November 2025

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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
Published online on: 10 November 2025

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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
Article Number: 35
Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
Published online on: 10 November 2025

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Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
Article Number: 22
Published online on: 31 October 2025

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Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review)

Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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February-2026 Volume 33 Issue 2

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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