Open Access

Role of Munc18-1 in the biological functions and pathogenesis of neurological disorders (Review)

  • Authors:
    • Fajuan Tang
    • Dongqiong Xiao
    • Lin Chen
    • Hu Gao
    • Xihong Li
  • View Affiliations

  • Published online on: January 12, 2021     https://doi.org/10.3892/mmr.2021.11837
  • Article Number: 198
  • Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The release of neurotransmitters following the fusion of synaptic vesicles and the presynaptic membrane is an important process in the transmission of neuronal information. Syntaxin-binding protein 1 (Munc18-1) is a synaptic fusion protein binding protein, which mainly regulates synaptic vesicle fusion and neurotransmitter release by interacting with soluble N-ethylmaleimide sensitive factor attachment protein receptor. In addition to affecting neurotransmitter transmission, Munc18-1 is also involved in regulating neurosynaptic plasticity, neurodevelopment and neuroendocrine cell release functions (including thyroxine and insulin release). A number of previous studies have demonstrated that Munc18-1 has diverse and vital biological functions, and that its abnormal expression serves an important role in the pathogenesis of a variety of neurological diseases, including epileptic encephalopathy, schizophrenia, autism, Parkinson's disease, Alzheimer's disease, multiple sclerosis, Duchenne's muscular dystrophy and neuronal ceroid lipofuscinosis. The present review summarizes the function of Munc18-1 and its possible relationship to the pathogenesis of various neurological diseases.
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March-2021
Volume 23 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Tang F, Xiao D, Chen L, Gao H and Li X: Role of Munc18-1 in the biological functions and pathogenesis of neurological disorders (Review). Mol Med Rep 23: 198, 2021
APA
Tang, F., Xiao, D., Chen, L., Gao, H., & Li, X. (2021). Role of Munc18-1 in the biological functions and pathogenesis of neurological disorders (Review). Molecular Medicine Reports, 23, 198. https://doi.org/10.3892/mmr.2021.11837
MLA
Tang, F., Xiao, D., Chen, L., Gao, H., Li, X."Role of Munc18-1 in the biological functions and pathogenesis of neurological disorders (Review)". Molecular Medicine Reports 23.3 (2021): 198.
Chicago
Tang, F., Xiao, D., Chen, L., Gao, H., Li, X."Role of Munc18-1 in the biological functions and pathogenesis of neurological disorders (Review)". Molecular Medicine Reports 23, no. 3 (2021): 198. https://doi.org/10.3892/mmr.2021.11837