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Allisartan isoproxil attenuates oxidative stress and inflammation through the SIRT1/Nrf2/NF‑κB signalling pathway in diabetic cardiomyopathy rats

  • Authors:
    • Qinyang Jin
    • Qin Zhu
    • Kai Wang
    • Mengli Chen
    • Xinli Li
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Nephrology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang 310007, P.R. China
    Copyright: © Jin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 215
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    Published online on: January 20, 2021
       https://doi.org/10.3892/mmr.2021.11854
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Abstract

Allisartan isoproxil is a new nonpeptide angiotensin II receptor blocker (ARB) precursor drug that is used to treat hypertension and reduce the risk of heart disease. The present study explored the effects of allisartan isoproxil on diabetic cardiomyopathy (DCM) and revealed the roles of hyperglycaemia‑induced oxidative stress and inflammation. A rat DCM model was established by high‑fat diet feeding in combination with intraperitoneal injection of streptozocin. Echocardiographs showed that diabetic rats exhibited significantly decreased cardiac function. Troponin T (cTnT) and B‑type natriuretic peptide (BNP) were significantly increased in DCM rats as obtained by ELISA. Allisartan isoproxil significantly improved the EF% and E'/A' ratio. Histopathologic staining showed that allisartan isoproxil prevented histological alterations, attenuated the accumulation of collagen, and ameliorated cTnT and BNP levels. Western blot and immunohistochemical results indicated that the expression levels of silent information regulator 2 homologue 1 (SIRT1) and nuclear factor erythroid 2‑related factor 2 (Nrf2) were decreased in the hearts of diabetic rats, and antioxidant defences were also decreased. In addition, allisartan isoproxil decreased the expression of NF‑κB p65 and the inflammatory cytokines TNF‑α and IL‑1β which were determined by reverse transcription‑quantitative PCR in the diabetic heart. Western blotting and TUNEL staining results also showed that cardiac Bax and cleaved caspase‑3 and the number of apoptotic myocardial cells were increased in the diabetic heart and decreased following treatment with allisartan isoproxil. In conclusion, the present results indicated that allisartan isoproxil alleviated DCM by attenuating diabetes‑induced oxidative stress and inflammation through the SIRT1/Nrf2/NF‑κB signalling pathway.
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View References

1 

Whiting DR, Guariguata L, Weil C and Shaw J: IDF diabetes atlas: Global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract. 94:311–321. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Liu X, Xiao J, Zhu H, Wei X, Platt C, Damilano F, Xiao C, Bezzerides V, Boström P, Che L, et al: miR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell Metab. 21:584–595. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Tribouilloy C, Rusinaru D, Mahjoub H, Tartière JM, Kesri-Tartière L, Godard S and Peltier M: Prognostic impact of diabetes mellitus in patients with heart failure and preserved ejection fraction: A prospective five-year study. Heart. 94:1450–1455. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Devereux RB, Roman MJ, Paranicas M, O'Grady MJ, Lee ET, Welty TK, Fabsitz RR, Robbins D, Rhoades ER and Howard BV: Impact of diabetes on cardiac structure and function: The strong heart study. Circulation. 101:2271–2276. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Howard BV, Cowan LD, Go O, Welty TK, Robbins DC and Lee ET: Adverse effects of diabetes on multiple cardiovascular disease risk factors in women. The Strong Heart Study. Diabetes Care. 21:1258–1265. 1998. View Article : Google Scholar : PubMed/NCBI

6 

Ma ZG, Yuan YP, Xu SC, Wei WY, Xu CR, Zhang X, Wu QQ, Liao HH, Ni J and Tang QZ: CTRP3 attenuates cardiac dysfunction, inflammation, oxidative stress and cell death in diabetic cardiomyopathy in rats. Diabetologia. 60:1126–1137. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Zhou X, An G and Lu X: Hydrogen sulfide attenuates the development of diabetic cardiomyopathy. Clin Sci (Lond). 128:325–335. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Zhao MX, Zhou B, Ling L, Xiong XQ, Zhang F, Chen Q, Li YH, Kang YM and Zhu GQ: Salusin-β contributes to oxidative stress and inflammation in diabetic cardiomyopathy. Cell Death Dis. 8:e26902017. View Article : Google Scholar : PubMed/NCBI

9 

Rajesh M, Bátkai S, Kechrid M, Mukhopadhyay P, Lee WS, Horváth B, Holovac E, Cinar R, Liaudet L, Mackie K, et al: Cannabinoid 1 receptor promotes cardiac dysfunction, oxidative stress, inflammation, and fibrosis in diabetic cardiomyopathy. Diabetes. 61:716–727. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Rajesh M, Mukhopadhyay P, Bátkai S, Patel V, Saito K, Matsumoto S, Kashiwaya Y, Horváth B, Mukhopadhyay B, Becker L, et al: Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy. J Am Coll Cardiol. 56:2115–2125. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Duecker R, Baer P, Eickmeier O, Strecker M, Kurz J, Schaible A, Henrich D, Zielen S and Schubert R: Oxidative stress-driven pulmonary inflammation and fibrosis in a mouse model of human ataxia-telangiectasia. Redox Biol. 14:645–655. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Rajasekaran NS, Varadharaj S, Khanderao GD, Davidson CJ, Kannan S, Firpo MA, Zweier JL and Benjamin IJ: Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice. Antioxid Redox Signal. 14:957–971. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Gu J, Cheng Y, Wu H, Kong L, Wang S, Xu Z, Zhang Z, Tan Y, Keller BB, Zhou H, et al: Metallothionein is downstream of Nrf2 and partially mediates sulforaphane prevention of diabetic cardiomyopathy. Diabetes. 66:529–542. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Lu MC, Ji JA, Jiang ZY and You QD: The Keap1-Nrf2-ARE pathway as a potential preventive and therapeutic target: An update. Med Res Rev. 36:924–963. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Magesh S, Chen Y and Hu L: Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents. Med Res Rev. 32:687–726. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Zhao L, Qi Y, Xu L, Tao X, Han X, Yin L and Peng J: MicroRNA-140-5p aggravates doxorubicin-induced cardiotoxicity by promoting myocardial oxidative stress via targeting Nrf2 and Sirt2. Redox Biol. 15:284–296. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Karbasforooshan H and Karimi G: The role of SIRT1 in diabetic cardiomyopathy. Biomed Pharmacother. 90:386–392. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Guo R, Liu W, Liu B, Zhang B, Li W and Xu Y: SIRT1 suppresses cardiomyocyte apoptosis in diabetic cardiomyopathy: An insight into endoplasmic reticulum stress response mechanism. Int J Cardiol. 191:36–45. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Huang K, Huang J, Xie X, Wang S, Chen C, Shen X, Liu P and Huang H: Sirt1 resists advanced glycation end products-induced expressions of fibronectin and TGF-β1 by activating the Nrf2/ARE pathway in glomerular mesangial cells. Free Radic Biol Med. 65:528–540. 2013. View Article : Google Scholar : PubMed/NCBI

20 

de Mingo Á, de Gregorio E, Moles A, Tarrats N, Tutusaus A, Colell A, Fernandez-Checa JC, Morales A and Marí M: Cysteine cathepsins control hepatic NF-κB-dependent inflammation via sirtuin-1 regulation. Cell Death Dis. 7:e24642016. View Article : Google Scholar : PubMed/NCBI

21 

Dong B, Yu QT, Dai HY, Gao YY, Zhou ZL, Zhang L, Jiang H, Gao F, Li SY, Zhang YH, et al: Angiotensin-converting enzyme-2 overexpression improves left ventricular remodeling and function in a rat model of diabetic cardiomyopathy. J Am Coll Cardiol. 59:739–747. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Mehta PK and Griendling KK: Angiotensin II cell signaling: Physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol. 292:C82–C97. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Mori J, Basu R, McLean BA, Das SK, Zhang L, Patel VB, Wagg CS, Kassiri Z, Lopaschuk GD and Oudit GY: Agonist-induced hypertrophy and diastolic dysfunction are associated with selective reduction in glucose oxidation: A metabolic contribution to heart failure with normal ejection fraction. Circ Heart Fail. 5:493–503. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Wu MY, Ma XJ, Yang C, Tao X, Liu AJ, Su DF and Liu JG: Effects of allisartan, a new AT(1) receptor blocker, on blood pressure and end-organ damage in hypertensive animals. Acta Pharmacol Sin. 30:307–313. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Zhang JQ, Yang GH, Zhou X, Liu JX, Shi R, Dong Y, Chen SB and Li YM: Effects of allisartan isoproxil on blood pressure and target organ injury in patients with mild to moderate essential hypertension. Medicine (Baltimore). 98:e149072019. View Article : Google Scholar : PubMed/NCBI

26 

Li Y, Li XH, Huang ZJ, Yang GP, Zhang GG, Zhao SP, Guo Y, Lu SJ, Ma JL, Meng FB, et al: A randomized, double blind, placebo-controlled, multicenter phase II trial of Allisartan Isoproxil in essential hypertensive population at low-medium risk. PLoS One. 10:e01175602015. View Article : Google Scholar : PubMed/NCBI

27 

Os I, Franco V, Kjeldsen SE, Manhem K, Devereux RB, Gerdts E, Hille DA, Lyle PA, Okin PM, Dahlöf B and Oparil S: Effects of losartan in women with hypertension and left ventricular hypertrophy: Results from the Losartan Intervention for Endpoint Reduction in Hypertension Study. Hypertension. 51:1103–1108. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Bokma JP, Winter MM, van Dijk AP, Vliegen HW, van Melle JP, Meijboom FJ, Post MC, Berbee JK, Boekholdt SM, Groenink M, et al: Effect of losartan on right ventricular dysfunction: Results from the double-blind, randomized REDEFINE Trial (Right ventricular dysfunction in tetralogy of fallot: Inhibition of the renin-angiotensin-aldosterone system) in adults with repaired tetralogy of fallot. Circulation. 137:1463–1471. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Wang L, Li J and Li D: Losartan reduces myocardial interstitial fibrosis in DCMrats by inhibiting JAK/STAT signaling pathway. Int J Clin Exp Pathol. 8:466–473. 2015.PubMed/NCBI

30 

Axelsson A, Iversen K, Vejlstrup N, Ho CY, Havndrup O, Kofoed KF, Norsk J, Jensen M and Bundgaard H: Functional effects of losartan in hypertrophic cardiomyopathy-a randomised clinical trial. Heart. 102:285–291. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Shimada YJ, Passeri JJ, Baggish AL, O'Callaghan C, Lowry PA, Yannekis G, Abbara S, Ghoshhajra BB, Rothman RD, Ho CY, et al: Effects of losartan on left ventricular hypertrophy and fibrosis in patients with nonobstructive hypertrophic cardiomyopathy. JACC Heart Fail. 1:480–407. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Carswell CI and Goa KL: Losartan in diabetic nephropathy. Drugs. 63:407–416. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Ti Y, Xie GL, Wang ZH, Bi XL, Ding WY, Wang J, Jiang GH, Bu PL, Zhang Y, Zhong M and Zhang W: TRB3 gene silencing alleviates DCMin a type 2 diabetic rat model. Diabetes. 60:2963–2974. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Bati K, Kwape TE and Chaturvedi P: Anti-Diabetic effects of an ethanol extract of cassia abbreviata stem bark on diabetic rats and possible mechanism of its action: -Anti-diabetic properties of cassia abbreviata. J Pharmacopuncture. 20:45–51. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Zheng D, Zhang Y, Hu Y, Guan J, Xu L, Xiao W, Zhong Q, Ren C, Lu J, Liang J and Hou J: Long noncoding RNA Crnde attenuates cardiac fibrosis via Smad3-Crnde negative feedback in diabetic cardiomyopathy. FEBS J. 286:1645–1655. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Ghorbanzadeh V, Mohammadi M, Dariushnejad H, Chodari L and Mohaddes G: Effects of crocin and voluntary exercise, alone or combined, on heart VEGF-A and HOMA-IR of HFD/STZ induced type 2 diabetic rats. J Endocrinol Invest. 39:1179–1186. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Hou Y, Shao J, Fu Q, Li J, Sun J and He Z: Spray-dried nanocrystals for a highly hydrophobic drug: Increased drug loading, enhanced redispersity, and improved oral bioavailability. Int J Pharm. 516:372–379. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Bai Y, Cui W, Xin Y, Miao X, Barati MT, Zhang C, Chen Q, Tan Y, Cui T, Zheng Y and Cai L: Prevention by sulforaphane of DCMis associated with up-regulation of Nrf2 expression and transcription activation. J Mol Cell Cardiol. 57:82–95. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Koller WC and Vetere-Overfield B: Usefulness of a writing aid in writer's cramp. Neurology. 39:149–150. 1989. View Article : Google Scholar : PubMed/NCBI

41 

Czarnecka AK, Milewski K and Zielińska M: Asymmetric dimethylarginine and hepatic encephalopathy: Cause, effect or association? Neurochem Res. 42:750–761. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Roul D and Recchia FA: Metabolic alterations induce oxidative stress in diabetic and failing hearts: Different pathways, same outcome. Antioxid Redox Signal. 22:1502–1514. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Palomer X, Pizarro-Delgado J and Vázquez-Carrera M: Emerging actors in diabetic cardiomyopathy: Heartbreaker biomarkers or therapeutic targets? Trends Pharmacol Sci. 39:452–467. 2018. View Article : Google Scholar : PubMed/NCBI

44 

Zhu Y, Qian X, Li J, Lin X, Luo J, Huang J and Jin Z: Astragaloside-IV protects H9C2(2-1) cardiomyocytes from high glucose-induced injury via miR-34a-mediated autophagy pathway. Artif Cells Nanomed Biotechnol. 47:4172–4181. 2019. View Article : Google Scholar : PubMed/NCBI

45 

Tsai TH, Lin CJ, Chua S, Chung SY, Chen SM, Lee CH and Hang CL: Deletion of RasGRF1 attenuated interstitial fibrosis in streptozotocin-induced DCMin mice through affecting inflammation and oxidative stress. Int J Mol Sci. 19:30942018. View Article : Google Scholar

46 

Li L, Luo W, Qian Y, Zhu W, Qian J, Li J, Jin Y, Xu X and Liang G: Luteolin protects against DCMby inhibiting NF-κB-mediated inflammation and activating the Nrf2-mediated antioxidant responses. Phytomedicine. 59:1527742019. View Article : Google Scholar : PubMed/NCBI

47 

Biernacka A, Cavalera M, Wang J, Russo I, Shinde A, Kong P, Gonzalez-Quesada C, Rai V, Dobaczewski M, Lee DW, et al: Smad3 signaling promotes fibrosis while preserving cardiac and aortic geometry in obese diabetic mice. Circ Heart Fail. 8:788–798. 2015. View Article : Google Scholar : PubMed/NCBI

48 

Gilmore TD: Introduction to NF-kappaB: Players, pathways, perspectives. Oncogene. 25:6680–6684. 2006. View Article : Google Scholar : PubMed/NCBI

49 

Rojas A, Delgado-López F, González I, Pérez-Castro R, Romero J and Rojas I: The receptor for advanced glycation end-products: A complex signaling scenario for a promiscuous receptor. Cell Signal. 25:609–614. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Lorenzo O, Picatoste B, Ares-Carrasco S, Ramírez E, Egido J and Tuñón J: Potential role of nuclear factor κB in diabetic cardiomyopathy. Mediators Inflamm. 2011:6520972011. View Article : Google Scholar : PubMed/NCBI

51 

Li H, Shi Y, Wang X, Li P, Zhang S, Wu T, Yan Y, Zhan Y, Ren Y, Rong X, et al: Piceatannol alleviates inflammation and oxidative stress via modulation of the Nrf2/HO-1 and NF-κB pathways in diabetic cardiomyopathy. Chem Biol Interact. 310:1087542019. View Article : Google Scholar : PubMed/NCBI

52 

Westermann D, Rutschow S, Van Linthout S, Linderer A, Bücker-Gärtner C, Sobirey M, Riad A, Pauschinger M, Schultheiss HP and Tschöpe C: Inhibition of p38 mitogen-activated protein kinase attenuates left ventricular dysfunction by mediating pro-inflammatory cardiac cytokine levels in a mouse model of diabetes mellitus. Diabetologia. 49:2507–2513. 2006. View Article : Google Scholar : PubMed/NCBI

53 

Westermann D, Rutschow S, Jäger S, Linderer A, Anker S, Riad A, Unger T, Schultheiss HP, Pauschinger M and Tschöpe C: Contributions of inflammation and cardiac matrix metalloproteinase activity to cardiac failure in diabetic cardiomyopathy: The role of angiotensin type 1 receptor antagonism. Diabetes. 56:641–646. 2007. View Article : Google Scholar : PubMed/NCBI

54 

Yu T, Sheu SS, Robotham JL and Yoon Y: Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species. Cardiovasc Res. 79:341–351. 2008. View Article : Google Scholar : PubMed/NCBI

55 

Guo Y, Zhuang X, Huang Z, Zou J, Yang D, Hu X, Du Z, Wang L and Liao X: Klotho protects the heart from hyperglycemia-induced injury by inactivating ROS and NF-κB-mediated inflammation both in vitro and in vivo. Biochim Biophys Acta Mol Basis Dis. 1864:238–251. 2018. View Article : Google Scholar : PubMed/NCBI

56 

Civantos E, Bosch E, Ramirez E, Zhenyukh O, Egido J, Lorenzo O and Mas S: Sitagliptin ameliorates oxidative stress in experimental diabetic nephropathy by diminishing the miR-200a/Keap-1/Nrf2 antioxidant pathway. Diabetes Metab Syndr Obes. 10:207–222. 2017. View Article : Google Scholar : PubMed/NCBI

57 

Xu Z, Wei Y, Gong J, Cho H, Park JK, Sung ER, Huang H, Wu L, Eberhart C, Handa JT, et al: NRF2 plays a protective role in diabetic retinopathy in mice. Diabetologia. 57:204–213. 2014. View Article : Google Scholar : PubMed/NCBI

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Jin Q, Zhu Q, Wang K, Chen M and Li X: Allisartan isoproxil attenuates oxidative stress and inflammation through the SIRT1/Nrf2/NF‑κB signalling pathway in diabetic cardiomyopathy rats. Mol Med Rep 23: 215, 2021.
APA
Jin, Q., Zhu, Q., Wang, K., Chen, M., & Li, X. (2021). Allisartan isoproxil attenuates oxidative stress and inflammation through the SIRT1/Nrf2/NF‑κB signalling pathway in diabetic cardiomyopathy rats. Molecular Medicine Reports, 23, 215. https://doi.org/10.3892/mmr.2021.11854
MLA
Jin, Q., Zhu, Q., Wang, K., Chen, M., Li, X."Allisartan isoproxil attenuates oxidative stress and inflammation through the SIRT1/Nrf2/NF‑κB signalling pathway in diabetic cardiomyopathy rats". Molecular Medicine Reports 23.3 (2021): 215.
Chicago
Jin, Q., Zhu, Q., Wang, K., Chen, M., Li, X."Allisartan isoproxil attenuates oxidative stress and inflammation through the SIRT1/Nrf2/NF‑κB signalling pathway in diabetic cardiomyopathy rats". Molecular Medicine Reports 23, no. 3 (2021): 215. https://doi.org/10.3892/mmr.2021.11854
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Spandidos Publications style
Jin Q, Zhu Q, Wang K, Chen M and Li X: Allisartan isoproxil attenuates oxidative stress and inflammation through the SIRT1/Nrf2/NF‑κB signalling pathway in diabetic cardiomyopathy rats. Mol Med Rep 23: 215, 2021.
APA
Jin, Q., Zhu, Q., Wang, K., Chen, M., & Li, X. (2021). Allisartan isoproxil attenuates oxidative stress and inflammation through the SIRT1/Nrf2/NF‑κB signalling pathway in diabetic cardiomyopathy rats. Molecular Medicine Reports, 23, 215. https://doi.org/10.3892/mmr.2021.11854
MLA
Jin, Q., Zhu, Q., Wang, K., Chen, M., Li, X."Allisartan isoproxil attenuates oxidative stress and inflammation through the SIRT1/Nrf2/NF‑κB signalling pathway in diabetic cardiomyopathy rats". Molecular Medicine Reports 23.3 (2021): 215.
Chicago
Jin, Q., Zhu, Q., Wang, K., Chen, M., Li, X."Allisartan isoproxil attenuates oxidative stress and inflammation through the SIRT1/Nrf2/NF‑κB signalling pathway in diabetic cardiomyopathy rats". Molecular Medicine Reports 23, no. 3 (2021): 215. https://doi.org/10.3892/mmr.2021.11854
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