Open Access

Coniferaldehyde prevents articular cartilage destruction in a murine model via Nrf2/HO‑1 pathway

  • Authors:
    • Dawei Cai
    • Jieling Wang
    • Sichun Chen
    • Longhai Jiang
    • Jinwei Chen
    • Ji Wu
    • Jian Qin
  • View Affiliations

  • Published online on: January 24, 2021     https://doi.org/10.3892/mmr.2021.11863
  • Article Number: 224
  • Copyright: © Cai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteoarthritis (OA) is the most prevalent joint disorder characterized by progressive cartilage damage, resulting in gradual disability among the elderly. We previously provided in vivo evidence that nuclear factor erythroid 2‑related factor 2 (Nrf2) deficiency is associated with the development of OA. It has been reported that coniferaldehyde (CFA) acts as a potential Nrf2 activator. The aim of the present study was to investigate the protective effects of CFA against osteoarthritis. A murine model of surgical‑induced OA was used in the present study and CFA was administered by peritoneal injection every day, and the knee joints were assessed by histological analysis. The results demonstrated that CFA activated the Nrf2 signaling pathway in primary chondrocytes and articular cartilage from the knee joints. Cartilage damage in mice subjected to the destabilization of the medial meniscus was evidently alleviated by CFA treatment. CFA also robustly suppressed apoptosis induced by H2O2 in murine chondrocytes and reduced the expression of matrix metalloproteinase (MMP)1, MMP3, interleukin (IL)‑1 and IL‑6 in vivo. On the whole, the findings suggested that CFA exerts a therapeutic effect against OA, and the activation of the Nrf2/heme oxygenase‑1 pathway may play a crucial role in CFA‑mediated cartilage protection.
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March-2021
Volume 23 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Cai D, Wang J, Chen S, Jiang L, Chen J, Wu J and Qin J: Coniferaldehyde prevents articular cartilage destruction in a murine model via Nrf2/HO‑1 pathway. Mol Med Rep 23: 224, 2021
APA
Cai, D., Wang, J., Chen, S., Jiang, L., Chen, J., Wu, J., & Qin, J. (2021). Coniferaldehyde prevents articular cartilage destruction in a murine model via Nrf2/HO‑1 pathway. Molecular Medicine Reports, 23, 224. https://doi.org/10.3892/mmr.2021.11863
MLA
Cai, D., Wang, J., Chen, S., Jiang, L., Chen, J., Wu, J., Qin, J."Coniferaldehyde prevents articular cartilage destruction in a murine model via Nrf2/HO‑1 pathway". Molecular Medicine Reports 23.3 (2021): 224.
Chicago
Cai, D., Wang, J., Chen, S., Jiang, L., Chen, J., Wu, J., Qin, J."Coniferaldehyde prevents articular cartilage destruction in a murine model via Nrf2/HO‑1 pathway". Molecular Medicine Reports 23, no. 3 (2021): 224. https://doi.org/10.3892/mmr.2021.11863