Open Access

Mechanism of herbal medicine on hypertensive nephropathy (Review)

  • Authors:
    • Zhaocheng Dong
    • Haoran Dai
    • Zhandong Feng
    • Wenbin Liu
    • Yu Gao
    • Fei Liu
    • Zihan Zhang
    • Na Zhang
    • Xuan Dong
    • Qihan Zhao
    • Xiaoshan Zhou
    • Jieli Du
    • Baoli Liu
  • View Affiliations

  • Published online on: January 26, 2021     https://doi.org/10.3892/mmr.2021.11873
  • Article Number: 234
  • Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hypertensive nephropathy is the most common complication of hypertension, and is one of the main causes of end‑stage renal disease (ESRD) in numerous countries. The basic pathological feature of hypertensive nephropathy is arteriolosclerosis followed by renal parenchymal damage. The etiology of this disease is complex, and its pathogenesis is mainly associated with renal hemodynamic changes and vascular remodeling. Despite the increased knowledge on the pathogenesis of hypertensive nephropathy, the current clinical treatment methods are still not effective in preventing the development of the disease to ESRD. Herbal medicine, which is used to relieve symptoms, can improve hypertensive nephropathy through multiple targets. Since there are few clinical studies on the treatment of hypertensive nephropathy with herbal medicine, this article aims to review the progress on the basic research on the treatment of hypertensive nephropathy with herbal medicine, including regulation of the renin angiotensin system, inhibition of sympathetic excitation, antioxidant stress and anti‑inflammatory protection of endothelial cells, and improvement of obesity‑associated factors. Herbal medicine with different components plays a synergistic and multi‑target role in the treatment of hypertensive nephropathy. The description of the mechanism of herbal medicine in the treatment of hypertensive nephropathy will contribute towards the progress of modern medicine.
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April-2021
Volume 23 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Dong Z, Dai H, Feng Z, Liu W, Gao Y, Liu F, Zhang Z, Zhang N, Dong X, Zhao Q, Zhao Q, et al: Mechanism of herbal medicine on hypertensive nephropathy (Review). Mol Med Rep 23: 234, 2021
APA
Dong, Z., Dai, H., Feng, Z., Liu, W., Gao, Y., Liu, F. ... Liu, B. (2021). Mechanism of herbal medicine on hypertensive nephropathy (Review). Molecular Medicine Reports, 23, 234. https://doi.org/10.3892/mmr.2021.11873
MLA
Dong, Z., Dai, H., Feng, Z., Liu, W., Gao, Y., Liu, F., Zhang, Z., Zhang, N., Dong, X., Zhao, Q., Zhou, X., Du, J., Liu, B."Mechanism of herbal medicine on hypertensive nephropathy (Review)". Molecular Medicine Reports 23.4 (2021): 234.
Chicago
Dong, Z., Dai, H., Feng, Z., Liu, W., Gao, Y., Liu, F., Zhang, Z., Zhang, N., Dong, X., Zhao, Q., Zhou, X., Du, J., Liu, B."Mechanism of herbal medicine on hypertensive nephropathy (Review)". Molecular Medicine Reports 23, no. 4 (2021): 234. https://doi.org/10.3892/mmr.2021.11873