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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April-2021 Volume 23 Issue 4

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Semaphorin 3A contributes to sepsis‑induced immunosuppression by impairing CD4+ T cell anergy

Yulei Gao, Chunxue Wang, Ziyi Wang, Wenjie Li, Yancun Liu, Songtao Shou, Yanfen Chai
Article Number: 302
Published online on: 24 February 2021

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Article Open Access

Dual PI3K/mTOR inhibitor NVP‑BEZ235 decreases the proliferation of doxorubicin‑resistant K562 cells

Jie Li, Xiaozi Wang, Chuanbao Ma, Shasha Xu, Mengyao Xu, Jie Yang, Ruicang Wang, Liying Xue
Article Number: 301
Published online on: 24 February 2021

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Article Open Access

circ‑0000212 promotes cell proliferation of colorectal cancer by sponging miR‑491 and modulating FOXP4 expression

Hongyu Wu, Yangbao Tao, Weiyuan Zhang, Guiyu Wang, Qian Zhang
Article Number: 300
Published online on: 24 February 2021

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Article Open Access

Hydrogen sulfide ameliorates doxorubicin‑induced myocardial fibrosis in rats via the PI3K/AKT/mTOR pathway

Liangui Nie, Maojun Liu, Jian Chen, Qian Wu, Yaling Li, Jiali Yi, Xia Zheng, Jingjing Zhang, Chun Chu, Jun Yang
Article Number: 299
Published online on: 24 February 2021

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Article Open Access

Peptidomics analysis revealed that a novel peptide VMP‑19 protects against Ang II‑induced injury in human umbilical vein endothelial cells

Zhongqing Xu, Jingjing Ding, Li Zhang, Xianzhen Feng, Jun Zhou, Xiaoyi Shen, Hong Lu, Lingmei Qian, Xun Li
Article Number: 298
Published online on: 23 February 2021

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Article Open Access

Tetrandrine attenuates ischemia/reperfusion‑induced neuronal damage in the subacute phase

Yu Wang, Xinjun Cai, Zhiheng Wu, Leilei Tang, Lingqun Lu, Yinyin Xu, Xiaogang Bao
Article Number: 297
Published online on: 23 February 2021

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Correction Open Access

[Corrigendum] miR‑182‑5p contributes to radioresistance in naso-pharyngeal carcinoma by regulating BNIP3 expression

Wei He, Hongyan Jin, Qian Liu, Quanxin Sun
Article Number: 296
Published online on: 23 February 2021

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Article Open Access

Rs41291957 polymorphism in the promoter region of microRNA‑143 serves as a prognostic biomarker for patients with intracranial hemorrhage

Xiaobo Yang, Zongduo Guo, Fang Cao, Zhipeng Teng, Zhijian Huang, Xiaochuan Sun
Article Number: 295
Published online on: 23 February 2021

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Article Open Access

Effects of combination treatment with transcranial magnetic stimulation and bone marrow mesenchymal stem cell transplantation or Raf inhibition on spinal cord injury in rats

Sining Feng, Shuai Wang, Shi Sun, Hao Su, Lixin Zhang
Article Number: 294
Published online on: 23 February 2021

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Article Open Access

κ‑opioid receptor agonist U50488H attenuates postoperative cognitive dysfunction of cardiopulmonary bypass rats through the PI3K/AKT/Nrf2/HO‑1 pathway

Jianing Fan, Long Li, Pengxia Qu, Yugang Diao, Yingjie Sun
Article Number: 293
Published online on: 23 February 2021

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Article

Anti‑fibrotic effects and the mechanism of action of miR‑29c in silicosis

Lei Huang, Yang Zhang, Jie Yang, Juan Li, Ju Wu, Faxuan Wang, Yajia Lan, Qin Zhang
Article Number: 292
Published online on: 22 February 2021

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Article Open Access

Ginsenoside Rg1 improves cognitive capability and affects the microbiota of large intestine of tree shrew model for Alzheimer's disease

Yuqian Guo, Limei Wang, Jiangli Lu, Jianlin Jiao, Yi Yang, Hongbin Zhao, Zhang Liang, Hong Zheng
Article Number: 291
Published online on: 22 February 2021

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Article Open Access

Novel insights into di‑(2‑ethylhexyl)phthalate activation: Implications for the hypothalamus‑pituitary‑thyroid axis

Haoyu Wu, Wanying Zhang, Yunbo Zhang, Zhen Kang, Xinxiunan Miao, Xiaolin Na
Article Number: 290
Published online on: 22 February 2021

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Article Open Access

Bioinformatics analysis of differentially expressed proteins in alcoholic fatty liver disease treated with recombinant human cytoglobin

Zi-Rong Zhang, Zheng-Gen Yang, Yan-Mei Xu, Zhe-Yan Wang, Jian Wen, Bo-Hong Chen, Ping Wang, Wei Wei, Zhen Li, Wen-Qi Dong
Article Number: 289
Published online on: 22 February 2021

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Article Open Access

Nerve growth factor regulates liver cancer cell polarity and motility

Haihua Lin, Huanjun Huang, Yuhong Yu, Weibin Chen, Shaomin Zhang, Yuanzhi Zhang
Article Number: 288
Published online on: 19 February 2021

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Article

Isoacteoside attenuates acute kidney injury induced by severe acute pancreatitis

Bin Wang, Xi-Han Li, Zhang Song, Min-Li Li, Xiao-Wei Wu, Mei-Xia Guo, Xiao-Hua Zhang, Xiao-Ping Zou
Article Number: 287
Published online on: 19 February 2021

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Article Open Access

Hyperoside protects cardiomyocytes against hypoxia‑induced injury via upregulation of microRNA‑138

Siyi He, Xiaoqiang Yin, Fan Wu, Shaojie Zeng, Feng Gao, Mei Xin, Jian Wang, Jie Chen, Le Zhang, Jinbao Zhang
Article Number: 286
Published online on: 19 February 2021

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Article Open Access

Size changes in miR‑21 knockout mice: Geometric morphometrics on teeth, alveolar bone and mandible

Uwe Yacine Schwarze, Yuxin Ni, Yanmin Zhou, Lucia Terlecki‑Ζaniewicz, Markus Schosserer, Matthias Hackl, Johannes Grillari, Reinhard Gruber
Article Number: 285
Published online on: 18 February 2021

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Article Open Access

Urantide decreases hepatic steatosis in rats with experimental atherosclerosis via the MAPK/Erk/JNK pathway

Haipeng Cui, Yingxue Lin, Lide Xie, Juan Zhao
Article Number: 284
Published online on: 18 February 2021

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Article Open Access

Inhibiting miR‑1 attenuates pulmonary arterial hypertension in rats

Yun Liu, Yong Li, Jinhai Li, Xiangrong Zuo, Quan Cao, Weiping Xie, Hong Wang
Article Number: 283
Published online on: 18 February 2021

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Article Open Access

Dynamic changes of inflammation and apoptosis in cerebral ischemia‑reperfusion injury in mice investigated by ferumoxytol‑enhanced magnetic resonance imaging

Lihua Zhuang, Yingnan Kong, Shuohui Yang, Fang Lu, Zhigang Gong, Songhua Zhan, Mengxiao Liu
Article Number: 282
Published online on: 18 February 2021

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Correction Open Access

[Corrigendum] Evaluation of eight reference genes for quantitative polymerase chain reaction analysis in human T lymphocytes co‑cultured with mesenchymal stem cells

Xiuying Li, Qiwei Yang, Jinping Bai, Yali Xuan, Yimin Wang
Article Number: 281
Published online on: 17 February 2021

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Article Open Access

CART mitigates oxidative stress and DNA damage in memory deficits of APP/PS1 mice via upregulating β‑amyloid metabolism‑associated enzymes

Hui Jiang, Fengnan Niu, Yan Zheng, Yun Xu
Article Number: 280
Published online on: 17 February 2021

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Article Open Access

Yuan‑zhi‑san inhibits tau protein aggregation in an Aβ1‑40‑induced Alzheimer's disease rat model via the ubiquitin‑proteasome system

Bin Li, Pei-Jun Xie, Yan-Wei Hao, Yu Guo, Jun-Rong Yu, Dao-Yin Gong, Jing Guo, Jin-Hao Zeng, Yi Zhang
Article Number: 279
Published online on: 15 February 2021

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Article

A large dose of methamphetamine inhibits drug‑evoked synaptic plasticity via ER stress in the hippocampus

Guang Chen, Gang Yu, Zheng Yong, Hui Yan, Ruibin Su, Huijun Wang
Article Number: 278
Published online on: 11 February 2021

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Article

Grap2 cyclin D interacting protein negatively regulates CREB‑binding protein, inhibiting fibroblast‑like synoviocyte growth

Hidetoshi Fujita, Satoko Aratani, Toshihiro Nakajima
Article Number: 277
Published online on: 11 February 2021

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Article Open Access

MicroRNA‑138‑5p drives the progression of heart failure via inhibiting sirtuin 1 signaling

Shuai Sun, Chun Wang, Jianxin Weng
Article Number: 276
Published online on: 11 February 2021

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Article Open Access

Genotype variant screening and phenotypic analysis of FBN1 in Chinese patients with isolated ectopia lentis

Yijing Zhou, Dongwei Guo, Qianzhong Cao, Xinyu Zhang, Guangming Jin, Danying Zheng
Article Number: 275
Published online on: 10 February 2021

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Article Open Access

Prenatal ethanol exposure impairs the formation of radial glial fibers and promotes the transformation of GFAPδ‑positive radial glial cells into astrocytes

Yu Li, Li-Na Zhang, Li Chong, Yue Liu, Feng-Yu Xi, Hong Zhang, Xiang-Long Duan
Article Number: 274
Published online on: 09 February 2021

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Article Open Access

Schistosoma japonicum cystatin suppresses osteoclastogenesis via manipulating the NF‑κB signaling pathway

Yu Chen, Bangguo Wei, Panpan Xu, Huadong Tang, Langlang Yang, Yuhang Wang, Yingxiao Fu, Xiaodi Yang, Yingji Mao
Article Number: 273
Published online on: 09 February 2021

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Correction Open Access

[Corrigendum] Long non‑coding RNA PITPNA‑AS1 silencing suppresses proliferation, metastasis and epithelial‑mesenchymal transition in non‑small cell lung cancer cells by targeting microRNA‑32‑5p

Gang Chen, Zhifeng Zheng, Junsheng Li, Peigang Zhang, Zhenjun Wang, Shiping Guo, Jun Ma, Jian  Shen, Huixin Li
Article Number: 272
Published online on: 09 February 2021

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Article

lncRNA PVT1 modulates NLRP3‑mediated pyroptosis in septic acute kidney injury by targeting miR‑20a‑5p

Long-Tian Deng, Qian-Lu Wang, Can Yu, Min Gao
Article Number: 271
Published online on: 09 February 2021

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Article

N1‑methylnicotinamide ameliorates insulin resistance in skeletal muscle of type 2 diabetic mice by activating the SIRT1/PGC‑1α signaling pathway

Yu Chen, Jingfan Zhang, Ping Li, Cong Liu, Ling Li
Article Number: 270
Published online on: 09 February 2021

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Article Open Access

NFIB promotes the progression of gastric cancer by upregulating circMAP7D1 to stabilize HER2 mRNA

Huimin Yang, Zhengzhen Wu, Xin Liu, Min Chen, Xin Zhang, Yong Jiang
Article Number: 269
Published online on: 09 February 2021

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Article Open Access

PWAR6 interacts with miR‑106a‑5p to regulate the osteogenic differentiation of human periodontal ligament stem cells

Juan Xiang, Ying Bian
Article Number: 268
Published online on: 08 February 2021

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Article Open Access

Procyanidin B2 inhibits lipopolysaccharide‑induced apoptosis by suppressing the Bcl‑2/Bax and NF‑κB signalling pathways in human umbilical vein endothelial cells

Da-Qiang Song, Jiao Liu, Fang Wang, Xiao-Fang Li, Ming-Hua Liu, Zhuo Zhang, Shou-Song Cao, Xian Jiang
Article Number: 267
Published online on: 08 February 2021

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Article Open Access

Orexin-A alleviates cerebral ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress-mediated apoptosis

Dandan Xu, Tingting Kong, Baohua Cheng, Rumin Zhang, Chunqing Yang, Jing Chen, Chunmei Wang
Article Number: 266
Published online on: 08 February 2021

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Article Open Access

Effect of mtDNA depletion from C6 glioma cells and characteristics of the generated C6ρ0 cells

Youcai Jin, Guangxiang Luan, Ji Li, Honglun Wang, Zhenhua Wang, Bo Bai
Article Number: 265
Published online on: 08 February 2021

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Article Open Access

Effects of Cirsium setidens (Dunn) Nakai on the osteogenic differentiation of stem cells

Sayan Deb Dutta, Dinesh K. Patel, Bin Jin, Sun-Il Choi, Ok Hwan Lee, Ki-Taek Lim
Article Number: 264
Published online on: 08 February 2021

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Article Open Access

Downregulated expression levels of USP46 promote the resistance of ovarian cancer to cisplatin and are regulated by PUM2 Retraction in /10.3892/mmr.2024.13297

Lei Xu, Bin Zhang, Wenlan Li
Article Number: 263
Published online on: 08 February 2021

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Review Open Access

Severe acute respiratory syndrome coronavirus 2 for physicians: Molecular characteristics and host immunity (Review)

Jin Shang, Lingyao Du, Ning Han, Duoduo Lv, Jiayi Wang, Hailing Yang, Lang Bai, Hong Tang
Article Number: 262
Published online on: 08 February 2021

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Article Open Access

MicroRNA‑592 promotes cell proliferation, migration and invasion in colorectal cancer by directly targeting SPARC

Zhenguo Pan, Rui Xie, Wei Song, Chengcheng Gao
Article Number: 261
Published online on: 08 February 2021

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Review Open Access

Antiangiogenic therapy in diabetic nephropathy: A double‑edged sword (Review)

Qian-Ru Tao, Ying-Ming Chu, Lan Wei, Chao Tu, Yuan-Yuan Han
Article Number: 260
Published online on: 08 February 2021

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Article Open Access

lncRNA‑MALAT1 promotes high glucose‑induced H9C2 cardiomyocyte pyroptosis by downregulating miR‑141‑3p expression

Aishan Wu, Weili Sun, Fengying Mou
Article Number: 259
Published online on: 08 February 2021

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Article Open Access

Comparison and optimisation of microRNA extraction from the plasma of healthy pregnant women

Victoria L. Parker, Bryony F. Cushen, Eleftherios Gavriil, Benjamin Marshall, Sarah Waite, Allan Pacey, Paul R. Heath
Article Number: 258
Published online on: 05 February 2021

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Article Open Access

Promotive role of microRNA‑150 in hippocampal neurons apoptosis in vascular dementia model rats

Chengqun Wei, Xiuzhi Xu, Hongyan Zhu, Xiuyan Zhang, Zhan Gao
Article Number: 257
Published online on: 05 February 2021

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Article Open Access

Transient forebrain ischemia under hyperthermic condition accelerates memory impairment and neuronal death in the gerbil hippocampus by increasing NMDAR1 expression

Bora Kim, Ji Hyeon Ahn, Dae Won Kim, Tae-Kyeong Lee, Yoon Sung Kim, Myoung Cheol Shin, Jun Hwi Cho, Young-Myeong Kim, Joon Ha Park, Il Jun Kang, Jae-Chul Lee, Moo-Ho Won
Article Number: 256
Published online on: 04 February 2021

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Article Open Access

Circ‑TOP2A acts as a ceRNA for miR‑346 and contributes to glioma progression via the modulation of sushi domain‑containing 2

Junzhi Sang, Xing Li, Luting Lv, Chunyu Zhang, Xiaoqian Zhang, Guoan Li
Article Number: 255
Published online on: 04 February 2021

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Article Open Access

Critical implication of the PTEN/PI3K/AKT pathway during BMP2-induced heterotopic ossification

Jun Dong, Xiqiang Xu, Qingyu Zhang, Zenong Yuan, Bingyi Tan
Article Number: 254
Published online on: 03 February 2021

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Article Open Access

MicroRNA‑186‑5p downregulation inhibits osteoarthritis development by targeting MAPK1

Qing Li, Mingjie Wu, Guofang Fang, Kuangwen Li, Wengang  Cui, Liang Li, Xia Li, Junsheng Wang, Yanhong Cang
Article Number: 253
Published online on: 03 February 2021

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Article Open Access

Comparison of steroid hormones in three different preeclamptic models

Ye Young Shin, Sung-Min An, Jea Sic Jeong, Seung Yun Yang, Geun-Shik Lee, Eui-Ju Hong, Eui-Bae Jeung, Seung Chul Kim, Beum-Soo An
Article Number: 252
Published online on: 02 February 2021

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Article Open Access

Benchmarking of next and third generation sequencing technologies and their associated algorithms for de novo genome assembly

Marios Gavrielatos, Konstantinos Kyriakidis, Demetrios A. Spandidos, Ioannis Michalopoulos
Article Number: 251
Published online on: 02 February 2021

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Article Open Access

Ginger facilitates cell migration and heat tolerance in mouse fibroblast cells

Naotoshi Sugimoto, Masanori Katakura, Kentaro Matsuzaki, Mayumi Miyamoto, Eri Sumiyoshi, Taizo Wada, Akihiro Yachie, Hiroyuki Nakamura, Osamu Shido
Article Number: 250
Published online on: 02 February 2021

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Article

Diagnostic value of microRNA‑125b in peripheral blood mononuclear cells for pulmonary tuberculosis

Xiaolu Sun, Kai Liu, Xinhong Wang, Tianhua Zhang, Xiaomou Li, Yan Zhao
Article Number: 249
Published online on: 01 February 2021

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Article

Apoptotic effects of alisol B 23‑acetate on gastric cancer cells

Min Ji Kwon, Jeong Nam Kim, Min Jae Lee, Woo   Kyung Kim, Joo Hyun Nam, Byung Joo Kim
Article Number: 248
Published online on: 01 February 2021

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Article

ER stress mediated‑autophagy contributes to neurological dysfunction in traumatic brain injury via the ATF6 UPR signaling pathway

Da-Yong Wang, Ming-Yan Hong, Jian Pei, Yun-He Gao, Yu Zheng, Xiang Xu
Article Number: 247
Published online on: 01 February 2021

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Article Open Access

GINS2 affects cell proliferation, apoptosis, migration and invasion in thyroid cancer via regulating MAPK signaling pathway

Saifei He, Miao Zhang, Ying Ye, Yanan Song, Xing Ma, Guoyu Wang, Juhua Zhuang, Wei Xia, Bin Zhao
Article Number: 246
Published online on: 01 February 2021

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Article Open Access

MYCN‑amplified neuroblastoma cell‑derived exosomal miR‑17‑5p promotes proliferation and migration of non‑MYCN amplified cells Corrigendum in /10.3892/mmr.2024.13349

Weiming Chen, Xiwei Hao, Binyi Yang, Yuezhen Zhang, Lingyun Sun, Yanan  Hua, Li Yang, Jiabin Yu, Jing Zhao, Lin Hou, Hongting Lu
Article Number: 245
Published online on: 01 February 2021

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Article Open Access

Astragaloside IV improves angiogenesis under hypoxic conditions by enhancing hypoxia‑inducible factor‑1α SUMOylation

Baoshen Wang, Chunyan Zhang, Dongmei Chu, Xiaofang Ma, Tian Yu, Xiaozhi Liu, Changqing Hu
Article Number: 244
Published online on: 01 February 2021

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Article Open Access

miR‑27a‑3p regulates the inhibitory influence of endothelin 3 on the tumorigenesis of papillary thyroid cancer cells Corrigendum in /10.3892/mmr.2021.12105

Hongxin Chen, Binlin Cai, Kun Liu, Qingquan Hua
Article Number: 243
Published online on: 01 February 2021

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Article Open Access

Notoginsenoside R1 induces DNA damage via PHF6 protein to inhibit cervical carcinoma cell proliferation

Ting Cai, Wenquan Wu, Longhua Guo, Yongwu Xia, Xiaoxin Jiang, Limei Zhang, Feiding Peng, Pinghong Ming
Article Number: 242
Published online on: 01 February 2021

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Article Open Access

Metabolomic profiling identifies a novel mechanism for heat stroke‑related acute kidney injury

Ling Xue, Wenli Guo, Li Li, Santao Ou, Tingting Zhu, Liang Cai, Wenfei Ding, Weihua Wu
Article Number: 241
Published online on: 28 January 2021

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Article Open Access

CDK6 is stimulated by hyperthermia and protects gastric cancer cells from hyperthermia‑induced damage

Guanghui Liu, Hongchao Zhao, Qingqing Ding, Haohao Li, Tao Liu, Hongwei Yang, Yuanhua Liu
Article Number: 240
Published online on: 28 January 2021

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The potential role and trend of HIF‑1α in intervertebral disc degeneration: Friend or foe? (Review)

Yongjin Li, Shen Liu, Dayu Pan, Baoshan Xu, Xuewu Xing, Hengxing Zhou, Bin Zhang, Suzhe Zhou, Guangzhi Ning, Shiqing Feng
Article Number: 239
Published online on: 28 January 2021

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Inhibition of PDGF-BB reduces alkali-induced corneal neovascularization in mice

Lei Chen, Hongya Wu, Chi Ren, Gaoqin Liu, Wenpeng Zhang, Weiming Liu, Peirong Lu
Article Number: 238
Published online on: 28 January 2021

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MicroRNA‑199a‑3p inhibits ovarian cancer cell viability by targeting the oncogene YAP1 Retraction in /10.3892/mmr.2022.12892

Yanfang He, Xiangyang Yu, Yajuan Tang, Yanjuan Guo, Jinling  Yuan, Jinghe Bai, Tao Yao, Xiongzhi Wu
Article Number: 237
Published online on: 27 January 2021

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[Retracted] LINC01638 silencing inhibits cancer cell proliferation in colorectal adenocarcinoma through interaction with RUNX2

Wenying Zhuo, Dengdi Hu, Xihua Chen, Tian Zhang
Article Number: 236
Published online on: 27 January 2021

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Heme oxygenase‑1 improves the survival of ischemic skin flaps (Review)

Yinhua Zheng, Zhenlan Li, Min Yin, Xu Gong
Article Number: 235
Published online on: 26 January 2021

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Mechanism of herbal medicine on hypertensive nephropathy (Review)

Zhaocheng Dong, Haoran Dai, Zhandong Feng, Wenbin Liu, Yu Gao, Fei Liu, Zihan Zhang, Na Zhang, Xuan Dong, Qihan Zhao, Xiaoshan Zhou, Jieli Du, Baoli Liu
Article Number: 234
Published online on: 26 January 2021

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FBXW7 mediates high glucose‑induced SREBP‑1 expression in renal tubular cells of diabetic nephropathy under PI3K/Akt pathway regulation

Lisha Li, Juxiang Yang, Fan Li, Lin Zhu, Jun Hao, Fan Gao
Article Number: 233
Published online on: 26 January 2021

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Effects of DLX3 on the osteogenic differentiation of induced pluripotent stem cell‑derived mesenchymal stem cells

Junyuan Li, Qiang Lin, Yixin Lin, Renfa Lai, Wen Zhang
Article Number: 232
Published online on: 26 January 2021

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Intrathecal injection of ozone alleviates CCI‑induced neuropathic pain via the GluR6‑NF‑κB/p65 signalling pathway in rats

Weiguang Zhang, Fei Wang, Licai Zhang, Tao Sun, Zhijian Fu
Article Number: 231
Published online on: 26 January 2021

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Involvement of TLR2/4‑MyD88‑NF‑κB signaling pathway in the pathogenesis of intracranial aneurysm

Xuezhi Zhang, Yilv Wan, Jiugeng Feng, Meihua Li, Zhiqun Jiang
Article Number: 230
Published online on: 26 January 2021

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[Retracted] Ferruginol exhibits anticancer effects in OVCAR‑3 human ovary cancer cells by inducing apoptosis, inhibition of cancer cell migration and G2/M phase cell cycle arrest

Wen-Dong Xiong, Jian Gong, Chao Xing
Article Number: 229
Published online on: 26 January 2021

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The microRNA-429/DUSP4 axis regulates the sensitivity of colorectal cancer cells to nintedanib

Guohua Cheng, Yarong Li, Zhaoyu Liu, Xiang Song
Article Number: 228
Published online on: 25 January 2021

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Metabolic remodeling in the right ventricle of rats with severe pulmonary arterial hypertension

Seiichiro Sakao, Eiryo Kawakami, Hiroki Shoji, Akira Naito, Hideki Miwa, Rika Suda, Takayuki Jujo Sanada, Nobuhiro Tanabe, Koichiro Tatsumi
Article Number: 227
Published online on: 25 January 2021

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January-2026 Volume 33 Issue 1

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Non‑coding RNAs in epithelial‑mesenchymal transition of renal cell carcinoma (Review)

Ziqiao Liu, Hanshen Zhou, Junxiao Shen, Yiming Qi, Xuke Gong, Cheng Zhang
Article Number: 51
Published online on: 24 November 2025

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FOXJ3 drives mesenchymal stem cell osteogenic differentiation via the Wnt/β‑catenin pathway: A novel regulator implicated in osteoporosis

Hongwei Xiao, Jianfeng Li, Wei Huang, Yi Qin
Article Number: 50
Published online on: 21 November 2025

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NEDD4 regulates VEGF signaling and mTOR to promote angiogenesis and the cell cycle in steroid‑induced osteonecrosis of the femoral head

Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
Article Number: 49
Published online on: 21 November 2025

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Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway

Chih-Hsuan Hsia, Chun-Ming Yang, Chao-Chien Chang, Ting-Lin Yen, Arief Gunawan Darmanto, Chi-Chang Huang, Joen-Rong Sheu
Article Number: 48
Published online on: 21 November 2025

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Research progress on molecular therapy for glaucoma (Review)

Weiwei Wang, Gangwei Cheng, Qi Zhou, Sheng Wang, Linyi Zhang
Article Number: 47
Published online on: 21 November 2025

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Natural compounds for the treatment of rheumatoid arthritis based on the ‘gut‑joint axis’ (Review)

Wenjie Hu, Rui Li, Zhongming Zhang
Article Number: 46
Published online on: 20 November 2025

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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

Pan Guo, Mengke Sun, Jingyu Zhang, Qianshu Yuan, Hong Cui, Junkai Huang, Jing Luo, Qianyu Zhu, Bingxin Zhang, Lizhi Hu
Article Number: 45
Published online on: 20 November 2025

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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

Banghao Sun, Zhenyu Zhao, Qingyu Meng, Luya Pu, Xingyu Jiang, Shuai Li, Fadi Cao, Fan Li
Article Number: 44
Published online on: 20 November 2025

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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
Published online on: 18 November 2025

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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
Published online on: 17 November 2025

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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
Article Number: 41
Published online on: 12 November 2025

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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
Article Number: 40
Published online on: 12 November 2025

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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
Published online on: 12 November 2025

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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
Published online on: 10 November 2025

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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
Article Number: 35
Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
Published online on: 10 November 2025

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Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
Article Number: 22
Published online on: 31 October 2025

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Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review)

Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Article

Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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Retraction Open Access

[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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Retraction Open Access

[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 33 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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