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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April-2021 Volume 23 Issue 4

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Semaphorin 3A contributes to sepsis‑induced immunosuppression by impairing CD4+ T cell anergy

Yulei Gao, Chunxue Wang, Ziyi Wang, Wenjie Li, Yancun Liu, Songtao Shou, Yanfen Chai
Article Number: 302
Published online on: 24 February 2021

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Article Open Access

Dual PI3K/mTOR inhibitor NVP‑BEZ235 decreases the proliferation of doxorubicin‑resistant K562 cells

Jie Li, Xiaozi Wang, Chuanbao Ma, Shasha Xu, Mengyao Xu, Jie Yang, Ruicang Wang, Liying Xue
Article Number: 301
Published online on: 24 February 2021

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Article Open Access

circ‑0000212 promotes cell proliferation of colorectal cancer by sponging miR‑491 and modulating FOXP4 expression

Hongyu Wu, Yangbao Tao, Weiyuan Zhang, Guiyu Wang, Qian Zhang
Article Number: 300
Published online on: 24 February 2021

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Article Open Access

Hydrogen sulfide ameliorates doxorubicin‑induced myocardial fibrosis in rats via the PI3K/AKT/mTOR pathway

Liangui Nie, Maojun Liu, Jian Chen, Qian Wu, Yaling Li, Jiali Yi, Xia Zheng, Jingjing Zhang, Chun Chu, Jun Yang
Article Number: 299
Published online on: 24 February 2021

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Article Open Access

Peptidomics analysis revealed that a novel peptide VMP‑19 protects against Ang II‑induced injury in human umbilical vein endothelial cells

Zhongqing Xu, Jingjing Ding, Li Zhang, Xianzhen Feng, Jun Zhou, Xiaoyi Shen, Hong Lu, Lingmei Qian, Xun Li
Article Number: 298
Published online on: 23 February 2021

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Article Open Access

Tetrandrine attenuates ischemia/reperfusion‑induced neuronal damage in the subacute phase

Yu Wang, Xinjun Cai, Zhiheng Wu, Leilei Tang, Lingqun Lu, Yinyin Xu, Xiaogang Bao
Article Number: 297
Published online on: 23 February 2021

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Correction Open Access

[Corrigendum] miR‑182‑5p contributes to radioresistance in naso-pharyngeal carcinoma by regulating BNIP3 expression

Wei He, Hongyan Jin, Qian Liu, Quanxin Sun
Article Number: 296
Published online on: 23 February 2021

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Article Open Access

Rs41291957 polymorphism in the promoter region of microRNA‑143 serves as a prognostic biomarker for patients with intracranial hemorrhage

Xiaobo Yang, Zongduo Guo, Fang Cao, Zhipeng Teng, Zhijian Huang, Xiaochuan Sun
Article Number: 295
Published online on: 23 February 2021

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Article Open Access

Effects of combination treatment with transcranial magnetic stimulation and bone marrow mesenchymal stem cell transplantation or Raf inhibition on spinal cord injury in rats

Sining Feng, Shuai Wang, Shi Sun, Hao Su, Lixin Zhang
Article Number: 294
Published online on: 23 February 2021

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Article Open Access

κ‑opioid receptor agonist U50488H attenuates postoperative cognitive dysfunction of cardiopulmonary bypass rats through the PI3K/AKT/Nrf2/HO‑1 pathway

Jianing Fan, Long Li, Pengxia Qu, Yugang Diao, Yingjie Sun
Article Number: 293
Published online on: 23 February 2021

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Article

Anti‑fibrotic effects and the mechanism of action of miR‑29c in silicosis

Lei Huang, Yang Zhang, Jie Yang, Juan Li, Ju Wu, Faxuan Wang, Yajia Lan, Qin Zhang
Article Number: 292
Published online on: 22 February 2021

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Article Open Access

Ginsenoside Rg1 improves cognitive capability and affects the microbiota of large intestine of tree shrew model for Alzheimer's disease

Yuqian Guo, Limei Wang, Jiangli Lu, Jianlin Jiao, Yi Yang, Hongbin Zhao, Zhang Liang, Hong Zheng
Article Number: 291
Published online on: 22 February 2021

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Article Open Access

Novel insights into di‑(2‑ethylhexyl)phthalate activation: Implications for the hypothalamus‑pituitary‑thyroid axis

Haoyu Wu, Wanying Zhang, Yunbo Zhang, Zhen Kang, Xinxiunan Miao, Xiaolin Na
Article Number: 290
Published online on: 22 February 2021

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Article Open Access

Bioinformatics analysis of differentially expressed proteins in alcoholic fatty liver disease treated with recombinant human cytoglobin

Zi-Rong Zhang, Zheng-Gen Yang, Yan-Mei Xu, Zhe-Yan Wang, Jian Wen, Bo-Hong Chen, Ping Wang, Wei Wei, Zhen Li, Wen-Qi Dong
Article Number: 289
Published online on: 22 February 2021

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Article Open Access

Nerve growth factor regulates liver cancer cell polarity and motility

Haihua Lin, Huanjun Huang, Yuhong Yu, Weibin Chen, Shaomin Zhang, Yuanzhi Zhang
Article Number: 288
Published online on: 19 February 2021

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Article

Isoacteoside attenuates acute kidney injury induced by severe acute pancreatitis

Bin Wang, Xi-Han Li, Zhang Song, Min-Li Li, Xiao-Wei Wu, Mei-Xia Guo, Xiao-Hua Zhang, Xiao-Ping Zou
Article Number: 287
Published online on: 19 February 2021

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Article Open Access

Hyperoside protects cardiomyocytes against hypoxia‑induced injury via upregulation of microRNA‑138

Siyi He, Xiaoqiang Yin, Fan Wu, Shaojie Zeng, Feng Gao, Mei Xin, Jian Wang, Jie Chen, Le Zhang, Jinbao Zhang
Article Number: 286
Published online on: 19 February 2021

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Article Open Access

Size changes in miR‑21 knockout mice: Geometric morphometrics on teeth, alveolar bone and mandible

Uwe Yacine Schwarze, Yuxin Ni, Yanmin Zhou, Lucia Terlecki‑Ζaniewicz, Markus Schosserer, Matthias Hackl, Johannes Grillari, Reinhard Gruber
Article Number: 285
Published online on: 18 February 2021

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Article Open Access

Urantide decreases hepatic steatosis in rats with experimental atherosclerosis via the MAPK/Erk/JNK pathway

Haipeng Cui, Yingxue Lin, Lide Xie, Juan Zhao
Article Number: 284
Published online on: 18 February 2021

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Article Open Access

Inhibiting miR‑1 attenuates pulmonary arterial hypertension in rats

Yun Liu, Yong Li, Jinhai Li, Xiangrong Zuo, Quan Cao, Weiping Xie, Hong Wang
Article Number: 283
Published online on: 18 February 2021

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Article Open Access

Dynamic changes of inflammation and apoptosis in cerebral ischemia‑reperfusion injury in mice investigated by ferumoxytol‑enhanced magnetic resonance imaging

Lihua Zhuang, Yingnan Kong, Shuohui Yang, Fang Lu, Zhigang Gong, Songhua Zhan, Mengxiao Liu
Article Number: 282
Published online on: 18 February 2021

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Correction Open Access

[Corrigendum] Evaluation of eight reference genes for quantitative polymerase chain reaction analysis in human T lymphocytes co‑cultured with mesenchymal stem cells

Xiuying Li, Qiwei Yang, Jinping Bai, Yali Xuan, Yimin Wang
Article Number: 281
Published online on: 17 February 2021

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Article Open Access

CART mitigates oxidative stress and DNA damage in memory deficits of APP/PS1 mice via upregulating β‑amyloid metabolism‑associated enzymes

Hui Jiang, Fengnan Niu, Yan Zheng, Yun Xu
Article Number: 280
Published online on: 17 February 2021

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Article Open Access

Yuan‑zhi‑san inhibits tau protein aggregation in an Aβ1‑40‑induced Alzheimer's disease rat model via the ubiquitin‑proteasome system

Bin Li, Pei-Jun Xie, Yan-Wei Hao, Yu Guo, Jun-Rong Yu, Dao-Yin Gong, Jing Guo, Jin-Hao Zeng, Yi Zhang
Article Number: 279
Published online on: 15 February 2021

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Article

A large dose of methamphetamine inhibits drug‑evoked synaptic plasticity via ER stress in the hippocampus

Guang Chen, Gang Yu, Zheng Yong, Hui Yan, Ruibin Su, Huijun Wang
Article Number: 278
Published online on: 11 February 2021

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Article

Grap2 cyclin D interacting protein negatively regulates CREB‑binding protein, inhibiting fibroblast‑like synoviocyte growth

Hidetoshi Fujita, Satoko Aratani, Toshihiro Nakajima
Article Number: 277
Published online on: 11 February 2021

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Article Open Access

MicroRNA‑138‑5p drives the progression of heart failure via inhibiting sirtuin 1 signaling

Shuai Sun, Chun Wang, Jianxin Weng
Article Number: 276
Published online on: 11 February 2021

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Article Open Access

Genotype variant screening and phenotypic analysis of FBN1 in Chinese patients with isolated ectopia lentis

Yijing Zhou, Dongwei Guo, Qianzhong Cao, Xinyu Zhang, Guangming Jin, Danying Zheng
Article Number: 275
Published online on: 10 February 2021

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Article Open Access

Prenatal ethanol exposure impairs the formation of radial glial fibers and promotes the transformation of GFAPδ‑positive radial glial cells into astrocytes

Yu Li, Li-Na Zhang, Li Chong, Yue Liu, Feng-Yu Xi, Hong Zhang, Xiang-Long Duan
Article Number: 274
Published online on: 09 February 2021

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Article Open Access

Schistosoma japonicum cystatin suppresses osteoclastogenesis via manipulating the NF‑κB signaling pathway

Yu Chen, Bangguo Wei, Panpan Xu, Huadong Tang, Langlang Yang, Yuhang Wang, Yingxiao Fu, Xiaodi Yang, Yingji Mao
Article Number: 273
Published online on: 09 February 2021

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Correction Open Access

[Corrigendum] Long non‑coding RNA PITPNA‑AS1 silencing suppresses proliferation, metastasis and epithelial‑mesenchymal transition in non‑small cell lung cancer cells by targeting microRNA‑32‑5p

Gang Chen, Zhifeng Zheng, Junsheng Li, Peigang Zhang, Zhenjun Wang, Shiping Guo, Jun Ma, Jian  Shen, Huixin Li
Article Number: 272
Published online on: 09 February 2021

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Article

lncRNA PVT1 modulates NLRP3‑mediated pyroptosis in septic acute kidney injury by targeting miR‑20a‑5p

Long-Tian Deng, Qian-Lu Wang, Can Yu, Min Gao
Article Number: 271
Published online on: 09 February 2021

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Article

N1‑methylnicotinamide ameliorates insulin resistance in skeletal muscle of type 2 diabetic mice by activating the SIRT1/PGC‑1α signaling pathway

Yu Chen, Jingfan Zhang, Ping Li, Cong Liu, Ling Li
Article Number: 270
Published online on: 09 February 2021

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Article Open Access

NFIB promotes the progression of gastric cancer by upregulating circMAP7D1 to stabilize HER2 mRNA

Huimin Yang, Zhengzhen Wu, Xin Liu, Min Chen, Xin Zhang, Yong Jiang
Article Number: 269
Published online on: 09 February 2021

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Article Open Access

PWAR6 interacts with miR‑106a‑5p to regulate the osteogenic differentiation of human periodontal ligament stem cells

Juan Xiang, Ying Bian
Article Number: 268
Published online on: 08 February 2021

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Article Open Access

Procyanidin B2 inhibits lipopolysaccharide‑induced apoptosis by suppressing the Bcl‑2/Bax and NF‑κB signalling pathways in human umbilical vein endothelial cells

Da-Qiang Song, Jiao Liu, Fang Wang, Xiao-Fang Li, Ming-Hua Liu, Zhuo Zhang, Shou-Song Cao, Xian Jiang
Article Number: 267
Published online on: 08 February 2021

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Article Open Access

Orexin-A alleviates cerebral ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress-mediated apoptosis

Dandan Xu, Tingting Kong, Baohua Cheng, Rumin Zhang, Chunqing Yang, Jing Chen, Chunmei Wang
Article Number: 266
Published online on: 08 February 2021

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Article Open Access

Effect of mtDNA depletion from C6 glioma cells and characteristics of the generated C6ρ0 cells

Youcai Jin, Guangxiang Luan, Ji Li, Honglun Wang, Zhenhua Wang, Bo Bai
Article Number: 265
Published online on: 08 February 2021

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Article Open Access

Effects of Cirsium setidens (Dunn) Nakai on the osteogenic differentiation of stem cells

Sayan Deb Dutta, Dinesh K. Patel, Bin Jin, Sun-Il Choi, Ok Hwan Lee, Ki-Taek Lim
Article Number: 264
Published online on: 08 February 2021

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Article Open Access

Downregulated expression levels of USP46 promote the resistance of ovarian cancer to cisplatin and are regulated by PUM2 Retraction in /10.3892/mmr.2024.13297

Lei Xu, Bin Zhang, Wenlan Li
Article Number: 263
Published online on: 08 February 2021

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Review Open Access

Severe acute respiratory syndrome coronavirus 2 for physicians: Molecular characteristics and host immunity (Review)

Jin Shang, Lingyao Du, Ning Han, Duoduo Lv, Jiayi Wang, Hailing Yang, Lang Bai, Hong Tang
Article Number: 262
Published online on: 08 February 2021

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Article Open Access

MicroRNA‑592 promotes cell proliferation, migration and invasion in colorectal cancer by directly targeting SPARC

Zhenguo Pan, Rui Xie, Wei Song, Chengcheng Gao
Article Number: 261
Published online on: 08 February 2021

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Review Open Access

Antiangiogenic therapy in diabetic nephropathy: A double‑edged sword (Review)

Qian-Ru Tao, Ying-Ming Chu, Lan Wei, Chao Tu, Yuan-Yuan Han
Article Number: 260
Published online on: 08 February 2021

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Article Open Access

lncRNA‑MALAT1 promotes high glucose‑induced H9C2 cardiomyocyte pyroptosis by downregulating miR‑141‑3p expression

Aishan Wu, Weili Sun, Fengying Mou
Article Number: 259
Published online on: 08 February 2021

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Article Open Access

Comparison and optimisation of microRNA extraction from the plasma of healthy pregnant women

Victoria L. Parker, Bryony F. Cushen, Eleftherios Gavriil, Benjamin Marshall, Sarah Waite, Allan Pacey, Paul R. Heath
Article Number: 258
Published online on: 05 February 2021

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Article Open Access

Promotive role of microRNA‑150 in hippocampal neurons apoptosis in vascular dementia model rats

Chengqun Wei, Xiuzhi Xu, Hongyan Zhu, Xiuyan Zhang, Zhan Gao
Article Number: 257
Published online on: 05 February 2021

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Article Open Access

Transient forebrain ischemia under hyperthermic condition accelerates memory impairment and neuronal death in the gerbil hippocampus by increasing NMDAR1 expression

Bora Kim, Ji Hyeon Ahn, Dae Won Kim, Tae-Kyeong Lee, Yoon Sung Kim, Myoung Cheol Shin, Jun Hwi Cho, Young-Myeong Kim, Joon Ha Park, Il Jun Kang, Jae-Chul Lee, Moo-Ho Won
Article Number: 256
Published online on: 04 February 2021

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Article Open Access

Circ‑TOP2A acts as a ceRNA for miR‑346 and contributes to glioma progression via the modulation of sushi domain‑containing 2

Junzhi Sang, Xing Li, Luting Lv, Chunyu Zhang, Xiaoqian Zhang, Guoan Li
Article Number: 255
Published online on: 04 February 2021

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Article Open Access

Critical implication of the PTEN/PI3K/AKT pathway during BMP2-induced heterotopic ossification

Jun Dong, Xiqiang Xu, Qingyu Zhang, Zenong Yuan, Bingyi Tan
Article Number: 254
Published online on: 03 February 2021

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Article Open Access

MicroRNA‑186‑5p downregulation inhibits osteoarthritis development by targeting MAPK1

Qing Li, Mingjie Wu, Guofang Fang, Kuangwen Li, Wengang  Cui, Liang Li, Xia Li, Junsheng Wang, Yanhong Cang
Article Number: 253
Published online on: 03 February 2021

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Article Open Access

Comparison of steroid hormones in three different preeclamptic models

Ye Young Shin, Sung-Min An, Jea Sic Jeong, Seung Yun Yang, Geun-Shik Lee, Eui-Ju Hong, Eui-Bae Jeung, Seung Chul Kim, Beum-Soo An
Article Number: 252
Published online on: 02 February 2021

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Article Open Access

Benchmarking of next and third generation sequencing technologies and their associated algorithms for de novo genome assembly

Marios Gavrielatos, Konstantinos Kyriakidis, Demetrios A. Spandidos, Ioannis Michalopoulos
Article Number: 251
Published online on: 02 February 2021

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Article Open Access

Ginger facilitates cell migration and heat tolerance in mouse fibroblast cells

Naotoshi Sugimoto, Masanori Katakura, Kentaro Matsuzaki, Mayumi Miyamoto, Eri Sumiyoshi, Taizo Wada, Akihiro Yachie, Hiroyuki Nakamura, Osamu Shido
Article Number: 250
Published online on: 02 February 2021

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Article

Diagnostic value of microRNA‑125b in peripheral blood mononuclear cells for pulmonary tuberculosis

Xiaolu Sun, Kai Liu, Xinhong Wang, Tianhua Zhang, Xiaomou Li, Yan Zhao
Article Number: 249
Published online on: 01 February 2021

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Article

Apoptotic effects of alisol B 23‑acetate on gastric cancer cells

Min Ji Kwon, Jeong Nam Kim, Min Jae Lee, Woo   Kyung Kim, Joo Hyun Nam, Byung Joo Kim
Article Number: 248
Published online on: 01 February 2021

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Article

ER stress mediated‑autophagy contributes to neurological dysfunction in traumatic brain injury via the ATF6 UPR signaling pathway

Da-Yong Wang, Ming-Yan Hong, Jian Pei, Yun-He Gao, Yu Zheng, Xiang Xu
Article Number: 247
Published online on: 01 February 2021

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Article Open Access

GINS2 affects cell proliferation, apoptosis, migration and invasion in thyroid cancer via regulating MAPK signaling pathway

Saifei He, Miao Zhang, Ying Ye, Yanan Song, Xing Ma, Guoyu Wang, Juhua Zhuang, Wei Xia, Bin Zhao
Article Number: 246
Published online on: 01 February 2021

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Article Open Access

MYCN‑amplified neuroblastoma cell‑derived exosomal miR‑17‑5p promotes proliferation and migration of non‑MYCN amplified cells Corrigendum in /10.3892/mmr.2024.13349

Weiming Chen, Xiwei Hao, Binyi Yang, Yuezhen Zhang, Lingyun Sun, Yanan  Hua, Li Yang, Jiabin Yu, Jing Zhao, Lin Hou, Hongting Lu
Article Number: 245
Published online on: 01 February 2021

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Article Open Access

Astragaloside IV improves angiogenesis under hypoxic conditions by enhancing hypoxia‑inducible factor‑1α SUMOylation

Baoshen Wang, Chunyan Zhang, Dongmei Chu, Xiaofang Ma, Tian Yu, Xiaozhi Liu, Changqing Hu
Article Number: 244
Published online on: 01 February 2021

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Article Open Access

miR‑27a‑3p regulates the inhibitory influence of endothelin 3 on the tumorigenesis of papillary thyroid cancer cells Corrigendum in /10.3892/mmr.2021.12105

Hongxin Chen, Binlin Cai, Kun Liu, Qingquan Hua
Article Number: 243
Published online on: 01 February 2021

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Article Open Access

Notoginsenoside R1 induces DNA damage via PHF6 protein to inhibit cervical carcinoma cell proliferation

Ting Cai, Wenquan Wu, Longhua Guo, Yongwu Xia, Xiaoxin Jiang, Limei Zhang, Feiding Peng, Pinghong Ming
Article Number: 242
Published online on: 01 February 2021

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Article Open Access

Metabolomic profiling identifies a novel mechanism for heat stroke‑related acute kidney injury

Ling Xue, Wenli Guo, Li Li, Santao Ou, Tingting Zhu, Liang Cai, Wenfei Ding, Weihua Wu
Article Number: 241
Published online on: 28 January 2021

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Article Open Access

CDK6 is stimulated by hyperthermia and protects gastric cancer cells from hyperthermia‑induced damage

Guanghui Liu, Hongchao Zhao, Qingqing Ding, Haohao Li, Tao Liu, Hongwei Yang, Yuanhua Liu
Article Number: 240
Published online on: 28 January 2021

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The potential role and trend of HIF‑1α in intervertebral disc degeneration: Friend or foe? (Review)

Yongjin Li, Shen Liu, Dayu Pan, Baoshan Xu, Xuewu Xing, Hengxing Zhou, Bin Zhang, Suzhe Zhou, Guangzhi Ning, Shiqing Feng
Article Number: 239
Published online on: 28 January 2021

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Inhibition of PDGF-BB reduces alkali-induced corneal neovascularization in mice

Lei Chen, Hongya Wu, Chi Ren, Gaoqin Liu, Wenpeng Zhang, Weiming Liu, Peirong Lu
Article Number: 238
Published online on: 28 January 2021

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MicroRNA‑199a‑3p inhibits ovarian cancer cell viability by targeting the oncogene YAP1 Retraction in /10.3892/mmr.2022.12892

Yanfang He, Xiangyang Yu, Yajuan Tang, Yanjuan Guo, Jinling  Yuan, Jinghe Bai, Tao Yao, Xiongzhi Wu
Article Number: 237
Published online on: 27 January 2021

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[Retracted] LINC01638 silencing inhibits cancer cell proliferation in colorectal adenocarcinoma through interaction with RUNX2

Wenying Zhuo, Dengdi Hu, Xihua Chen, Tian Zhang
Article Number: 236
Published online on: 27 January 2021

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Heme oxygenase‑1 improves the survival of ischemic skin flaps (Review)

Yinhua Zheng, Zhenlan Li, Min Yin, Xu Gong
Article Number: 235
Published online on: 26 January 2021

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Mechanism of herbal medicine on hypertensive nephropathy (Review)

Zhaocheng Dong, Haoran Dai, Zhandong Feng, Wenbin Liu, Yu Gao, Fei Liu, Zihan Zhang, Na Zhang, Xuan Dong, Qihan Zhao, Xiaoshan Zhou, Jieli Du, Baoli Liu
Article Number: 234
Published online on: 26 January 2021

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FBXW7 mediates high glucose‑induced SREBP‑1 expression in renal tubular cells of diabetic nephropathy under PI3K/Akt pathway regulation

Lisha Li, Juxiang Yang, Fan Li, Fan Gao, Lin Zhu, Jun Hao
Article Number: 233
Published online on: 26 January 2021

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Effects of DLX3 on the osteogenic differentiation of induced pluripotent stem cell‑derived mesenchymal stem cells

Junyuan Li, Qiang Lin, Yixin Lin, Renfa Lai, Wen Zhang
Article Number: 232
Published online on: 26 January 2021

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Intrathecal injection of ozone alleviates CCI‑induced neuropathic pain via the GluR6‑NF‑κB/p65 signalling pathway in rats

Weiguang Zhang, Fei Wang, Licai Zhang, Tao Sun, Zhijian Fu
Article Number: 231
Published online on: 26 January 2021

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Involvement of TLR2/4‑MyD88‑NF‑κB signaling pathway in the pathogenesis of intracranial aneurysm

Xuezhi Zhang, Yilv Wan, Jiugeng Feng, Meihua Li, Zhiqun Jiang
Article Number: 230
Published online on: 26 January 2021

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[Retracted] Ferruginol exhibits anticancer effects in OVCAR‑3 human ovary cancer cells by inducing apoptosis, inhibition of cancer cell migration and G2/M phase cell cycle arrest

Wen-Dong Xiong, Jian Gong, Chao Xing
Article Number: 229
Published online on: 26 January 2021

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The microRNA-429/DUSP4 axis regulates the sensitivity of colorectal cancer cells to nintedanib

Guohua Cheng, Yarong Li, Zhaoyu Liu, Xiang Song
Article Number: 228
Published online on: 25 January 2021

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Metabolic remodeling in the right ventricle of rats with severe pulmonary arterial hypertension

Seiichiro Sakao, Eiryo Kawakami, Hiroki Shoji, Akira Naito, Hideki Miwa, Rika Suda, Takayuki Jujo Sanada, Nobuhiro Tanabe, Koichiro Tatsumi
Article Number: 227
Published online on: 25 January 2021

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August-2026 Volume 34 Issue 2

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Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Regulatory function of ten‑eleven translocation‑2 in transcriptional mechanisms of demethylated myeloma cells

Lenka Slavickova, Michaela Nemcova, Dominika Svehlova, Veronika Frybortova, Jirina Manakova, Eva Kriegova, Jiri Minarik, Katerina Smesny Trtkova
Article Number: 237
Published online on: 25 June 2026

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Mulberroside A attenuates H2O2‑induced oxidative stress and barrier dysfunction in Caco‑2 cells through Nrf2/HO‑1‑associated antioxidant signaling

Jianxin Chen, Xiufeng Huang, Xi Chen, Wenhai Jin, Dawei Lin
Article Number: 236
Published online on: 25 June 2026

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[Retracted] Puerarin promotes DUSP1 expression by regulating miR‑133a‑3p in breast cancer

Zhifeng Li, Weiwei Xu, Xiaoyan Ren, Jinhua Xu, Jianxin Chen
Article Number: 235
Published online on: 23 June 2026

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Sulforaphane attenuates cisplatin‑induced acute kidney injury by inhibiting oxidative stress, inflammation and apoptosis via regulation of NRF2

Zeyu Wu, Mengting Lu, Lei Xu, Ming Luo, Limei Shan, Hongxia Xing, Wenwen Li, Junling Qian
Article Number: 234
Published online on: 19 June 2026

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Effects of β‑hydroxybutyrate on restoring autophagic flux and mitochondrial function in macrophages exposed to oxidized low‑density lipoprotein

Weiguang Luo, Mei He, Huiling Wang
Article Number: 233
Published online on: 19 June 2026

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Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review)

Xiaokang Wang, Qiwen Tan, Jingcheng Xu, Yunlin Yang, Haoyue Huang, Xiaomei Teng, Weihua Wu
Article Number: 232
Published online on: 18 June 2026

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Degraded sulfated galactan derived from Gracilaria fisheri induces immunogenic cell death in MDA‑MB‑231 cells

Tawut Rudtanatip, Yada Polsan, Waraporn Sakaew, Somsuda Somintara, Jenjiralai Phanphak, Jamal El‑Abid, Kanokpan Wongprasert, Choowadee Pariwatthanakun
Article Number: 231
Published online on: 17 June 2026

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Irbesartan ameliorates high‑glucose‑induced epithelial‑mesenchymal transition by downregulating the expression of NLRP3 in HK‑2 cells

Qing Deng, Xiujuan Liu, Dan Wen, Yuhua Cheng, Qing Zhao, Yu Wang, Yu Xiang, Qinkai Chen, Jinlei Lv
Article Number: 230
Published online on: 17 June 2026

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A β‑1,3‑1,6‑glucan from Aureobasidium pullulans enhances apoptotic and autophagic pathways in colorectal cancer cells

Ji-Won Park, Gyeong Mim Mun, Tae Min Jo, Ji A Shin, Takao Kuge, Hisashi Kimoto, Jin-Kyung Kim
Article Number: 229
Published online on: 16 June 2026

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Growth pattern and molecular biological analysis of primary meningioma cell cultures under different conditions

Stefan Linsler, Anna-Lena Moroldo, Walter Schulz‑Schaeffer, Ralf Ketter, Joachim Oertel, Steffi Urbschat
Article Number: 228
Published online on: 12 June 2026

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Melatonin alleviates mitochondrial damage by regulating SIRT3‑mediated mitochondrial dynamics in granulosa cells under PCOS‑like conditions

Congcong Xie, Zehao Liu, Tong Chen, Hui Lu, Xiujia Zhang, Wenbo Yu, Jiaxin Zhang, Dandan Shang, Xueying Wang
Article Number: 227
Published online on: 11 June 2026

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Strontium‑based metal‑organic framework/alendronate‑silk fibroin hydrogels promote tendon‑bone interface healing

Tao Yang, Hanji Zhang, Mingjun Li, Yiming Ren, Yunbo Sun, Weiyu Hou, Mengqiang Tian
Article Number: 226
Published online on: 11 June 2026

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Retraction Open Access

[Retracted] Tripterygium glycoside suppresses epithelial‑to‑­­ mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway

Mei Tao, Danna Zheng, Xudong Liang, Diandian Wu, Kang Hu, Juan Jin, Qiang He
Article Number: 225
Published online on: 08 June 2026

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Gut microbiota‑derived metabolites in cardiovascular disease: Focus on trimethylamine N‑oxide, short‑chain fatty acids and bile acids (Review)

Meizhu Gao, Zhenming Hao, Yiling Li, Weixue Liu, Fubao Zhang
Article Number: 224
Published online on: 08 June 2026

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Fucoxanthin alleviates chondrocyte inflammation and osteoarthritis by modulating the JAK2/STAT3 signaling pathway

Miradj Siddick Adam, Huangming Zhuang, Xunshan Ren, Yuelong Zhang, Panghu Zhou
Article Number: 223
Published online on: 08 June 2026

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Prediction of molecular targets for zedoary turmeric oil in inhibiting proliferation and inducing apoptosis in non‑small cell lung cancer

Huaiyong Li, Lili Liu, Qingzhu Yang, Yao Li, Yongli Song, Jing Jiang, Zhenzhong Wu, Weiwei Zhang, Baisong Lou
Article Number: 222
Published online on: 08 June 2026

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Molecular mechanisms of iron metabolism and ferroptosis in cardiovascular diseases and intervention strategies targeting natural products (Review)

Liangqing Ge, Tianqing Zhang, Jiangbiao Yu, Sijie Xiao, Yu Zhou, Li Luo
Article Number: 221
Published online on: 05 June 2026

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[Corrigendum] Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis

Ruiqiao Guan, Zhihao Li, Xiaohong Dai, Wei Zou, Xueping Yu, Hao Liu, Qiuxin Chen, Wei Teng, Peng Liu, Xiaoying Liu, Shanshan Dong
Article Number: 220
Published online on: 03 June 2026

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LINC01117 promotes the malignant proliferation of lung adenocarcinoma by increasing HOXD8 mRNA stability

Lizhong Zeng, Jie Shi, Cai Zhang, Yujiao Dong, Yang Chen, Qiuhong Zhang, Long Zhang, Shuanying Yang
Article Number: 219
Published online on: 03 June 2026

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Targeting regulatory T cells in the prostate cancer microenvironment: From mechanisms to therapeutics (Review)

Hua Luo
Article Number: 218
Published online on: 03 June 2026

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Dapagliflozin alleviates heart failure with preserved ejection fraction potentially by regulating the AIM2/caspase‑1/GSDMD pathway and attenuating pyroptosis

Sailiang Ding, Hao Yang, Ting Lu, Yibin Luo, Liang Xu, Xianghui Zeng
Article Number: 217
Published online on: 03 June 2026

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[Retracted] Carnosic acid alleviates brain injury through NF‑κB‑regulated inflammation and Caspase‑3‑associated apoptosis in high fat‑induced mouse models

Yong Liu, Yan Zhang, Ming Hu, Yu-Hu Li, Xing-Hua Cao
Article Number: 216
Published online on: 02 June 2026

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SIRT1/AMPK/PGC1α pathway in ischemic stroke: Elucidating neuroprotective strategies (Review)

Irum Naz Abbasi, Nashwa Amin, Qiaolu Xu, Azhar Badry Hussain, Fei Wu, Xia Yuan, Yang Yang, Suhong Ye, Marong Fang, Yihua Jiang
Article Number: 215
Published online on: 02 June 2026

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Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review)

Yinhuan Wang, Jiefang Guan
Article Number: 214
Published online on: 29 May 2026

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Journal Cover
September-2026 Volume 34 Issue 3

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Sedanolide alleviates LPS‑induced depressive‑like behaviors by modulating the C3a/C3aR signaling axis and microglial glycolysis

Shaocong Lu, Fangla Luo, Niqi Chen, Gongde Shi, Yeru Chen
Article Number: 257
Published online on: 16 July 2026

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[Expression of Concern] Chrysophanol inhibits proliferation and induces apoptosis through NF‑κB/cyclin D1 and NF‑κB/Bcl‑2 signaling cascade in breast cancer cell lines

Li Ren, Zhouping Li, Chunmei Dai, Danyu Zhao, Yanjie Wang, Chunyu Ma, Chun Liu
Article Number: 256
Published online on: 15 July 2026

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PCSK9 alleviates doxorubicin‑induced pyroptosis of cardiomyocytes

Chaochu Cui, Jinyu Zhao, Xiaoqian Li, Shengming Huang, Gang Liu, Xinhui Xu, Can Guo, Tiesuo Zhao, Jiang Du, Shipeng Li, Xianwei Wang, Jianbo Yang
Article Number: 255
Published online on: 14 July 2026

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From cell to disease: Regulatory networks and mechanisms of super‑enhancers in aging (Review)

Xiaodan Wang, Weiqian Deng, Shuangxi Tu, Haojun Tang, Kai Yin, Xiao Zhu
Article Number: 254
Published online on: 14 July 2026

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[Retracted] Matrine‑induced apoptosis in Hep3B cells via the inhibition of MDM2

Ning Zhou, Jiequn Li, Ting Li, Guangshun Chen, Zhongqiang Zhang, Zhongzhou Si
Article Number: 253
Published online on: 13 July 2026

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Role of PANoptosis in the development of gastric immunity and related gastric mucosal disease (Review)

Lan Wang, Zhiyuan Ma, Bei Ji, Shuhui Liu, Shuji Terai, Biguang Tuo, Taolang Li, Xuemei Liu
Article Number: 252
Published online on: 09 July 2026

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Leonurine inhibits the proliferation and metastasis of liver cancer cells by regulating the PI3K/AKT signaling pathway via epithelial‑mesenchymal transition

Bowen Hu, Maher Al Hussan, Jiakai Zhang, Peihao Wen, Changjun Huang, Yang Chen, Huanfei Ding
Article Number: 251
Published online on: 08 July 2026

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[Corrigendum] Resistin aggravates the expression of proinflammatory cytokines in cerulein‑stimulated AR42J pancreatic acinar cells

Chong-Yi Jiang, Wei Wang
Article Number: 250
Published online on: 08 July 2026

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A‑Raf: A serine/threonine protein kinase with important biological functions (Review)

Muhan Yang, Mengying Chen, Jinmei Wei, Yanling Li, Chen Long, Yan Lei, Yanhong Zhou
Article Number: 249
Published online on: 07 July 2026

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Gut dysbiosis‑derived butyrate loss predicts feeding intolerance: Multiomics evidence guiding nurse‑driven microbiota‑supportive interventions (Review)

Ling Wei, Xiaohua Kong, Yuying Li, Huixia Wu, Yirong Gan, Fang Sun
Article Number: 248
Published online on: 07 July 2026

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[Retracted] Network pharmacology combined with experimental validation to investigate the effect of Rongjin Niantong Fang on chondrocyte apoptosis in knee osteoarthritis

Jun Chen, Ting Zhang, Qingqing Luo, Ruyi Wang, Yuting Dai, Zhenyuan Chen, Chutian Zhang, Xuzheng Chen, Guangwen Wu
Article Number: 247
Published online on: 06 July 2026

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Laggera alata attenuates LPS‑induced systemic inflammation and hepatic‑pulmonary injury by regulating PINK1/Parkin-associated mitophagy and macrophage polarization

Jiangcun Wei, Wen Zhong, Guangyun Zhou, Mingtao Huang, Xiaodong Huang, Jing Liang
Article Number: 246
Published online on: 02 July 2026

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Proteolysis‑targeting chimeras in oral squamous cell carcinoma: Current evidence, translational challenges and future directions (Review)

Yun Bai, Danhua Ma, Xi Yang, Min Wang
Article Number: 245
Published online on: 02 July 2026

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Evolving role of biomarkers beyond prostate‑specific antigen in refining prostate cancer screening: From blood‑based tests to urinary and genetic markers (Review)

Luxi Li, Linyue Zhang, Zehong Li, Keqiang Chai, Weidong Ren
Article Number: 244
Published online on: 02 July 2026

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Nanocurcumin attenuates brain injury in rats with desert dry‑heat‑induced exertional heat stroke by suppressing TLR4/MyD88/NF‑κB signaling

Lisong Su, Jinquan Qu, Jiajia Li, Wenhui Shi, Laiyang Song, Feixing Liang, Jiangwei Liu
Article Number: 243
Published online on: 02 July 2026

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TREM2 in glioma: Reprogramming the immune microenvironment from mechanistic understanding to clinical translation (Review)

Junqi Fan, Hongyan Shen, Dan Liu, Songbai Luo, Qingqing Huang, Yi Wen, Libang Yuan
Article Number: 242
Published online on: 02 July 2026

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Human parvovirus B19 VP1u‑induced osteoclastogenesis is enhanced by RANKL in RAW264.7 macrophage cells

Chun-Yu Lin, Bor-Show Tzang, Yi-Hsuan Lin, Chih-Chen Tzang, Tsai-Ching Hsu
Article Number: 241
Published online on: 30 June 2026

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[Retracted] Anti‑tumor peptide AP25 decreases cyclin D1 expression and inhibits MGC‑803 proliferation via phospho­extracellular signal‑regulated kinase‑, Src‑, c‑Jun N‑terminal kinase‑ and phosphoinositide 3­-kinase‑associated pathways  

Jialiang Hu, Tao Cheng, Lijun Zhang, Beicheng Sun, Lei Deng, Hanmei Xu
Article Number: 240
Published online on: 29 June 2026

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Aspirin prevents postoperative peritoneal adhesions by inhibiting the TGF‑β1/Smad signaling pathway in rats

Siqi Yan, Yuan Ren, Bingyan Liu, Pai Xiong, Yimin Sun
Article Number: 239
Published online on: 29 June 2026

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Morinda officinalis oligosaccharides ameliorate corticosterone‑induced depression‑like behaviour in mice by modulating the BDNF signalling pathway and gut microbiota

Mengjie He, Zixuan Liu, Yuxin Chen, Xiaoru Wu, Xueling Dai, Qian Liu, Shuo Wang, Zeping Zuo, Yaxuan Sun
Article Number: 238
Published online on: 29 June 2026

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