Open Access

Comparison of steroid hormones in three different preeclamptic models

  • Authors:
    • Ye Young Shin
    • Sung-Min An
    • Jea Sic Jeong
    • Seung Yun Yang
    • Geun-Shik Lee
    • Eui-Ju Hong
    • Eui-Bae Jeung
    • Seung Chul Kim
    • Beum-Soo An
  • View Affiliations

  • Published online on: February 2, 2021     https://doi.org/10.3892/mmr.2021.11891
  • Article Number: 252
  • Copyright: © Shin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Preeclampsia (PE) is a complication of pregnancy and is characterized by hypertension and proteinuria, threatening both the mother and the fetus. However, the etiology of PE has not yet been fully understood. Since the imbalance of steroid hormones is associated with the pathogenesis of PE, investigating steroidogenic mechanisms under various PE conditions is essential to understand the entire spectrum of pregnancy disorders. Therefore, the current study established three PE in vitro and in vivo models, and compared the levels of steroid hormones and steroidogenic enzymes within them. In cellular PE models induced by hypoxia, N‑nitro‑L‑arginine methyl ester hydrocholride (L‑NAME) and catechol‑o‑methyltransferase inhibitor, the levels of steroid hormones, including pregnenolone (P5), progesterone (P4), dehydroepiandrosterone (DHEA) and testosterone tended to decrease during steroidogenesis. Injection of L‑NAME in pregnant rats led to a reduction in the levels of estradiol and P4 through regulation of cholesterol side‑chain cleavage enzyme (CYP11A1) and 3β‑hydroxysteroid dehydrogenase/δ5 4‑isomerase type 1 (HSD3B1), whereas rats treated with COMT‑I exhibited elevated levels of P5 and DHEA by regulation of the CYP11A1 and aromatase cytochrome P450 (CYP19A1) in the placenta and plasma. The reduced uterine perfusion pressure operation decreased CYP11A1 and increased CYP19A1 expression in placental tissues, whereas steroid hormone levels were not altered. In conclusion, the results of the present study suggest that the induction of PE conditions dysregulates the steroid hormones via regulation of steroidogenic enzymes, depending on specific PE symptoms. These findings can contribute to the development of novel diagnostic and therapeutic modalities for PE, by monitoring and supplying appropriate levels of steroid hormones.
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April-2021
Volume 23 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Shin Y, An S, Jeong J, Yang S, Lee G, Hong E, Jeung E, Kim S and An B: Comparison of steroid hormones in three different preeclamptic models. Mol Med Rep 23: 252, 2021.
APA
Shin, Y., An, S., Jeong, J., Yang, S., Lee, G., Hong, E. ... An, B. (2021). Comparison of steroid hormones in three different preeclamptic models. Molecular Medicine Reports, 23, 252. https://doi.org/10.3892/mmr.2021.11891
MLA
Shin, Y., An, S., Jeong, J., Yang, S., Lee, G., Hong, E., Jeung, E., Kim, S., An, B."Comparison of steroid hormones in three different preeclamptic models". Molecular Medicine Reports 23.4 (2021): 252.
Chicago
Shin, Y., An, S., Jeong, J., Yang, S., Lee, G., Hong, E., Jeung, E., Kim, S., An, B."Comparison of steroid hormones in three different preeclamptic models". Molecular Medicine Reports 23, no. 4 (2021): 252. https://doi.org/10.3892/mmr.2021.11891