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Article Open Access

Circ‑TOP2A acts as a ceRNA for miR‑346 and contributes to glioma progression via the modulation of sushi domain‑containing 2

  • Authors:
    • Junzhi Sang
    • Xing Li
    • Luting Lv
    • Chunyu Zhang
    • Xiaoqian Zhang
    • Guoan Li
  • View Affiliations / Copyright

    Affiliations: Department of Magnetic Resonance Imaging, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161000, P.R. China, Department of Ultrasonics, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161000, P.R. China, Department of Neurology, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161000, P.R. China
    Copyright: © Sang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 255
    |
    Published online on: February 4, 2021
       https://doi.org/10.3892/mmr.2021.11894
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Abstract

Dysregulated circular RNAs (circRNAs) are involved in the carcinogenesis and progression of multiple human malignancies. Knowledge of circRNAs in glioma (GM) is limited and further study to uncover new therapeutic targets for GM is urgently required. The present study demonstrated that circ‑TOP2A was elevated in GM tissue specimens and cells and that circ‑TOP2A levels indicated an unfavorable clinical prognosis in GM. Functionally, circ‑TOP2A knockdown reduced viability, migration and invasion and triggered apoptosis in LN229 cells. Ectopic expression of circ‑TOP2A aggravated these malignant behaviors in U87MG cells. In terms of mechanism, RNA‑seq was performed to discover the potential targets regulated by circ‑TOP2A. Circ‑TOP2A acted as a competing endogenous RNA to upregulate sushi domain‑containing 2 (SUSD2) expression by sponging microRNA (miR) 346. Rescue assays revealed that the oncogenic function of circ‑TOP2A was partially dependent on its regulation of the miR‑346/SUSD2 axis. In conclusion, the present study identified that circ‑TOP2A promoted GM proliferation and aggressiveness via miR‑346/SUSD2 signaling, which is a potential prognostic biomarker and therapeutic target for GM.
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1 

Farina P, Lombardi G, Bergo E, Roma A and Zagonel V: Treatment of malignant gliomas in elderly patients: A concise overview of the literature. Biomed Res Int. 2014:7342812014. View Article : Google Scholar : PubMed/NCBI

2 

Wen PY and Huse JT: 2016 World Health Organization classification of central nervous system tumors. Continuum (Minneap Minn). 23:1531–1547. 2017.PubMed/NCBI

3 

Omuro A and DeAngelis LM: Glioblastoma and other malignant gliomas: A clinical review. JAMA. 310:1842–1850. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Gusyatiner O and Hegi ME: Glioma epigenetics: From subclassification to novel treatment options. Semin Cancer Biol. 51:50–58. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Salzman J: Circular RNA expression: Its potential regulation and function. Trends Genet. 32:309–316. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Eger N, Schoppe L, Schuster S, Laufs U and Boeckel JN: Circular RNA Splicing. Adv Exp Med Biol. 1087:41–52. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Sanger HL, Klotz G, Riesner D, Gross HJ and Kleinschmidt AK: Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures. Proc Natl Acad Sci USA. 73:3852–3856. 1976. View Article : Google Scholar : PubMed/NCBI

8 

Han B, Chao J and Yao H: Circular RNA and its mechanisms in disease: From the bench to the clinic. Pharmacol Ther. 187:31–44. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Belousova EA, Filipenko ML and Kushlinskii NE: Circular RNA: New regulatory molecules. Bull Exp Biol Med. 164:803–815. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Chen B and Huang S: Circular RNA: An emerging non-coding RNA as a regulator and biomarker in cancer. Cancer Lett. 418:41–50. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Xu Y, Yao Y, Zhong X, Leng K, Qin W, Qu L, Cui Y and Jiang X: Downregulated circular RNA hsa_circ_0001649 regulates proliferation, migration and invasion in cholangiocarcinoma cells. Biochem Biophys Res Commun. 496:455–461. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Wang R, Zhang S, Chen X, Li N, Li J, Jia R, Pan Y and Liang H: EIF4A3-induced circular RNA MMP9 (circMMP9) acts as a sponge of miR-124 and promotes glioblastoma multiforme cell tumorigenesis. Mol Cancer. 17:1662018. View Article : Google Scholar : PubMed/NCBI

13 

Hu H, Wang Y, Zhang T, Zhang C, Liu Y, Li G, Zhou D and Lu S: Association of LncRNA-GACAT3 with MRI features of breast cancer and its molecular mechanism. J BUON. 24:2377–2384. 2019.PubMed/NCBI

14 

Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 3:1101–1108. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Mannhalter C, Koizar D and Mitterbauer G: Evaluation of RNA isolation methods and reference genes for RT-PCR analyses of rare target RNA. Clin Chem Lab Med. 38:171–177. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Dudekula DB, Panda AC, Grammatikakis I, De S, Abdelmohsen K and Gorospe M: CircInteractome: A web tool for exploring circular RNAs and their interacting proteins and microRNAs. RNA Biol. 13:34–42. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Li JH, Liu S, Zhou H, Qu LH and Yang JH: starBase v2.0: Decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res. 42:D92–D97. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Xu Y, Yao Y, Leng K, Ji D, Qu L, Liu Y and Cui Y: Increased expression of circular RNA circ_0005230 indicates dismal prognosis in breast cancer and regulates cell proliferation and invasion via miR-618/CBX8 signal pathway. Cell Physiol Biochem. 51:1710–1722. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Xu Y, Yao Y, Gao P and Cui Y: Upregulated circular RNA circ_0030235 predicts unfavorable prognosis in pancreatic ductal adenocarcinoma and facilitates cell progression by sponging miR-1253 and miR-1294. Biochem Biophys Res Commun. 509:138–142. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Qi X, Zhang DH, Wu N, Xiao JH, Wang X and Ma W: ceRNA in cancer: Possible functions and clinical implications. J Med Genet. 52:710–718. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Wang Q, Shi L, Shi K, Yuan B, Cao G, Kong C, Fu J, Man Z, Li X, Zhang X, et al: CircCSPP1 functions as a ceRNA to promote colorectal carcinoma cell EMT and liver metastasis by upregulating COL1A1. Front Oncol. 10:8502020. View Article : Google Scholar : PubMed/NCBI

22 

Bai N, Peng E, Qiu X, Lyu N, Zhang Z, Tao Y, Li X and Wang Z: circFBLIM1 act as a ceRNA to promote hepatocellular cancer progression by sponging miR-346. J Exp Clin Cancer Res. 37:1722018. View Article : Google Scholar : PubMed/NCBI

23 

Zhu W, Qian J, Ma L, Ma P, Yang F and Shu Y: MiR-346 suppresses cell proliferation through SMYD3 dependent approach in hepatocellular carcinoma. Oncotarget. 8:65218–65229. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Li Y, Xu J, Zhang J, Zhang J, Zhang J and Lu X: MicroRNA-346 inhibits the growth of glioma by directly targeting NFIB. Cancer Cell Int. 19:2942019. View Article : Google Scholar : PubMed/NCBI

25 

Hultgren EM, Patrick ME, Evans RL, Stoos CT and Egland KA: SUSD2 promotes tumor-associated macrophage recruitment by increasing levels of MCP-1 in breast cancer. PLoS One. 12:e01770892017. View Article : Google Scholar : PubMed/NCBI

26 

Xu Y, Miao C, Jin C, Qiu C, Li Y, Sun X, Gao M, Lu N and Kong B: SUSD2 promotes cancer metastasis and confers cisplatin resistance in high grade serous ovarian cancer. Exp Cell Res. 363:160–170. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Cheng Y, Wang X, Wang P, Li T, Hu F, Liu Q, Yang F, Wang J, Xu T and Han W: SUSD2 is frequently downregulated and functions as a tumor suppressor in RCC and lung cancer. Tumour Biol. 37:9919–9930. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Sheets JN, Patrick ME and Egland KA: SUSD2 expression correlates with decreased metastasis and increased survival in a high-grade serous ovarian cancer xenograft murine model. Oncotarget. 11:2290–2301. 2020. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sang J, Li X, Lv L, Zhang C, Zhang X and Li G: Circ‑TOP2A acts as a ceRNA for miR‑346 and contributes to glioma progression via the modulation of sushi domain‑containing 2. Mol Med Rep 23: 255, 2021.
APA
Sang, J., Li, X., Lv, L., Zhang, C., Zhang, X., & Li, G. (2021). Circ‑TOP2A acts as a ceRNA for miR‑346 and contributes to glioma progression via the modulation of sushi domain‑containing 2. Molecular Medicine Reports, 23, 255. https://doi.org/10.3892/mmr.2021.11894
MLA
Sang, J., Li, X., Lv, L., Zhang, C., Zhang, X., Li, G."Circ‑TOP2A acts as a ceRNA for miR‑346 and contributes to glioma progression via the modulation of sushi domain‑containing 2". Molecular Medicine Reports 23.4 (2021): 255.
Chicago
Sang, J., Li, X., Lv, L., Zhang, C., Zhang, X., Li, G."Circ‑TOP2A acts as a ceRNA for miR‑346 and contributes to glioma progression via the modulation of sushi domain‑containing 2". Molecular Medicine Reports 23, no. 4 (2021): 255. https://doi.org/10.3892/mmr.2021.11894
Copy and paste a formatted citation
x
Spandidos Publications style
Sang J, Li X, Lv L, Zhang C, Zhang X and Li G: Circ‑TOP2A acts as a ceRNA for miR‑346 and contributes to glioma progression via the modulation of sushi domain‑containing 2. Mol Med Rep 23: 255, 2021.
APA
Sang, J., Li, X., Lv, L., Zhang, C., Zhang, X., & Li, G. (2021). Circ‑TOP2A acts as a ceRNA for miR‑346 and contributes to glioma progression via the modulation of sushi domain‑containing 2. Molecular Medicine Reports, 23, 255. https://doi.org/10.3892/mmr.2021.11894
MLA
Sang, J., Li, X., Lv, L., Zhang, C., Zhang, X., Li, G."Circ‑TOP2A acts as a ceRNA for miR‑346 and contributes to glioma progression via the modulation of sushi domain‑containing 2". Molecular Medicine Reports 23.4 (2021): 255.
Chicago
Sang, J., Li, X., Lv, L., Zhang, C., Zhang, X., Li, G."Circ‑TOP2A acts as a ceRNA for miR‑346 and contributes to glioma progression via the modulation of sushi domain‑containing 2". Molecular Medicine Reports 23, no. 4 (2021): 255. https://doi.org/10.3892/mmr.2021.11894
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