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MicroRNA‑592 promotes cell proliferation, migration and invasion in colorectal cancer by directly targeting SPARC

  • Authors:
    • Zhenguo Pan
    • Rui Xie
    • Wei Song
    • Chengcheng Gao
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China
    Copyright: © Pan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 261
    |
    Published online on: February 8, 2021
       https://doi.org/10.3892/mmr.2021.11900
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Abstract

Colorectal cancer (CRC), one of the most common cancer types, causes a large number of cancer‑related mortalities annually worldwide. Dysregulated microRNAs (miRNAs/miR) are closely associated with the malignant progression of CRC. Therefore, the present study aimed to investigate the expression and regulatory role of miR‑592 in CRC. It was found that miR‑592 expression was significantly elevated in CRC tissues and cell lines, and was associated with the prognosis of patients. Cellular phenotype assays demonstrated that miR‑592 could promote CRC cell proliferation, migration and invasion. Bioinformatics analysis demonstrated that miR‑592 mainly participated in the positive regulation of transcription, as well as the regulation of cell motility. Moreover, miR‑592 targets were enriched in several signaling pathways, such as the ‘mTOR’ and ‘FoxO’ signaling pathways. In addition, secreted protein acidic and rich in cysteine (SPARC) was identified as a target of miR‑592 in CRC. The present results suggested that miR‑592 acts as an oncogene in CRC, in part, by directly inhibiting SPARC expression. Collectively, the present study provides a novel potential therapeutic strategy for CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Pan Z, Xie R, Song W and Gao C: MicroRNA‑592 promotes cell proliferation, migration and invasion in colorectal cancer by directly targeting SPARC. Mol Med Rep 23: 261, 2021.
APA
Pan, Z., Xie, R., Song, W., & Gao, C. (2021). MicroRNA‑592 promotes cell proliferation, migration and invasion in colorectal cancer by directly targeting SPARC. Molecular Medicine Reports, 23, 261. https://doi.org/10.3892/mmr.2021.11900
MLA
Pan, Z., Xie, R., Song, W., Gao, C."MicroRNA‑592 promotes cell proliferation, migration and invasion in colorectal cancer by directly targeting SPARC". Molecular Medicine Reports 23.4 (2021): 261.
Chicago
Pan, Z., Xie, R., Song, W., Gao, C."MicroRNA‑592 promotes cell proliferation, migration and invasion in colorectal cancer by directly targeting SPARC". Molecular Medicine Reports 23, no. 4 (2021): 261. https://doi.org/10.3892/mmr.2021.11900
Copy and paste a formatted citation
x
Spandidos Publications style
Pan Z, Xie R, Song W and Gao C: MicroRNA‑592 promotes cell proliferation, migration and invasion in colorectal cancer by directly targeting SPARC. Mol Med Rep 23: 261, 2021.
APA
Pan, Z., Xie, R., Song, W., & Gao, C. (2021). MicroRNA‑592 promotes cell proliferation, migration and invasion in colorectal cancer by directly targeting SPARC. Molecular Medicine Reports, 23, 261. https://doi.org/10.3892/mmr.2021.11900
MLA
Pan, Z., Xie, R., Song, W., Gao, C."MicroRNA‑592 promotes cell proliferation, migration and invasion in colorectal cancer by directly targeting SPARC". Molecular Medicine Reports 23.4 (2021): 261.
Chicago
Pan, Z., Xie, R., Song, W., Gao, C."MicroRNA‑592 promotes cell proliferation, migration and invasion in colorectal cancer by directly targeting SPARC". Molecular Medicine Reports 23, no. 4 (2021): 261. https://doi.org/10.3892/mmr.2021.11900
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