A large dose of methamphetamine inhibits drug‑evoked synaptic plasticity via ER stress in the hippocampus

Chen,Guang; Yu,Gang; Yong,Zheng; Yan,Hui; Su,Ruibin; Wang,Huijun

doi:10.3892/mmr.2021.11917

A large dose of methamphetamine inhibits drug‑evoked synaptic plasticity via ER stress in the hippocampus

Authors:
- Guang Chen
- Gang Yu
- Zheng Yong
- Hui Yan
- Ruibin Su
- Huijun Wang
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Affiliations: School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, P.R. China
Published online on: February 11, 2021 https://doi.org/10.3892/mmr.2021.11917
Article Number: 278

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Abstract

Drug addiction is a chronic and recurrent disease associated with learning and memory. Shaped by drug use and cues from the environment, drug memory serves a key role in drug‑seeking behaviour. Methamphetamine (MA), a globally abused drug, causes cognitive impairment, and endoplasmic reticulum (ER) stress is one of the mechanisms via which this occurs. In the current study, it was hypothesized that ER stress may serve a role in the disturbance of drug memory. The present study demonstrated that 5 mg/kg MA inhibited conditioned place preference behaviour via ER stress, which caused a disruption in long‑term potentiation in the hippocampus. When mice were pre‑treated with the ER stress inhibitors 4‑phenyl butyric acid or tauroursodeoxycholic acid, drug‑evoked synaptic plasticity was induced. Western blotting results indicated that treatment with 5 mg/kg MA enhanced the expression of cyclin‑dependent kinase‑5 and decreased the expression of Ca²⁺/calmodulin‑dependent protein kinase II α via ER stress. Collectively, the present results suggested that a large dose of MA inhibited drug‑evoked synaptic plasticity and disrupted drug memory by inducing ER stress.

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