1
|
Mokdad AA, Lopez AD, Shahraz S, Lozano R,
Mokdad AH, Stanaway J, Murray CJ and Naghavi M: Liver cirrhosis
mortality in 187 countries between 1980 and 2010: A systematic
analysis. BMC Med. 12:1452014. View Article : Google Scholar : PubMed/NCBI
|
2
|
Schuppan D and Afdhal NH: Liver cirrhosis.
Lancet. 371:838–851. 2008. View Article : Google Scholar : PubMed/NCBI
|
3
|
Bataller R and Brenner DA: Liver fibrosis.
J Clin Invest. 115:209–218. 2005. View Article : Google Scholar : PubMed/NCBI
|
4
|
Weiskirchen R and Tacke F: Liver fibrosis:
From pathogenesis to novel therapies. Dig Dis. 34:410–422. 2016.
View Article : Google Scholar : PubMed/NCBI
|
5
|
Ginès P, Cárdenas A, Arroyo V and Rodés J:
Management of cirrhosis and ascites. N Engl J Med. 350:1646–1654.
2004. View Article : Google Scholar : PubMed/NCBI
|
6
|
Bárcena C, Stefanovic M, Tutusaus A,
Joannas L, Menéndez A, García-Ruiz C, Sancho-Bru P, Marí M,
Caballeria J, Rothlin CV, et al: Gas6/Axl pathway is activated in
chronic liver disease and its targeting reduces fibrosis via
hepatic stellate cell inactivation. J Hepatol. 63:670–678. 2015.
View Article : Google Scholar : PubMed/NCBI
|
7
|
Koh HB, Scruggs AM and Huang SK:
Transforming growth factor-β1 increases DNA methyltransferase 1 and
3a expression through distinct post-transcriptional mechanisms in
lung fibroblasts. J Biol Chem. 291:19287–19298. 2016. View Article : Google Scholar : PubMed/NCBI
|
8
|
Mann J, Oakley F, Akiboye F, Elsharkawy A,
Thorne AW and Mann DA: Regulation of myofibroblast
transdifferentiation by DNA methylation and MeCP2: Implications for
wound healing and fibrogenesis. Cell Death Differ. 14:275–285.
2007. View Article : Google Scholar : PubMed/NCBI
|
9
|
Watson CJ, Collier P, Tea I, Neary R,
Watson JA, Robinson C, Phelan D, Ledwidge MT, McDonald KM, McCann
A, et al: Hypoxia-induced epigenetic modifications are associated
with cardiac tissue fibrosis and the development of a
myofibroblast-like phenotype. Hum Mol Genet. 23:2176–2188. 2014.
View Article : Google Scholar : PubMed/NCBI
|
10
|
Liu N, He S, Ma L, Ponnusamy M, Tang J,
Tolbert E, Bayliss G, Zhao TC, Yan H and Zhuang S: Blocking the
class I histone deacetylase ameliorates renal fibrosis and inhibits
renal fibroblast activation via modulating TGF-beta and EGFR
signaling. PLoS One. 8:e540012013. View Article : Google Scholar : PubMed/NCBI
|
11
|
Marumo T, Hishikawa K, Yoshikawa M,
Hirahashi J, Kawachi S and Fujita T: Histone deacetylase modulates
the proinflammatory and -fibrotic changes in tubulointerstitial
injury. Am J Physiol Renal Physiol. 298:F133–F141. 2010. View Article : Google Scholar : PubMed/NCBI
|
12
|
Tung CW, Hsu YC, Cai CJ, Shih YH, Wang CJ,
Chang PJ and Lin CL: Trichostatin A ameliorates renal
tubulointerstitial fibrosis through modulation of the JNK-dependent
Notch-2 signaling pathway. Sci Rep. 7:144952017. View Article : Google Scholar : PubMed/NCBI
|
13
|
Wu M, Lin P, Li L, Chen D, Yang X, Xu L,
Zhou B, Wang C, Zhang Y, Luo C and Ye C: Reduced asymmetric
dimethylarginine accumulation through inhibition of the type I
protein arginine methyltransferases promotes renal fibrosis in
obstructed kidneys. FASEB J. 33:6948–6956. 2019. View Article : Google Scholar : PubMed/NCBI
|
14
|
Peng J, Li J, Huang J, Xu P, Huang H, Liu
Y, Yu L, Yang Y, Zhou B, Jiang H, et al: p300/CBP inhibitor A-485
alleviates acute liver injury by regulating macrophage activation
and polarization. Theranostics. 9:8344–8361. 2019. View Article : Google Scholar : PubMed/NCBI
|
15
|
Tomaselli D, Lucidi A, Rotili D and Mai A:
Epigenetic polypharmacology: A new frontier for epi-drug discovery.
Med Res Rev. 40:190–244. 2020. View Article : Google Scholar : PubMed/NCBI
|
16
|
Tsuchida T, Lee YA, Fujiwara N, Ybanez M,
Allen B, Martins S, Fiel MI, Goossens N, Chou HI, Hoshida Y and
Friedman SL: A simple diet- and chemical-induced murine NASH model
with rapid progression of steatohepatitis, fibrosis and liver
cancer. J Hepatol. 69:385–395. 2018. View Article : Google Scholar : PubMed/NCBI
|
17
|
Scholten D, Trebicka J, Liedtke C and
Weiskirchen R: The carbon tetrachloride model in mice. Lab Anim.
49((1 Suppl)): S4–S11. 2015. View Article : Google Scholar
|
18
|
National Research Council (US) Committee
for the Update of the Guide for the Care and Use of Laboratory
Animals, . Guide for the Care and Use of Laboratory Animals. 8th
edition. Washington (DC). National Academies Press; Washington
(DC): 2011
|
19
|
Milan M, Pace V, Maiullari F, Chirivì M,
Baci D, Maiullari S, Madaro L, Maccari S, Stati T, Marano G, et al:
Givinostat reduces adverse cardiac remodeling through regulating
fibroblasts activation. Cell Death Dis. 9:1082018. View Article : Google Scholar : PubMed/NCBI
|
20
|
Lan T, Li C, Yang G, Sun Y, Zhuang L, Ou
Y, Li H, Wang G, Kisseleva T, Brenner D and Guo J: Sphingosine
kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated
inhibition of CCR2. Hepatology. 68:1070–1086. 2018. View Article : Google Scholar : PubMed/NCBI
|
21
|
Zhang K, Han X, Zhang Z, Zheng L, Hu Z,
Yao Q, Cui H, Shu G, Si M, Li C, et al: The liver-enriched
lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch
pathways. Nat Commun. 8:1442017. View Article : Google Scholar : PubMed/NCBI
|
22
|
Dobin A, Davis CA, Schlesinger F, Drenkow
J, Zaleski C, Jha S, Batut P, Chaisson M and Gingeras TR: STAR:
Ultrafast universal RNA-seq aligner. Bioinformatics. 29:15–21.
2013. View Article : Google Scholar : PubMed/NCBI
|
23
|
Liao Y, Smyth GK and Shi W: FeatureCounts:
An efficient general-purpose program for assigning sequence reads
to genomic features. Bioinformatics. 30:923–930. 2014. View Article : Google Scholar : PubMed/NCBI
|
24
|
Robinson MD, McCarthy DJ and Smyth GK:
edgeR: A Bioconductor package for differential expression analysis
of digital gene expression data. Bioinformatics. 26:139–140. 2010.
View Article : Google Scholar : PubMed/NCBI
|
25
|
Jose AF: The Benjamini-Hochberg method in
the case of discrete test statistics. Int J Biostat. 3:112007.
|
26
|
Huang DW, Sherman BT and Lempicki RA:
Systematic and integrative analysis of large gene lists using DAVID
Bioinformatics Resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar : PubMed/NCBI
|
27
|
Shannon P, Markiel A, Ozier O, Baliga NS,
Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A
software environment for integrated models of biomolecular
interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI
|
28
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
29
|
Pan RL, Xiang LX, Wang P, Liu XY, Nie L,
Huang W and Shao JZ: Low-molecular-weight fibroblast growth factor
2 attenuates hepatic fibrosis by epigenetic down-regulation of
Delta-like1. Hepatology. 61:1708–1720. 2015. View Article : Google Scholar : PubMed/NCBI
|
30
|
Suh YG, Kim JK, Byun JS, Yi HS, Lee YS,
Eun HS, Kim SY, Han KH, Lee KS, Duester G, et al: CD11b+
Gr1+ bone marrow cells ameliorate liver fibrosis by
producing interleukin-10 in mice. Hepatology. 56:1902–1912. 2012.
View Article : Google Scholar : PubMed/NCBI
|
31
|
Satishchandran A, Ambade A, Rao S, Hsueh
YC, Iracheta-Vellve A, Tornai D, Lowe P, Gyongyosi B, Li J,
Catalano D, et al: MicroRNA 122, regulated by GRLH2, protects
livers of mice and patients from ethanol-induced liver disease.
Gastroenterology. 154:238–252.e7. 2018. View Article : Google Scholar : PubMed/NCBI
|
32
|
King A, Houlihan DD, kavanagh D, Haldar D,
Luu N, Owen A, Suresh S, Than NN, Reynolds G, Penny J, et al:
Sphingosine-1-phosphate prevents egress of hematopoietic stem cells
from liver to reduce fibrosis. Gastroenterology. 153:233–248.e16.
2017. View Article : Google Scholar : PubMed/NCBI
|
33
|
Han CY, Koo JH, Kim SH, Gardenghi S,
Rivella S, Strnad P, Hwang SJ and Kim SG: Hepcidin inhibits Smad3
phosphorylation in hepatic stellate cells by impeding
ferroportin-mediated regulation of Akt. Nat Commun. 7:138172016.
View Article : Google Scholar : PubMed/NCBI
|
34
|
Jia Y, Wang F, Guo Q, Li M, Wang L, Zhang
Z, Jiang S, Jin H, Chen A, Tan S, et al: Curcumol induces
RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling
in hepatic stellate cells. Redox Biol. 19:375–387. 2018. View Article : Google Scholar : PubMed/NCBI
|
35
|
Hinz B, Phan SH, Thannickal VJ, Galli A,
Bochaton-Piallat ML and Gabbiani G: The myofibroblast: One
function, multiple origins. Am J Pathol. 170:1807–1816. 2007.
View Article : Google Scholar : PubMed/NCBI
|
36
|
Mederacke I, Hsu CC, Troeger JS, Huebener
P, Mu X, Dapito DH, Pradere JP and Schwabe RF: Fate tracing reveals
hepatic stellate cells as dominant contributors to liver fibrosis
independent of its aetiology. Nat Commun. 4:28232013. View Article : Google Scholar : PubMed/NCBI
|
37
|
Friedman SL: Hepatic stellate cells:
Protean, multifunctional, and enigmatic cells of the liver. Physiol
Rev. 88:125–172. 2008. View Article : Google Scholar : PubMed/NCBI
|
38
|
Wang YG, Xu L, Wang T, Wei J, Meng WY,
Wang N and Shi M: Givinostat inhibition of hepatic stellate cell
proliferation and protein acetylation. World J Gastroenterol.
21:8326–8339. 2015. View Article : Google Scholar : PubMed/NCBI
|
39
|
Yang Y, Bae M, Park YK, Lee Y, Pham TX,
Rudraiah S, Manautou J, Koo SI and Lee JY: Histone deacetylase 9
plays a role in the antifibrogenic effect of astaxanthin in hepatic
stellate cells. J Nutr Biochem. 40:172–177. 2017. View Article : Google Scholar : PubMed/NCBI
|
40
|
Seki E, De Minicis S, Osterreicher CH,
Kluwe J, Osawa Y, Brenner DA and Schwabe RF: TLR4 enhances TGF-beta
signaling and hepatic fibrosis. Nat Med. 13:1324–1332. 2007.
View Article : Google Scholar : PubMed/NCBI
|
41
|
Ramzy MM, Abdelghany HM, Zenhom NM and
El-Tahawy NF: Effect of histone deacetylase inhibitor on
epithelial-mesenchymal transition of liver fibrosis. IUBMB Life.
70:511–518. 2018. View Article : Google Scholar : PubMed/NCBI
|