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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May-2021 Volume 23 Issue 5

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review

Role of connexins in neurodegenerative diseases (Review)

Juping Xing, Changshui Xu
Article Number: 395
Published online on: 23 March 2021

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Article Open Access

Roles of the microRNA‑338‑3p/NOVA1 axis in retinoblastoma

Shoubin Sun, Runze Wang, Sisi Yi, Sijia Li, Lei Wang, Jianwen Wang
Article Number: 394
Published online on: 22 March 2021

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Review

Advances in the study of the role and molecular mechanism of with‑no‑lysine kinase 3 in nervous system diseases (Review)

Ya-Ting Gong, Mu-Yao Wu, Jia-Feng Tang, Jin-Chao Shen, Jie  Li, Rong Gao, Bao-Qi Dang, Gang Chen
Article Number: 393
Published online on: 22 March 2021

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Article Open Access

Phosphorylated‑myosin light chain mediates the destruction of small intestinal epithelial tight junctions in mice with acute liver failure

Fan Wu, Hui Li, Heng Zhang, Yusheng Liao, Huanping Ren, Jie Wu, Dan Zheng
Article Number: 392
Published online on: 22 March 2021

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Article Open Access

Protective effects of curcumin against rat intestinal inflammation‑related motility disorders

Yang Yao, Ranyuan Luo, Shu Xiong, Chang Zhang, Yukun Zhang
Article Number: 391
Published online on: 22 March 2021

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Article Open Access

ASMq protects against early burn wound progression in rats by alleviating oxidative stress and secondary mitochondria‑associated apoptosis via the Erk/p90RSK/Bad pathway

Hanlei Zhou, Quan Fang, Nan Li, Meirong Yu, Hongming Chen, Songxue Guo
Article Number: 390
Published online on: 22 March 2021

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Article Open Access

Connective tissue growth factor promotes retinal pigment epithelium mesenchymal transition via the PI3K/AKT signaling pathway

Yafen Wang, Tianfang Chang, Tong Wu, Wei Ye, Yusheng Wang, Guorui Dou, Hongjun Du, Yannian Hui, Changmei Guo
Article Number: 389
Published online on: 22 March 2021

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Article Open Access

Long non‑coding RNA OIP5‑AS1 facilitates the progression of ovarian cancer via the miR‑128‑3p/CCNG1 axis

Yuanyuan Liu, Xiaomin Fu, Xiuyun Wang, Yanling Liu, Xiaoyan Song
Article Number: 388
Published online on: 22 March 2021

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Article Open Access

Circular RNA ABCB10 promotes cell proliferation and invasion, but inhibits apoptosis via regulating the microRNA‑1271‑mediated Capn4/Wnt/β‑catenin signaling pathway in epithelial ovarian cancer

Xuefang Lin, Yan Chen, Xiabin Ye, Xuemei Xia
Article Number: 387
Published online on: 19 March 2021

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Article Open Access

MicroRNA‑1271‑5p alleviates the malignant development of hepatitis B virus‑mediated liver cancer via binding to AQP5

Zhigang Li, Lin Ma, Lingling Di, Xutao Lin
Article Number: 386
Published online on: 19 March 2021

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Article Open Access

Tumor suppressor miR‑613 induces cisplatin sensitivity in non‑small cell lung cancer cells by targeting GJA1 Retraction in /10.3892/mmr.2024.13291

Jianhua Luo, Yan Jin, Mengyuan Li, Liyang Dong
Article Number: 385
Published online on: 18 March 2021

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Article Open Access

Functional role and molecular mechanisms underlying prohibitin 2 in platelet mitophagy and activation

Long-Long Hu, Kai Zou, Yuan Chen, Li-Juan Wu, Jie Cao, Xiao-Ying Xiong, Ling Wang, Xiao-Shu Cheng, Qing-Zhong Xiao, Ren-Qiang Yang
Article Number: 384
Published online on: 18 March 2021

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Article Open Access

MST1 inhibits the progression of breast cancer by regulating the Hippo signaling pathway and may serve as a prognostic biomarker

Xiang Jin, Lihua Zhu, Sheng Xiao, Zhuhong Cui, Jing Tang, Jiangyong Yu, Mingjun Xie
Article Number: 383
Published online on: 18 March 2021

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Review Open Access

A novel update on vitamin D in recurrent pregnancy loss (Review)

Haoyu Zhao, Xiaoqi Wei, Xiuhua Yang
Article Number: 382
Published online on: 17 March 2021

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Article Open Access

MicroRNA-124 facilitates lens epithelial cell apoptosis by inhibiting SPRY2 and MMP-2

Yan Liu, Shuting Li, Yao Liu, Xujing Lv, Qing Zhou
Article Number: 381
Published online on: 17 March 2021

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Article

Long non‑coding RNA GAS5 protects against Mycoplasma pneumoniae pneumonia by regulating the microRNA‑222‑3p/TIMP3 axis

Likun Yang, Xifeng Zhang, Xiufen Liu
Article Number: 380
Published online on: 17 March 2021

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Article Open Access

0.5‑Gy X‑ray irradiation induces reorganization of cytoskeleton and differentiation of osteoblasts

Qun Huang, Hao Chai, Shendong Wang, Yongming Sun, Wei Xu
Article Number: 379
Published online on: 17 March 2021

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Article Open Access

Fine particulate matter induces airway inflammation by disturbing the balance between Th1/Th2 and regulation of GATA3 and Runx3 expression in BALB/c mice

Lingling Pang, Pengfei Yu, Xueping Liu, Yingqi Fan, Ying Shi, Shenchun Zou
Article Number: 378
Published online on: 17 March 2021

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Article Open Access

Bakkenolide‑IIIa ameliorates lipopolysaccharide‑induced inflammatory injury in human umbilical vein endothelial cells by upregulating LINC00294

Jichong Xu, Hao Feng, Lin Ma, Huaqiao Tan, Shuo Yan, Chun Fang
Article Number: 377
Published online on: 17 March 2021

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Article Open Access

Islet transplantation ameliorates diabetes-induced testicular interstitial fibrosis and is associated with inhibition of TGF-β1/Smad2 pathway in a rat model of type 1 diabetes

Yuan-Cai Zheng, Yi-Ling Feng, Yi-Hong Wang, Li-Jun Kong, Ming-Shi Zhou, Min-Min Wu, Cheng-Yang Liu, Hua-Chun Weng, Hong-Wei Wang
Article Number: 376
Published online on: 17 March 2021

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Article Open Access

Circular RNA circ‑CCT3 promotes hepatocellular carcinoma progression by regulating the miR‑1287‑5p/TEAD1/PTCH1/LOX axis

Wennan Lin, Tianyu Zhang, Guoxu Ding, Liguo Hao, Bingquan Zhang, Jing Yu, Yu Pang, Feng Geng, Lan Zhan, Minglu Zhou, Qiyu Yan, Yuguang Wang, Chunlei Zheng, Hui Li
Article Number: 375
Published online on: 16 March 2021

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Article Open Access

Piperazine ferulate attenuates high glucose‑induced mesangial cell injury via the regulation of p66Shc

Yong-Yu Yang, Rong-Rong Deng, Zhuo Chen, Liang-Yuan Yao, Xi-Ding Yang, Da-Xiong Xiang
Article Number: 374
Published online on: 16 March 2021

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Article

Upregulation of miR‑126 inhibits podocyte injury in sepsis via EGFL6/DKC1 signaling pathway

Jianming Su, Limin Ding
Article Number: 373
Published online on: 16 March 2021

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Retraction Open Access

[Retracted] Anticancer activity of caffeic acid n‑butyl ester against A431 skin carcinoma cell line occurs via induction of apoptosis and inhibition of the mTOR/PI3K/AKT signaling pathway

Ning Zeng, Tang Hongbo, Yi Xu, Min Wu, Yiping Wu
Article Number: 372
Published online on: 16 March 2021

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Article Open Access

Tanshinone IIA regulates microRNA‑125b/foxp3/caspase‑1 signaling and inhibits cell viability of nasopharyngeal carcinoma

Youhu Wang, Wenyao Jin, Junbo Wang
Article Number: 371
Published online on: 16 March 2021

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Article Open Access

Galectin‑3 facilitates the proliferation and migration of nasopharyngeal carcinoma cells via activation of the ERK1/2 and Akt signaling pathways, and is positively correlated with the inflammatory state of nasopharyngeal carcinoma

Mei Li, Yu Bin Chen, Fen Liu, Jia Quan Qu, Li Cheng Ren, Jin Chai, Can E. Tang
Article Number: 370
Published online on: 16 March 2021

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Article Open Access

MicroRNA‑378d inhibits Glut4 by targeting Rsbn1 in vitamin D deficient ovarian granulosa cells

Huiting Sun, Yichao Shi, Yuwei Shang, Xia Chen, Fei Xia
Article Number: 369
Published online on: 16 March 2021

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Article Open Access

miR‑122‑5p suppresses the oncogenesis of PTC by inhibiting DUSP4 expression

Ning Hu, Yanhua Tian, Yanmei Song, Leilei Zang
Article Number: 368
Published online on: 16 March 2021

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Article Open Access

SIRT6‑specific inhibitor OSS‑128167 exacerbates diabetic cardiomyopathy by aggravating inflammation and oxidative stress

Yibo Huang, Junkai Zhang, Dongdong Xu, Yu Peng, Yuan Jin, Lei Zhang
Article Number: 367
Published online on: 16 March 2021

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Article Open Access

LINC01116 promotes the proliferation and invasion of glioma by regulating the microRNA‑744‑5p‑MDM2‑p53 axis

Li Jiang, Chao Cheng, Wei Ji, Hao Wang, Quan Du, Xiaoqiao Dong, Junfei Shao, Wenhua Yu
Article Number: 366
Published online on: 16 March 2021

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Article

Protective effect of electrical stimulation of the vagus nerve in lipopolysaccharide‑induced acute lung injury in rats

Weijuan Hu, Yibing Wang, Bin Cheng, Luyang Xu, Yin Zhou, Lidong Wu
Article Number: 365
Published online on: 16 March 2021

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Review Open Access

Interaction of non‑parenchymal hepatocytes in the process of hepatic fibrosis (Review)

Qi-Ni Cheng, Xue Yang, Jiang-Feng Wu, Wen-Bing Ai, Yi-Ran Ni
Article Number: 364
Published online on: 16 March 2021

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Review

Potential role of microRNAs in the regulation of pyroptosis (Review)

Xinli Hu, Chenyu Wu, Junsheng Lou, Haiwei Ma, Xingyu Wang, Yu Xu, Yijie Chen, Sunren Sheng, Hui Xu, Huazi Xu, Xiangyang Wang, Wenfei Ni, Kailiang Zhou
Article Number: 363
Published online on: 16 March 2021

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Review Open Access

A combination of PD‑1/PD‑L1 inhibitors: The prospect of overcoming the weakness of tumor immunotherapy (Review)

Xianbin Kong, Peng Lu, Chuanxin Liu, Yuzhu Guo, Yuying Yang, Yingying Peng, Fangyuan Wang, Zhichao Bo, Xiaoxin Dou, Haoyang Shi, Jingyan Meng
Article Number: 362
Published online on: 16 March 2021

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Article Open Access

IL‑33/ST2 promotes the malignant progression of gastric cancer via the MAPK pathway

Ning Huang, Xing Cui, Wen Li, Chunlai Zhang, Liqing Liu, Jinxing Li
Article Number: 361
Published online on: 16 March 2021

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Article Open Access

Inhibition of chaperone‑mediated autophagy reduces tumor growth and metastasis and promotes drug sensitivity in colorectal cancer

Ying Xuan, Shuang Zhao, Xingjun Xiao, Liwei Xiang, Hua-Chuan Zheng
Article Number: 360
Published online on: 12 March 2021

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Article

miR‑101‑3p negatively regulates inflammation in systemic lupus erythematosus via MAPK1 targeting and inhibition of the NF‑κB pathway

Xiaoying Zhao, Sijia Li, Zhe Wang, Ning Bai, Yuan Feng
Article Number: 359
Published online on: 12 March 2021

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Article Open Access

Hydrogen sulfide improves ox‑LDL‑induced expression levels of Lp‑PLA2 in THP‑1 monocytes via the p38MAPK pathway

Heng-Jing Hu, Jie Qiu, Chi Zhang, Zhi-Han Tang, Shun-Lin Qu, Zhi-Sheng Jiang
Article Number: 358
Published online on: 12 March 2021

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Article Open Access

miR‑320a‑3P alleviates the epithelial‑mesenchymal transition of A549 cells by activation of STAT3/SMAD3 signaling in a pulmonary fibrosis model

Xin Wang, Jing Wang, Guichuan Huang, Yishi Li, Shuliang Guo
Article Number: 357
Published online on: 12 March 2021

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Article Open Access

miR‑143‑3p inhibits endometriotic stromal cell proliferation and invasion by inactivating autophagy in endometriosis

Hong Yang, Tianqi Hu, Panwei Hu, Cong Qi, Lin Qian
Article Number: 356
Published online on: 12 March 2021

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Article Open Access

The effect of anti‑HLA class I antibodies on the immunological properties of human glomerular endothelial cells and their modification by mTOR inhibition or GCN2 kinase activation

Theodoros Eleftheriadis, Georgios Pissas, Marta Crespo, Georgios Filippidis, Nikolaos Antoniadis, Vassilios Liakopoulos, Ioannis Stefanidis
Article Number: 355
Published online on: 12 March 2021

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Article Open Access

IDH1 gene mutation activates Smad signaling molecules to regulate the expression levels of cell cycle and biological rhythm genes in human glioma U87‑MG cells

Yongying Gao, Yanwei Wu, Ningmei Zhang, Hongmei Yuan, Fei Wang, Hui Xu, Jiaxiang Yu, Jie Ma, Shaozhang Hou, Xiangmei Cao
Article Number: 354
Published online on: 12 March 2021

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Article

miR‑519d‑3p/HIF‑2α axis increases the chemosensitivity of human cervical cancer cells to cisplatin via inactivation of PI3K/AKT signaling

Lixia Jiang, Shaohua Shi, Feng Li, Qiaofa Shi, Tianyu Zhong, Huijuan Zhang, Yu Xia
Article Number: 353
Published online on: 12 March 2021

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Review Open Access

HIF‑1α in myocardial ischemia‑reperfusion injury (Review)

Jie Zheng, Peier Chen, Jianfeng Zhong, Yu Cheng, Hao Chen, Yuan He, Can Chen
Article Number: 352
Published online on: 12 March 2021

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Case Report Open Access

Updates in neonatal coronavirus disease 2019: What can we learn from detailed case reports? (Review)

Xingchao Li, Li Sun, Tao Li
Article Number: 351
Published online on: 11 March 2021

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Article Open Access

Berberine ameliorates the LPS-induced imbalance of osteogenic and adipogenic differentiation in rat bone marrow-derived mesenchymal stem cells

Rong Zhou, Fubo Chen, Haixia Liu, Xueqin Zhu, Xueyun Wen, Fang Yu, Guangwei Shang, Shengcai Qi, Yuanzhi Xu
Article Number: 350
Published online on: 11 March 2021

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Article Open Access

Circular RNA hsa_circ_0072309 inhibits the proliferation, invasion and migration of gastric cancer cells via inhibition of PI3K/AKT signaling by activating PPARγ/PTEN signaling

Xingpo Guo, Mingde Qin, Han Hong, Xiaofeng Xue, Jian Fang, Linhua Jiang, Yuting Kuang, Ling Gao
Article Number: 349
Published online on: 11 March 2021

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Article

Salvia miltiorrhiza induces depolarization of pacemaker potentials in murine small intestinal interstitial cells of Cajal via extracellular Ca2+ and Na+ influx

Donghun Han, Jeong Nam Kim, Min Ji Kwon, Taewon Han, Yun Tai Kim, Byung Joo Kim
Article Number: 348
Published online on: 11 March 2021

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Review Open Access

Interplay between cyclooxygenase‑2 and microRNAs in cancer (Review)

Zexiong Gong, Weiguo Huang, Baiyun Wang, Na Liang, Songkai Long, Wanjun Li, Qier Zhou
Article Number: 347
Published online on: 11 March 2021

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Article Open Access

miR‑224‑5p regulates the proliferation, migration and invasion of pancreatic mucinous cystadenocarcinoma by targeting PTEN

Xiaobo Peng, Chengtao Guo, Yanjun Wu, Mingzhen Ying, Renxu Chang, Lele Song, Lixing Zhan, Xianbao Zhan
Article Number: 346
Published online on: 10 March 2021

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Article Open Access

Total flavonoids of Rhizoma drynariae ameliorate steroid‑induced avascular necrosis of the femoral head via the PI3K/AKT pathway

Wenxue Lv, Mingxiu Yu, Qingyi Yang, Peng Kong, Bing Yan
Article Number: 345
Published online on: 09 March 2021

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Article Open Access

Cytokine secretion and pyroptosis of cholesteatoma keratinocytes mediated by AIM2 inflammasomes in response to cytoplasmic DNA

Chen Zhang, Min Chen, Zhangcai Chi
Article Number: 344
Published online on: 09 March 2021

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Article Open Access

HK2 is associated with the Warburg effect and proliferation in liver cancer: Targets for effective therapy with glycyrrhizin Corrigendum in /10.3892/mmr.2021.12143

Zengpeng Sun, Zhiguo Tan, Chuang Peng, Weimin Yi
Article Number: 343
Published online on: 09 March 2021

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Article

SERPINE2 feedback regulates EGF/EGFR signaling in human papillary thyroid carcinoma cells

Huimin Chu, Bo Hu, Xinyu Su
Article Number: 342
Published online on: 09 March 2021

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Article Open Access

Exogenous melatonin alleviates hemorrhagic shock‑induced hepatic ischemic injury in rats by inhibiting the NF‑κB/IκBα signaling pathway

Hai‑Wei Li, Pan Ying, Qi‑Qi Cai, Zhi‑Hui Yang, Xian‑Long Wu
Article Number: 341
Published online on: 09 March 2021

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Article Open Access

linc‑ROR facilitates hepatocellular carcinoma resistance to doxorubicin by regulating TWIST1‑mediated epithelial‑mesenchymal transition

Yuanbiao Zhang, Weiding Wu, Qiang Sun, Longyun Ye, Dongkai Zhou, Weilin Wang
Article Number: 340
Published online on: 09 March 2021

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Article

Protective effect of trichostatin A on CD19+CD5+CD1dhigh regulatory B cells in heart transplantation

Bing Zhou, Fuyang Mei, Changhao Wu, Heyun Xu, Zhifang Liu, Yong Cui
Article Number: 339
Published online on: 09 March 2021

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Article Open Access

Cyanidin‑3‑O‑β‑glucoside protects against pulmonary artery hypertension induced by monocrotaline via the TGF‑β1/p38 MAPK/CREB signaling pathway

Shao Ouyang, Wei Chen, Zeng Gaofeng, Lei Changcheng, Tian Guoping, Zhu Minyan, Liu Yang, Yang Min, Jiahao Luo
Article Number: 338
Published online on: 09 March 2021

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Article

Estrogen 17β‑estradiol accelerates the proliferation of uterine junctional zone smooth muscle cells via the let‑7a/Lin28B axis in adenomyosis

Jun-Hua Huang, Hua Duan, Sha Wang, Yi-Yi Wang
Article Number: 337
Published online on: 08 March 2021

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Article Open Access

Tumor suppressor role of sFRP‑4 in hepatocellular carcinoma via the Wnt/β‑catenin signaling pathway

Quanxin Wu, Cheng Xu, Xianghua Zeng, Zhimin Zhang, Bo Yang, Zhiguo Rao
Article Number: 336
Published online on: 08 March 2021

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Article Open Access

Silibinin improves nonalcoholic fatty liver by regulating the expression of miR‑122: An in vitro and in vivo study

Liying Yang, Qianqian Liu, He Zhang, Yichao Wang, Yang Li, Shuchun Chen, Guangyao Song, Luping Ren
Article Number: 335
Published online on: 08 March 2021

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Article Open Access

Regulatory role of the TLR4/JNK signaling pathway in sepsis‑induced myocardial dysfunction

Chao Chang, Liya Hu, Shanshan Sun, Yanqiu Song, Shan Liu, Jing Wang, Peijun Li
Article Number: 334
Published online on: 08 March 2021

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Article Open Access

Propofol alleviates inflammation and apoptosis in HCY‑induced HUVECs by inhibiting endoplasmic reticulum stress

Cunliang Ji, Hu Yi, Jing Huang, Wenzhong Zhang, Mingzhi Zheng
Article Number: 333
Published online on: 08 March 2021

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Run Xu, Xue-Mei Zhou, Yu-Shan Li, Li Ren, Xin-Rong He
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Yan Wen, Yao Chun, Zhong Qing Lian, Zhang Wei Yong, Yang Mei Lan, Liao Huan, Chen Yi Xi, Li Shu Juan, Zhong Wen Qing, Cheng Jia, Zhang Huan Ji
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GASC1 promotes glioma progression by enhancing NOTCH1 signaling

Zhengzheng Xiao, Xiaoli Yang, Zebin Liu, Zheng Shao, Chaojun  Song, Kun Zhang, Xiaobin Wang, Zhengwei Li
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Downregulation of lncRNA RPLP0P2 inhibits cell proliferation, invasion and migration, and promotes apoptosis in colorectal cancer

Hang Yuan, Shiliang Tu, Yingyu Ma, Yueming Sun
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Chidamide induces apoptosis in DLBCL cells by suppressing the HDACs/STAT3/Bcl‑2 pathway

Hongwei Zhang, Fenqing Chi, Keru Qin, Xiuli Mu, Lieyang Wang, Bin  Yang, Yanli Wang, Min Bai, Zhenhua Li, Liping Su, Baofeng Yu
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Longfei Yang, Xiaofeng Zou, Junrong Zou, Guoxi Zhang
Article Number: 307
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20(s)‑ginseonside‑Rg3 modulation of AMPK/FoxO3 signaling to attenuate mitochondrial dysfunction in a dexamethasone‑injured C2C12 myotube‑based model of skeletal atrophy in vitro Corrigendum in /10.3892/mmr.2021.12259

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Histone deacetylase inhibitor givinostat alleviates liver fibrosis by regulating hepatic stellate cell activation

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MicroRNA‑199a/b‑5p inhibits endometrial cancer cell metastasis and invasion by targeting FAM83B in the epithelial‑to‑mesenchymal transition signaling pathway

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miR‑875‑5p regulates IR and inflammation via targeting TXNRD1 in gestational diabetes rats

Songbo Fu, Songquan Fu, Xiaoni Ma, Xiaomei Yang, Jizu Ling
Article Number: 303
Published online on: 25 February 2021

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Article Number: 50
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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
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Ayman A. Althubity
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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

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Article Number: 32
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Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

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Article Number: 21
Published online on: 29 October 2025

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Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

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Ye Wang, Yue Zhao, Jihong Zhang
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Published online on: 29 October 2025

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Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
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Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
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Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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February-2026 Volume 33 Issue 2

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CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

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SCImago Journal Rank (SJR): 0.841

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Mitophagy and oxidative stress in chronic kidney disease (Review)

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Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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