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Therapeutic effects of quinine in a mouse model of atopic dermatitis

  • Authors:
    • Qian Zhang
    • Hongjing Jiang
    • Miao Liu
    • Xinchen Li
    • Murong Zhou
    • Yansi Lyu
    • Jingkai Huang
    • Si Chen
    • Li Wang
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Shenzhen University General Hospital, Shenzhen University, Shenzhen, Guangdong 518060, P.R. China, Shenzhen University Health Science Center, Shenzhen, Guangdong 518060, P.R. China, School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xian, Shaanxi 710021, P.R. China, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, Guangdong 518060, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 313
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    Published online on: March 2, 2021
       https://doi.org/10.3892/mmr.2021.11952
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Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease that seriously affects quality of life. Quinine is a bitter taste receptor agonist that exhibits antimalarial effects. The aim of the present study was to examine the therapeutic effects of quinine in AD‑like mice. AD was induced with 2,4‑dinitrochlorobenzene, and the mice were treated with 10 mg/kg quinine for 1, 4 and 7 days. A total of 60 BALB/c mice were divided into the following groups: Healthy, AD‑like, AD‑like + quinine and healthy + quinine, with 1, 4 and 7 days groups for each treatment. Blood was extracted from all mice and ELISA was performed to detect immunoglobulin E (IgE) levels. H&E‑stained tissue sections were prepared from skin lesions on the backs of the mice and pathological changes were observed. Cytokines were detected via ELISA, and the filaggrin (FLG) and kallikrein‑7 (KLK7) proteins were detected via western blotting and immunohistochemistry. IKKα and NF‑κB mRNA were analyzed via reverse transcription‑quantitative PCR. Quinine ameliorated skin damage in the AD‑like mice, reduced IgE expression in the blood, inhibited expression of IKKα and NF‑κB, reduced cytokine secretion, reduced KLK7 expression, reduced scratching frequency, increased FLG expression and repaired the skin barrier. These results suggested that quinine exhibited therapeutic effects in AD‑like mice.
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1 

Nutten S: Atopic dermatitis: Global epidemiology and risk factors. Ann Nutr Metab. 66 (Suppl 1):S8–S16. 2015. View Article : Google Scholar

2 

Eichenfield LF, Tom WL, Chamlin SL, Feldman SR, Hanifin JM, Simpson EL, Berger TG, Bergman JN, Cohen DE, Cooper KD, et al: Guidelines of care for the management of atopic dermatitis: Section 1. Diagnosis and assessment of atopic dermatitis. J Am Acad Dermatol. 70:338–351. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Weidinger S and Novak N: Atopic dermatitis. Lancet. 387:1109–1122. 2016. View Article : Google Scholar : PubMed/NCBI

4 

De Benedetto A, Kubo A and Beck LA: Skin barrier disruption: A requirement for allergen sensitization? J Invest Dermatol. 132:949–963. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Leung DY: New insights into atopic dermatitis: Role of skin barrier and immune dysregulation. Allergol Int. 62:151–161. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Leung DY: Atopic dermatitis: New insights and opportunities for therapeutic intervention. J Allergy Clin Immunol. 105:860–876. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Han H, Roan F and Ziegler SF: The atopic march: Current insights into skin barrier dysfunction and epithelial cell-derived cytokines. Immunol Rev. 278:116–130. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Kasperkiewicz M, Schmidt E, Ludwig RJ and Zillikens D: Targeting IgE antibodies by immunoadsorption in atopic dermatitis. Front Immunol. 9:2542018. View Article : Google Scholar : PubMed/NCBI

9 

Jeruzal-Świątecka J, Fendler W and Pietruszewska W: Clinical role of extraoral bitter taste receptors. Int J Mol Sci. 21:51562020. View Article : Google Scholar

10 

Workman AD, Palmer JN, Adappa ND and Cohen NA: The role of bitter and sweet taste receptors in upper airway immunity. Curr Allergy Asthma Rep. 15:722015. View Article : Google Scholar : PubMed/NCBI

11 

Deshpande DA, Wang WCH, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JS and Liggett SB: Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nat Med. 16:1299–1304. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Orsmark-Pietras C, James A, Konradsen JR, Nordlund B, Söderhäll C, Pulkkinen V, Pedroletti C, Daham K, Kupczyk M, Dahlén B, et al: Transcriptome analysis reveals upregulation of bitter taste receptors in severe asthmatics. Eur Respir J. 42:65–78. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Ekoff M, Choi JH, James A, Dahlén B, Nilsson G and Dahlén SE: Bitter taste receptor (TAS2R) agonists inhibit IgE-dependent mast cell activation. J Allergy Clin Immunol. 134:475–478. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Tomic S: L'Analyse chimique des végétaux: Le cas du quinquina. Ann Sci. 58:287–309. 2001. View Article : Google Scholar

15 

Achan J, Talisuna AO, Erhart A, Yeka A, Tibenderana JK, Baliraine FN, Rosenthal PJ and D'Alessandro U: Quinine, an old anti-malarial drug in a modern world: Role in the treatment of malaria. Malar J. 10:1442011. View Article : Google Scholar : PubMed/NCBI

16 

Tse EG, Korsik M and Todd MH: The past, present and future of anti-malarial medicines. Malar J. 18:932019. View Article : Google Scholar : PubMed/NCBI

17 

Gachelin G, Garner P, Ferroni E, Tröhler U and Chalmers I: Evaluating Cinchona bark and quinine for treating and preventing malaria. J R Soc Med. 110:31–40. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Sharma P, Yi R, Nayak AP, Wang N, Tang F, Knight MJ, Pan S, Oliver B and Deshpande DA: Bitter taste receptor agonists mitigate features of allergic asthma in mice. Sci Rep. 7:461662017. View Article : Google Scholar : PubMed/NCBI

19 

Shaw L, Mansfield C, Colquitt L, Lin C, Ferreira J, Emmetsberger J and Reed DR: Personalized expression of bitter ‘taste’ receptors in human skin. PLoS One. 13:e02053222018. View Article : Google Scholar : PubMed/NCBI

20 

Yang H, Jung EM, Ahn C, Lee GS, Lee SY, Kim SH, Choi IG, Park MJ, Lee SS, Choi DH and Jeung EB: Elemol from chamaecyparis obtusa ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis. Int J Mol Med. 36:463–472. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Caglayan Sozmen S, Karaman M, Cilaker Micili S, Isik S, Arikan Ayyildiz Z, Bagriyanik A, Uzuner N and Karaman O: Resveratrol ameliorates 2,4-dinitrofluorobenzene-induced atopic dermatitis-like lesions through effects on the epithelium. PeerJ. 4:e18892016. View Article : Google Scholar : PubMed/NCBI

22 

Yamamoto M, Haruna T, Yasui K, Takahashi H, Iduhara M, Takaki S, Deguchi M and Arimura A: A novel atopic dermatitis model induced by topical application with dermatophagoides farinae extract in NC/Nga mice. Allergol Int. 56:139–148. 2007. View Article : Google Scholar : PubMed/NCBI

23 

National Institutes of Health, . Guide for the care and use of laboratory animals. 7th edition. Washington DC: National Academy Press; 1996

24 

Jin W, Huang W, Chen L, Jin M, Wang Q, Gao Z and Jin Z: Topical application of JAK1/JAK2 inhibitor momelotinib exhibits significant anti-inflammatory responses in DNCB-induced atopic dermatitis model mice. Int J Mol Sci. 19:39732018. View Article : Google Scholar

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Grewe M, Bruijnzeel-Koomen CA, Schöpf E, Thepen T, Langeveld-Wildschut AG, Ruzicka T and Krutmann J: A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis. Immunol Today. 19:359–361. 1998. View Article : Google Scholar : PubMed/NCBI

27 

Yatoo MI, Gopalakrishnan A, Saxena A, Parray OR, Tufani NA, Chakraborty S, Tiwari R, Dhama K and Iqbal HMN: Anti-inflammatory drugs and herbs with special emphasis on herbal medicines for countering inflammatory diseases and disorders-a review. Recent Pat Inflamm Allergy Drug Discov. 12:39–58. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Lambrecht BN, Hammad H and Fahy JV: The cytokines of asthma. Immunity. 50:975–991. 2019. View Article : Google Scholar : PubMed/NCBI

29 

Igawa S, Kishibe M, Minami-Hori M, Honma M, Tsujimura H, Ishikawa J, Fujimura T, Murakami M and Ishida-Yamamoto A: Incomplete KLK7 secretion and upregulated LEKTI expression underlie hyperkeratotic stratum corneum in atopic dermatitis. J Invest Dermatol. 137:449–456. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Guo CJ, Mack MR, Oetjen LK, Trier AM, Council ML, Pavel AB, Guttman-Yassky E, Kim BS and Liu Q: Kallikrein 7 promotes atopic dermatitis-associated itch independently of skin inflammation. J Invest Dermatol. 140:1244–1252.e4. 2020. View Article : Google Scholar : PubMed/NCBI

31 

Mukherjee SP, Quintas PO, McNulty R, Komives EA and Dyson HJ: Structural characterization of the ternary complex that mediates termination of NF-κB signaling by IκBα. Proc Natl Acad Sci USA. 113:6212–6217. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Shanks GD: Historical review: Problematic malaria prophylaxis with quinine. Am J Trop Med Hyg. 95:269–272. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Jeong CW, Ahn KS, Rho NK, Park YD, Lee DY, Lee JH, Lee ES and Yang JM: Differential in vivo cytokine mRNA expression in lesional skin of intrinsic vs extrinsic atopic dermatitis patients using semiquantitative RT-PCR. Clin Exp Allergy. 33:1717–1724. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Callard RE and Harper JI: The skin barrier, atopic dermatitis and allergy: A role for Langerhans cells? Trends Immunol. 28:294–298. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Jakasa I, de Jongh CM, Verberk MM, Bos JD and Kezić S: Percutaneous penetration of sodium lauryl sulphate is increased in uninvolved skin of patients with atopic dermatitis compared with control subjects. Br J Dermatol. 155:104–109. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Naeem AS, Tommasi C, Cole C, Brown SJ, Zhu Y, Way B, Willis Owen SA, Moffatt M, Cookson WO, Harper JI, et al: A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis. J Allergy Clin Immunol. 139:1228–1241. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Komatsu N, Saijoh K, Kuk C, Liu AC, Khan S, Shirasaki F, Takehara K and Diamandis EP: Human tissue kallikrein expression in the stratum corneum and serum of atopic dermatitis patients. Exp Dermatol. 16:513–519. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Briot A, Deraison C, Lacroix M, Bonnart C, Robin A, Besson C, Dubus P and Hovnanian A: Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome. J Exp Med. 206:1135–1147. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Barnes PJ and Karin M: Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases. N Engl J Med. 336:1066–1071. 1997. View Article : Google Scholar : PubMed/NCBI

40 

Fisher CL, Pineault N, Brookes C, Helgason CD, Ohta H, Bodner C, Hess JL, Humphries RK and Brock HW: Loss-of-function additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia. Blood. 115:38–46. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Sue SC, Alverdi V, Komives EA and Dyson HJ: Detection of a ternary complex of NF-kappaB and IkappaBalpha with DNA provides insights into how IkappaBalpha removes NF-kappaB from transcription sites. Proc Natl Acad Sci USA. 108:1367–1372. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Hayden MS and Ghosh S: Signaling to NF-kappaB. Genes Dev. 18:2195–2224. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Q, Jiang H, Liu M, Li X, Zhou M, Lyu Y, Huang J, Chen S and Wang L: Therapeutic effects of quinine in a mouse model of atopic dermatitis. Mol Med Rep 23: 313, 2021.
APA
Zhang, Q., Jiang, H., Liu, M., Li, X., Zhou, M., Lyu, Y. ... Wang, L. (2021). Therapeutic effects of quinine in a mouse model of atopic dermatitis. Molecular Medicine Reports, 23, 313. https://doi.org/10.3892/mmr.2021.11952
MLA
Zhang, Q., Jiang, H., Liu, M., Li, X., Zhou, M., Lyu, Y., Huang, J., Chen, S., Wang, L."Therapeutic effects of quinine in a mouse model of atopic dermatitis". Molecular Medicine Reports 23.5 (2021): 313.
Chicago
Zhang, Q., Jiang, H., Liu, M., Li, X., Zhou, M., Lyu, Y., Huang, J., Chen, S., Wang, L."Therapeutic effects of quinine in a mouse model of atopic dermatitis". Molecular Medicine Reports 23, no. 5 (2021): 313. https://doi.org/10.3892/mmr.2021.11952
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Q, Jiang H, Liu M, Li X, Zhou M, Lyu Y, Huang J, Chen S and Wang L: Therapeutic effects of quinine in a mouse model of atopic dermatitis. Mol Med Rep 23: 313, 2021.
APA
Zhang, Q., Jiang, H., Liu, M., Li, X., Zhou, M., Lyu, Y. ... Wang, L. (2021). Therapeutic effects of quinine in a mouse model of atopic dermatitis. Molecular Medicine Reports, 23, 313. https://doi.org/10.3892/mmr.2021.11952
MLA
Zhang, Q., Jiang, H., Liu, M., Li, X., Zhou, M., Lyu, Y., Huang, J., Chen, S., Wang, L."Therapeutic effects of quinine in a mouse model of atopic dermatitis". Molecular Medicine Reports 23.5 (2021): 313.
Chicago
Zhang, Q., Jiang, H., Liu, M., Li, X., Zhou, M., Lyu, Y., Huang, J., Chen, S., Wang, L."Therapeutic effects of quinine in a mouse model of atopic dermatitis". Molecular Medicine Reports 23, no. 5 (2021): 313. https://doi.org/10.3892/mmr.2021.11952
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