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Exosomal microRNA-301a-3p promotes the proliferation and invasion of nasopharyngeal carcinoma cells by targeting BTG1 mRNA

  • Authors:
    • Qiang Cheng
    • Qiang Li
    • Lingen Xu
    • Hui Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, Jinshan Hospital Affiliated to Fudan University, Shanghai 201508, P.R. China
    Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 328
    |
    Published online on: March 8, 2021
       https://doi.org/10.3892/mmr.2021.11967
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Abstract

Aberrant microRNA (miRNA/miR) expression plays an important role in the pathogenesis of nasopharyngeal carcinoma (NPC). In the present study, the role and underlying molecular mechanism of miR‑301a‑3p in NPC cells were determined. It was observed that miR‑301a‑3p upregulation promoted NPC cell proliferation, migration, invasion and epithelial‑mesenchymal transition in vitro, whereas its downregulation resulted in the opposite effect. B‑cell translocation gene 1 (BTG1) mRNA was identified as the novel target of miR‑301a‑3p. BTG1 overexpression partially attenuated miR‑301a‑3p‑induced increase in cell proliferation and invasion. miR‑301a‑3p can be transferred by exosomes and positively regulate the proliferation and invasion of NPC cells. Altogether, the present study highlights that exosomal miR‑301a‑3p can promote NPC cell proliferation and invasion by repressing BTG1, thereby resulting in the development of NPC.
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Copy and paste a formatted citation
Spandidos Publications style
Cheng Q, Li Q, Xu L and Jiang H: Exosomal microRNA-301a-3p promotes the proliferation and invasion of nasopharyngeal carcinoma cells by targeting BTG1 mRNA. Mol Med Rep 23: 328, 2021.
APA
Cheng, Q., Li, Q., Xu, L., & Jiang, H. (2021). Exosomal microRNA-301a-3p promotes the proliferation and invasion of nasopharyngeal carcinoma cells by targeting BTG1 mRNA. Molecular Medicine Reports, 23, 328. https://doi.org/10.3892/mmr.2021.11967
MLA
Cheng, Q., Li, Q., Xu, L., Jiang, H."Exosomal microRNA-301a-3p promotes the proliferation and invasion of nasopharyngeal carcinoma cells by targeting BTG1 mRNA". Molecular Medicine Reports 23.5 (2021): 328.
Chicago
Cheng, Q., Li, Q., Xu, L., Jiang, H."Exosomal microRNA-301a-3p promotes the proliferation and invasion of nasopharyngeal carcinoma cells by targeting BTG1 mRNA". Molecular Medicine Reports 23, no. 5 (2021): 328. https://doi.org/10.3892/mmr.2021.11967
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng Q, Li Q, Xu L and Jiang H: Exosomal microRNA-301a-3p promotes the proliferation and invasion of nasopharyngeal carcinoma cells by targeting BTG1 mRNA. Mol Med Rep 23: 328, 2021.
APA
Cheng, Q., Li, Q., Xu, L., & Jiang, H. (2021). Exosomal microRNA-301a-3p promotes the proliferation and invasion of nasopharyngeal carcinoma cells by targeting BTG1 mRNA. Molecular Medicine Reports, 23, 328. https://doi.org/10.3892/mmr.2021.11967
MLA
Cheng, Q., Li, Q., Xu, L., Jiang, H."Exosomal microRNA-301a-3p promotes the proliferation and invasion of nasopharyngeal carcinoma cells by targeting BTG1 mRNA". Molecular Medicine Reports 23.5 (2021): 328.
Chicago
Cheng, Q., Li, Q., Xu, L., Jiang, H."Exosomal microRNA-301a-3p promotes the proliferation and invasion of nasopharyngeal carcinoma cells by targeting BTG1 mRNA". Molecular Medicine Reports 23, no. 5 (2021): 328. https://doi.org/10.3892/mmr.2021.11967
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