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Tumor suppressor role of sFRP‑4 in hepatocellular carcinoma via the Wnt/β‑catenin signaling pathway

  • Authors:
    • Quanxin Wu
    • Cheng Xu
    • Xianghua Zeng
    • Zhimin Zhang
    • Bo Yang
    • Zhiguo Rao
  • View Affiliations / Copyright

    Affiliations: Cadre Ward Two, General Hospital of The Central Theater Command of The People's Liberation Army, Wuhan, Hubei 430070, P.R. China, Department of Oncology, General Hospital of The Central Theater Command of The People's Liberation Army, Wuhan, Hubei 430070, P.R. China, Department of Oncology, Chongqing Traditional Chinese Medicine Hospital, Chongqing 400021, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 336
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    Published online on: March 8, 2021
       https://doi.org/10.3892/mmr.2021.11975
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Abstract

Hepatocellular carcinoma (HCC) is a malignant tumor located in the liver. Secreted frizzled‑related protein 4 (sFRP‑4) is associated with cancer occurrence, but the relationship between sFRP‑4 and HCC is not completely understood. The present study aimed to investigate the role and mechanism underlying sFRP‑4 in HCC. sFRP‑4 mRNA expression levels were determined via reverse transcription‑quantitative PCR and immunohistochemistry. The Cell Counting Kit‑8 assay was performed to evaluate HCCLM3 and Huh7 cell viability. Moreover, HCCLM3 and Huh7 cell proliferation were assessed using the BrdU ELISA assay kit, and cell apoptosis was measured via flow cytometry. Western blotting was conducted to measure β‑catenin and GSK‑3β protein expression levels. The results demonstrated that sFRP‑4 expression was significantly downregulated in HCC tissues and cells compared with adjacent healthy tissues and MIHA cells, respectively. Moreover, the results indicated that compared with the control group, sFRP‑4 overexpression inhibited HCC cell viability and proliferation, and accelerated HCC cell apoptosis. Furthermore, the results suggested that sFRP‑4 inhibited the Wnt/β‑catenin signaling pathway by upregulating GSK‑3β expression and downregulating β‑catenin expression, thus restraining the malignant behavior of HCC cells. In conclusion, the present study indicated that sFRP‑4 served a tumor suppressor role in HCC cells by restraining the Wnt/β‑catenin signaling pathway.
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1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Llovet JM, Zucman-Rossi J, Pikarsky E, Sangro B, Schwartz M, Sherman M and Gores G: Hepatocellular carcinoma. Nat Rev Dis Primers. 2:160182016. View Article : Google Scholar : PubMed/NCBI

3 

Xiang X, Zhong JH, Wang YY, You XM, Ma L, Xiang BD and Li LQ: Distribution of tumor stage and initial treatment modality in patients with primary hepatocellular carcinoma. Clin Transl Oncol. 19:891–897. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Han J, Wang F, Lan Y, Wang J, Nie C, Liang Y, Song R, Zheng T, Pan S, Pei T, et al: KIFC1 regulated by miR-532-3p promotes epithelial-to-mesenchymal transition and metastasis of hepatocellular carcinoma via gankyrin/AKT signaling. Oncogene. 38:406–420. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Vilchez V, Turcios L, Marti F and Gedaly R: Targeting Wnt/beta-catenin pathway in hepatocellular carcinoma treatment. World J Gastroenterol. 22:823–832. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Saran U, Humar B, Kolly P and Dufour JF: Hepatocellular carcinoma and lifestyles. J Hepatol. 64:203–214. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Ozakyol A: Global epidemiology of hepatocellular carcinoma (HCC epidemiology). J Gastrointest Cancer. 48:238–240. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Serper M, Taddei TH, Mehta R, D'Addeo K, Dai F, Aytaman A, Baytarian M, Fox R, Hunt K, Goldberg DS, et al: Association of provider specialty and multidisciplinary care with hepatocellular carcinoma treatment and mortality. Gastroenterology. 152:1954–1964. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Cheng D, Deng J, Zhang B, He X, Meng Z, Li G, Ye H, Zheng S, Wei L, Deng X, et al: lncRNA HOTAIR epigenetically suppresses miR-122 expression in hepatocellular carcinoma via DNA methylation. EBioMedicine. 36:159–170. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Bukhari SA, Yasmin A, Zahoor MA, Mustafa G, Sarfraz I and Rasul A: Secreted frizzled-related protein 4 and its implication in obesity and type-2 diabetes. IUBMB Life. 71:1701–1710. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Agostino M, Pohl S and Dharmarajan A: Structure-based prediction of Wnt binding affinities for Frizzled-type cysteine-rich domains. J Biol Chem. 292:11218–11229. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Feng Han Q, Zhao W, Bentel J, Shearwood AM, Zeps N, Joseph D, Iacopetta B and Dharmarajan A: Expression of sFRP-4 and beta-catenin in human colorectal carcinoma. Cancer Lett. 231:129–137. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Deshmukh A, Arfuso F, Newsholme P and Dharmarajan A: Regulation of cancer stem cell metabolism by secreted frizzled-related protein 4 (sFRP4). Cancers (Basel). 10:402018. View Article : Google Scholar

14 

Wang H, Duan XL, Qi XL, Meng L, Xu YS, Wu T and Dai PG: Concurrent hypermethylation of SFRP2 and DKK2 activates the Wnt/β-catenin pathway and is associated with poor prognosis in patients with gastric cancer. Mol Cells. 40:45–53. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Ford CE, Jary E, Ma SS, Nixdorf S, Heinzelmann-Schwarz VA and Ward RL: The Wnt gatekeeper SFRP4 modulates EMT, cell migration and downstream Wnt signalling in serous ovarian cancer cells. PLoS One. 8:e543622013. View Article : Google Scholar : PubMed/NCBI

16 

Brebi P, Hoffstetter R, Andana A, Ili CG, Saavedra K, Viscarra T, Retamal J, Sanchez R and Roa JC: Evaluation of ZAR1 and SFRP4 methylation status as potentials biomarkers for diagnosis in cervical cancer: Exploratory study phase I. Biomarkers. 19:181–188. 2014. View Article : Google Scholar : PubMed/NCBI

17 

He B, Lee AY, Dadfarmay S, You L, Xu Z, Reguart N, Mazieres J, Mikami I, McCormick F and Jablons DM: Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells. Cancer Res. 65:743–748. 2005.PubMed/NCBI

18 

Pereira TDSF, Diniz MG, França JA, Moreira RG, Menezes GHF, Sousa SF, Castro WH, Gomes CC and Gomez RS: The Wnt/β-catenin pathway is deregulated in cemento-ossifying fibromas. Oral Surg Oral Med Oral Pathol Oral Radiol. 125:172–178. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Sandsmark E, Andersen MK, Bofin AM, Bertilsson H, Drabløs F, Bathen TF, Rye MB and Tessem MB: SFRP4 gene expression is increased in aggressive prostate cancer. Sci Rep. 7:142762017. View Article : Google Scholar : PubMed/NCBI

20 

Yang MW, Tao LY, Yang JY, Jiang YS, Fu XL, Liu W, Huo YM, Li J, Zhang JF, Hua R, et al: SFRP4 is a prognostic marker and correlated with Treg cell infiltration in pancreatic ductal adenocarcinoma. Am J Cancer Res. 9:363–377. 2019.PubMed/NCBI

21 

Nfonsam LE, Jandova J, Jecius HC, Omesiete PN and Nfonsam VN: SFRP4 expression correlates with epithelial mesenchymal transition-linked genes and poor overall survival in colon cancer patients. World J Gastrointest Oncol. 11:589–598. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Huang D, Yu B, Deng Y, Sheng W, Peng Z, Qin W and Du X: SFRP4 was overexpressed in colorectal carcinoma. J Cancer Res Clin Oncol. 136:395–401. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Xu C, Zeng XH, Wang L, Tao SQ, Wu QX, Zhu P, Deng GH and Wang YM: sFRP-4, a potential novel serum marker for chronic hepatitis B-related hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int. 14:164–170. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Chen J, Rajasekaran M and Hui KM: Atypical regulators of Wnt/β-catenin signaling as potential therapeutic targets in Hepatocellular Carcinoma. Exp Biol Med (Maywood). 242:1142–1149. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Rao TP and Kuhl M: An updated overview on Wnt signaling pathways: A prelude for more. Circ Res. 106:1798–1806. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Wang W, Li S, Liu P, Sideras K, van de Werken HJG, van der Heide M, Cao W, Lavrijsen M, Peppelenbosch MP, Bruno M, et al: Oncogenic STRAP supports hepatocellular carcinoma growth by enhancing Wnt/β-catenin signaling. Mol Cancer Res. 17:521–531. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Zhan T, Rindtorff N and Boutros M: Wnt signaling in cancer. Oncogene. 36:1461–1473. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Duchartre Y, Kim YM and Kahn M: The Wnt signaling pathway in cancer. Crit Rev Oncol Hematol. 99:141–149. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Wang R, Wu Y, Huang W and Chen W: MicroRNA-940 Targets INPP4A or GSK3beta and Activates the Wnt/beta-Catenin pathway to regulate the malignant behavior of bladder cancer Cells. Oncol Res. 26:145–155. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Peng Y, Zhang X, Ma Q, Yan R, Qin Y, Zhao Y, Cheng Y, Yang M, Wang Q, Feng X, et al: miRNA-194 activates the Wnt/β-catenin signaling pathway in gastric cancer by targeting the negative Wnt regulator, SUFU. Cancer Lett. 385:117–127. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Ren Y, Tao J, Jiang Z, Guo D and Tang J: Pimozide suppresses colorectal cancer via inhibition of Wnt/beta-catenin signaling pathway. Life Sci. 209:267–273. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Zhang J, Hu SL, Qiao CH, Ye JF, Li M, Ma HM, Wang JH, Xin SY and Yuan ZL: lncRNA-NEF inhibits proliferation, migration and invasion of esophageal squamous-cell carcinoma cells by inactivating wnt/β-catenin pathway. Eur Rev Med Pharmacol Sci. 22:6824–6831. 2018.PubMed/NCBI

33 

Zhou P, Li Y, Li B, Zhang M, Liu Y, Yao Y and Li D: NMIIA promotes tumor growth and metastasis by activating the Wnt/β-catenin signaling pathway and EMT in pancreatic cancer. Oncogene. 38:5500–5515. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Hu Z, Wang P, Lin J, Zheng X, Yang F, Zhang G, Chen D, Xie J, Gao Z, Peng L and Xie C: MicroRNA-197 promotes metastasis of hepatocellular carcinoma by activating Wnt/β-catenin signaling. Cell Physiol Biochem. 51:470–486. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Song J, Xie C, Jiang L, Wu G, Zhu J, Zhang S, Tang M, Song L and Li J: Transcription factor AP-4 promotes tumorigenic capability and activates the Wnt/β-catenin pathway in hepatocellular carcinoma. Theranostics. 8:3571–3583. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

37 

Wang Q, Lv Q, Bian H, Yang L, Guo KL, Ye SS, Dong XF and Tao LL: A novel tumor suppressor SPINK5 targets Wnt/β-catenin signaling pathway in esophageal cancer. Cancer Med. 8:2360–2371. 2019. View Article : Google Scholar : PubMed/NCBI

38 

Shin H, Kim JH, Lee YS and Lee YC: Change in gene expression profiles of secreted frizzled-related proteins (SFRPs) by sodium butyrate in gastric cancers: Induction of promoter demethylation and histone modification causing inhibition of Wnt signaling. Int J Oncol. 40:1533–1542. 2012.PubMed/NCBI

39 

Pannone G, Bufo P, Santoro A, Franco R, Aquino G, Longo F, Botti G, Serpico R, Cafarelli B, Abbruzzese A, et al: WNT pathway in oral cancer: Epigenetic inactivation of WNT-inhibitors. Oncol Rep. 24:1035–1041. 2010.PubMed/NCBI

40 

Deshmukh A, Arfuso F, Newsholme P and Dharmarajan A: Epigenetic demethylation of sFRPs, with emphasis on sFRP4 activation, leading to Wnt signalling suppression and histone modifications in breast, prostate, and ovary cancer stem cells. Int J Biochem Cell Biol. 109:23–32. 2019. View Article : Google Scholar : PubMed/NCBI

41 

Perumal V, Dharmarajan AM and Fox SA: The Wnt regulator SFRP4 inhibits mesothelioma cell proliferation, migration, and antagonizes Wnt3a via its netrin-like domain. Int J Oncol. 51:362–368. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Pawar NM and Rao P: Secreted frizzled related protein 4 (sFRP4) update: A brief review. Cell Signal. 45:63–70. 2018. View Article : Google Scholar : PubMed/NCBI

43 

Bhuvanalakshmi G, Arfuso F, Millward M, Dharmarajan A and Warrier S: Secreted frizzled-related protein 4 inhibits glioma stem-like cells by reversing epithelial to mesenchymal transition, inducing apoptosis and decreasing cancer stem cell properties. PLoS One. 10:e01275172015. View Article : Google Scholar : PubMed/NCBI

44 

Bhuvanalakshmi G, Gamit N, Patil M, Arfuso F, Sethi G, Dharmarajan A, Kumar AP and Warrier S: Stemness, pluripotentiality, and Wnt antagonism: sFRP4, a wnt antagonist mediates pluripotency and stemness in glioblastoma. Cancers (Basel). 11:252018. View Article : Google Scholar

45 

Takagi H, Sasaki S, Suzuki H, Toyota M, Maruyama R, Nojima M, Yamamoto H, Omata M, Tokino T, Imai K and Shinomura Y: Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma. J Gastroenterol. 43:378–389. 2008. View Article : Google Scholar : PubMed/NCBI

46 

Yu J, Xie Y, Li M, Zhou F, Zhong Z, Liu Y, Wang F and Qi J: Association between SFRP promoter hypermethylation and different types of cancer: A systematic review and meta-analysis. Oncol Lett. 18:3481–3492. 2019.PubMed/NCBI

47 

Zhang T, Ma Z, Liu L, Sun J, Tang H, Zhang B, Zou Y and Li H: DDX39 promotes hepatocellular carcinoma growth and metastasis through activating Wnt/β-catenin pathway. Cell Death Dis. 9:6752018. View Article : Google Scholar : PubMed/NCBI

48 

Lin J, Lin W, Ye Y, Wang L, Chen X, Zang S and Huang A: Kindlin-2 promotes hepatocellular carcinoma invasion and metastasis by increasing Wnt/β-catenin signaling. J Exp Clin Cancer Res. 36:1342017. View Article : Google Scholar : PubMed/NCBI

49 

MacDonald BT, Tamai K and He X: Wnt/beta-catenin signaling: Components, mechanisms, and diseases. Dev Cell. 17:9–26. 2009. View Article : Google Scholar : PubMed/NCBI

50 

Katoh M and Katoh M: WNT signaling pathway and stem cell signaling network. Clin Cancer Res. 13:4042–4045. 2007. View Article : Google Scholar : PubMed/NCBI

51 

Cai J, Guan H, Fang L, Yang Y, Zhu X, Yuan J, Wu J and Li M: MicroRNA-374a activates Wnt/β-catenin signaling to promote breast cancer metastasis. J Clin Invest. 123:566–579. 2013.PubMed/NCBI

52 

Fang L, Cai J, Chen B, Wu S, Li R, Xu X, Yang Y, Guan H, Zhu X, Zhang L, et al: Aberrantly expressed miR-582-3p maintains lung cancer stem cell-like traits by activating Wnt/β-catenin signalling. Nat Commun. 6:86402015. View Article : Google Scholar : PubMed/NCBI

53 

Peng Y, Zhang X, Feng X, Fan X and Jin Z: The crosstalk between microRNAs and the Wnt/beta-catenin signaling pathway in cancer. Oncotarget. 8:14089–14106. 2017. View Article : Google Scholar : PubMed/NCBI

54 

Staal FJ and Clevers H: Tcf/Lef transcription factors during T-cell development: Unique and overlapping functions. Hematol J. 1:3–6. 2000. View Article : Google Scholar : PubMed/NCBI

55 

Kramps T, Peter O, Brunner E, Nellen D, Froesch B, Chatterjee S, Murone M, Züllig S and Basler K: Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. Cell. 109:47–60. 2002. View Article : Google Scholar : PubMed/NCBI

56 

Warrier S, Bhuvanalakshmi G, Arfuso F, Rajan G, Millward M and Dharmarajan A: Cancer stem-like cells from head and neck cancers are chemosensitized by the Wnt antagonist, sFRP4, by inducing apoptosis, decreasing stemness, drug resistance and epithelial to mesenchymal transition. Cancer Gene Ther. 21:381–388. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wu Q, Xu C, Zeng X, Zhang Z, Yang B and Rao Z: Tumor suppressor role of sFRP‑4 in hepatocellular carcinoma via the Wnt/β‑catenin signaling pathway. Mol Med Rep 23: 336, 2021.
APA
Wu, Q., Xu, C., Zeng, X., Zhang, Z., Yang, B., & Rao, Z. (2021). Tumor suppressor role of sFRP‑4 in hepatocellular carcinoma via the Wnt/β‑catenin signaling pathway. Molecular Medicine Reports, 23, 336. https://doi.org/10.3892/mmr.2021.11975
MLA
Wu, Q., Xu, C., Zeng, X., Zhang, Z., Yang, B., Rao, Z."Tumor suppressor role of sFRP‑4 in hepatocellular carcinoma via the Wnt/β‑catenin signaling pathway". Molecular Medicine Reports 23.5 (2021): 336.
Chicago
Wu, Q., Xu, C., Zeng, X., Zhang, Z., Yang, B., Rao, Z."Tumor suppressor role of sFRP‑4 in hepatocellular carcinoma via the Wnt/β‑catenin signaling pathway". Molecular Medicine Reports 23, no. 5 (2021): 336. https://doi.org/10.3892/mmr.2021.11975
Copy and paste a formatted citation
x
Spandidos Publications style
Wu Q, Xu C, Zeng X, Zhang Z, Yang B and Rao Z: Tumor suppressor role of sFRP‑4 in hepatocellular carcinoma via the Wnt/β‑catenin signaling pathway. Mol Med Rep 23: 336, 2021.
APA
Wu, Q., Xu, C., Zeng, X., Zhang, Z., Yang, B., & Rao, Z. (2021). Tumor suppressor role of sFRP‑4 in hepatocellular carcinoma via the Wnt/β‑catenin signaling pathway. Molecular Medicine Reports, 23, 336. https://doi.org/10.3892/mmr.2021.11975
MLA
Wu, Q., Xu, C., Zeng, X., Zhang, Z., Yang, B., Rao, Z."Tumor suppressor role of sFRP‑4 in hepatocellular carcinoma via the Wnt/β‑catenin signaling pathway". Molecular Medicine Reports 23.5 (2021): 336.
Chicago
Wu, Q., Xu, C., Zeng, X., Zhang, Z., Yang, B., Rao, Z."Tumor suppressor role of sFRP‑4 in hepatocellular carcinoma via the Wnt/β‑catenin signaling pathway". Molecular Medicine Reports 23, no. 5 (2021): 336. https://doi.org/10.3892/mmr.2021.11975
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