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miR‑224‑5p regulates the proliferation, migration and invasion of pancreatic mucinous cystadenocarcinoma by targeting PTEN

  • Authors:
    • Xiaobo Peng
    • Chengtao Guo
    • Yanjun Wu
    • Mingzhen Ying
    • Renxu Chang
    • Lele Song
    • Lixing Zhan
    • Xianbao Zhan
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Changhai Hospital Affiliated to Naval Military Medical University, Shanghai 200433, P.R. China, CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, P.R. China
    Copyright: © Peng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 346
    |
    Published online on: March 10, 2021
       https://doi.org/10.3892/mmr.2021.11985
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Abstract

Pancreatic mucinous cystadenocarcinoma (MCC) is a rare malignant tumor, with a limited number of studies. The present study aimed to investigate the function and mechanism of microRNA (miR)‑224‑5p on proliferation, migration and invasion of MCC of the pancreas. Reverse transcription‑quantitative PCR was used to explorethe expression of miR‑224‑5p and the PTEN gene. MTT, wound healing, Transwell and tumorigenesis assays were conducted to investigate the proliferation, migration and invasion of MCC1 cells in vitro and in vivo. Western blot analysis was employed to test the protein expression of PTEN. The target gene of miR‑224‑5p was assessed and verified by luciferase assay. miR‑224‑5p expression was notably higher, while PTEN expression was lower, in MCC1 cells compared with normal tissues and cells. Overexpression of miR‑224‑5p promoted the proliferation, migration and invasion of MCC and knockdown of miR‑224‑5p inhibited these functions. Bioinformatics analysis and luciferase assay indicated that PTEN was the direct target gene of miR‑224‑5p. The negative correlation between miR‑224‑5p and PTEN was confirmed both in vitro and in vivo. PTEN reversed the effects of miR‑224‑5p on proliferation, migration and invasion of MCC1 cells. The present study revealed for the first time, to the best of the authors' knowledge, that miR‑224‑5p was highly expressed and served an oncogenic role in MCC. miR‑224‑5p not only regulated the proliferation, migration and invasion of pancreatic MCC but may also be a potential therapeutic target for MCC.
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View References

1 

Brewer Gutierrez OI and Lennon AM: Pancreatic Cysts: Sinister Findings or Incidentalomas? Med Clin North Am. 103:163–172. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Dorobanţu BM, Matei E, Herlea V, Boroş M, Tivadar B and Ciurea SH: Diagnosis, morphopathological profile and treatment of mucinous cystadenoma of the pancreas - a single center experience. Rom J Morphol Embryol. 59:1155–1163. 2018.PubMed/NCBI

3 

Becker WF, Welsh RA and Pratt HS: Cystadenoma and cystadenocarcinoma of the pancreas. Ann Surg. 161:845–863. 1965. View Article : Google Scholar : PubMed/NCBI

4 

Katoh H, Rossi RL, Braasch JW, Munson JL, Shimozawa E and Tanabe T: Cystadenoma and cystadenocarcinoma of the pancreas. Hepatogastroenterology. 36:424–430. 1989.PubMed/NCBI

5 

Doulamis IP, Mylonas KS, Kalfountzos CE, Mou D, Haj-Ibrahim H and Nasioudis D: Pancreatic mucinous cystadenocarcinoma: Epidemiology and outcomes. Int J Surg. 35:76–82. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Lichtenstein L: Papillarycystadenocarcinoma of pancreas. case report, with notes on classification of malignant cystic tumors of pancreas. Am J Cancer. 21:542–553. 1934. View Article : Google Scholar

7 

Le Borgne J, de Calan L and Partensky C; French Surgical Association, : Cystadenomas and cystadenocarcinomas of the pancreas: A multiinstitutional retrospective study of 398 cases. Ann Surg. 230:152–161. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Compagno J and Oertel JE: Mucinous cystic neoplasms of the pancreas with overt and latent malignancy (cystadenocarcinoma and cystadenoma). A clinicopathologic study of 41 cases. Am J Clin Pathol. 69:573–580. 1978. View Article : Google Scholar : PubMed/NCBI

9 

Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, et al: MicroRNA expression profiles classify human cancers. Nature. 435:834–838. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Van Roosbroeck K and Calin GA: Cancer Hallmarks and MicroRNAs: The Therapeutic Connection. Adv Cancer Res. 135:119–149. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Rawat M, Kadian K, Gupta Y, Kumar A, Chain PSG, Kovbasnjuk O, Kumar S and Parasher G: MicroRNA in Pancreatic Cancer: From Biology to Therapeutic Potential. Genes (Basel). 10:752–773. 2019. View Article : Google Scholar

12 

Zhang B, Guo X, Zhang J, Liu X, Zhan X and Li Z: MicroRNA 224 is downregulated in mucinous cystic neoplasms of the pancreas and may regulate tumorigenesis by targeting Jagged1. Mol Med Rep. 10:3303–3309. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Aaltonen LA and Hamilton SR: World Health Organization, International Agency for Research on Cancer. Pathology and Genetics of Tumours of the Digestive System. Oxford University Press; Lyon, Oxford: 2000

14 

Li S, Zhang J, Zhao Y, Wang F, Chen Y and Fei X: miR-224 enhances invasion and metastasis by targeting HOXD10 in non-small cell lung cancer cells. Oncol Lett. 15:7069–7075. 2018.PubMed/NCBI

15 

Zhou J, Hu M, Wang F, Song M, Huang Q and Ge B: miR-224 Controls Human Colorectal Cancer Cell Line HCT116 Proliferation by Targeting Smad4. Int J Med Sci. 14:937–942. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Lu Y, Huang W, Chen H, Wei H, Luo A, Xia G, Deng X and Zhang G: MicroRNA-224, negatively regulated by c-jun, inhibits growth and epithelial-to-mesenchymal transition phenotype via targeting ADAM17 in oral squamous cell carcinoma. J Cell Mol Med. 23:4913–4920. 2019. View Article : Google Scholar : PubMed/NCBI

17 

Cullen PK Jr, Remine WH and Dahlin DC: A clinicopathological study of cystadenocarcinoma of the pancreas. Surg Gynecol Obstet. 117:189–195. 1963.PubMed/NCBI

18 

Chang R, Song L, Xu Y, Wu Y, Dai C, Wang X, Sun X, Hou Y, Li W, Zhan X, et al: Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis. Nat Commun. 9:34862018. View Article : Google Scholar : PubMed/NCBI

19 

Song L, Guo J, Chang R, Peng X, Li J, Xu X, Zhan X and Zhan L: LKB1 obliterates Snail stability and inhibits pancreatic cancer metastasis in response to metformin treatment. Cancer Sci. 109:1382–1392. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Zhou Y, Chang R, Ji W, Wang N, Qi M, Xu Y, Guo J and Zhan L: Loss of Scribble Promotes Snail Translation through Translocation of HuR and Enhances Cancer Drug Resistance. J Biol Chem. 291:291–302. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Hieronymus H, Iaquinta PJ, Wongvipat J, Gopalan A, Murali R, Mao N, Carver BS and Sawyers CL: Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis. Nat Commun. 8:1081–1090. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Huang C, Wang Z, Zhang K, Dong Y, Zhang A, Lu C and Liu L: MicroRNA-107 inhibits proliferation and invasion of laryngeal squamous cell carcinoma cells by targeting CACNA2D1 in vitro. Anticancer Drugs. 31:260–271. 2020. View Article : Google Scholar : PubMed/NCBI

25 

Ma X, Feng J, Lu M, Tang W, Han J, Luo X, Zhao Q and Yang L and Yang L: microRNA-501-5p promotes cell proliferation and migration in gastric cancer by downregulating LPAR1. J Cell Biochem. 121:1911–1922. 2020. View Article : Google Scholar : PubMed/NCBI

26 

Ye J, Xie W, Zuo Y, Jing G and Tong J: MicroRNA-496 suppresses tumor cell proliferation by targeting BDNF in osteosarcoma. Exp Ther Med. 19:1425–1431. 2020.PubMed/NCBI

27 

Guo C, Peng X, Song L, Ying M, Wu Y, Chang R, Li J, Feng D, Zhan L and Zhan X: Autophagy promotes malignant migration and invasion via miR-224-5p/BCL2 in pancreatic mucinous cystadenocarcinoma MCC1 cells. Oncol Lett. 20:2762020. View Article : Google Scholar : PubMed/NCBI

28 

Liu H, Li P, Li B, Sun P, Zhang J, Wang B and Jia B: RKIP suppresses gastric cancer cell proliferation and invasion and enhances apoptosis regulated by microRNA-224. Tumour Biol. 35:10095–10103. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Li Q, Ding C, Chen C, Zhang Z, Xiao H, Xie F, Lei L, Chen Y, Mao B, Jiang M, et al: miR-224 promotion of cell migration and invasion by targeting Homeobox D 10 gene in human hepatocellular carcinoma. J Gastroenterol Hepatol. 29:835–842. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Lin ZY, Huang YQ, Zhang YQ, Han ZD, He HC, Ling XH, Fu X, Dai QS, Cai C, Chen JH, et al: MicroRNA-224 inhibits progression of human prostate cancer by downregulating TRIB1. Int J Cancer. 135:541–550. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Brown JA and Bourke E: Practical Bioinformatics Analysis of miRNA Data Using Online Tools. Methods Mol Biol. 1509:195–208. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Lewis BP, Shih IH, Jones-Rhoades MW, Bartel DP and Burge CB and Burge CB: Prediction of mammalian microRNA targets. Cell. 115:787–798. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Krek A, Grün D, Poy MN, Wolf R, Rosenberg L, Epstein EJ, MacMenamin P, da Piedade I, Gunsalus KC, Stoffel M, et al: Combinatorial microRNA target predictions. Nat Genet. 37:495–500. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Zhu B and Wei Y: Antitumor activity of celastrol by inhibition of proliferation, invasion, and migration in cholangiocarcinoma via PTEN/PI3K/Akt pathway. Cancer Med. 9:783–796. 2020. View Article : Google Scholar : PubMed/NCBI

35 

Ramírez-Moya J, Wert-Lamas L and Santisteban P: MicroRNA-146b promotes PI3K/AKT pathway hyperactivation and thyroid cancer progression by targeting PTEN. Oncogene. 37:3369–3383. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Di Cristofano A and Pandolfi PP: The multiple roles of PTEN in tumor suppression. Cell. 100:387–390. 2000. View Article : Google Scholar : PubMed/NCBI

37 

Lin Y, Chen Q, Liu QX, Zhou D, Lu X, Deng XF, Yang H, Zheng H and Qiu Y: High expression of DJ-1 promotes growth and invasion via the PTEN-AKT pathway and predicts a poor prognosis in colorectal cancer. Cancer Med. 7:809–819. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Zhao YS, Yang WC, Xin HW, Han JX and Ma SG: miR-182-5p knockdown targeting PTEN inhibits cell proliferation and invasion of breast cancer cells. Yonsei Med J. 60:148–157. 2019. View Article : Google Scholar : PubMed/NCBI

39 

Jiang XM, Yu XN, Liu TT, Zhu HR, Shi X, Bilegsaikhan E, Guo HY, Song GQ, Weng SQ, Huang XX, et al: microRNA-19a-3p promotes tumor metastasis and chemoresistance through the PTEN/Akt pathway in hepatocellular carcinoma. Biomed Pharmacother. 105:1147–1154. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Macgregor-Das AM and Iacobuzio-Donahue CA: Molecular pathways in pancreatic carcinogenesis. J Surg Oncol. 107:8–14. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Peng X, Guo C, Wu Y, Ying M, Chang R, Song L, Zhan L and Zhan X: miR‑224‑5p regulates the proliferation, migration and invasion of pancreatic mucinous cystadenocarcinoma by targeting <em>PTEN</em>. Mol Med Rep 23: 346, 2021.
APA
Peng, X., Guo, C., Wu, Y., Ying, M., Chang, R., Song, L. ... Zhan, X. (2021). miR‑224‑5p regulates the proliferation, migration and invasion of pancreatic mucinous cystadenocarcinoma by targeting <em>PTEN</em>. Molecular Medicine Reports, 23, 346. https://doi.org/10.3892/mmr.2021.11985
MLA
Peng, X., Guo, C., Wu, Y., Ying, M., Chang, R., Song, L., Zhan, L., Zhan, X."miR‑224‑5p regulates the proliferation, migration and invasion of pancreatic mucinous cystadenocarcinoma by targeting <em>PTEN</em>". Molecular Medicine Reports 23.5 (2021): 346.
Chicago
Peng, X., Guo, C., Wu, Y., Ying, M., Chang, R., Song, L., Zhan, L., Zhan, X."miR‑224‑5p regulates the proliferation, migration and invasion of pancreatic mucinous cystadenocarcinoma by targeting <em>PTEN</em>". Molecular Medicine Reports 23, no. 5 (2021): 346. https://doi.org/10.3892/mmr.2021.11985
Copy and paste a formatted citation
x
Spandidos Publications style
Peng X, Guo C, Wu Y, Ying M, Chang R, Song L, Zhan L and Zhan X: miR‑224‑5p regulates the proliferation, migration and invasion of pancreatic mucinous cystadenocarcinoma by targeting <em>PTEN</em>. Mol Med Rep 23: 346, 2021.
APA
Peng, X., Guo, C., Wu, Y., Ying, M., Chang, R., Song, L. ... Zhan, X. (2021). miR‑224‑5p regulates the proliferation, migration and invasion of pancreatic mucinous cystadenocarcinoma by targeting <em>PTEN</em>. Molecular Medicine Reports, 23, 346. https://doi.org/10.3892/mmr.2021.11985
MLA
Peng, X., Guo, C., Wu, Y., Ying, M., Chang, R., Song, L., Zhan, L., Zhan, X."miR‑224‑5p regulates the proliferation, migration and invasion of pancreatic mucinous cystadenocarcinoma by targeting <em>PTEN</em>". Molecular Medicine Reports 23.5 (2021): 346.
Chicago
Peng, X., Guo, C., Wu, Y., Ying, M., Chang, R., Song, L., Zhan, L., Zhan, X."miR‑224‑5p regulates the proliferation, migration and invasion of pancreatic mucinous cystadenocarcinoma by targeting <em>PTEN</em>". Molecular Medicine Reports 23, no. 5 (2021): 346. https://doi.org/10.3892/mmr.2021.11985
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