Open Access

Interplay between cyclooxygenase‑2 and microRNAs in cancer (Review)

  • Authors:
    • Zexiong Gong
    • Weiguo Huang
    • Baiyun Wang
    • Na Liang
    • Songkai Long
    • Wanjun Li
    • Qier Zhou
  • View Affiliations

  • Published online on: March 11, 2021     https://doi.org/10.3892/mmr.2021.11986
  • Article Number: 347
  • Copyright: © Gong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Tumor‑associated inflammation and aberrantly expressed biomarkers have been demonstrated to play crucial roles in the cancer microenvironment. Cyclooxygenase‑2 (COX‑2), a prominent inflammatory factor, is highly expressed in tumor cells and contributes to tumor growth, recurrence and metastasis. Overexpression of COX‑2 may occur at both transcriptional and post‑transcriptional levels. Thus, an improved understanding of the regulatory mechanisms of COX‑2 can facilitate the development of novel antitumor therapies. MicroRNAs (miRNAs) are a group of small non‑coding RNAs that act as translation repressors of target mRNAs, and play vital roles in regulating cancer development and progression. The present review discusses the association between miRNAs and COX‑2 expression in different types of cancer. Understanding the regulatory role of miRNAs in COX‑2 post‑transcription can provide novel insight for suppressing COX‑2 expression via gene silencing mechanisms, which offer new perspectives and future directions for the development of novel COX‑2 selective inhibitors based on miRNAs.
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May-2021
Volume 23 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Gong Z, Huang W, Wang B, Liang N, Long S, Li W and Zhou Q: Interplay between cyclooxygenase‑2 and microRNAs in cancer (Review). Mol Med Rep 23: 347, 2021
APA
Gong, Z., Huang, W., Wang, B., Liang, N., Long, S., Li, W., & Zhou, Q. (2021). Interplay between cyclooxygenase‑2 and microRNAs in cancer (Review). Molecular Medicine Reports, 23, 347. https://doi.org/10.3892/mmr.2021.11986
MLA
Gong, Z., Huang, W., Wang, B., Liang, N., Long, S., Li, W., Zhou, Q."Interplay between cyclooxygenase‑2 and microRNAs in cancer (Review)". Molecular Medicine Reports 23.5 (2021): 347.
Chicago
Gong, Z., Huang, W., Wang, B., Liang, N., Long, S., Li, W., Zhou, Q."Interplay between cyclooxygenase‑2 and microRNAs in cancer (Review)". Molecular Medicine Reports 23, no. 5 (2021): 347. https://doi.org/10.3892/mmr.2021.11986