Open Access

Interaction of non‑parenchymal hepatocytes in the process of hepatic fibrosis (Review)

  • Authors:
    • Qi-Ni Cheng
    • Xue Yang
    • Jiang-Feng Wu
    • Wen-Bing Ai
    • Yi-Ran Ni
  • View Affiliations

  • Published online on: March 16, 2021     https://doi.org/10.3892/mmr.2021.12003
  • Article Number: 364
  • Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hepatic fibrosis (HF) is the process of fibrous scar formation caused by chronic liver injury of different etiologies. Previous studies have hypothesized that the activation of hepatic stellate cells (HSCs) is the central process in HF. The interaction between HSCs and surrounding cells is also crucial. Additionally, hepatic sinusoids capillarization, inflammation, angiogenesis and fibrosis develop during HF. The process involves multiple cell types that are highly connected and work in unison to maintain the homeostasis of the hepatic microenvironment, which serves a key role in the initiation and progression of HF. The current review provides novel insight into the intercellular interaction among liver sinusoidal endothelial cells, HSCs and Kupffer cells, as well as the hepatic microenvironment in the development of HF.
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May-2021
Volume 23 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Cheng Q, Yang X, Wu J, Ai W and Ni Y: Interaction of non‑parenchymal hepatocytes in the process of hepatic fibrosis (Review). Mol Med Rep 23: 364, 2021.
APA
Cheng, Q., Yang, X., Wu, J., Ai, W., & Ni, Y. (2021). Interaction of non‑parenchymal hepatocytes in the process of hepatic fibrosis (Review). Molecular Medicine Reports, 23, 364. https://doi.org/10.3892/mmr.2021.12003
MLA
Cheng, Q., Yang, X., Wu, J., Ai, W., Ni, Y."Interaction of non‑parenchymal hepatocytes in the process of hepatic fibrosis (Review)". Molecular Medicine Reports 23.5 (2021): 364.
Chicago
Cheng, Q., Yang, X., Wu, J., Ai, W., Ni, Y."Interaction of non‑parenchymal hepatocytes in the process of hepatic fibrosis (Review)". Molecular Medicine Reports 23, no. 5 (2021): 364. https://doi.org/10.3892/mmr.2021.12003