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Galectin‑3 facilitates the proliferation and migration of nasopharyngeal carcinoma cells via activation of the ERK1/2 and Akt signaling pathways, and is positively correlated with the inflammatory state of nasopharyngeal carcinoma

  • Authors:
    • Mei Li
    • Yu Bin Chen
    • Fen Liu
    • Jia Quan Qu
    • Li Cheng Ren
    • Jin Chai
    • Can E. Tang
  • View Affiliations / Copyright

    Affiliations: Institute of Medical Science Research, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Department of Cardiac Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Cholestatic Liver Diseases Center and Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China, Department of Burn and Reconstructive Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 370
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    Published online on: March 16, 2021
       https://doi.org/10.3892/mmr.2021.12009
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Abstract

Nasopharyngeal carcinoma (NPC) is an epithelial carcinoma originating from the nasopharyngeal mucosal tissue and is highly prevalent in southeast Asia. Galectin‑3 (gal‑3) serves crucial roles in many cancers but its role in NPC remains to be elucidated. The aim of the present study was to investigate the role of gal‑3 in NPC. Immunohistochemistry and ELISA were used to determine the expression level of gal‑3 in patients with NPC or chronic rhinitis (CR). Gal‑3 short hairpin (sh)RNA was established to knockdown gal‑3 in 5‑8F and 6‑10B cells, allowing for the evaluation of the roles of gal‑3 in proliferation, migration and apoptosis in NPC cell lines. Immunohistochemistry staining of IL‑6 and IL‑8 was applied to access the inflammatory state of tumor tissues, and the correlation between the inflammatory state and gal‑3 was analyzed. The results demonstrated that gal‑3 was upregulated in patients with NPC compared with patients with CR. Knockdown of gal‑3 inhibited proliferation and migration in 5‑8F and 6‑10B cells, as well as promoted apoptosis in these cells. The expression levels of MMP‑9 and IL‑8 were also decreased in 5‑8F and 6‑10B cells after transfection with gal‑3 shRNA. A positive correlation was identified between the expression level of gal‑3 and the inflammatory state of NPC. The phosphorylation levels of ERK1/2 and Akt were downregulated after knockdown of gal‑3 in 5‑8F and 6‑10B cells. In conclusion, the expression level of gal‑3 was upregulated in patients with NPC and was positively correlated with the inflammatory state of NPC. The results suggested that gal‑3 promoted the proliferation and migration of 5‑8F and 6‑10B cells, while inhibiting the apoptosis of these cells. Moreover, activation of ERK1/2 and Akt may be the underlying mechanism of the effects of gal‑3 on NPC.
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View References

1 

Chen YP, Chan ATC, Le QT, Blanchard P, Sun Y and Ma J: Nasopharyngeal carcinoma. Lancet. 394:64–80. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Cao Y: EBV based cancer prevention and therapy in nasopharyngeal carcinoma. NPJ Precis Oncol. 1:102017. View Article : Google Scholar : PubMed/NCBI

3 

Wu M, Li X, Li X and Li G: Signaling transduction network mediated by tumor suppressor/susceptibility genes in NPC. Curr Genomics. 10:216–222. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2016. CA Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Kontny U, Franzen S, Behrends U, Bührlen M, Christiansen H, Delecluse H, Eble M, Feuchtinger T, Gademann G, Granzen B, et al: Diagnosis and treatment of nasopharyngeal carcinoma in children and adolescents - recommendations of the GPOH-NPC study group. Klin Padiatr. 228:105–112. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Newlaczyl AU and Yu LG: Galectin-3-a jack-of-all-trades in cancer. Cancer Lett. 313:123–128. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Sciacchitano S, Lavra L, Morgante A, Ulivieri A, Magi F, De Francesco GP, Bellotti C, Salehi LB and Ricci A: Galectin-3: One molecule for an alphabet of diseases, from A to Z. Int J Mol Sci. 19:3792018. View Article : Google Scholar

9 

Elad-Sfadia G, Haklai R, Balan E and Kloog Y: Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activity. J Biol Chem. 279:34922–34930. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Honjo Y, Nangia-Makker P, Inohara H and Raz A: Down- regulation of galectin-3 suppresses tumorigenicity of human breast carcinoma cells. Clin Cancer Res. 7:661–668. 2001.PubMed/NCBI

11 

Iurisci I, Tinari N, Natoli C, Angelucci D, Cianchetti E and Iacobelli S: Concentrations of galectin-3 in the sera of normal controls and cancer patients. Clin Cancer Res. 6:1389–1393. 2000.PubMed/NCBI

12 

Nangia-Makker P, Honjo Y, Sarvis R, Akahani S, Hogan V, Pienta KJ and Raz A: Galectin-3 induces endothelial cell morphogenesis and angiogenesis. Am J Pathol. 156:899–909. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Méndez-Huergo SP, Blidner AG and Rabinovich GA: Galectins: Emerging regulatory checkpoints linking tumor immunity and angiogenesis. Curr Opin Immunol. 45:8–15. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Han YY, Liu K, Xie J, Li F, Wang Y and Yan B: LINC00114 promoted nasopharyngeal carcinoma progression and radioresistance in vitro and in vivo through regulating ERK/JNK signaling pathway via targeting miR-203. Eur Rev Med Pharmacol Sci. 24:2491–2504. 2020.PubMed/NCBI

15 

Lv B, Li F, Liu X and Lin L: The tumor-suppressive role of microRNA-873 in nasopharyngeal carcinoma correlates with downregulation of ZIC2 and inhibition of AKT signaling pathway. Cancer Gene Ther. 28:74–88. 2020. View Article : Google Scholar : PubMed/NCBI

16 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Hara A and Okayasu I: Cyclooxygenase-2 and inducible nitric oxide synthase expression in human astrocytic gliomas: Correlation with angiogenesis and prognostic significance. Acta Neuropathol. 108:43–48. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Chen Y, Liu F, Han F, Lv L, Tang CE, Xie Z and Luo F: Omentin-1 is associated with atrial fibrillation in patients with cardiac valve disease. BMC Cardiovasc Disord. 20:2142020. View Article : Google Scholar : PubMed/NCBI

19 

Moloudizargari M, Moradkhani F, Hekmatirad S, Fallah M, Asghari MH and Reiter RJ: Therapeutic targets of cancer drugs: Modulation by melatonin. Life Sci. 267:1189342021. View Article : Google Scholar : PubMed/NCBI

20 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Bruce JP, Yip K, Bratman SV, Ito E and Liu FF: Nasopharyngeal cancer: Molecular landscape. J Clin Oncol. 33:3346–3355. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Tang LL, Chen WQ, Xue WQ, He YQ, Zheng RS, Zeng YX and Jia WH: Global trends in incidence and mortality of nasopharyngeal carcinoma. Cancer Lett. 374:22–30. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Lee AW, Ng WT, Chan YH, Sze H, Chan C and Lam TH: The battle against nasopharyngeal cancer. Radiother Oncol. 104:272–278. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Thijssen VL, Heusschen R, Caers J and Griffioen AW: Galectin expression in cancer diagnosis and prognosis: A systematic review. Biochim Biophys Acta. 1855:235–247. 2015.PubMed/NCBI

25 

Tang CE, Tan T, Li C, Chen ZC, Ruan L, Wang HH, Su T, Zhang PF and Xiao ZQ: Identification of Galectin-1 as a novel biomarker in nasopharyngeal carcinoma by proteomic analysis. Oncol Rep. 24:495–500. 2010.PubMed/NCBI

26 

Wu KL, Kuo CM, Huang EY, Pan HM, Huang CC, Chen YF, Hsiao CC and Yang KD: Extracellular galectin-3 facilitates colon cancer cell migration and is related to the epidermal growth factor receptor. Am J Transl Res. 10:2402–2412. 2018.PubMed/NCBI

27 

Wang L, Li YS, Yu LG, Zhang XK, Zhao L, Gong FL, Yang XX and Guo XL: Galectin-3 expression and secretion by tumor-associated macrophages in hypoxia promotes breast cancer progression. Biochem Pharmacol. 178:1141132020. View Article : Google Scholar : PubMed/NCBI

28 

Li CH, Chang YC, Hsiao M and Liang SM: FOXD1 and Gal-3 form a positive regulatory loop to regulate lung cancer aggressiveness. Cancers (Basel). 11:18972019. View Article : Google Scholar

29 

Teymoortash A, Pientka A, Schrader C, Tiemann M and Werner JA: Expression of galectin-3 in adenoid cystic carcinoma of the head and neck and its relationship with distant metastasis. J Cancer Res Clin Oncol. 132:51–56. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Chien MH, Lin CW, Cheng CW, Wen YC and Yang SF: Matrix metalloproteinase-2 as a target for head and neck cancer therapy. Expert Opin Ther Targets. 17:203–216. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Zhang X and Zhuang R: Dione-thiophene conjugate inhibits proliferation and metastasis of nasopharyngeal carcinoma cells through calcium binding protein-P down-regulation. Eur J Med Chem. 168:199–206. 2019. View Article : Google Scholar : PubMed/NCBI

32 

Lan YY, Chang FH, Tsai JH and Chang Y: Epstein-Barr virus Rta promotes invasion of bystander tumor cells through paracrine of matrix metalloproteinase 9. Biochem Biophys Res Commun. 503:2160–2166. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Li YY, Chung GT, Lui VW, To KF, Ma BB, Chow C, Woo JK, Yip KY, Seo J, Hui EP, et al: Exome and genome sequencing of nasopharynx cancer identifies NF-kappaB pathway activating mutations. Nat Commun. 8:141212017. View Article : Google Scholar : PubMed/NCBI

34 

Xia Y, Shen S and Verma IM: NF-kappaB, an active player in human cancers. Cancer Immunol Res. 2:823–830. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Zhang X, Yang J, Bian Z, Shi D and Cao Z: Long noncoding RNA DANCR promotes nasopharyngeal carcinoma progression by interacting with STAT3, enhancing IL-6/JAK1/STAT3 signaling. Biomed Pharmacother. 113:1087132019. View Article : Google Scholar : PubMed/NCBI

36 

Farnworth SL, Henderson NC, Mackinnon AC, Atkinson KM, Wilkinson T, Dhaliwal K, Hayashi K, Simpson AJ, Rossi AG, Haslett C and Sethi T: Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function. Am J Pathol. 172:395–405. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Wang L, Friess H, Zhu Z, Frigeri L, Zimmermann A, Korc M, Berberat PO and Büchler MW: Galectin-1 and galectin-3 in chronic pancreatitis. Lab. Invest. 80:1233–1241. 2000.

38 

Li Y, Lv Y, Cheng C, Huang Y, Yang L, He J, Tao X, Hu Y, Ma Y, Su Y, et al: SPEN induces miR-4652-3p to target HIPK2 in nasopharyngeal carcinoma. Cell Death Dis. 11:5092020. View Article : Google Scholar : PubMed/NCBI

39 

Zheng P, Chen X, Xie J, Chen X, Lin S, Ye L, Chen L, Lin J, Yu X and Zheng M: Capn4 is induced by and required for Epstein-Barr virus latent membrane protein 1 promotion of nasopharyngeal carcinoma metastasis through ERK/AP-1 signaling. Cancer Sci. 111:72–83. 2020. View Article : Google Scholar : PubMed/NCBI

40 

Wang Z, Liu G, Mao J, Xie M, Zhao M, Guo X, Liang S, Li H, Li X and Wang R: IGF-1R inhibition suppresses cell proliferation and increases radiosensitivity in nasopharyngeal carcinoma cells. Mediators Inflamm. 2019:54974672019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li M, Chen Y, Liu F, Qu J, Ren L, Chai J and Tang CE: Galectin‑3 facilitates the proliferation and migration of nasopharyngeal carcinoma cells via activation of the ERK1/2 and Akt signaling pathways, and is positively correlated with the inflammatory state of nasopharyngeal carcinoma. Mol Med Rep 23: 370, 2021.
APA
Li, M., Chen, Y., Liu, F., Qu, J., Ren, L., Chai, J., & Tang, C.E. (2021). Galectin‑3 facilitates the proliferation and migration of nasopharyngeal carcinoma cells via activation of the ERK1/2 and Akt signaling pathways, and is positively correlated with the inflammatory state of nasopharyngeal carcinoma. Molecular Medicine Reports, 23, 370. https://doi.org/10.3892/mmr.2021.12009
MLA
Li, M., Chen, Y., Liu, F., Qu, J., Ren, L., Chai, J., Tang, C. E."Galectin‑3 facilitates the proliferation and migration of nasopharyngeal carcinoma cells via activation of the ERK1/2 and Akt signaling pathways, and is positively correlated with the inflammatory state of nasopharyngeal carcinoma". Molecular Medicine Reports 23.5 (2021): 370.
Chicago
Li, M., Chen, Y., Liu, F., Qu, J., Ren, L., Chai, J., Tang, C. E."Galectin‑3 facilitates the proliferation and migration of nasopharyngeal carcinoma cells via activation of the ERK1/2 and Akt signaling pathways, and is positively correlated with the inflammatory state of nasopharyngeal carcinoma". Molecular Medicine Reports 23, no. 5 (2021): 370. https://doi.org/10.3892/mmr.2021.12009
Copy and paste a formatted citation
x
Spandidos Publications style
Li M, Chen Y, Liu F, Qu J, Ren L, Chai J and Tang CE: Galectin‑3 facilitates the proliferation and migration of nasopharyngeal carcinoma cells via activation of the ERK1/2 and Akt signaling pathways, and is positively correlated with the inflammatory state of nasopharyngeal carcinoma. Mol Med Rep 23: 370, 2021.
APA
Li, M., Chen, Y., Liu, F., Qu, J., Ren, L., Chai, J., & Tang, C.E. (2021). Galectin‑3 facilitates the proliferation and migration of nasopharyngeal carcinoma cells via activation of the ERK1/2 and Akt signaling pathways, and is positively correlated with the inflammatory state of nasopharyngeal carcinoma. Molecular Medicine Reports, 23, 370. https://doi.org/10.3892/mmr.2021.12009
MLA
Li, M., Chen, Y., Liu, F., Qu, J., Ren, L., Chai, J., Tang, C. E."Galectin‑3 facilitates the proliferation and migration of nasopharyngeal carcinoma cells via activation of the ERK1/2 and Akt signaling pathways, and is positively correlated with the inflammatory state of nasopharyngeal carcinoma". Molecular Medicine Reports 23.5 (2021): 370.
Chicago
Li, M., Chen, Y., Liu, F., Qu, J., Ren, L., Chai, J., Tang, C. E."Galectin‑3 facilitates the proliferation and migration of nasopharyngeal carcinoma cells via activation of the ERK1/2 and Akt signaling pathways, and is positively correlated with the inflammatory state of nasopharyngeal carcinoma". Molecular Medicine Reports 23, no. 5 (2021): 370. https://doi.org/10.3892/mmr.2021.12009
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