Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
May-2021 Volume 23 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2021 Volume 23 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.xlsx
    • Supplementary_Data3.xlsx
    • Supplementary_Data4.xlsx
    • Supplementary_Data5.xlsx
Article Open Access

Bakkenolide‑IIIa ameliorates lipopolysaccharide‑induced inflammatory injury in human umbilical vein endothelial cells by upregulating LINC00294

  • Authors:
    • Jichong Xu
    • Hao Feng
    • Lin Ma
    • Huaqiao Tan
    • Shuo Yan
    • Chun Fang
  • View Affiliations / Copyright

    Affiliations: Department of Interventional Radiology, Tongji Hospital of Tongji University, Shanghai 200065, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 377
    |
    Published online on: March 17, 2021
       https://doi.org/10.3892/mmr.2021.12016
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Inflammation, which causes injury to vascular endothelial cells, is one of the major factors associated with atherosclerosis (AS); therefore, inhibition of endothelial inflammation is a key step toward preventing AS. The present study aimed to investigate the effects of bakkenolide‑IIIa (Bak‑IIIa), an important active component of bakkenolides, on endothelial inflammation, as well as the mechanisms underlying such effects. Lipopolysaccharide (LPS)‑damaged human umbilical vein endothelial cells (HUVECs) were treated with Bak‑IIIa. The results of the MTT assay and enzyme‑linked immunosorbent assay indicated that Bak‑IIIa significantly alleviated survival inhibition, and decreased the levels of LPS‑induced TNF‑α, interleukin (IL)‑1β, IL‑8, and IL‑6. Furthermore, long noncoding RNA (lncRNA) microarray analyses revealed 70 differentially expressed lncRNAs (DELs) in LPS‑damaged HUVECs treated with Bak‑IIIa. lncRNA target prediction results revealed that 44 DELs had 52 cis‑targets, whereas 12 DELs covered 386 trans‑targets. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes analyses of the trans‑targets indicated that three GO terms were associated with inflammation. Therefore, 17 targets involved in these GO terms and six relevant DELs were screened out. Validation via reverse transcription‑quantitative PCR indicated that the fold change of NR_015451 (LINC00294) was the highest among the six candidates and that overexpression of LINC00294 significantly alleviated LPS‑induced survival inhibition and inflammatory damage in HUVECs. In conclusion, Bak‑IIIa ameliorated LPS‑induced inflammatory damage in HUVECs by upregulating LINC00294. Thus, Bak‑IIIa exhibited potential for preventing vascular inflammation.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Roth GA, Johnson C, Abajobir A, Abd-Allah F, Abera SF, Abyu G, Ahmed M, Aksut B, Alam T, Alam K, et al: Global, regional, and national burden of cardiovascular diseases for 10 causes, 1990 to 2015. J Am Coll Cardiol. 70:1–25. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Wolf MP and Hunziker P: Atherosclerosis: Insights into vascular pathobiology and outlook to novel treatments. J Cardiovasc Transl Res. 13:744–757. 2020. View Article : Google Scholar : PubMed/NCBI

3 

Tabas I, Garcia-Cardeña G and Owens GK: Recent insights into the cellular biology of atherosclerosis. J Cell Biol. 209:13–22. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Libby P, Buring JE, Badimon L, Hansson GK, Deanfield J, Bittencourt MS, Tokgözoğlu L and Lewis EF: Atherosclerosis. Nat Rev Dis Primers. 5:562019. View Article : Google Scholar : PubMed/NCBI

5 

Meng G, Liu Y, Lou C and Yang H: Emodin suppresses lipopolysaccharide-induced pro-inflammatory responses and NF-κB activation by disrupting lipid rafts in CD14-negative endothelial cells. Br J Pharmacol. 161:1628–1644. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Zeng XK, Guan YF, Remick DG and Wang X: Signal pathways underlying homocysteine-induced production of MCP-1 and IL-8 in cultured human whole blood. Acta Pharmacol Sin. 26:85–91. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Moroni F, Ammirati E, Norata GD, Magnoni M and Camici PG: The role of monocytes and macrophages in human atherosclerosis, plaque neoangiogenesis, and atherothrombosis. Mediators Inflamm. 2019:74343762019. View Article : Google Scholar : PubMed/NCBI

8 

Pei L, Dai D, Bao Y, Chen F, Zheng J, Li J, Liu S and Chen X: Determination of bakkenolide A in rat plasma using liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study. J Mass Spectrom. 47:962–968. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Wang YL, Li RP, Guo ML, Zhang G, Zhang N and Ma YL: Bakkenolides from Petasites tricholobus and their neuroprotective effects related to antioxidant activities. Planta Med. 75:230–235. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Jiang Q, Li RP, Tang Y, Wang YQ, Liu C and Guo ML: Bakkenolide-IIIa protects against cerebral damage via inhibiting NF-κB activation. CNS Neurosci Ther. 21:943–952. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Skaper SD, Facci L, Zusso M and Giusti P: An inflammation-centric view of neurological disease: Beyond the neuron. Front Cell Neurosci. 12:722018. View Article : Google Scholar : PubMed/NCBI

12 

Aryal B and Suárez Y: Non-coding RNA regulation of endothelial and macrophage functions during atherosclerosis. Vascul Pharmacol. 114:64–75. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Zhang HN, Xu QQ, Thakur A, Alfred MO, Chakraborty M, Ghosh A and Yu XB: Endothelial dysfunction in diabetes and hypertension: Role of microRNAs and long non-coding RNAs. Life Sci. 213:258–268. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Zhu X, Chen D, Liu Y, Yu J, Qiao L, Lin S, Chen D, Zhong G, Lu X, Wang Y, et al: Long noncoding RNA HOXA-AS3 integrates NF-κB signaling to regulate endothelium inflammation. Mol Cell Biol. 39:e00139–19. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Cao L, Zhang Z, Li Y, Zhao P and Chen Y: LncRNA H19/miR-let-7 axis participates in the regulation of ox-LDL-induced endothelial cell injury via targeting periostin. Int Immunopharmacol. 72:496–503. 2019. View Article : Google Scholar : PubMed/NCBI

16 

Zhu X, Liu Y, Yu J, Du J, Guo R, Feng Y, Zhong G, Jiang Y and Lin J: LncRNA HOXA-AS2 represses endothelium inflammation by regulating the activity of NF-κB signaling. Atherosclerosis. 281:38–46. 2019. View Article : Google Scholar : PubMed/NCBI

17 

Li S, Sun Y, Zhong L, Xiao Z, Yang M, Chen M, Wang C, Xie X and Chen X: The suppression of ox-LDL-induced inflammatory cytokine release and apoptosis of HCAECs by long non-coding RNA-MALAT1 via regulating microRNA-155/SOCS1 pathway. Nutr Metab Cardiovasc Dis. 28:1175–1187. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Casper J, Zweig AS, Villarreal C, Tyner C, Speir ML, Rosenbloom KR, Raney BJ, Lee CM, Lee BT, Karolchik D, et al: The UCSC genome browser database: 2018 update. Nucleic Acids Res. 46D:D762–D769. 2018. View Article : Google Scholar

19 

Tafer H and Hofacker IL: RNAplex: A fast tool for RNA-RNA interaction search. Bioinformatics. 24:2657–2663. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Song L, Kang C, Sun Y, Huang W, Liu W and Qian Z: Crocetin inhibits lipopolysaccharide-induced inflammatory response in human umbilical vein endothelial cells. Cell Physiol Biochem. 40:443–452. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Yin X, Liang Z, Yun Y and Pei L: Intravenous transplantation of BMP2-transduced endothelial progenitor cells attenuates lipopolysaccharide-induced acute lung injury in rats. Cell Physiol Biochem. 35:2149–2158. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Uhlig S, Yang Y, Waade J, Wittenberg C, Babendreyer A and Kuebler WM: Differential regulation of lung endothelial permeability in vitro and in situ. Cell Physiol Biochem. 34:1–19. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Kim JH, Jeong JH, Jeon ST, Kim H, Ock J, Suk K, Kim SI, Song KS and Lee WH: Decursin inhibits induction of inflammatory mediators by blocking nuclear factor-kappaB activation in macrophages. Mol Pharmacol. 69:1783–1790. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Zhang M, Pan H, Xu Y, Wang X, Qiu Z and Jiang L: Allicin decreases lipopolysaccharide-induced oxidative stress and inflammation in human umbilical vein endothelial cells through suppression of mitochondrial dysfunction and activation of Nrf2. Cell Physiol Biochem. 41:2255–2267. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Hou X, Yang S and Yin J: Blocking the REDD1/TXNIP axis ameliorates LPS-induced vascular endothelial cell injury through repressing oxidative stress and apoptosis. Am J Physiol Cell Physiol. 316:C104–C110. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Makó V, Czúcz J, Weiszhár Z, Herczenik E, Matkó J, Prohászka Z and Cervenak L: Proinflammatory activation pattern of human umbilical vein endothelial cells induced by IL-1β, TNF-α, and LPS. Cytometry A. 77:962–970. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Mangoni AA, Zinellu A, Sotgia S, Carru C, Piga M and Erre GL: Protective effects of methotrexate against proatherosclerotic cytokines: A review of the evidence. Mediators Inflamm. 2017:96328462017. View Article : Google Scholar : PubMed/NCBI

29 

Khan R, Rheaume E and Tardif JC: Examining the role of and treatment directed at IL-1β in atherosclerosis. Curr Atheroscler Rep. 20:532018. View Article : Google Scholar : PubMed/NCBI

30 

Kopp F and Mendell JT: Functional classification and experimental dissection of long noncoding RNAs. Cell. 172:393–407. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Marques RE, Guabiraba R, Russo RC and Teixeira MM: Targeting CCL5 in inflammation. Expert Opin Ther Targets. 17:1439–1460. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Nosalski R and Guzik TJ: Perivascular adipose tissue inflammation in vascular disease. Br J Pharmacol. 174:3496–3513. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Gao Y, Zhang J, Li G, Xu H, Yi Y, Wu Q, Song M, Bee YM, Huang L, Tan M, et al: Protection of vascular endothelial cells from high glucose-induced cytotoxicity by emodin. Biochem Pharmacol. 94:39–45. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Sachdev U and Lotze MT: Perpetual change: Autophagy, the endothelium, and response to vascular injury. J Leukoc Biol. 102:221–235. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Cai W, Duan XM, Liu Y, Yu J, Tang YL, Liu ZL, Jiang S, Zhang CP, Liu JY and Xu JX: Uric acid induces endothelial dysfunction by activating the HMGB1/RAGE signaling pathway. Biomed Res Int. 2017:43919202017. View Article : Google Scholar : PubMed/NCBI

36 

Tang ST, Wang F, Shao M, Wang Y and Zhu HQ: MicroRNA-126 suppresses inflammation in endothelial cells under hyperglycemic condition by targeting HMGB1. Vascul Pharmacol. 88:48–55. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Kim WH, Lee JW, Suh YH, Lee HJ, Lee SH, Oh YK, Gao B and Jung MH: AICAR potentiates ROS production induced by chronic high glucose: Roles of AMPK in pancreatic beta-cell apoptosis. Cell Signal. 19:791–805. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Bijland S, Mancini SJ and Salt IP: Role of AMP-activated protein kinase in adipose tissue metabolism and inflammation. Clin Sci (Lond). 124:491–507. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Ewart MA and Kennedy S: AMPK and vasculoprotection. Pharmacol Ther. 131:242–253. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Hu R, Wang MQ, Ni SH, Wang M, Liu LY, You HY, Wu XH, Wang YJ, Lu L and Wei LB: Salidroside ameliorates endothelial inflammation and oxidative stress by regulating the AMPK/NF-κB/NLRP3 signaling pathway in AGEs-induced HUVECs. Eur J Pharmacol. 867:1727972020. View Article : Google Scholar : PubMed/NCBI

41 

Dennhardt S, Finke KR, Huwiler A and Coldewey SM: Sphingosine-1-phosphate promotes barrier-stabilizing effects in human microvascular endothelial cells via AMPK-dependent mechanisms. Biochim Biophys Acta Mol Basis Dis. 1865:774–781. 2019. View Article : Google Scholar : PubMed/NCBI

42 

Gupta SC, Awasthee N, Rai V, Chava S, Gunda V and Challagundla KB: Long non-coding RNAs and nuclear factor-κB crosstalk in cancer and other human diseases. Biochim Biophys Acta Rev Cancer. 1873:1883162020. View Article : Google Scholar : PubMed/NCBI

43 

Castellanos-Rubio A, Kratchmarov R, Sebastian M, Garcia-Etxebarria K, Garcia L, Irastorza I and Ghosh S: Cytoplasmic form of carlr lncRNA facilitates inflammatory gene expression upon NF-κB activation. J Immunol. 199:581–588. 2017. View Article : Google Scholar : PubMed/NCBI

44 

Özeş AR, Miller DF, Özeş ON, Fang F, Liu Y, Matei D, Huang T and Nephew KP: NF-κB-HOTAIR axis links DNA damage response, chemoresistance and cellular senescence in ovarian cancer. Oncogene. 35:5350–5361. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Chen S, Thorne RF, Zhang XD, Wu M and Liu L: Non-coding RNAs, guardians of the p53 galaxy. Semin Cancer Biol. Sep 11–2020.(Epub ahead of print). doi: 10.1016/j.semcancer.2020.09.002. View Article : Google Scholar

46 

Sun CC, Zhu W, Li SJ, Hu W, Zhang J, Zhuo Y, Zhang H, Wang J, Zhang Y, Huang SX, et al: FOXC1-mediated LINC00301 facilitates tumor progression and triggers an immune-suppressing microenvironment in non-small cell lung cancer by regulating the HIF1α pathway. Genome Med. 12:772020. View Article : Google Scholar : PubMed/NCBI

47 

Jung TW, Park HS, Choi GH, Kim D, Ahn SH, Kim DS, Lee T and Jeong JH: Maresin 1 attenuates pro-inflammatory reactions and ER stress in HUVECs via PPARα-mediated pathway. Mol Cell Biochem. 448:335–347. 2018. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xu J, Feng H, Ma L, Tan H, Yan S and Fang C: Bakkenolide‑IIIa ameliorates lipopolysaccharide‑induced inflammatory injury in human umbilical vein endothelial cells by upregulating LINC00294. Mol Med Rep 23: 377, 2021.
APA
Xu, J., Feng, H., Ma, L., Tan, H., Yan, S., & Fang, C. (2021). Bakkenolide‑IIIa ameliorates lipopolysaccharide‑induced inflammatory injury in human umbilical vein endothelial cells by upregulating LINC00294. Molecular Medicine Reports, 23, 377. https://doi.org/10.3892/mmr.2021.12016
MLA
Xu, J., Feng, H., Ma, L., Tan, H., Yan, S., Fang, C."Bakkenolide‑IIIa ameliorates lipopolysaccharide‑induced inflammatory injury in human umbilical vein endothelial cells by upregulating LINC00294". Molecular Medicine Reports 23.5 (2021): 377.
Chicago
Xu, J., Feng, H., Ma, L., Tan, H., Yan, S., Fang, C."Bakkenolide‑IIIa ameliorates lipopolysaccharide‑induced inflammatory injury in human umbilical vein endothelial cells by upregulating LINC00294". Molecular Medicine Reports 23, no. 5 (2021): 377. https://doi.org/10.3892/mmr.2021.12016
Copy and paste a formatted citation
x
Spandidos Publications style
Xu J, Feng H, Ma L, Tan H, Yan S and Fang C: Bakkenolide‑IIIa ameliorates lipopolysaccharide‑induced inflammatory injury in human umbilical vein endothelial cells by upregulating LINC00294. Mol Med Rep 23: 377, 2021.
APA
Xu, J., Feng, H., Ma, L., Tan, H., Yan, S., & Fang, C. (2021). Bakkenolide‑IIIa ameliorates lipopolysaccharide‑induced inflammatory injury in human umbilical vein endothelial cells by upregulating LINC00294. Molecular Medicine Reports, 23, 377. https://doi.org/10.3892/mmr.2021.12016
MLA
Xu, J., Feng, H., Ma, L., Tan, H., Yan, S., Fang, C."Bakkenolide‑IIIa ameliorates lipopolysaccharide‑induced inflammatory injury in human umbilical vein endothelial cells by upregulating LINC00294". Molecular Medicine Reports 23.5 (2021): 377.
Chicago
Xu, J., Feng, H., Ma, L., Tan, H., Yan, S., Fang, C."Bakkenolide‑IIIa ameliorates lipopolysaccharide‑induced inflammatory injury in human umbilical vein endothelial cells by upregulating LINC00294". Molecular Medicine Reports 23, no. 5 (2021): 377. https://doi.org/10.3892/mmr.2021.12016
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team