A novel update on vitamin D in recurrent pregnancy loss (Review)
- Authors:
- Haoyu Zhao
- Xiaoqi Wei
- Xiuhua Yang
-
Affiliations: Department of Hepatobiliary Surgery and Organ Transplant, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Obstetrics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China - Published online on: March 17, 2021 https://doi.org/10.3892/mmr.2021.12021
- Article Number: 382
-
Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
 |
|
Muyayalo KP, Li ZH, Mor G and Liao AH: Modulatory effect of intravenous immunoglobulin on Th17/Treg cell balance in women with unexplained recurrent spontaneous abortion. Am J Reprod Immunol. 80:e130182018. View Article : Google Scholar : PubMed/NCBI | |
|
Chen X, Yin B, Lian RC, Zhang T, Zhang HZ, Diao LH, Li YY, Huang CY, Liang DS and Zeng Y: Modulatory effects of vitamin D on peripheral cellular immunity in patients with recurrent miscarriage. Am J Reprod Immunol. 76:432–438. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Yang X, Yang E, Wang WJ, He Q, Jubiz G, Katukurundage D, Dambaeva S, Beaman K and Kwak-Kim J: Decreased HLA-C1 alleles in couples of KIR2DL2 positive women with recurrent pregnancy loss. J Reprod Immunol. 142:1031862020. View Article : Google Scholar : PubMed/NCBI | |
|
Yan X, Wang L, Yan C, Zhang X, Hui L, Sheng Q, Xue M and Yu X: Decreased expression of the vitamin D receptor in women with recurrent pregnancy loss. Arch Biochem Biophys. 606:128–133. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Jeve YB and Davies W: Evidence-based management of recurrent miscarriages. J Hum Reprod Sci. 7:159–169. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Rand JH, Wu XX, Andree HA, Lockwood CJ, Guller S, Scher J and Harpel PC: Pregnancy loss in the antiphospholipid-antibody syndrome-a possible thrombogenic mechanism. N Engl J Med. 337:154–160. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Mecacci F, Parretti E, Cioni R, Lucchetti R, Magrini A, La Torre P, Mignosa M, Acanfora L and Mello G: Thyroid autoimmunity and its association with non-organ-specific antibodies and subclinical alterations of thyroid function in women with a history of pregnancy loss or preeclampsia. J Reprod Immunol. 46:39–50. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Cavalcante MB, Cavalcante C, Sarno M, da Silva ACB and Barini R: Antinuclear antibodies and recurrent miscarriage: Systematic review and meta-analysis. Am J Reprod Immunol. 83:e132152020. View Article : Google Scholar : PubMed/NCBI | |
|
Sakthiswary R, Rajalingam S, Norazman MR and Hussein H: Antinuclear antibodies predict a higher number of pregnancy loss in unexplained recurrent pregnancy loss. Clin Ter. 166:e98–e101. 2015.PubMed/NCBI | |
|
Kwak JY, Beaman KD, Gilman-Sachs A, Ruiz JE, Schewitz D and Beer AE: Up-regulated expression of CD56+, CD56+/CD16+, and CD19+ cells in peripheral blood lymphocytes in pregnant women with recurrent pregnancy losses. Am J Reprod Immunol. 34:93–99. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Aoki K, Kajiura S, Matsumoto Y, Ogasawara M, Okada S, Yagami Y and Gleicher N: Preconceptional natural-killer-cell activity as a predictor of miscarriage. Lancet. 345:1340–1342. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Yougbaré I, Tai WS, Zdravic D, Oswald BE, Lang S, Zhu G, Leong-Poi H, Qu D, Yu L, Dunk C, et al: Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia. Nat Commun. 8:2242017. View Article : Google Scholar : PubMed/NCBI | |
|
Sasaki Y, Sakai M, Miyazaki S, Higuma S, Shiozaki A and Saito S: Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases. Mol Hum Reprod. 10:347–353. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Stricker RB, Steinleitner A and Winger EE: Intravenous immunoglobulin (IVIG) therapy for immunologic abortion. Clin Appl Immunol Rev. 2:187–199. 2002. View Article : Google Scholar | |
|
Bansal AS, Bajardeen B and Thum MY: The basis and value of currently used immunomodulatory therapies in recurrent miscarriage. J Reprod Immunol. 93:41–51. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Novac N, Baus D, Dostert A and Heinzel T: Competition between glucocorticoid receptor and NFkappaB for control of the human FasL promoter. FASEB J. 20:1074–1081. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Pasquier E, de Saint-Martin L, Marhic G, Chauleur C, Bohec C, Bretelle F, Lejeune-Saada V, Hannigsberg J, Plu-Bureau G, Cogulet V, et al: Hydroxychloroquine for prevention of recurrent miscarriage: Study protocol for a multicentre randomised placebo-controlled trial BBQ study. BMJ Open. 9:e0256492019. View Article : Google Scholar : PubMed/NCBI | |
|
Lee SK, Kim JY, Han AR, Hur SE, Kim CJ, Kim TH, Cho BR, Han JW, Han SG, Na BJ and Kwak-Kim J: Intravenous immunoglobulin G improves pregnancy outcome in women with recurrent pregnancy losses with cellular immune abnormalities. Am J Reprod Immunol. 75:59–68. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Kim DJ, Lee SK, Kim JY, Na BJ, Hur SE, Lee M and Kwak-Kim J: Intravenous immunoglobulin G modulates peripheral blood Th17 and Foxp3(+) regulatory T cells in pregnant women with recurrent pregnancy loss. Am J Reprod Immunol. 71:441–450. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Kwak JY, Quilty EA, Gilman-Sachs A, Beaman KD and Beer AE: Intravenous immunoglobulin infusion therapy in women with recurrent spontaneous abortions of immune etiologies. J Reprod Immunol. 28:175–188. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Han AR, Ahn H, Vu P, Park JC, Gilman-Sachs A, Beaman K and Kwak-Kim J: Obstetrical outcome of anti-inflammatory and anticoagulation therapy in women with recurrent pregnancy loss or unexplained infertility. Am J Reprod Immunol. 68:418–427. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Schwab I and Nimmerjahn F: Intravenous immunoglobulin therapy: How does IgG modulate the immune system? Nat Rev Immunol. 13:176–189. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Hutton B, Sharma R, Fergusson D, Tinmouth A, Hebert P, Jamieson J and Walker M: Use of intravenous immunoglobulin for treatment of recurrent miscarriage: A systematic review. BJOG. 114:134–142. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Panda DK, Miao D, Tremblay ML, Sirois J, Farookhi R, Hendy GN and Goltzman D: Targeted ablation of the 25-hydroxyvitamin D 1alpha-hydroxylase enzyme: Evidence for skeletal, reproductive, and immune dysfunction. Proc Natl Acad Sci USA. 98:7498–7503. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Brannon PM: Vitamin D and adverse pregnancy outcomes: Beyond bone health and growth. Proc Nutr Soc. 71:205–212. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Mora JR, Iwata M and von Andrian UH: Vitamin effects on the immune system: Vitamins A and D take centre stage. Nat Rev Immunol. 8:685–698. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Ota K, Dambaeva S, Kim MW, Han AR, Fukui A, Gilman-Sachs A, Beaman K and Kwak-Kim J: 1,25-dihydroxy-vitamin D3 regulates NK-cell cytotoxicity, cytokine secretion, and degranulation in women with recurrent pregnancy losses. Eur J Immunol. 45:3188–3199. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Mulligan ML, Felton SK, Riek AE and Bernal-Mizrachi C: Implications of vitamin D deficiency in pregnancy and lactation. Am J Obstet Gynecol. 202:429.e1–e9. 2010. View Article : Google Scholar | |
|
Ota K, Dambaeva S, Han AR, Beaman K, Gilman-Sachs A and Kwak-Kim J: Vitamin D deficiency may be a risk factor for recurrent pregnancy losses by increasing cellular immunity and autoimmunity. Hum Reprod. 29:208–219. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Lee SK, Na BJ, Kim JY, Hur SE, Lee M, Gilman-Sachs A and Kwak-Kim J: Determination of clinical cellular immune markers in women with recurrent pregnancy loss. Am J Reprod Immunol. 70:398–411. 2013.PubMed/NCBI | |
|
Fukui A, Kwak-Kim J, Ntrivalas E, Gilman-Sachs A, Lee SK and Beaman K: Intracellular cytokine expression of peripheral blood natural killer cell subsets in women with recurrent spontaneous abortions and implantation failures. Fertil Steril. 89:157–165. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Ford HB and Schust DJ: Recurrent pregnancy loss: Etiology, diagnosis, and therapy. Rev Obstet Gynecol. 2:76–83. 2009.PubMed/NCBI | |
|
Tavakoli M, Jeddi-Tehrani M, Salek-Moghaddam A, Rajaei S, Mohammadzadeh A, Sheikhhasani S, Kazemi-Sefat GE and Zarnani AH: Effects of 1,25(OH)2 vitamin D3 on cytokine production by endometrial cells of women with recurrent spontaneous abortion. Fertil Steril. 96:751–757. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Lagana AS, Vitale SG, Ban Frangez H, Vrtacnik-Bokal E and D'Anna R: Vitamin D in human reproduction: The more, the better? An evidence-based critical appraisal. Eur Rev Med Pharmacol Sci. 21:4243–4251. 2017.PubMed/NCBI | |
|
Chighizola CB, de Jesus GR and Branch DW: The hidden world of anti-phospholipid antibodies and female infertility: A literature appraisal. Autoimmun Rev. 15:493–500. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Cyprian F, Lefkou E, Varoudi K and Girardi G: Immunomodulatory effects of Vitamin D in pregnancy and beyond. Front Immunol. 10:27392019. View Article : Google Scholar : PubMed/NCBI | |
|
Carp HJ and Shoenfeld Y: Anti-phospholipid antibodies and infertility. Clin Rev Allergy Immunol. 32:159–161. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Redecha P, Franzke CW, Ruf W, Mackman N and Girardi G: Neutrophil activation by the tissue factor/Factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndrome. J Clin Invest. 118:3453–3461. 2008.PubMed/NCBI | |
|
Tobaldini LQ, Arantes FT, Saraiva SDS, Mazetto BM, Colella MP, de Paula EV, Annichino-Bizzachi J and Orsi FA: Circulating levels of tissue factor and the risk of thrombosis associated with antiphospholipid syndrome. Thromb Res. 171:114–120. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Tedesco F, Borghi MO, Gerosa M, Chighizola CB, Macor P, Lonati PA, Gulino A, Belmonte B and Meroni PL: Pathogenic role of complement in antiphospholipid syndrome and therapeutic implications. Front Immunol. 9:13882018. View Article : Google Scholar : PubMed/NCBI | |
|
Oku K, Atsumi T, Bohgaki M, Amengual O, Kataoka H, Horita T, Yasuda S and Koike T: Complement activation in patients with primary antiphospholipid syndrome. Ann Rheum Dis. 68:1030–1035. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Breen KA, Seed P, Parmar K, Moore GW, Stuart-Smith SE and Hunt BJ: Complement activation in patients with isolated antiphospholipid antibodies or primary antiphospholipid syndrome. Thromb Haemost. 107:423–429. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
De Carolis S, Botta A, Santucci S, Salvi S, Moresi S, Di Pasquo E, Del Sordo G and Martino C: Complementemia and obstetric outcome in pregnancy with antiphospholipid syndrome. Lupus. 21:776–778. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Reggia R, Ziglioli T, Andreoli L, Bellisai F, Iuliano A, Gerosa M, Ramoni V, Tani C, Brucato A, Galeazzi M, et al: Primary anti-phospholipid syndrome: Any role for serum complement levels in predicting pregnancy complications? Rheumatology (Oxford). 51:2186–2190. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Girardi G, Berman J, Redecha P, Spruce L, Thurman JM, Kraus D, Hollmann TJ, Casali P, Caroll MC, Wetsel RA, et al: Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. J Clin Invest. 112:1644–1654. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Redecha P, Tilley R, Tencati M, Salmon JE, Kirchhofer D, Mackman N and Girardi G: Tissue factor: A link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury. Blood. 110:2423–2431. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Izban MG, Nowicki BJ and Nowicki S: 1,25-Dihydroxyvitamin D3 promotes a sustained LPS-induced NF-κB-dependent expression of CD55 in human monocytic THP-1 cells. PLoS One. 7:e493182012. View Article : Google Scholar : PubMed/NCBI | |
|
Agmon-Levin N, Blank M, Zandman-Goddard G, Orbach H, Meroni PL, Tincani A, Doria A, Cervera R, Miesbach W, Stojanovich L, et al: Vitamin D: An instrumental factor in the anti-phospholipid syndrome by inhibition of tissue factor expression. Ann Rheum Dis. 70:145–150. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
van den Hoogen LL, van Roon JA, Radstake TR, Fritsch-Stork RD and Derksen RH: Delineating the deranged immune system in the antiphospholipid syndrome. Autoimmun Rev. 15:50–60. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Martinez-Moreno JM, Herencia C, Montes de Oca A, Muñoz-Castañeda JR, Rodríguez-Ortiz ME, Díaz-Tocados JM, Peralbo-Santaella E, Camargo A, Canalejo A, Rodriguez M, et al: Vitamin D modulates tissue factor and protease-activated receptor 2 expression in vascular smooth muscle cells. FASEB J. 30:1367–1376. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Santos TDS, Ieque AL, de Carvalho HC, Sell AM, Lonardoni MVC, Demarchi IG, de Lima Neto QA and Teixeira JJV: Antiphospholipid syndrome and recurrent miscarriage: A systematic review and meta-analysis. J Reprod Immunol. 123:78–87. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Matalon ST, Blank M, Ornoy A and Shoenfeld Y: The association between anti-thyroid antibodies and pregnancy loss. Am J Reprod Immunol. 45:72–77. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Poppe K, Velkeniers B and Glinoer D: Thyroid disease and female reproduction. Clin Endocrinol. 66:309–321. 2007. View Article : Google Scholar | |
|
Kivity S, Agmon-Levin N, Zisappl M, Shapira Y, Nagy EV, Dankó K, Szekanecz Z, Langevitz P and Shoenfeld Y: Vitamin D and autoimmune thyroid diseases. Cell Mol Immunol. 8:243–247. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
D'Aurizio F, Villalta D, Metus P, Doretto P and Tozzoli R: Is vitamin D a player or not in the pathophysiology of autoimmune thyroid diseases? Autoimmun Rev. 14:363–369. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Shin DY, Kim KJ, Kim D, Hwang S and Lee EJ: Low serum vitamin D is associated with anti-thyroid peroxidase antibody in autoimmune thyroiditis. Yonsei Med J. 55:476–481. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Bhattacharyya R, Mukherjee K, Das A, Biswas MR, Basunia SR and Mukherjee A: Anti-thyroid peroxidase antibody positivity during early pregnancy is associated with pregnancy complications and maternal morbidity in later life. J Nat Sci Biol Med. 6:402–405. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Ozkan S, Jindal S, Greenseid K, Shu J, Zeitlian G, Hickmon C and Pal L: Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertil Steril. 94:1314–1319. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Daftary GS and Taylor HS: Endocrine regulation of HOX genes. Endocrine Rev. 27:331–355. 2006. View Article : Google Scholar | |
|
Cippitelli M and Santoni A: Vitamin D3: A transcriptional modulator of the interferon-gamma gene. Eur J Immunol. 28:3017–3030. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Takeuchi A, Reddy GS, Kobayashi T, Okano T, Park J and Sharma S: Nuclear factor of activated T cells (NFAT) as a molecular target for 1alpha,25-dihydroxyvitamin D3-mediated effects. J Immunol. 160:209–218. 1998.PubMed/NCBI | |
|
van Etten E and Mathieu C: Immunoregulation by 1,25-dihydroxyvitamin D3: Basic concepts. J Steroid Biochem Mol Biol. 97:93–101. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Piccinni MP, Scaletti C, Maggi E and Romagnani S: Role of hormone-controlled Th1- and Th2-type cytokines in successful pregnancy. J Neuroimmunol. 109:30–33. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Adams JS and Hewison M: Unexpected actions of vitamin D: New perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab. 4:80–90. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Boonstra A, Barrat FJ, Crain C, Heath VL, Savelkoul HF and O'Garra A: 1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells. J Immunol. 167:4974–4980. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Overbergh L, Decallonne B, Waer M, Rutgeerts O, Valckx D, Casteels KM, Laureys J, Bouillon R and Mathieu C: 1alpha,25-dihydroxyvitamin D3 induces an autoantigen-specific T-helper 1/T-helper 2 immune shift in NOD mice immunized with GAD65 (p524-543). Diabetes. 49:1301–1307. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Gonçalves DR, Braga A, Braga J and Marinho A: Recurrent pregnancy loss and vitamin D: A review of the literature. Am J Reprod Immunol. 80:e130222018. View Article : Google Scholar : PubMed/NCBI | |
|
Peterson CA and Heffernan ME: Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy women. J Inflamm (Lond). 5:102008. View Article : Google Scholar : PubMed/NCBI | |
|
Abdollahi E, Saghafi N, Rezaee SA, Rastin M, Jarahi L, Clifton V and Rafatpanah H: Evaluation of 1,25(OH)2D3 Effects on FOXP3, ROR-γt, GITR, and CTLA-4 Gene expression in the PBMCs of Vitamin D-Deficient Women with unexplained recurrent pregnancy loss (URPL). Iran Biomed J. 24:295–305. 2020.PubMed/NCBI | |
|
Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH and Weaver CM; Endocrine Society, : Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 96:1911–1930. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Jeffery LE, Burke F, Mura M, Zheng Y, Qureshi OS, Hewison M, Walker LS, Lammas DA, Raza K and Sansom DM: 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. J Immunol. 183:5458–5467. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Ibrahim ZM, madany EH, Abdel Aal RM and El Biely MM: Role of 1,25-dihydroxyvitamin D (vitamin D3) as immunomodulator in recurrent missed miscarriage. Middle East Fertility Soc J. 18:171–176. 2013. View Article : Google Scholar | |
|
Figueiredo AS and Schumacher A: The T helper type 17/regulatory T cell paradigm in pregnancy. Immunology. 148:13–21. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Vijayendra Chary A, Hemalatha R, Seshacharyulu M, Vasudeva Murali M, Jayaprakash D and Dinesh Kumar B: Vitamin D deficiency in pregnant women impairs regulatory T cell function. J Steroid Biochem Mol Biol. 147:48–55. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Abdollahi E, Rezaee R, Saghafi N, Rastin M, Clifton V, Sahebkar A and Rafatpanah H: Evaluation of the effects of 1,25 vitamin D3 on regulatory T cells and T helper 17 cells in Vitamin D-deficient women with unexplained recurrent pregnancy loss. Curr Mol Pharmacol. 13:306–317. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Ji J, Zhai H, Zhou H, Song S, Mor G and Liao A: The role and mechanism of vitamin D-mediated regulation of Treg/Th17 balance in recurrent pregnancy loss. Am J Reprod Immunol. 81:e131122019. View Article : Google Scholar : PubMed/NCBI | |
|
Rafiee M, Gharagozloo M, Ghahiri A, Mehrabian F, Maracy MR, Kouhpayeh S, Pieper IL and Rezaei A: Altered Th17/Treg ratio in recurrent miscarriage after treatment with paternal lymphocytes and Vitamin D3: A Double-blind placebo-controlled study. Iran J Immunol. 12:252–262. 2015.PubMed/NCBI | |
|
Li N, Wu HM, Hang F, Zhang YS and Li MJ: Women with recurrent spontaneous abortion have decreased 25(OH) vitamin D and VDR at the fetal-maternal interface. Braz J Med Biol Res. 50:e65272017. View Article : Google Scholar : PubMed/NCBI | |
|
Samimi M, Foroozanfard F, Amini F and Sehat M: Effect of Vitamin D supplementation on unexplained recurrent spontaneous abortion: A double-blind randomized controlled trial. Global J Health Sci. 9:95–102. 2017. View Article : Google Scholar | |
|
Yang X, Gilman-Sachs A and Kwak-Kim J: Ovarian and endometrial immunity during the ovarian cycle. J Reprod Immunol. 133:7–14. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Scarpellini F and Sbracia M: Use of granulocyte colony-stimulating factor for the treatment of unexplained recurrent miscarriage: A randomised controlled trial. Hum Reprod. 24:2703–2708. 2009. View Article : Google Scholar : PubMed/NCBI |
