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ASMq protects against early burn wound progression in rats by alleviating oxidative stress and secondary mitochondria‑associated apoptosis via the Erk/p90RSK/Bad pathway

  • Authors:
    • Hanlei Zhou
    • Quan Fang
    • Nan Li
    • Meirong Yu
    • Hongming Chen
    • Songxue Guo
  • View Affiliations / Copyright

    Affiliations: Department of Vascular Surgery, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China, Department of Plastic Surgery, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China, Clinical Research Center, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China, Department of Plastic Surgery, International Medical Center of The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 390
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    Published online on: March 22, 2021
       https://doi.org/10.3892/mmr.2021.12029
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Abstract

Burn wounds present an evolutionary progression, in which the initial wound tissue deepens and expands following thermal injury. Progressive tissue damage in the zone of stasis may worsen burn injury, which is associated with oxidative stress and secondary apoptosis, and worsen the prognosis of patients with burn wounds. The mitochondrial apoptotic pathway is involved in receiving oxidative signals and regulating tissue apoptosis. Previously, Abnormal Savda Munziq (ASMq), a natural compound of traditional Uyghur Medicine, which includes ten types of herb, has been reported to exhibit a number of effects, including anti‑inflammatory, antioxidative and anti‑apoptotic activities. The present study demonstrated that ASMq protected against early burn wound progression following thermal injury in rats; this effect may be mediated by its ability to attenuate oxidative stress‑induced mitochondria‑associated apoptosis. The present study may provide a novel therapeutic method to prevent early burn wound progression following burn injury.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou H, Fang Q, Li N, Yu M, Chen H and Guo S: ASMq protects against early burn wound progression in rats by alleviating oxidative stress and secondary mitochondria‑associated apoptosis via the Erk/p90RSK/Bad pathway. Mol Med Rep 23: 390, 2021.
APA
Zhou, H., Fang, Q., Li, N., Yu, M., Chen, H., & Guo, S. (2021). ASMq protects against early burn wound progression in rats by alleviating oxidative stress and secondary mitochondria‑associated apoptosis via the Erk/p90RSK/Bad pathway. Molecular Medicine Reports, 23, 390. https://doi.org/10.3892/mmr.2021.12029
MLA
Zhou, H., Fang, Q., Li, N., Yu, M., Chen, H., Guo, S."ASMq protects against early burn wound progression in rats by alleviating oxidative stress and secondary mitochondria‑associated apoptosis via the Erk/p90RSK/Bad pathway". Molecular Medicine Reports 23.5 (2021): 390.
Chicago
Zhou, H., Fang, Q., Li, N., Yu, M., Chen, H., Guo, S."ASMq protects against early burn wound progression in rats by alleviating oxidative stress and secondary mitochondria‑associated apoptosis via the Erk/p90RSK/Bad pathway". Molecular Medicine Reports 23, no. 5 (2021): 390. https://doi.org/10.3892/mmr.2021.12029
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou H, Fang Q, Li N, Yu M, Chen H and Guo S: ASMq protects against early burn wound progression in rats by alleviating oxidative stress and secondary mitochondria‑associated apoptosis via the Erk/p90RSK/Bad pathway. Mol Med Rep 23: 390, 2021.
APA
Zhou, H., Fang, Q., Li, N., Yu, M., Chen, H., & Guo, S. (2021). ASMq protects against early burn wound progression in rats by alleviating oxidative stress and secondary mitochondria‑associated apoptosis via the Erk/p90RSK/Bad pathway. Molecular Medicine Reports, 23, 390. https://doi.org/10.3892/mmr.2021.12029
MLA
Zhou, H., Fang, Q., Li, N., Yu, M., Chen, H., Guo, S."ASMq protects against early burn wound progression in rats by alleviating oxidative stress and secondary mitochondria‑associated apoptosis via the Erk/p90RSK/Bad pathway". Molecular Medicine Reports 23.5 (2021): 390.
Chicago
Zhou, H., Fang, Q., Li, N., Yu, M., Chen, H., Guo, S."ASMq protects against early burn wound progression in rats by alleviating oxidative stress and secondary mitochondria‑associated apoptosis via the Erk/p90RSK/Bad pathway". Molecular Medicine Reports 23, no. 5 (2021): 390. https://doi.org/10.3892/mmr.2021.12029
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