Role of C14orf166 in viral infection and RNA metabolism and its relationship with cancer (Review)

  • Authors:
    • Qiangxing Chen
    • Rong Li
  • View Affiliations

  • Published online on: March 26, 2021     https://doi.org/10.3892/mmr.2021.12039
  • Article Number: 400
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Chromosome 14 open reading frame 166 (C14orf166) encodes a 28‑kDa nuclear and cytoplasmic protein that is involved in viral infection, RNA metabolism, and centrosome structure. It binds to the polymerase acidic protein subunit of the influenza A virus, which is associated with several transcription factors, RNA polymerase II, to activate transcription initiation and promote virus infection. It also interacts with a mature hepatitis C virus core protein to regulate the infection process. In physiological conditions, C14orf166 associates with the proteins, DDX1, HSPC117 and FAM98B, and regulates RNA metabolism and fate. In addition, C14orf166 is overexpressed in a variety of cancer types. Upregulation of C14orf166 may contribute toward cancer malignancy through its impact on glycogen synthase kinase 3β‑mediated signaling, the downregulation of retinoblastoma protein, or the upregulation of IL‑6. Therefore, C14orf166 could be used as a biomarker for the diagnosis and prognosis of various cancer types. This review summarized the existent literature about C14orf166, focusing on its functions in physiological and pathological situations.
View Figures
View References

Related Articles

Journal Cover

June-2021
Volume 23 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Chen Q and Chen Q: Role of C14orf166 in viral infection and RNA metabolism and its relationship with cancer (Review). Mol Med Rep 23: 400, 2021
APA
Chen, Q., & Chen, Q. (2021). Role of C14orf166 in viral infection and RNA metabolism and its relationship with cancer (Review). Molecular Medicine Reports, 23, 400. https://doi.org/10.3892/mmr.2021.12039
MLA
Chen, Q., Li, R."Role of C14orf166 in viral infection and RNA metabolism and its relationship with cancer (Review)". Molecular Medicine Reports 23.6 (2021): 400.
Chicago
Chen, Q., Li, R."Role of C14orf166 in viral infection and RNA metabolism and its relationship with cancer (Review)". Molecular Medicine Reports 23, no. 6 (2021): 400. https://doi.org/10.3892/mmr.2021.12039