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Review

Role of C14orf166 in viral infection and RNA metabolism and its relationship with cancer (Review)

  • Authors:
    • Qiangxing Chen
    • Rong Li
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The Second Xiangya Hospital, Changsha, Hunan 410011, P.R. China
  • Article Number: 400
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    Published online on: March 26, 2021
       https://doi.org/10.3892/mmr.2021.12039
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Abstract

Chromosome 14 open reading frame 166 (C14orf166) encodes a 28‑kDa nuclear and cytoplasmic protein that is involved in viral infection, RNA metabolism, and centrosome structure. It binds to the polymerase acidic protein subunit of the influenza A virus, which is associated with several transcription factors, RNA polymerase II, to activate transcription initiation and promote virus infection. It also interacts with a mature hepatitis C virus core protein to regulate the infection process. In physiological conditions, C14orf166 associates with the proteins, DDX1, HSPC117 and FAM98B, and regulates RNA metabolism and fate. In addition, C14orf166 is overexpressed in a variety of cancer types. Upregulation of C14orf166 may contribute toward cancer malignancy through its impact on glycogen synthase kinase 3β‑mediated signaling, the downregulation of retinoblastoma protein, or the upregulation of IL‑6. Therefore, C14orf166 could be used as a biomarker for the diagnosis and prognosis of various cancer types. This review summarized the existent literature about C14orf166, focusing on its functions in physiological and pathological situations.
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1 

Elvira G, Wasiak S, Blandford V, Tong XK, Serrano A, Fan X, del Rayo Sánchez-Carbente M, Servant F, Bell AW, Boismenu D, et al: Characterization of an RNA granule from developing brain. Mol Cell Proteomics. 5:635–651. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Kanai Y, Dohmae N and Hirokawa N: Kinesin transports RNA: Isolation and characterization of an RNA-transporting granule. Neuron. 43:513–525. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Howng SL, Hsu HC, Cheng TS, Lee YL, Chang LK, Lu PJ and Hong YR: A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors. FEBS Lett. 566:162–168. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Wang J, Gu Y, Wang L, Hang X, Gao Y, Wang H and Zhang C: HUPO BPP pilot study: A proteomics analysis of the mouse brain of different developmental stages. Proteomics. 7:4008–4015. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Rappsilber J, Ryder U, Lamond AI and Mann M: Large-scale proteomic analysis of the human spliceosome. Genome Res. 12:1231–1245. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Popow J, Englert M, Weitzer S, Schleiffer A, Mierzwa B, Mechtler K, Trowitzsch S, Will CL, Lührmann R, Söll D and Martinez J: HSPC117 is the essential subunit of a human tRNA splicing ligase complex. Science. 331:760–764. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Jeronimo C, Forget D, Bouchard A, Li Q, Chua G, Poitras C, Thérien C, Bergeron D, Bourassa S, Greenblatt J, et al: Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Mol Cell. 27:262–274. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Lupi I, Broman KW, Tzou SC, Gutenberg A, Martino E and Caturegli P: Novel autoantigens in autoimmune hypophysitis. Clin Endocrinol (Oxf). 69:269–278. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Uemura M, Nouso K, Kobayashi Y, Tanaka H, Nakamura S, Higashi T, Ono T, Nakayama E, Hanafusa T and Shiratori Y: Identification of the antigens predominantly reacted with serum from patients with hepatocellular carcinoma. Cancer. 97:2474–2479. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Zhao X, Wang Y, Cui Q, Li P, Wang L, Chen Z, Rong L and Du R: A parallel phenotypic versus Target-Based screening strategy for RNA-Dependent RNA polymerase inhibitors of the influenza A Virus. Viruses. 11:8262019. View Article : Google Scholar

11 

Isel C, Munier S and Naffakh N: Experimental approaches to study genome packaging of influenza A Viruses. Viruses. 8:2182016. View Article : Google Scholar

12 

Ghorbani A, Ngunjiri JM and Lee CW: Influenza A Virus subpopulations and their implication in pathogenesis and vaccine development. Annu Rev Anim Biosci. 8:247–267. 2020. View Article : Google Scholar : PubMed/NCBI

13 

Eisfeld AJ, Neumann G and Kawaoka Y: At the centre: Influenza A virus ribonucleoproteins. Nat Rev Microbiol. 13:28–41. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Ma X, Xie L, Wartchow C, Warne R, Xu Y, Rivkin A, Tully D, Shia S, Uehara K, Baldwin DM, et al: Structural basis for therapeutic inhibition of influenza A polymerase PB2 subunit. Sci Rep. 7:93852017. View Article : Google Scholar : PubMed/NCBI

15 

Tomescu AI, Robb NC, Hengrung N, Fodor E and Kapanidis AN: Single-molecule FRET reveals a corkscrew RNA structure for the polymerase-bound influenza virus promoter. Proc Natl Acad Sci USA. 111:E3335–E3342. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Noshi T, Kitano M, Taniguchi K, Yamamoto A, Omoto S, Baba K, Hashimoto T, Ishida K, Kushima Y, Hattori K, et al: In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit. Antiviral Res. 160:109–117. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Zheng W, Li J, Wang S, Cao S, Jiang J, Chen C, Ding C, Qin C, Ye X, Gao GF and Liu W: Phosphorylation controls the nuclear-cytoplasmic shuttling of influenza A virus nucleoprotein. J Virol. 89:5822–5834. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Wu CY, Jeng KS and Lai MM: The SUMOylation of matrix protein M1 modulates the assembly and morphogenesis of influenza A virus. J Virol. 85:6618–6628. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Reuther P, Giese S, Götz V, Riegger D and Schwemmle M: Phosphorylation of highly conserved serine residues in the influenza A virus nuclear export protein NEP plays a minor role in viral growth in human cells and mice. J Virol. 88:7668–7673. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Zhou YW, Li R, Duan CJ, Gao Y, Cheng YD, He ZW, Zeng JX and Zhang CF: Expression and clinical significance of C14orf166 in esophageal squamous cell carcinoma. Mol Med Rep. 15:605–612. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Rodriguez A, Pérez-González A and Nieto A: Cellular human CLE/C14orf166 protein interacts with influenza virus polymerase and is required for viral replication. J Virol. 85:12062–12066. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Tafforeau L, Chantier T, Pradezynski F, Pellet J, Mangeot PE, Vidalain PO, Andre P, Rabourdin-Combe C and Lotteau V: Generation and comprehensive analysis of an influenza virus polymerase cellular interaction network. J Virol. 85:13010–13018. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Pérez-González A, Rodriguez A, Huarte M, Salanueva IJ and Nieto A: hCLE/CGI-99, a human protein that interacts with the influenza virus polymerase, is a mRNA transcription modulator. J Mol Biol. 362:887–900. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Rodriguez-Frandsen A, de Lucas S, Pérez-González A, Pérez-Cidoncha M, Roldan-Gomendio A, Pazo A, Marcos-Villar L, Landeras-Bueno S, Ortín J and Nieto A: hCLE/C14orf166, a cellular protein required for viral replication, is incorporated into influenza virus particles. Sci Rep. 6:207442016. View Article : Google Scholar : PubMed/NCBI

25 

Lee JW, Liao PC, Young KC, Chang CL, Chen SS, Chang TT, Lai MD and Wang SW: Identification of hnRNPH1, NF45, and C14orf166 as novel host interacting partners of the mature hepatitis C virus core protein. J Proteome Res. 10:4522–4534. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Emmott E, Munday D, Bickerton E, Britton P, Rodgers MA, Whitehouse A, Zhou EM and Hiscox JA: The cellular interactome of the coronavirus infectious bronchitis virus nucleocapsid protein and functional implications for virus biology. J Virol. 87:9486–9500. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Kula A, Guerra J, Knezevich A, Kleva D, Myers MP and Marcello A: Characterization of the HIV-1 RNA associated proteome identifies Matrin 3 as a nuclear cofactor of Rev function. Retrovirology. 8:602011. View Article : Google Scholar : PubMed/NCBI

28 

Amiel J, Rio M, de Pontual L, Redon R, Malan V, Boddaert N, Plouin P, Carter NP, Lyonnet S, Munnich A and Colleaux L: Mutations in TCF4, encoding a class I basic helix-loop-helix transcription factor, are responsible for Pitt-Hopkins syndrome, a severe epileptic encephalopathy associated with autonomic dysfunction. Am J Hum Genet. 80:988–993. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Fukuda A, Shimada M, Nakadai T, Nishimura K and Hisatake K: Heterogeneous nuclear ribonucleoprotein R cooperates with mediator to facilitate transcription reinitiation on the c-Fos gene. PLoS One. 8:e724962013. View Article : Google Scholar : PubMed/NCBI

30 

Makise M, Mackay DR, Elgort S, Shankaran SS, Adam SA and Ullman KS: The Nup153-Nup50 protein interface and its role in nuclear import. J Biol Chem. 287:38515–38522. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Cheang TY, Zhou HY, Chen W, Zhang B, Liu L, Yang J, Wang S and Li H: C14orf166 overexpression correlates with tumor progression and poor prognosis of breast cancer. J Transl Med. 14:542016. View Article : Google Scholar : PubMed/NCBI

32 

Chen HC, Lin WC, Tsay YG, Lee SC and Chang CJ: An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K. J Biol Chem. 277:40403–40409. 2002. View Article : Google Scholar : PubMed/NCBI

33 

Robertson-Anderson RM, Wang J, Edgcomb SP, Carmel AB, Williamson JR and Millar DP: Single-molecule studies reveal that DEAD box protein DDX1 promotes oligomerization of HIV-1 Rev on the Rev response element. J Mol Biol. 410:959–971. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Pérez-González A, Pazo A, Navajas R, Ciordia S, Rodriguez-Frandsen A and Nieto A: hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex. PLoS One. 9:e909572014. View Article : Google Scholar : PubMed/NCBI

35 

Pazo A, Pérez-González A, Oliveros JC, Huarte M, Chavez JP and Nieto A: hCLE/RTRAF-HSPC117-DDX1-FAM98B: A new Cap-Binding complex that activates mRNA Translation. Front Physiol. 10:922019. View Article : Google Scholar : PubMed/NCBI

36 

Freibaum BD, Chitta RK, High AA and Taylor JP: Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. J Proteome Res. 9:1104–1120. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Thakkar S, Sharma D, Kalia K and Tekade RK: Tumor microenvironment targeted nanotherapeutics for cancer therapy and diagnosis: A review. Acta Biomater. 101:43–68. 2020. View Article : Google Scholar : PubMed/NCBI

38 

Jacobs KM, Bhave SR, Ferraro DJ, Jaboin JJ, Hallahan DE and Thotala D: GSK-3β: A bifunctional role in cell death pathways. Int J Cell Biol. 2012:9307102012. View Article : Google Scholar : PubMed/NCBI

39 

Yu H, Pardoll D and Jove R: STATs in cancer inflammation and immunity: A leading role for STAT3. Nat Rev Cancer. 9:798–809. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Zhang W, Ou J, Lei F, Hou T, Wu S, Niu C, Xu L and Zhang Y: C14ORF166 overexpression is associated with pelvic lymph node metastasis and poor prognosis in uterine cervical cancer. Tumour Biol. 37:369–379. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Chen M, Ye Y, Zou B, Guo S, Zhou F, Lu K, Liu J, Xu Z, Han H, Liu Z, et al: C14orf166 is a high-risk biomarker for bladder cancer and promotes bladder cancer cell proliferation. J Transl Med. 14:552016. View Article : Google Scholar : PubMed/NCBI

42 

Yang L, Li F, Lei F, Wang Y, Wu S, Song L and Chen Y: Overexpression of chromosome 14 open reading frame 166 correlates with disease progression and poorer prognosis in human NPC. Tumour Biol. 36:7977–7986. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Wang H, Sun L, Jiang J, Yu S and Zhou Q: Suppression of the proliferation and invasion of breast cancer cells by ST7L occurs through inhibition of activation of Wnt/GSK-3β/β-catenin signalling. Clin Exp Pharmacol Physiol. 47:119–126. 2020. View Article : Google Scholar : PubMed/NCBI

44 

Jain S, Ghanghas P, Rana C and Sanyal SN: Role of GSK-3β in Regulation of Canonical Wnt/β-catenin Signaling and PI3-K/Akt oncogenic pathway in colon cancer. Cancer Invest. 35:473–483. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Chen X, Ying Z, Lin X, Lin H, Wu J, Li M and Song L: Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells. J Clin Invest. 123:2576–2589. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Aryappalli P, Shabbiri K, Masad RJ, Al-Marri RH, Haneefa SM, Mohamed YA, Arafat K, Attoub S, Cabral-Marques O, Ramadi KB, et al: Inhibition of Tyrosine-Phosphorylated STAT3 in human breast and lung cancer cells by Manuka Honey is mediated by selective antagonism of the IL-6 Receptor. Int J Mol Sci. 20:43402019. View Article : Google Scholar

47 

Lin C, Liao W, Jian Y, Peng Y, Zhang X, Ye L, Cui Y, Wang B, Wu X, Xiong Z, et al: CGI-99 promotes breast cancer metastasis via autocrine interleukin-6 signaling. Oncogene. 36:3695–3705. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Cui Y, Wu J, Zong M, Song G, Jia Q, Jiang J and Han J: Proteomic profiling in pancreatic cancer with and without lymph node metastasis. Int J Cancer. 124:1614–1621. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Chen J, Chen J, Gong Y, Zou B, Liu X, Ding L, Huang J, Zhang B and Li J: C14orf166 Is a biomarker for predicting hepatocellular carcinoma recurrence. J Invest Surgery. 33:914–923. 2020. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Chen Q and Li R: Role of C14orf166 in viral infection and RNA metabolism and its relationship with cancer (Review). Mol Med Rep 23: 400, 2021.
APA
Chen, Q., & Li, R. (2021). Role of C14orf166 in viral infection and RNA metabolism and its relationship with cancer (Review). Molecular Medicine Reports, 23, 400. https://doi.org/10.3892/mmr.2021.12039
MLA
Chen, Q., Li, R."Role of C14orf166 in viral infection and RNA metabolism and its relationship with cancer (Review)". Molecular Medicine Reports 23.6 (2021): 400.
Chicago
Chen, Q., Li, R."Role of C14orf166 in viral infection and RNA metabolism and its relationship with cancer (Review)". Molecular Medicine Reports 23, no. 6 (2021): 400. https://doi.org/10.3892/mmr.2021.12039
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Q and Li R: Role of C14orf166 in viral infection and RNA metabolism and its relationship with cancer (Review). Mol Med Rep 23: 400, 2021.
APA
Chen, Q., & Li, R. (2021). Role of C14orf166 in viral infection and RNA metabolism and its relationship with cancer (Review). Molecular Medicine Reports, 23, 400. https://doi.org/10.3892/mmr.2021.12039
MLA
Chen, Q., Li, R."Role of C14orf166 in viral infection and RNA metabolism and its relationship with cancer (Review)". Molecular Medicine Reports 23.6 (2021): 400.
Chicago
Chen, Q., Li, R."Role of C14orf166 in viral infection and RNA metabolism and its relationship with cancer (Review)". Molecular Medicine Reports 23, no. 6 (2021): 400. https://doi.org/10.3892/mmr.2021.12039
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