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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June-2021 Volume 23 Issue 6

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Compound heterozygous CAPN3 variants identified in a family with limb-girdle muscular dystrophy recessive 1

Cheng Zhang, Xueping Zheng, Deguo Lu, Lulu Xu, Fengyuan Che, Shiguo Liu
Article Number: 480
Published online on: 23 April 2021

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Article Open Access

The silencing of FNDC1 inhibits the tumorigenesis of breast cancer cells via modulation of the PI3K/Akt signaling pathway

Chen Yunwen, Gao Shanshan, Ben Zhifei, Chen Saijun, Yin Hua
Article Number: 479
Published online on: 22 April 2021

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Article

Salvianolic acid B inhibits myofibroblast differentiation and extracellular matrix accumulation in nasal polyp fibroblasts via the TGF-β1 signaling pathway

Zhenfeng Sun, Dan Luo, Sang Wang, Ruofei Huang, Pin Dong
Article Number: 478
Published online on: 22 April 2021

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Article

KISS1/KISS1R mediates Sertoli cell apoptosis via the PI3K/AKT signalling pathway in a high‑glucose environment

Dong-Mei Gan, Ping-Ping Zhang, Jian-Ping Zhang, Shu-Xia Ding, Jie Fang, Yang Liu
Article Number: 477
Published online on: 22 April 2021

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Article

HIF‑1α protein SUMOylation is an important protective mechanism of action of hypothermia in hypoxic cardiomyocytes

Huaqin Liu, Xiyun Bian, Meili Xu, Xiaofang Ma, Chunyan Zhang, Jinjin Jiang, Jianfeng Fu, Xiaozhi Liu
Article Number: 476
Published online on: 22 April 2021

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Article Open Access

Expression analysis of progesterone‑regulated miRNAs in cells derived from human glioblastoma

Diana Elisa Velázquez‑Vázquez, Aylin Del Moral‑Morales, Jenie   Marian Cruz‑Burgos, Eduardo  Martínez‑Martínez, Mauricio  Rodríguez‑Dorantes, Ignacio Camacho‑Αrroyo
Article Number: 475
Published online on: 22 April 2021

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Article Open Access

Vascular damage effect of circulating microparticles in patients with ACS is aggravated by type 2 diabetes

Xu-Lan Wang, Wei Zhang, Zhe Li, Wen-Qi Han, Hao-Yu Wu, Qun-Rang Wang, Xin-Hong Liu, Kun Xing, Gong Cheng, Feng-Jun Chang
Article Number: 474
Published online on: 21 April 2021

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Article Open Access

Mangiferin inhibits cell migration and angiogenesis via PI3K/AKT/mTOR signaling in high glucose‑ and hypoxia‑induced RRCECs

Jia Shi, Hongbin Lv, Chen Tang, Yujie Li, Jing Huang, Hong Zhang
Article Number: 473
Published online on: 21 April 2021

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Article Open Access

Role of indoleamine 2,3-dioxygenase in ischemia-reperfusion injury of renal tubular epithelial cells

Theodoros Eleftheriadis, Georgios Pissas, Spyridon Golfinopoulos, Vassilios Liakopoulos, Ioannis Stefanidis
Article Number: 472
Published online on: 21 April 2021

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Article

Downregulation of miR‑106b‑3p increases sensitivity to cisplatin in esophageal cancer cells by targeting TGM3

Yong Zhu, Yun Zhang, Xiaohua Li, Yuntao Su, Nina Wang, Minli Chen, Zhe Yang
Article Number: 471
Published online on: 21 April 2021

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Article Open Access

hsa_circ_0058357 acts as a ceRNA to promote non‑small cell lung cancer progression via the hsa‑miR‑24‑3p/AVL9 axis

Dongshan Wei, Lifang Sun, Wei Feng
Article Number: 470
Published online on: 20 April 2021

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Article Open Access

Hsa_circ_0010957 level is increased and sponges microRNA‑125b in CD4+ T cells of patients with systemic lupus erythematosus

Shan He, Hongwei Du, Yingfang Wang, Xiaowei Shi, Yongwei Zhou
Article Number: 469
Published online on: 20 April 2021

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Article Open Access

H3K14 hyperacetylation‑mediated c‑Myc binding to the miR‑30a‑5p gene promoter under hypoxia postconditioning protects senescent cardiomyocytes from hypoxia/reoxygenation injury

Lingbo Xu, Huiping Zhang, Yanhua Wang, Wei Guo, Lingyu Gu, Anning Yang, Shengchao Ma, Yong Yang, Kai Wu, Yideng Jiang
Article Number: 468
Published online on: 19 April 2021

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Article Open Access

Transcriptomic alterations in malignant pleural mesothelioma cells in response to long‑term treatment with bullfrog sialic acid‑binding lectin

Takeo Tatsuta, Arisu Nakasato, Shigeki Sugawara, Masahiro Hosono
Article Number: 467
Published online on: 19 April 2021

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Correction Open Access

[Corrigendum] miR‑27a‑3p regulates the inhibitory influence of endothelin 3 on the tumorigenesis of papillary thyroid cancer cells

Hongxin Chen, Binlin Cai, Kun Liu, Qingquan Hua
Article Number: 466
Published online on: 19 April 2021

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Article Open Access

Long non‑coding RNA BANCR promotes proliferation, invasion and migration in esophageal squamous cell carcinoma cells via the Raf/MEK/ERK signaling pathway

Xiaogang Yu, Meng Huang, Guodong Yang
Article Number: 465
Published online on: 19 April 2021

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Article Open Access

circ-PRKCI targets miR-1294 and miR-186-5p by downregulating FOXK1 expression to suppress glycolysis in hepatocellular carcinoma

Wenqi Chen, Yuehua Li, Jing Zhong, Gebo Wen
Article Number: 464
Published online on: 19 April 2021

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Article Open Access

miR‑146a reduces depressive behavior by inhibiting microglial activation

Chuan-Peng Liu, Ming Zhong, Jun-Xia Sun, Jin He, Yong Gao, Fang-Xia Qin
Article Number: 463
Published online on: 19 April 2021

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Retraction Open Access

[Retracted] Polyphenol‑rich extract of Saliva chinensis exhibits anticancer activity in different cancer cell lines, and induces cell cycle arrest at the G0/G1‑phase, apoptosis and loss of mitochondrial membrane potential in pancreatic cancer cells

Quan Zhao, Xue-Chen Huo, Fu-Dong Sun, Rui-Qian Dong
Article Number: 462
Published online on: 19 April 2021

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Retraction Open Access

[Retracted] Anticancer activity of taraxerol acetate in human glioblastoma cells and a mouse xenograft model via induction of autophagy and apoptotic cell death, cell cycle arrest and inhibition of cell migration

Jing-Fang Hong, Ying-Fang Song, Zheng Liu, Zhao-Cong Zheng, Hong-Jie Chen, Shou-Sen Wang
Article Number: 461
Published online on: 19 April 2021

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Article Open Access

lncRNA FGD5‑AS1 promotes breast cancer progression by regulating the hsa‑miR‑195‑5p/NUAK2 axis Retraction in /10.3892/mmr.2025.13457

Kun Fang, Zheng-Jie Xu, Su-Xiao Jiang, De-Sheng Tang, Chang-Sheng Yan, You-Yuan Deng, Fu-Ying Zhao
Article Number: 460
Published online on: 16 April 2021

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Article

Structured triglyceride attenuates lung injury and inflammation in lipopolysaccharide‑induced acute lung injury by enhancing GPR120 expression

Haiyun Sun, Yanmin Pang, Dan Zhao, Wenyao Li
Article Number: 459
Published online on: 16 April 2021

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Article Open Access

FOXP3‑induced LINC00885 promotes the proliferation and invasion of cervical cancer cells

Yawen Liu, Haiyan Tu, Lingling Zhang, Jianping Xiong, Ling Li
Article Number: 458
Published online on: 16 April 2021

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Article Open Access

Ginkgolide B‑induced AMPK pathway activation protects astrocytes by regulating endoplasmic reticulum stress, oxidative stress and energy metabolism induced by Aβ1‑42

Jing Wang, Yan Ding, Linwu Zhuang, Zhenzhong Wang, Wei Xiao, Jingbo Zhu
Article Number: 457
Published online on: 16 April 2021

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Article

Effects of S1PR2 antagonist on blood pressure and angiogenesis imbalance in preeclampsia rats

Tengfei Zhang, Danjie Guo, Weiping Zheng, Qunyun Dai
Article Number: 456
Published online on: 16 April 2021

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Review Open Access

Major signaling pathways and key mediators of macrophages in acute kidney injury (Review)

Ning Li, Jiale Chen, Pengtao Wang, Haojun Fan, Shike Hou, Yanhua Gong
Article Number: 455
Published online on: 16 April 2021

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Article Open Access

GTSE1 promotes SNAIL1 degradation by facilitating its nuclear export in hepatocellular carcin oma cells

Shan-Shan Li, Dong-Mei Chen, Lu-Biao Chen, Huan Wei, Jia-Liang Wang, Jian Xiao, Yue-Hua Huang, Yi-Fan Lian
Article Number: 454
Published online on: 15 April 2021

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Article Open Access

hsa‑miR‑5580‑3p inhibits oral cancer cell viability, proliferation and migration by suppressing LAMC2

Rong Fang, Qian Lu, Bo Xu
Article Number: 453
Published online on: 15 April 2021

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Article Open Access

Germacrone induces lung cancer cell apoptosis and cell cycle arrest via the Akt/MDM2/p53 signaling pathway

Yang Zhao, Jie Cai, Kaihu Shi, Hang Li, Jin Du, Dinghui Hu, Zuntao Liu, Wei Wang
Article Number: 452
Published online on: 15 April 2021

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Article

CHFR‑mediated epithelial‑to‑mesenchymal transition promotes metastasis in human breast cancer cells

Guobin Jiang, Hongyan Fang, Xi Shang, Xiaopin Chen, Feilin Cao
Article Number: 451
Published online on: 15 April 2021

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Article Open Access

Musk ketone induces apoptosis of gastric cancer cells via downregulation of sorbin and SH3 domain containing 2

Juan An, Haiyan Wang, Xiaoming Ma, Binwen Hu, Yunfei Yan, Yupeng Yan, Zhanhai Su
Article Number: 450
Published online on: 13 April 2021

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Article Open Access

Itgb3-integrin-deficient mice may not be a sufficient model for patients with Glanzmann thrombasthenia

Dongya Li, Jie Peng, Tiantian Li, Yichen Liu, Min Chen, Xiaofeng Shi
Article Number: 449
Published online on: 13 April 2021

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Article Open Access

Humulus japonicus rescues autistic‑like behaviours in the BTBR T+ Itpr3tf/J mouse model of autism

Hye-Yeon Park, Jun Go, Young-Kyoung Ryu, Dong-Hee Choi, Jung-Ran Noh, Jin-Pyo An, Won-Keun Oh, Pyung-Lim Han, Chul-Ho Lee, Kyoung-Shim Kim
Article Number: 448
Published online on: 13 April 2021

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Article Open Access

Knockdown of lncRNA DLEU1 inhibits the tumorigenesis of oral squamous cell carcinoma via regulation of miR‑149‑5p/CDK6 axis

Tianzhu Lv, Hongjing Liu, Yadong Wu, Wentao Huang
Article Number: 447
Published online on: 13 April 2021

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Article Open Access

Long non‑coding RNA SChLAP1 regulates the proliferation of triple negative breast cancer cells via the miR‑524‑5p/HMGA2 axis

Xiangdong Bai, Shengxiao Zhang, Jun Qiao, Xiaolong Xing, Weina Li, Huanhu Zhang, Jun Xie
Article Number: 446
Published online on: 12 April 2021

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Article Open Access

Tryptophan 2, 3‑dioxygenase promotes proliferation, migration and invasion of ovarian cancer cells

Yuemei Zhao, Fengxing Tao, Jiayu Jiang, Lina Chen, Jizao Du, Xiaoxiao Cheng, Qin He, Shouhui Zhong, Wei Chen, Xiaoli Wu, Rongying Ou, Yunsheng Xu, Kai-Fu Tang
Article Number: 445
Published online on: 12 April 2021

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Article Open Access

miR‑654‑5p inhibits autophagy by targeting ATG7 via mTOR signaling in intervertebral disc degeneration

Shanzheng Wang, Yudong Guo, Xuejun Zhang, Chen Wang
Article Number: 444
Published online on: 12 April 2021

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Article

Zinc‑finger E‑box‑binding homeobox 1 alleviates acute kidney injury by activating autophagy and the AMPK/mTOR pathway

Dehua Sun, Xiaohua Liu, Lijuan Zhu, Bin Zhang
Article Number: 443
Published online on: 12 April 2021

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Article

Temporal changes in the chest based on findings from imaging in severe patients with novel coronavirus pneumonia

Ping Li, Helun Cai, Yong Wang, Lisha Wang, Jiwu He, Yan Dong
Article Number: 442
Published online on: 12 April 2021

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Retraction Open Access

[Retracted] Regulation of the cell cycle and PI3K/Akt/mTOR signaling pathway by tanshinone I in human breast cancer cell lines

Li Wang, Jianzhong Wu, Jianwei Lu, Rong Ma, Dawei Sun, Jinhai Tang
Article Number: 441
Published online on: 12 April 2021

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Retraction Open Access

[Retracted] Anticancer and apoptotic activities of oleanolic acid are mediated through cell cycle arrest and disruption of mitochondrial membrane potential in HepG2 human hepatocellular carcinoma cells

Yue-Yong Zhu, Hong-Yan Huang, Yin-Lian Wu
Article Number: 440
Published online on: 12 April 2021

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Article Open Access

Propofol modulates the proliferation, invasion and migration of bladder cancer cells through the miR‑145‑5p/TOP2A axis Retraction in /10.3892/mmr.2024.13218

Yi Du, Xudong Zhang, Hongwei Zhang, Yiding Chen, Shuying Zhu, Jinjun Shu, Hui Pan
Article Number: 439
Published online on: 09 April 2021

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Article Open Access

Exploration of the hepatoprotective effect and mechanism of magnesium isoglycyrrhizinate in mice with arsenic trioxide‑induced acute liver injury

Miaomiao Liu, Bin Zheng, Panpan Liu, Jianping Zhang, Xi Chu, Chunhui Dong, Jing Shi, Yingran Liang, Li Chu, Yanshuang Liu, Xue Han
Article Number: 438
Published online on: 09 April 2021

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Article Open Access

Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy

Yunfeng Zhu, Yong Su, Jie Zhang, Yanhua Zhang, Yan Li, Yuli Han, Xianan Dong, Weizu Li, Weiping Li
Article Number: 437
Published online on: 09 April 2021

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Article Open Access

MicroRNA‑524‑5p regulates the proliferation and invasion of HTR‑8/SVneo trophoblasts by targeting NUMB in the Notch signaling pathway

Linmei Zheng, Jie Song, Rong Tang, Xiaoju Chen, Li Wang, Dongcai Wu, Hui Cen, Lei Shi
Article Number: 436
Published online on: 08 April 2021

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Article Open Access

Long non‑coding RNA LINC00460 serves as a potential biomarker and oncogene via regulation of the miR‑320b/PBX3 axis in acute myeloid leukemia

Qiang Zhuang, Zhenlin Jin, Xiangkuo Zheng, Ting Jin, Lina Xiang
Article Number: 435
Published online on: 08 April 2021

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Article Open Access

LncRNA NR024118 is downregulated in sepsis and inhibits LPS‑induced apoptosis of cardiomyocytes

Gang Qin, Liuqing Wei, Fufu Jiang, Jiayan Li, Bo Zhang, Dongxu Pan, Xinglin Lu
Article Number: 434
Published online on: 08 April 2021

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Article Open Access

ROS‑associated mechanism of different concentrations of pinacidil postconditioning in the rat cardiac Nrf2‑ARE signaling pathway

Wei Chen, Mengyuan Deng, Haiying Wang, Ying Wang, Wenjing Zhou, Tian Yu
Article Number: 433
Published online on: 08 April 2021

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Article Open Access

MicroRNA‑29‑3p regulates the β‑catenin pathway by targeting IGF1 to inhibit the proliferation of prolactinoma cells

Jie Xia, Songmei Li, Dianfei Ma, Wenyujie Guo, Hong Long, Weiping Yin
Article Number: 432
Published online on: 08 April 2021

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Article Open Access

Changes in the phosphorylation of nucleotide metabolism‑associated proteins by leukemia inhibitory factor in mouse embryonic stem cells

Hwa-Ryung Song, Han-Kyu Kim, Seung-Gook Kim, Hyung-Jin Lim, Hyun-Yi Kim, Myung-Kwan Han
Article Number: 431
Published online on: 08 April 2021

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Article Open Access

The antidiabetic drug troglitazone protects against PrP (106‑126)‑induced neurotoxicity via the PPARγ‑autophagy pathway in neuronal cells

Ji-Hong Moon, Jeong-Min Hong, Sang-Youel Park
Article Number: 430
Published online on: 07 April 2021

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Article Open Access

Apatinib suppresses the migration, invasion and angiogenesis of hepatocellular carcinoma cells by blocking VEGF and PI3K/AKT signaling pathways

Jifu Song, Zhibin Guan, Chao Song, Maojiang Li, Zhiwei Gao, Yongli Zhao
Article Number: 429
Published online on: 07 April 2021

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Article Open Access

Upregulation of antioxidant and autophagy pathways via NRF2 activation protects spinal cord neurons from ozone damage

Cong Zhang, Shulin Ma, Xu Zhao, Bei Wen, Panpan Sun, Zhijian Fu
Article Number: 428
Published online on: 07 April 2021

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Article Open Access

SEC61G is upregulated and required for tumor progression in human kidney cancer

Hui Meng, Xuewen Jiang, Jian Wang, Zunmeng Sang, Longfei Guo, Gang Yin, Yu Wang
Article Number: 427
Published online on: 07 April 2021

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Article

Radiological and histopathological features of short rib‑polydactyly syndrome type III and identification of two novel DYNC2H1 variants

Chun-Ling Xia, Shi-Qi Xiao, Xue Yang, Cai-Xia Liu, Hao Qiu, Hong-Kun Jiang, Jesse Li‑Ling, Yuan Lyu
Article Number: 426
Published online on: 07 April 2021

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Article Open Access

γ‑irradiated prednisolone promotes apoptosis of liver cancer cells via activation of intrinsic apoptosis signaling pathway

Fatuma Jumapili Ramadhani, Seong Hee Kang, Remigius Ambrose Kawala, Byung Yeoup Chung, Hyoung-Woo Bai, Bo Sun Kang
Article Number: 425
Published online on: 07 April 2021

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Article Open Access

Cryptotanshinone interferes with chondrocyte apoptosis in osteoarthritis by inhibiting the expression of miR‑574‑5p

Songtao Yue, Xiaochuan Su, Junyan Teng, Jiangyi Wang, Malong Guo
Article Number: 424
Published online on: 07 April 2021

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Article

TrkB/C-induced HOXC6 activation enhances the ADAM8-mediated metastasis of chemoresistant colon cancer cells

Ga Bin Park, Sangbong Choi, Yoo Sang Yoon, Daejin Kim
Article Number: 423
Published online on: 07 April 2021

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Article Open Access

Lentivirus vector‑mediated genetic manipulation of oncogenic pathways induces tumor formation in rabbit brain

Farizan Ahmad, Anna Hyvärinen, Agnieszka Pirinen, Venla Olsson, Jaana Rummukainen, Arto Immonen, Johanna Närväinen, Pasi Tuunanen, Timo Liimatainen, Virve Kärkkäinen, Jari Koistinaho, Seppo Ylä‑Herttuala
Article Number: 422
Published online on: 06 April 2021

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Article Open Access

Hsa‑circRNA‑G004213 promotes cisplatin sensitivity by regulating miR‑513b‑5p/PRPF39 in liver cancer Corrigendum in /10.3892/mmr.2021.12359

Ling Qin, Zibo Zhan, Chunxue Wei, Xuemei Li, Tongqin Zhang, Jun Li
Article Number: 421
Published online on: 01 April 2021

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Article Open Access

A novel KCNQ4 gene variant (c.857A>G; p.Tyr286Cys) in an extended family with non‑syndromic deafness 2A

Qiong Li, Pengfei Liang, Shujuan Wang, Wei Li, Jian Wang, Yang Yang, Xiaogang An, Jun Chen, Dingjun Zha
Article Number: 420
Published online on: 01 April 2021

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Phgdh serves a protective role in Il‑1β induced chondrocyte inflammation and oxidative‑stress damage

Hefei Huang, Keting Liu, Hua Ou, Xuankun Qian, Jianshan Wan
Article Number: 419
Published online on: 01 April 2021

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Plasmodium infection prevents recurrence and metastasis of hepatocellular carcinoma possibly via inhibition of the epithelial‑mesenchymal transition

Yun Liang, Xiao Chen, Zhu Tao, Meng Ma, Dickson Adah, Xiaofen Li, Lingling Dai, Wenting Ding, Songwe Fanuel, Siting Zhao, Li Qin, Xiaoping Chen, Xiaowen Zhang
Article Number: 418
Published online on: 31 March 2021

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Acute spinal cord injury: Pathophysiology and pharmacological intervention (Review)

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Published online on: 31 March 2021

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Berberine inhibits the proliferation, invasion and migration of endometrial stromal cells by downregulating miR‑429

Yongjuan Gu, Zhigang Zhou
Article Number: 416
Published online on: 31 March 2021

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Inhibitory role of ginsenoside Rb2 in endothelial senescence and inflammation mediated by microRNA‑216a

Yutong Chen, Shuting Wang, Shujun Yang, Rongxia Li, Yunyun Yang, Yu Chen, Weili Zhang
Article Number: 415
Published online on: 30 March 2021

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Dioscin inhibits SCC15 cell proliferation via the RASSF1A/MST2/YAP axis

Hui Tian, Xiyan Chen, Yafei Zhang, Ying Wang, Xucheng Fu, Weiting Gu, Yong Wen
Article Number: 414
Published online on: 30 March 2021

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Identification of two novel mutations in the PLCD1 gene in Chinese patients with hereditary leukonychia

Shuzhan Shen, Minhua Shao, Uma Keyal, Xiuli Wang, Ming Li, Guolong Zhang
Article Number: 413
Published online on: 30 March 2021

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ABT‑737, a Bcl‑2 family inhibitor, has a synergistic effect with apoptosis by inducing urothelial carcinoma cell necroptosis Retraction in /10.3892/mmr.2025.13705

Rui Cheng, Xiaolong Liu, Zheng Wang, Kunlong Tang
Article Number: 412
Published online on: 30 March 2021

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Costunolide attenuates oxygen‑glucose deprivation/reperfusion‑induced mitochondrial‑mediated apoptosis in PC12 cells

Lanqing Meng, Huixia Ma, Jinni Meng, Tingting Li, Yafei Zhu, Qipeng Zhao
Article Number: 411
Published online on: 30 March 2021

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3D‑printed Ti6Al4V scaffolds combined with pulse electromagnetic fields enhance osseointegration in osteoporosis

Mingfu Ye, Wenjun Liu, Lihui Yan, Shaolong Cheng, Xiaoxiong Li, Shichong Qiao
Article Number: 410
Published online on: 29 March 2021

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Emerging landscape of circHIPK3 and its role in cancer and other diseases (Review)

Qi Shao, Yong Huang, Cai Zhang, Xiaochan Gao, Shiyang Gao
Article Number: 409
Published online on: 29 March 2021

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Sevoflurane inhibits cell proliferation and migration of glioma by targeting the miR‑27b/VEGF axis

Xi Zhan, Changcheng Lei, Linzhu Yang
Article Number: 408
Published online on: 29 March 2021

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[Corrigendum] A serum microRNA signature as a prognostic factor for patients with advanced NSCLC and its association with tissue microRNA expression profiles

Jing Guo, Rui Meng, Zhongyuan Yin, Pengcheng Li, Rui Zhou, Sheng Zhang, Xiaorong Dong, Li Liu, Gang Wu
Article Number: 407
Published online on: 29 March 2021

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Identification of miR‑25‑3p as a tumor biomarker: Regulation of cellular functions via TOB1 in breast cancer

Tianyi Zhao, Wenjing Meng, Yenlie Chin, Lili Gao, Xiyue Yang, Shuangyu Sun, Xingfang Pan, Lihong He
Article Number: 406
Published online on: 26 March 2021

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Fluorofenidone attenuates paraquat‑induced pulmonary fibrosis by regulating the PI3K/Akt/mTOR signaling pathway and autophagy

Feiya Jiang, Sha Li, Yu Jiang, Zhuo Chen, Tongtong Wang, Wen Liu
Article Number: 405
Published online on: 26 March 2021

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Tanshinone IIA attenuates heart failure via inhibiting oxidative stress in myocardial infarction rats

Ruijuan Chen, Wenli Chen, Xiaoling Huang, Qinglin Rui
Article Number: 404
Published online on: 26 March 2021

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A crosstalk between type 2 innate lymphoid cells and alternative macrophages in lung development and lung diseases (Review)

Lan-Lan Mi, Yue Zhu, Hong-Yan Lu
Article Number: 403
Published online on: 26 March 2021

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Sacubitril/valsartan inhibits ox‑LDL‑induced MALAT1 expression, inflammation and apoptosis by suppressing the TLR4/NF‑κB signaling pathway in HUVECs

Wenlou Bai, Tiantian Huo, Xuefeng Chen, Xuelian Song, Cunliang Meng, Yi Dang, Chunli Rong, Liwen Dou, Xiaoyong Qi
Article Number: 402
Published online on: 26 March 2021

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Paeonol prevents migration and invasion, and promotes apoptosis of cervical cancer cells by inhibiting 5‑lipoxygenase

Shao-Qin Sheng, Lei-Yuan Yu, Xian-Wei Zhou, Hong-Yi Pan, Feng-Ying Hu, Jia-Li Liu
Article Number: 401
Published online on: 26 March 2021

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Role of C14orf166 in viral infection and RNA metabolism and its relationship with cancer (Review)

Qiangxing Chen, Rong Li
Article Number: 400
Published online on: 26 March 2021

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X‑irradiation induces acute and early term inflammatory responses in atherosclerosis‑prone ApoE‑/‑ mice and in endothelial cells

Raghda Ramadan, Michaël Claessens, Ellen Cocquyt, Mohamed Mysara, Elke Decrock, Sarah Baatout, An Aerts, Luc Leybaert
Article Number: 399
Published online on: 25 March 2021

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Molecular insights into the benefits of nicotine on memory and cognition (Review)

Ahmad Alhowail
Article Number: 398
Published online on: 25 March 2021

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Dihydromyricetin inhibits oxidative stress and apoptosis in oxygen and glucose deprivation/reoxygenation‑induced HT22 cells by activating the Nrf2/HO‑1 pathway

Qian Zhang, Jia Wang, Huili Zhang, Tao Zeng
Article Number: 397
Published online on: 25 March 2021

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NF‑κB is negatively associated with Nurr1 to reduce the inflammatory response in Parkinson's disease

Hua Gao, Dan Wang, Sen Jiang, Jieping Mao, Xinling Yang
Article Number: 396
Published online on: 25 March 2021

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Journal Cover
February-2026 Volume 33 Issue 2

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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ISX promotes tumor migration and invasion in lung cancer by upregulating COL1A1 in vitro

Yihe Ma, Ye Chen, Yuhui Liang, Yun Huang, Miao Gong, Lifeng Tian, Xiaojun Xiao, Jingyan Liu, Qinmiao Huang
Article Number: 77
Published online on: 31 December 2025

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Role and mechanism of miR‑222‑5p in endothelial cell apoptosis

Shimeng Wang, Boxin Zhao, Ying Cui, Lin Gui, Jingyao Fan, Lijuan Huang
Article Number: 76
Published online on: 31 December 2025

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[Expression of Concern] MicroRNA-29c inhibits proliferation and promotes apoptosis in non-small cell lung cancer cells by targeting VEGFA

Shijuan Zhan, Chunfeng Wang, Fangqing Yin
Article Number: 75
Published online on: 22 December 2025

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Melatonin induces autophagy in neuroblastoma by alleviating Pak2‑mediated endoplasmic reticulum stress

Qian-Qi Qiu, Na Zhang, Ying-Yi Xu, Jing-Wen Qin, Gao-Feng Yu, Xing-Rong Song
Article Number: 74
Published online on: 22 December 2025

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ST3Gal1 modulates intestinal barrier function and impacts human ulcerative colitis

Yin Tian, Yun Liu, Yangyang Shang, Lijian Ran, Li Liu, Rongquan Wang, Jun Ye
Article Number: 73
Published online on: 18 December 2025

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Mechanistic study of miR‑369‑3p in regulating the Wnt/β‑catenin signaling pathway via targeting SPTBN1 in inflammatory response and bone destruction of rheumatoid arthritis

Aihong Wu, Yuan Wang, Feifei Liu, Zhoufang Cao, Shuhui Du, Mengyu Sun
Article Number: 72
Published online on: 18 December 2025

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CACNB1 alleviates mepivacaine‑induced myocardial ischemia/reperfusion injury by promoting Nrf2 nuclear translocation

Qingbo Shao, Ji Zhang, Huaying Wang
Article Number: 71
Published online on: 17 December 2025

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[Expression of Concern] Effects of cullin 4B on the proliferation and invasion of human gastric cancer cells

Feng He, Xiu-Mei Cheng, Wen-Long Gu
Article Number: 70
Published online on: 17 December 2025

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Aggravated effects of human parvovirus B19 NS1 protein on bleomycin‑induced pulmonary fibrosis

Tsai-Ching Hsu, Chih-Chen Tzang, Chia-Wei Kuo, Zhi-Han Wen, Der-Yuan Chen, Bor-Show Tzang
Article Number: 69
Published online on: 16 December 2025

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Advances regarding the mechanism of endoplasmic reticulum stress in diabetic kidney disease and pharmacological interventions (Review)

Pai Zhang, Yabin Cui, Chunyan Liu, Chengji Cui, Shoulin Zhang, Yue Zhang, Fan Li
Article Number: 68
Published online on: 16 December 2025

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Retraction Open Access

[Retracted] N‑Myc downstream‑regulated gene 2 suppresses the proliferation of T24 human bladder cancer cells via induction of oncosis

Jie Huang, Zhou Wu, Guangxiu Wang, Yingxian Cai, Minshan Cai, Yaozhang Li
Article Number: 67
Published online on: 15 December 2025

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Deciphering epigenetic regulation in cardiac developmental toxicity: Mechanisms and implications (Review)

Ziling Qin, Ranran Chen, Dianrong Song
Article Number: 66
Published online on: 11 December 2025

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Gut microbiota as a multifaceted modulator of prostate cancer: Mechanistic insights, therapeutic opportunities and clinical challenges (Review)

Zhenming Hao, Yongqiang Xie, Ru Zhang, Hui Sang, Luxi Li, Yulin Liu, Jinbo Hu, Jijun Wang, Keqiang Chai, Qiang Zhao
Article Number: 65
Published online on: 11 December 2025

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Expression of Concern Open Access

[Expression of Concern] lncRNA FLVCR1‑AS1 drives colorectal cancer progression via modulation of the miR‑381/RAP2A axis

Yi Han, Xiaoyan Wang, Enqiang Mao, Boyong Shen, Liang Huang
Article Number: 64
Published online on: 10 December 2025

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Influence and treatment of insulin receptor substrate/PI3K/Akt‑mediated insulin resistance in diabetes mellitus (Review)

Weikang Tang, Huixia Liu, Xuan Li, Siyao Deng, Changyu Gao
Article Number: 63
Published online on: 09 December 2025

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[Retracted] Long non‑coding RNA ANRIL knockdown suppresses apoptosis and pro‑inflammatory cytokines while enhancing neurite outgrowth via binding microRNA‑125a in a cellular model of Alzheimer’s disease

Bingling Zhou, Lijuan Li, Xin Qiu, Jiashun Wu, Lei Xu, Wei Shao
Article Number: 62
Published online on: 08 December 2025

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Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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Article

MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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Correction Open Access

[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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Journal Cover
March-2026 Volume 33 Issue 3

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Cigarette smoke combined with Klebsiella pneumoniae induce damage to the air‑blood barrier in chronic obstructive pulmonary disease rats via the MAPK/NF‑κB/IκBα pathway

Yange Tian, Kexin Xu, Ruilong Lu, Kangchen Li, Xuejie Shao, Yixi Liao, Yakun Zhao, Zhiguang Qiu, Haoran Dong, Xuefang Liu
Article Number: 87
Published online on: 12 January 2026

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[Retracted] 8‑bromo‑7‑methoxychrysin induces apoptosis by regulating Akt/FOXO3a pathway in cisplatin‑sensitive and resistant ovarian cancer cells

Qing Ding, Yi Chen, Qing Zhang, Yanling Guo, Zhi Huang, Liqing Dai, Sudan Cao
Article Number: 86
Published online on: 12 January 2026

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Anxiety‑induced overactive bladder: The role of oxidative stress and NF‑κB signaling pathway with Hsp90 as a potential biomarker

Zhipeng Zhou, Lina Xu, Han Wu, Huaishan Hong
Article Number: 85
Published online on: 12 January 2026

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Echinacoside alleviates asthenozoospermia by upregulating Sox5‑mediated transcriptional activation of the CatSper gene

Zi-Run Jin, Yong-Wei Huo, Bo-Heng Liu, Hong Tian, Shuo Yuan, Yue Tian, Ke Xi, Jie Cai, Hui Jiang, Yong Jiang, Guo-Gang Xing
Article Number: 84
Published online on: 12 January 2026

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Artemisiae Scopariae Herba (Yinchen) suppresses ferroptosis in mice with osteoporosis via the Nrf2/Slc7a11/Gpx4 pathway

Pei Li, Xinyu Wan, Wenjie Li, Ding Cheng, Ying Yang, Yuhan Wang, Ruyuan Zhu, Yanjing Chen, Haixia Liu, Zhiguo Zhang
Article Number: 83
Published online on: 12 January 2026

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Prolyl hydroxylase domain proteins: Localization, regulation, function and their role in erythropoiesis (Review)

Yan Hou, Zhao-Hua Zhang, Wen-Qian Li, Guo-Xiong Han, Kuo Shen, You-Bang Xie
Article Number: 82
Published online on: 12 January 2026

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Therapeutic potential of saponins for allergic rhinitis: Molecular mechanisms and clinical perspectives (Review)

Bing-Yu Liang, Zi-Yue Fu, Fen-Fen Li, Ping-Ting Zhou, Zi-Hui Xie, Ke Han, Yan-Xun Han, Shan-Wen Chen, Yi Zhao, Hai-Feng Pan, Ye-Hai Liu, Yu-Chen Liu
Article Number: 81
Published online on: 07 January 2026

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Interleukin‑6 and ischemic stroke: From mechanisms to clinical prospects (Review)

Xinyue Wang, Xiaohang Zhang, Jianing Lin, Ping Lin
Article Number: 80
Published online on: 05 January 2026

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Preliminary exploration of the putative function of SF3A2 in clear cell renal cell carcinoma

Ru Chen, Jie Xu
Article Number: 79
Published online on: 05 January 2026

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Retraction Open Access

[Retracted] TIPE‑2 suppresses growth and aggressiveness of hepatocellular carcinoma cells through downregulation of the phosphoinositide 3‑kinase/AKT signaling pathway

Lin Wang, Chen Chen, Shuzhi Feng, Jianli Tian
Article Number: 78
Published online on: 05 January 2026

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