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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June-2021 Volume 23 Issue 6

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Compound heterozygous CAPN3 variants identified in a family with limb-girdle muscular dystrophy recessive 1

Cheng Zhang, Xueping Zheng, Deguo Lu, Lulu Xu, Fengyuan Che, Shiguo Liu
Article Number: 480
Published online on: 23 April 2021

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Article Open Access

The silencing of FNDC1 inhibits the tumorigenesis of breast cancer cells via modulation of the PI3K/Akt signaling pathway

Chen Yunwen, Gao Shanshan, Ben Zhifei, Chen Saijun, Yin Hua
Article Number: 479
Published online on: 22 April 2021

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Article

Salvianolic acid B inhibits myofibroblast differentiation and extracellular matrix accumulation in nasal polyp fibroblasts via the TGF-β1 signaling pathway

Zhenfeng Sun, Dan Luo, Sang Wang, Ruofei Huang, Pin Dong
Article Number: 478
Published online on: 22 April 2021

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Article

KISS1/KISS1R mediates Sertoli cell apoptosis via the PI3K/AKT signalling pathway in a high‑glucose environment

Dong-Mei Gan, Ping-Ping Zhang, Jian-Ping Zhang, Shu-Xia Ding, Jie Fang, Yang Liu
Article Number: 477
Published online on: 22 April 2021

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Article

HIF‑1α protein SUMOylation is an important protective mechanism of action of hypothermia in hypoxic cardiomyocytes

Huaqin Liu, Xiyun Bian, Meili Xu, Xiaofang Ma, Chunyan Zhang, Jinjin Jiang, Jianfeng Fu, Xiaozhi Liu
Article Number: 476
Published online on: 22 April 2021

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Article Open Access

Expression analysis of progesterone‑regulated miRNAs in cells derived from human glioblastoma

Diana Elisa Velázquez‑Vázquez, Aylin Del Moral‑Morales, Jenie   Marian Cruz‑Burgos, Eduardo  Martínez‑Martínez, Mauricio  Rodríguez‑Dorantes, Ignacio Camacho‑Αrroyo
Article Number: 475
Published online on: 22 April 2021

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Article Open Access

Vascular damage effect of circulating microparticles in patients with ACS is aggravated by type 2 diabetes

Xu-Lan Wang, Wei Zhang, Zhe Li, Wen-Qi Han, Hao-Yu Wu, Qun-Rang Wang, Xin-Hong Liu, Kun Xing, Gong Cheng, Feng-Jun Chang
Article Number: 474
Published online on: 21 April 2021

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Article Open Access

Mangiferin inhibits cell migration and angiogenesis via PI3K/AKT/mTOR signaling in high glucose‑ and hypoxia‑induced RRCECs

Jia Shi, Hongbin Lv, Chen Tang, Yujie Li, Jing Huang, Hong Zhang
Article Number: 473
Published online on: 21 April 2021

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Article Open Access

Role of indoleamine 2,3-dioxygenase in ischemia-reperfusion injury of renal tubular epithelial cells

Theodoros Eleftheriadis, Georgios Pissas, Spyridon Golfinopoulos, Vassilios Liakopoulos, Ioannis Stefanidis
Article Number: 472
Published online on: 21 April 2021

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Article

Downregulation of miR‑106b‑3p increases sensitivity to cisplatin in esophageal cancer cells by targeting TGM3

Yong Zhu, Yun Zhang, Xiaohua Li, Yuntao Su, Nina Wang, Minli Chen, Zhe Yang
Article Number: 471
Published online on: 21 April 2021

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Article Open Access

hsa_circ_0058357 acts as a ceRNA to promote non‑small cell lung cancer progression via the hsa‑miR‑24‑3p/AVL9 axis

Dongshan Wei, Lifang Sun, Wei Feng
Article Number: 470
Published online on: 20 April 2021

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Article Open Access

Hsa_circ_0010957 level is increased and sponges microRNA‑125b in CD4+ T cells of patients with systemic lupus erythematosus

Shan He, Hongwei Du, Yingfang Wang, Xiaowei Shi, Yongwei Zhou
Article Number: 469
Published online on: 20 April 2021

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Article Open Access

H3K14 hyperacetylation‑mediated c‑Myc binding to the miR‑30a‑5p gene promoter under hypoxia postconditioning protects senescent cardiomyocytes from hypoxia/reoxygenation injury

Lingbo Xu, Huiping Zhang, Yanhua Wang, Wei Guo, Lingyu Gu, Anning Yang, Shengchao Ma, Yong Yang, Kai Wu, Yideng Jiang
Article Number: 468
Published online on: 19 April 2021

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Article Open Access

Transcriptomic alterations in malignant pleural mesothelioma cells in response to long‑term treatment with bullfrog sialic acid‑binding lectin

Takeo Tatsuta, Arisu Nakasato, Shigeki Sugawara, Masahiro Hosono
Article Number: 467
Published online on: 19 April 2021

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Correction Open Access

[Corrigendum] miR‑27a‑3p regulates the inhibitory influence of endothelin 3 on the tumorigenesis of papillary thyroid cancer cells

Hongxin Chen, Binlin Cai, Kun Liu, Qingquan Hua
Article Number: 466
Published online on: 19 April 2021

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Article Open Access

Long non‑coding RNA BANCR promotes proliferation, invasion and migration in esophageal squamous cell carcinoma cells via the Raf/MEK/ERK signaling pathway

Xiaogang Yu, Meng Huang, Guodong Yang
Article Number: 465
Published online on: 19 April 2021

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Article Open Access

circ-PRKCI targets miR-1294 and miR-186-5p by downregulating FOXK1 expression to suppress glycolysis in hepatocellular carcinoma

Wenqi Chen, Yuehua Li, Jing Zhong, Gebo Wen
Article Number: 464
Published online on: 19 April 2021

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Article Open Access

miR‑146a reduces depressive behavior by inhibiting microglial activation

Chuan-Peng Liu, Ming Zhong, Jun-Xia Sun, Jin He, Yong Gao, Fang-Xia Qin
Article Number: 463
Published online on: 19 April 2021

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Retraction Open Access

[Retracted] Polyphenol‑rich extract of Saliva chinensis exhibits anticancer activity in different cancer cell lines, and induces cell cycle arrest at the G0/G1‑phase, apoptosis and loss of mitochondrial membrane potential in pancreatic cancer cells

Quan Zhao, Xue-Chen Huo, Fu-Dong Sun, Rui-Qian Dong
Article Number: 462
Published online on: 19 April 2021

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Retraction Open Access

[Retracted] Anticancer activity of taraxerol acetate in human glioblastoma cells and a mouse xenograft model via induction of autophagy and apoptotic cell death, cell cycle arrest and inhibition of cell migration

Jing-Fang Hong, Ying-Fang Song, Zheng Liu, Zhao-Cong Zheng, Hong-Jie Chen, Shou-Sen Wang
Article Number: 461
Published online on: 19 April 2021

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Article Open Access

lncRNA FGD5‑AS1 promotes breast cancer progression by regulating the hsa‑miR‑195‑5p/NUAK2 axis Retraction in /10.3892/mmr.2025.13457

Kun Fang, Zheng-Jie Xu, Su-Xiao Jiang, De-Sheng Tang, Chang-Sheng Yan, You-Yuan Deng, Fu-Ying Zhao
Article Number: 460
Published online on: 16 April 2021

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Article

Structured triglyceride attenuates lung injury and inflammation in lipopolysaccharide‑induced acute lung injury by enhancing GPR120 expression

Haiyun Sun, Yanmin Pang, Dan Zhao, Wenyao Li
Article Number: 459
Published online on: 16 April 2021

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Article Open Access

FOXP3‑induced LINC00885 promotes the proliferation and invasion of cervical cancer cells

Yawen Liu, Haiyan Tu, Lingling Zhang, Jianping Xiong, Ling Li
Article Number: 458
Published online on: 16 April 2021

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Article Open Access

Ginkgolide B‑induced AMPK pathway activation protects astrocytes by regulating endoplasmic reticulum stress, oxidative stress and energy metabolism induced by Aβ1‑42

Jing Wang, Yan Ding, Linwu Zhuang, Zhenzhong Wang, Wei Xiao, Jingbo Zhu
Article Number: 457
Published online on: 16 April 2021

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Article

Effects of S1PR2 antagonist on blood pressure and angiogenesis imbalance in preeclampsia rats

Tengfei Zhang, Danjie Guo, Weiping Zheng, Qunyun Dai
Article Number: 456
Published online on: 16 April 2021

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Review Open Access

Major signaling pathways and key mediators of macrophages in acute kidney injury (Review)

Ning Li, Jiale Chen, Pengtao Wang, Haojun Fan, Shike Hou, Yanhua Gong
Article Number: 455
Published online on: 16 April 2021

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Article Open Access

GTSE1 promotes SNAIL1 degradation by facilitating its nuclear export in hepatocellular carcin oma cells

Shan-Shan Li, Dong-Mei Chen, Lu-Biao Chen, Huan Wei, Jia-Liang Wang, Jian Xiao, Yue-Hua Huang, Yi-Fan Lian
Article Number: 454
Published online on: 15 April 2021

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Article Open Access

hsa‑miR‑5580‑3p inhibits oral cancer cell viability, proliferation and migration by suppressing LAMC2

Rong Fang, Qian Lu, Bo Xu
Article Number: 453
Published online on: 15 April 2021

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Article Open Access

Germacrone induces lung cancer cell apoptosis and cell cycle arrest via the Akt/MDM2/p53 signaling pathway

Yang Zhao, Jie Cai, Kaihu Shi, Hang Li, Jin Du, Dinghui Hu, Zuntao Liu, Wei Wang
Article Number: 452
Published online on: 15 April 2021

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Article

CHFR‑mediated epithelial‑to‑mesenchymal transition promotes metastasis in human breast cancer cells

Guobin Jiang, Hongyan Fang, Xi Shang, Xiaopin Chen, Feilin Cao
Article Number: 451
Published online on: 15 April 2021

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Article Open Access

Musk ketone induces apoptosis of gastric cancer cells via downregulation of sorbin and SH3 domain containing 2

Juan An, Haiyan Wang, Xiaoming Ma, Binwen Hu, Yunfei Yan, Yupeng Yan, Zhanhai Su
Article Number: 450
Published online on: 13 April 2021

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Article Open Access

Itgb3-integrin-deficient mice may not be a sufficient model for patients with Glanzmann thrombasthenia

Dongya Li, Jie Peng, Tiantian Li, Yichen Liu, Min Chen, Xiaofeng Shi
Article Number: 449
Published online on: 13 April 2021

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Article Open Access

Humulus japonicus rescues autistic‑like behaviours in the BTBR T+ Itpr3tf/J mouse model of autism

Hye-Yeon Park, Jun Go, Young-Kyoung Ryu, Dong-Hee Choi, Jung-Ran Noh, Jin-Pyo An, Won-Keun Oh, Pyung-Lim Han, Chul-Ho Lee, Kyoung-Shim Kim
Article Number: 448
Published online on: 13 April 2021

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Article Open Access

Knockdown of lncRNA DLEU1 inhibits the tumorigenesis of oral squamous cell carcinoma via regulation of miR‑149‑5p/CDK6 axis

Tianzhu Lv, Hongjing Liu, Yadong Wu, Wentao Huang
Article Number: 447
Published online on: 13 April 2021

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Article Open Access

Long non‑coding RNA SChLAP1 regulates the proliferation of triple negative breast cancer cells via the miR‑524‑5p/HMGA2 axis

Xiangdong Bai, Shengxiao Zhang, Jun Qiao, Xiaolong Xing, Weina Li, Huanhu Zhang, Jun Xie
Article Number: 446
Published online on: 12 April 2021

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Article Open Access

Tryptophan 2, 3‑dioxygenase promotes proliferation, migration and invasion of ovarian cancer cells

Yuemei Zhao, Fengxing Tao, Jiayu Jiang, Lina Chen, Jizao Du, Xiaoxiao Cheng, Qin He, Shouhui Zhong, Wei Chen, Xiaoli Wu, Rongying Ou, Yunsheng Xu, Kai-Fu Tang
Article Number: 445
Published online on: 12 April 2021

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Article Open Access

miR‑654‑5p inhibits autophagy by targeting ATG7 via mTOR signaling in intervertebral disc degeneration

Shanzheng Wang, Yudong Guo, Xuejun Zhang, Chen Wang
Article Number: 444
Published online on: 12 April 2021

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Article

Zinc‑finger E‑box‑binding homeobox 1 alleviates acute kidney injury by activating autophagy and the AMPK/mTOR pathway

Dehua Sun, Xiaohua Liu, Lijuan Zhu, Bin Zhang
Article Number: 443
Published online on: 12 April 2021

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Article

Temporal changes in the chest based on findings from imaging in severe patients with novel coronavirus pneumonia

Ping Li, Helun Cai, Yong Wang, Lisha Wang, Jiwu He, Yan Dong
Article Number: 442
Published online on: 12 April 2021

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Retraction Open Access

[Retracted] Regulation of the cell cycle and PI3K/Akt/mTOR signaling pathway by tanshinone I in human breast cancer cell lines

Li Wang, Jianzhong Wu, Jianwei Lu, Rong Ma, Dawei Sun, Jinhai Tang
Article Number: 441
Published online on: 12 April 2021

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Retraction Open Access

[Retracted] Anticancer and apoptotic activities of oleanolic acid are mediated through cell cycle arrest and disruption of mitochondrial membrane potential in HepG2 human hepatocellular carcinoma cells

Yue-Yong Zhu, Hong-Yan Huang, Yin-Lian Wu
Article Number: 440
Published online on: 12 April 2021

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Article Open Access

Propofol modulates the proliferation, invasion and migration of bladder cancer cells through the miR‑145‑5p/TOP2A axis Retraction in /10.3892/mmr.2024.13218

Yi Du, Xudong Zhang, Hongwei Zhang, Yiding Chen, Shuying Zhu, Jinjun Shu, Hui Pan
Article Number: 439
Published online on: 09 April 2021

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Article Open Access

Exploration of the hepatoprotective effect and mechanism of magnesium isoglycyrrhizinate in mice with arsenic trioxide‑induced acute liver injury

Miaomiao Liu, Bin Zheng, Panpan Liu, Jianping Zhang, Xi Chu, Chunhui Dong, Jing Shi, Yingran Liang, Li Chu, Yanshuang Liu, Xue Han
Article Number: 438
Published online on: 09 April 2021

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Article Open Access

Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy

Yunfeng Zhu, Yong Su, Jie Zhang, Yanhua Zhang, Yan Li, Yuli Han, Xianan Dong, Weizu Li, Weiping Li
Article Number: 437
Published online on: 09 April 2021

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Article Open Access

MicroRNA‑524‑5p regulates the proliferation and invasion of HTR‑8/SVneo trophoblasts by targeting NUMB in the Notch signaling pathway

Linmei Zheng, Jie Song, Rong Tang, Xiaoju Chen, Li Wang, Dongcai Wu, Hui Cen, Lei Shi
Article Number: 436
Published online on: 08 April 2021

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Article Open Access

Long non‑coding RNA LINC00460 serves as a potential biomarker and oncogene via regulation of the miR‑320b/PBX3 axis in acute myeloid leukemia

Qiang Zhuang, Zhenlin Jin, Xiangkuo Zheng, Ting Jin, Lina Xiang
Article Number: 435
Published online on: 08 April 2021

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Article Open Access

LncRNA NR024118 is downregulated in sepsis and inhibits LPS‑induced apoptosis of cardiomyocytes

Gang Qin, Liuqing Wei, Fufu Jiang, Jiayan Li, Bo Zhang, Dongxu Pan, Xinglin Lu
Article Number: 434
Published online on: 08 April 2021

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Article Open Access

ROS‑associated mechanism of different concentrations of pinacidil postconditioning in the rat cardiac Nrf2‑ARE signaling pathway

Wei Chen, Mengyuan Deng, Haiying Wang, Ying Wang, Wenjing Zhou, Tian Yu
Article Number: 433
Published online on: 08 April 2021

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Article Open Access

MicroRNA‑29‑3p regulates the β‑catenin pathway by targeting IGF1 to inhibit the proliferation of prolactinoma cells

Jie Xia, Songmei Li, Dianfei Ma, Wenyujie Guo, Hong Long, Weiping Yin
Article Number: 432
Published online on: 08 April 2021

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Article Open Access

Changes in the phosphorylation of nucleotide metabolism‑associated proteins by leukemia inhibitory factor in mouse embryonic stem cells

Hwa-Ryung Song, Han-Kyu Kim, Seung-Gook Kim, Hyung-Jin Lim, Hyun-Yi Kim, Myung-Kwan Han
Article Number: 431
Published online on: 08 April 2021

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Article Open Access

The antidiabetic drug troglitazone protects against PrP (106‑126)‑induced neurotoxicity via the PPARγ‑autophagy pathway in neuronal cells

Ji-Hong Moon, Jeong-Min Hong, Sang-Youel Park
Article Number: 430
Published online on: 07 April 2021

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Article Open Access

Apatinib suppresses the migration, invasion and angiogenesis of hepatocellular carcinoma cells by blocking VEGF and PI3K/AKT signaling pathways

Jifu Song, Zhibin Guan, Chao Song, Maojiang Li, Zhiwei Gao, Yongli Zhao
Article Number: 429
Published online on: 07 April 2021

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Article Open Access

Upregulation of antioxidant and autophagy pathways via NRF2 activation protects spinal cord neurons from ozone damage

Cong Zhang, Shulin Ma, Xu Zhao, Bei Wen, Panpan Sun, Zhijian Fu
Article Number: 428
Published online on: 07 April 2021

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Article Open Access

SEC61G is upregulated and required for tumor progression in human kidney cancer

Hui Meng, Xuewen Jiang, Jian Wang, Zunmeng Sang, Longfei Guo, Gang Yin, Yu Wang
Article Number: 427
Published online on: 07 April 2021

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Article

Radiological and histopathological features of short rib‑polydactyly syndrome type III and identification of two novel DYNC2H1 variants

Chun-Ling Xia, Shi-Qi Xiao, Xue Yang, Cai-Xia Liu, Hao Qiu, Hong-Kun Jiang, Jesse Li‑Ling, Yuan Lyu
Article Number: 426
Published online on: 07 April 2021

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Article Open Access

γ‑irradiated prednisolone promotes apoptosis of liver cancer cells via activation of intrinsic apoptosis signaling pathway

Fatuma Jumapili Ramadhani, Seong Hee Kang, Remigius Ambrose Kawala, Byung Yeoup Chung, Hyoung-Woo Bai, Bo Sun Kang
Article Number: 425
Published online on: 07 April 2021

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Article Open Access

Cryptotanshinone interferes with chondrocyte apoptosis in osteoarthritis by inhibiting the expression of miR‑574‑5p

Songtao Yue, Xiaochuan Su, Junyan Teng, Jiangyi Wang, Malong Guo
Article Number: 424
Published online on: 07 April 2021

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Article

TrkB/C-induced HOXC6 activation enhances the ADAM8-mediated metastasis of chemoresistant colon cancer cells

Ga Bin Park, Sangbong Choi, Yoo Sang Yoon, Daejin Kim
Article Number: 423
Published online on: 07 April 2021

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Article Open Access

Lentivirus vector‑mediated genetic manipulation of oncogenic pathways induces tumor formation in rabbit brain

Farizan Ahmad, Anna Hyvärinen, Agnieszka Pirinen, Venla Olsson, Jaana Rummukainen, Arto Immonen, Johanna Närväinen, Pasi Tuunanen, Timo Liimatainen, Virve Kärkkäinen, Jari Koistinaho, Seppo Ylä‑Herttuala
Article Number: 422
Published online on: 06 April 2021

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Article Open Access

Hsa‑circRNA‑G004213 promotes cisplatin sensitivity by regulating miR‑513b‑5p/PRPF39 in liver cancer Corrigendum in /10.3892/mmr.2021.12359

Ling Qin, Zibo Zhan, Chunxue Wei, Xuemei Li, Tongqin Zhang, Jun Li
Article Number: 421
Published online on: 01 April 2021

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Article Open Access

A novel KCNQ4 gene variant (c.857A>G; p.Tyr286Cys) in an extended family with non‑syndromic deafness 2A

Qiong Li, Pengfei Liang, Shujuan Wang, Wei Li, Jian Wang, Yang Yang, Xiaogang An, Jun Chen, Dingjun Zha
Article Number: 420
Published online on: 01 April 2021

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Phgdh serves a protective role in Il‑1β induced chondrocyte inflammation and oxidative‑stress damage

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Article Number: 419
Published online on: 01 April 2021

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Plasmodium infection prevents recurrence and metastasis of hepatocellular carcinoma possibly via inhibition of the epithelial‑mesenchymal transition

Yun Liang, Xiao Chen, Zhu Tao, Meng Ma, Dickson Adah, Xiaofen Li, Lingling Dai, Wenting Ding, Songwe Fanuel, Siting Zhao, Li Qin, Xiaoping Chen, Xiaowen Zhang
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Published online on: 31 March 2021

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Published online on: 31 March 2021

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Berberine inhibits the proliferation, invasion and migration of endometrial stromal cells by downregulating miR‑429

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Article Number: 416
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Inhibitory role of ginsenoside Rb2 in endothelial senescence and inflammation mediated by microRNA‑216a

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Article Number: 415
Published online on: 30 March 2021

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Dioscin inhibits SCC15 cell proliferation via the RASSF1A/MST2/YAP axis

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Article Number: 414
Published online on: 30 March 2021

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Identification of two novel mutations in the PLCD1 gene in Chinese patients with hereditary leukonychia

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Article Number: 413
Published online on: 30 March 2021

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ABT‑737, a Bcl‑2 family inhibitor, has a synergistic effect with apoptosis by inducing urothelial carcinoma cell necroptosis Retraction in /10.3892/mmr.2025.13705

Rui Cheng, Xiaolong Liu, Zheng Wang, Kunlong Tang
Article Number: 412
Published online on: 30 March 2021

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Costunolide attenuates oxygen‑glucose deprivation/reperfusion‑induced mitochondrial‑mediated apoptosis in PC12 cells

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Article Number: 411
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3D‑printed Ti6Al4V scaffolds combined with pulse electromagnetic fields enhance osseointegration in osteoporosis

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Article Number: 410
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Article Number: 409
Published online on: 29 March 2021

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Sevoflurane inhibits cell proliferation and migration of glioma by targeting the miR‑27b/VEGF axis

Xi Zhan, Changcheng Lei, Linzhu Yang
Article Number: 408
Published online on: 29 March 2021

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[Corrigendum] A serum microRNA signature as a prognostic factor for patients with advanced NSCLC and its association with tissue microRNA expression profiles

Jing Guo, Rui Meng, Zhongyuan Yin, Pengcheng Li, Rui Zhou, Sheng Zhang, Xiaorong Dong, Li Liu, Gang Wu
Article Number: 407
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Identification of miR‑25‑3p as a tumor biomarker: Regulation of cellular functions via TOB1 in breast cancer

Tianyi Zhao, Wenjing Meng, Yenlie Chin, Lili Gao, Xiyue Yang, Shuangyu Sun, Xingfang Pan, Lihong He
Article Number: 406
Published online on: 26 March 2021

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Fluorofenidone attenuates paraquat‑induced pulmonary fibrosis by regulating the PI3K/Akt/mTOR signaling pathway and autophagy

Feiya Jiang, Sha Li, Yu Jiang, Zhuo Chen, Tongtong Wang, Wen Liu
Article Number: 405
Published online on: 26 March 2021

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Tanshinone IIA attenuates heart failure via inhibiting oxidative stress in myocardial infarction rats

Ruijuan Chen, Wenli Chen, Xiaoling Huang, Qinglin Rui
Article Number: 404
Published online on: 26 March 2021

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A crosstalk between type 2 innate lymphoid cells and alternative macrophages in lung development and lung diseases (Review)

Lan-Lan Mi, Yue Zhu, Hong-Yan Lu
Article Number: 403
Published online on: 26 March 2021

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Sacubitril/valsartan inhibits ox‑LDL‑induced MALAT1 expression, inflammation and apoptosis by suppressing the TLR4/NF‑κB signaling pathway in HUVECs

Wenlou Bai, Tiantian Huo, Xuefeng Chen, Xuelian Song, Cunliang Meng, Yi Dang, Chunli Rong, Liwen Dou, Xiaoyong Qi
Article Number: 402
Published online on: 26 March 2021

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Paeonol prevents migration and invasion, and promotes apoptosis of cervical cancer cells by inhibiting 5‑lipoxygenase

Shao-Qin Sheng, Lei-Yuan Yu, Xian-Wei Zhou, Hong-Yi Pan, Feng-Ying Hu, Jia-Li Liu
Article Number: 401
Published online on: 26 March 2021

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Role of C14orf166 in viral infection and RNA metabolism and its relationship with cancer (Review)

Qiangxing Chen, Rong Li
Article Number: 400
Published online on: 26 March 2021

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X‑irradiation induces acute and early term inflammatory responses in atherosclerosis‑prone ApoE‑/‑ mice and in endothelial cells

Raghda Ramadan, Michaël Claessens, Ellen Cocquyt, Mohamed Mysara, Elke Decrock, Sarah Baatout, An Aerts, Luc Leybaert
Article Number: 399
Published online on: 25 March 2021

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Molecular insights into the benefits of nicotine on memory and cognition (Review)

Ahmad Alhowail
Article Number: 398
Published online on: 25 March 2021

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Dihydromyricetin inhibits oxidative stress and apoptosis in oxygen and glucose deprivation/reoxygenation‑induced HT22 cells by activating the Nrf2/HO‑1 pathway

Qian Zhang, Jia Wang, Huili Zhang, Tao Zeng
Article Number: 397
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NF‑κB is negatively associated with Nurr1 to reduce the inflammatory response in Parkinson's disease

Hua Gao, Dan Wang, Sen Jiang, Jieping Mao, Xinling Yang
Article Number: 396
Published online on: 25 March 2021

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Non‑coding RNAs in epithelial‑mesenchymal transition of renal cell carcinoma (Review)

Ziqiao Liu, Hanshen Zhou, Junxiao Shen, Yiming Qi, Xuke Gong, Cheng Zhang
Article Number: 51
Published online on: 24 November 2025

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FOXJ3 drives mesenchymal stem cell osteogenic differentiation via the Wnt/β‑catenin pathway: A novel regulator implicated in osteoporosis

Hongwei Xiao, Jianfeng Li, Wei Huang, Yi Qin
Article Number: 50
Published online on: 21 November 2025

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NEDD4 regulates VEGF signaling and mTOR to promote angiogenesis and the cell cycle in steroid‑induced osteonecrosis of the femoral head

Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
Article Number: 49
Published online on: 21 November 2025

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Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway

Chih-Hsuan Hsia, Chun-Ming Yang, Chao-Chien Chang, Ting-Lin Yen, Arief Gunawan Darmanto, Chi-Chang Huang, Joen-Rong Sheu
Article Number: 48
Published online on: 21 November 2025

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Research progress on molecular therapy for glaucoma (Review)

Weiwei Wang, Gangwei Cheng, Qi Zhou, Sheng Wang, Linyi Zhang
Article Number: 47
Published online on: 21 November 2025

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Natural compounds for the treatment of rheumatoid arthritis based on the ‘gut‑joint axis’ (Review)

Wenjie Hu, Rui Li, Zhongming Zhang
Article Number: 46
Published online on: 20 November 2025

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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

Pan Guo, Mengke Sun, Jingyu Zhang, Qianshu Yuan, Hong Cui, Junkai Huang, Jing Luo, Qianyu Zhu, Bingxin Zhang, Lizhi Hu
Article Number: 45
Published online on: 20 November 2025

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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

Banghao Sun, Zhenyu Zhao, Qingyu Meng, Luya Pu, Xingyu Jiang, Shuai Li, Fadi Cao, Fan Li
Article Number: 44
Published online on: 20 November 2025

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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
Published online on: 18 November 2025

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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
Published online on: 17 November 2025

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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
Article Number: 41
Published online on: 12 November 2025

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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
Article Number: 40
Published online on: 12 November 2025

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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
Published online on: 12 November 2025

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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
Published online on: 10 November 2025

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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
Article Number: 35
Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
Published online on: 10 November 2025

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Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
Article Number: 22
Published online on: 31 October 2025

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Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review)

Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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February-2026 Volume 33 Issue 2

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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