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3D‑printed Ti6Al4V scaffolds combined with pulse electromagnetic fields enhance osseointegration in osteoporosis

  • Authors:
    • Mingfu Ye
    • Wenjun Liu
    • Lihui Yan
    • Shaolong Cheng
    • Xiaoxiong Li
    • Shichong Qiao
  • View Affiliations / Copyright

    Affiliations: Department of Oral Implantology, Xiamen Key Laboratory of Stomatological Disease Diagnosis and Treatment, Stomatological Hospital of Xiamen Medical College, Xiamen, Fujian 361008, P.R. China, Department of Pain, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201112, P.R. China, Department of Implant Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China
    Copyright: © Ye et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 410
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    Published online on: March 29, 2021
       https://doi.org/10.3892/mmr.2021.12049
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Abstract

The loosening and displacement of prostheses after dental implantation and arthroplasty is a substantial medical burden due to the complex correction surgery. Three‑dimensional (3D)‑printed porous titanium (pTi) alloy scaffolds are characterized by low stiffness, are beneficial to bone ingrowth, and may be used in orthopedic applications. However, for the bio‑inert nature between host bone and implants, titanium alloy remains poorly compatible with osseointegration, especially in disease conditions, such as osteoporosis. In the present study, 3D‑printed pTi scaffolds with ideal pore size and porosity matching the bone tissue, were combined with pulse electromagnetic fields (PEMF), an exogenous osteogenic induction stimulation, to evaluate osseointegration in osteoporosis. In vitro, external PEMF significantly improved osteoporosis‑derived bone marrow mesenchymal stem cell proliferation and osteogenic differentiation on the surface of pTi scaffolds by enhancing the expression of alkaline phosphatase, runt‑related transcription factor‑2, osteocalcin, and bone morphogenetic protein‑2. In vivo, Microcomputed tomography analysis and histological evaluation indicated the external PEMF markedly enhanced bone regeneration and osseointegration. This novel therapeutic strategy has potential to promote osseointegration of dental implants or artificial prostheses for patients with osteoporosis.
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Copy and paste a formatted citation
Spandidos Publications style
Ye M, Liu W, Yan L, Cheng S, Li X and Qiao S: 3D‑printed Ti6Al4V scaffolds combined with pulse electromagnetic fields enhance osseointegration in osteoporosis. Mol Med Rep 23: 410, 2021.
APA
Ye, M., Liu, W., Yan, L., Cheng, S., Li, X., & Qiao, S. (2021). 3D‑printed Ti6Al4V scaffolds combined with pulse electromagnetic fields enhance osseointegration in osteoporosis. Molecular Medicine Reports, 23, 410. https://doi.org/10.3892/mmr.2021.12049
MLA
Ye, M., Liu, W., Yan, L., Cheng, S., Li, X., Qiao, S."3D‑printed Ti6Al4V scaffolds combined with pulse electromagnetic fields enhance osseointegration in osteoporosis". Molecular Medicine Reports 23.6 (2021): 410.
Chicago
Ye, M., Liu, W., Yan, L., Cheng, S., Li, X., Qiao, S."3D‑printed Ti6Al4V scaffolds combined with pulse electromagnetic fields enhance osseointegration in osteoporosis". Molecular Medicine Reports 23, no. 6 (2021): 410. https://doi.org/10.3892/mmr.2021.12049
Copy and paste a formatted citation
x
Spandidos Publications style
Ye M, Liu W, Yan L, Cheng S, Li X and Qiao S: 3D‑printed Ti6Al4V scaffolds combined with pulse electromagnetic fields enhance osseointegration in osteoporosis. Mol Med Rep 23: 410, 2021.
APA
Ye, M., Liu, W., Yan, L., Cheng, S., Li, X., & Qiao, S. (2021). 3D‑printed Ti6Al4V scaffolds combined with pulse electromagnetic fields enhance osseointegration in osteoporosis. Molecular Medicine Reports, 23, 410. https://doi.org/10.3892/mmr.2021.12049
MLA
Ye, M., Liu, W., Yan, L., Cheng, S., Li, X., Qiao, S."3D‑printed Ti6Al4V scaffolds combined with pulse electromagnetic fields enhance osseointegration in osteoporosis". Molecular Medicine Reports 23.6 (2021): 410.
Chicago
Ye, M., Liu, W., Yan, L., Cheng, S., Li, X., Qiao, S."3D‑printed Ti6Al4V scaffolds combined with pulse electromagnetic fields enhance osseointegration in osteoporosis". Molecular Medicine Reports 23, no. 6 (2021): 410. https://doi.org/10.3892/mmr.2021.12049
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