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Article

KISS1/KISS1R mediates Sertoli cell apoptosis via the PI3K/AKT signalling pathway in a high‑glucose environment

  • Authors:
    • Dong-Mei Gan
    • Ping-Ping Zhang
    • Jian-Ping Zhang
    • Shu-Xia Ding
    • Jie Fang
    • Yang Liu
  • View Affiliations / Copyright

    Affiliations: Department of Pediatric Endocrinology, Ningbo Women and Children's Hospital, Ningbo, Zhejiang 315000, P.R. China, Department of Pediatrics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
  • Article Number: 477
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    Published online on: April 22, 2021
       https://doi.org/10.3892/mmr.2021.12116
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Abstract

In male patients with diabetes, reduced sperm motility and fertility are observed. KiSS‑1 metastasis suppressor (KISS1)/KISS1 receptor (KISS1R) serves an important role in regulating adolescent sexual maturity and reproductive system development in mammals; however, the mechanism underlying KISS1/KISS1R in reproductive dysfunction in male patients with diabetes is not completely understood. The aim of the present study was to examine the role of KISS1/KISS1R in Sertoli cells. High glucose (HG)‑induced mouse Sertoli cells were used to model diabetes in vitro. KISS1/KISS1R overexpression and knockdown were established in mouse Sertoli cells. Reverse transcription‑quantitative PCR and western blotting were performed to measure the expression levels of KISS1/KISS1R and apoptosis‑related proteins. Cell viability and apoptosis was assessed by performing Cell Counting Kit‑8, TUNEL staining and flow cytometry assays, respectively. Western blotting was performed to assess the expression levels of PI3K/AKT signalling‑related proteins. KISS1/KISS1R expression levels were downregulated in HG‑induced mouse Sertoli cells compared with control cells. KISS1/KISS1R overexpression significantly suppressed HG‑induced apoptosis and decrease of viability in mouse Sertoli cells. Moreover, the western blotting results indicated that KISS1/KISS1R activated PI3K/AKT signalling. Treatment with PI3K/AKT pathway inhibitor significantly reversed KISS1/KISS1R‑mediated protective effects. Collectively, the results of the present study suggested that KISS1/KISS1R mediated Sertoli cell apoptosis via the PI3K/AKT signalling pathway under HG conditions, which provided reliable targets for the treatment of reproductive dysfunction in male patients with diabetes.
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1 

Chen L, Magliano DJ and Zimmet PZ: The worldwide epidemiology of type 2 diabetes mellitus-present and future perspectives. Nat Rev Endocrinol. 8:228–236. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Zheng Y, Ley SH and Hu FB: Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 14:88–98. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Nathan DM: Long-term complications of diabetes mellitus. N Engl J Med. 328:1676–1685. 1993. View Article : Google Scholar : PubMed/NCBI

4 

Kyathanahalli C, Bangalore S, Hanumanthappa K and Muralidhara: Experimental diabetes-induced testicular damage in prepubertal rats. J Diabetes. 6:48–59. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Maresch CC, Stute DC, Alves MG, Oliveira PF, de Kretser DM and Linn T: Diabetes-induced hyperglycemia impairs male reproductive function: A systematic review. Hum Reprod Update. 24:86–105. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Jangir RN and Jain GC: Diabetes mellitus induced impairment of male reproductive functions: A review. Curr Diabetes Rev. 10:147–157. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Frenkel GP, Homonnai Z, Drasnin N, Sofer A, Kaplan R and Kraicer PF: Fertility of the streptozotocin-diabetic male rat. Andrologia. 10:127–136. 1978. View Article : Google Scholar : PubMed/NCBI

8 

Kühn-Velten N, Waldenburger D and Staib W: Evaluation of steroid biosynthetic lesions in isolated leydig cells from the testes of streptozotocin-diabetic rats. Diabetologia. 23:529–533. 1982. View Article : Google Scholar

9 

Amaral S, Moreno AJ, Santos MS, Seiça R and Ramalho-Santos J: Effects of hyperglycemia on sperm and testicular cells of Goto-Kakizaki and streptozotocin-treated rat models for diabetes. Theriogenology. 66:2056–2067. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Shukla KK, Mahdi AA, Ahmad MK, Shankhwar SN, Rajender S and Jaiswar SP: Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis. Fertil Steril. 92:1934–1940. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Li ZM, Liu N, Jiang YP, Yang JM, Zheng J, Sun M, Li YX, Sun T, Wu J and Yu JQ: Vitexin alleviates streptozotocin-induced sexual dysfunction and fertility impairments in male mice via modulating the hypothalamus-pituitary-gonadal axis. Chem Biological Interact. 297:119–129. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Fink G: Neuroendocrine regulation of pituitary function. Neuroendocrinology in Physiology and Medicine. Conn PM and Freeman ME: Humana Press; Totowa, NJ: https://doi.org/10.1007/978-1-59259-707-9_7

13 

Caraty A, Franceschini I and Hoffman GE: Kisspeptin and the preovulatory gonadotrophin-releasing hormone/luteinising hormone surge in the ewe: Basic aspects and potential applications in the control of ovulation. J Neuroendocrinol. 22:710–715. 2010.PubMed/NCBI

14 

Dhillo WS, Chaudhri OB, Thompson EL, Murphy KG, Patterson M, Ramachandran R, Nijher GK, Amber V, Kokkinos A, Donaldson M, et al: Kisspeptin-54 stimulates gonadotropin release most potently during the preovulatory phase of the menstrual cycle in women. J Clin Endocrinol Metab. 92:3958–3966. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Hu KL, Zhao H, Min Z, He Y, Li T, Zhen X, Ren Y, Chang HM, Yu Y and Li R: Increased expression of KISS1 and KISS1 receptor in human granulosa lutein cells-potential pathogenesis of polycystic ovary syndrome. Reprod Sci. 26:1429–1438. 2019. View Article : Google Scholar : PubMed/NCBI

16 

Hu KL, Zhao H, Chang HM, Yu Y and Qiao J: Kisspeptin/kisspeptin receptor system in the ovary. Front Endocrinol (Lausanne). 8:3652018. View Article : Google Scholar : PubMed/NCBI

17 

Yu H, Liu J, Han Y, Chen C and Meng F: Correlation between serum Kisspeptin and spermatogenic function in men. bioRxiv. Oct 18–2019.doi: https://doi.org/10.1101/810572.

18 

Funes S, Hedrick JA, Vassileva G, Markowitz L, Abbondanzo S, Golovko A, Yang S, Monsma FJ and Gustafson EL: The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system. Biochem Biophys Res Commun. 312:1357–1363. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Franke TF: PI3K/Akt: Getting it right matters. Oncogene. 27:6473–6488. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Foster FM, Traer CJ, Abraham SM and Fry MJ: The phosphoinositide (PI) 3-kinase family. J Cell Sci. 116:3037–3040. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Lin A, Piao H, Zhuang L, Sarbassov dos D, Ma L and Gan B: FoxO transcription factors promote AKT Ser473 phosphorylation and renal tumor growth in response to pharmacologic inhibition of the PI3K-AKT pathway. Cancer Res. 74:1682–1693. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Beymer M, Negrón AL, Yu G, Wu S, Mayer C, Lin RZ, Boehm U and Acosta-Martínez M: Kisspeptin cell-specific PI3K signaling regulates hypothalamic kisspeptin expression and participates in the regulation of female fertility. Am J Physiol Endocrinol Metab. 307:E969–E982. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Chen S, Chen W, Zhang X, Lin S and Chen Z: Overexpression of KiSS-1 reduces colorectal cancer cell invasion by downregulating MMP-9 via blocking PI3K/Akt/NF-κB signal pathway. Int J Oncol. 48:1391–1398. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Xin X, Li Z, Zhong Y, Li Q, Wang J, Zhang H, Yuan X, Li J and Zhang Z: KISS1 suppresses apoptosis and stimulates the synthesis of E2 in porcine ovarian Granulosa cells. Animals (Basel). 9:542019. View Article : Google Scholar : PubMed/NCBI

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Dowarah J and Singh VP: Anti-diabetic drugs recent approaches and advancements. Bioorg Med Chem. 28:1152632020. View Article : Google Scholar : PubMed/NCBI

27 

Birben E, Sahiner UM, Sackesen C, Erzurum S and Kalayci O: Oxidative stress and antioxidant defense. World Allergy Organ J. 5:9–19. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Adedara IA, Okpara ES, Busari EO, Omole O, Owumi SE and Farombi EO: Dietary protocatechuic acid abrogates male reproductive dysfunction in streptozotocin-induced diabetic rats via suppression of oxidative damage, inflammation and caspase-3 activity. Eur J Pharmacol. 849:30–42. 2019. View Article : Google Scholar : PubMed/NCBI

29 

Johnson A, Cheng SC, Tsou D and Kong ZL: Attenuation of reproductive dysfunction in diabetic male rats with timber cultured Antrodia cinnamomea ethanol extract. Biomed Pharmacother. 112:1086842019. View Article : Google Scholar : PubMed/NCBI

30 

Jiang YP, Ye RJ, Yang JM, Liu N, Zhang WJ, Ma L, Sun T, Niu JG, Zheng P and Yu JQ: Protective effects of Salidroside on spermatogenesis in streptozotocin induced type-1 diabetic male mice by inhibiting oxidative stress mediated blood-testis barrier damage. Chem Biol Interact. 315:1088692020. View Article : Google Scholar : PubMed/NCBI

31 

Liu J, Wang Y, Gong L and Sun C: Oxidation of glyceraldehyde- 3-phosphate dehydrogenase decreases sperm motility in diabetes mellitus. Biochem Biophys Res Commun. 465:245–248. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Luo D, Zhang M, Su X, Liu L, Zhou X, Zhang X, Zheng D, Yu C and Guan Q: High fat diet impairs spermatogenesis by regulating glucose and lipid metabolism in Sertoli cells. Life Sci. 257:1180282020. View Article : Google Scholar : PubMed/NCBI

33 

Gahete MD, Vázquez-Borrego MC, Martínez-Fuentes AJ, Tena-Sempere M, Castaño JP and Luque RM: Role of the Kiss1/Kiss1r system in the regulation of pituitary cell function. Mol Cell Endocrinol. 438:100–106. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Ke R, Ma X and Lee LTO: Understanding the functions of kisspeptin and kisspeptin receptor (Kiss1R) from clinical case studies. Peptides. 120:1700192019. View Article : Google Scholar : PubMed/NCBI

35 

George JT, Millar RP and Anderson RA: Hypothesis: Kisspeptin mediates male hypogonadism in obesity and type 2 diabetes. Neuroendocrinology. 91:302–307. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Li X, Zhu Y, Zhang C, Liu J, Zhou G, Jing L, Shi Z, Sun Z and Zhou X: BDE-209 induces male reproductive toxicity via cell cycle arrest and apoptosis mediated by DNA damage response signaling pathways. Environ Pollut. 255:1130972019. View Article : Google Scholar : PubMed/NCBI

37 

Khodamoradi K, Amini-Khoei H, Khosravizadeh Z, Hosseini SR, Dehpour AR and Hassanzadeh G: Oxidative stress, inflammatory reactions and apoptosis mediated the negative effect of chronic stress induced by maternal separation on the reproductive system in male mice. Reprod Biol. 19:340–348. 2019. View Article : Google Scholar : PubMed/NCBI

38 

Chen Z, Wen D, Wang F, Wang C and Yang L: Curcumin protects against palmitic acid-induced apoptosis via the inhibition of endoplasmic reticulum stress in testicular Leydig cells. Reprod Biol Endocrinol. 17:712019. View Article : Google Scholar : PubMed/NCBI

39 

Yang L, Lei L, Zhao Q, Gong Y, Guan G and Huang S: C-Type natriuretic peptide/natriuretic peptide receptor 2 is involved in cell proliferation and testosterone production in mouse leydig cells. World J Mens Health. 37:186–198. 2019. View Article : Google Scholar : PubMed/NCBI

40 

Ma Y, Qin H and Cui Y: MiR-34a targets GAS1 to promote cell proliferation and inhibit apoptosis in papillary thyroid carcinoma via PI3K/Akt/Bad pathway. Biochem Biophys Res Commun. 44:958–963. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Zhang XH, Chen SY, Tang L, Shen YZ, Luo L, Xu CW, Liu Q and Li D: Myricetin induces apoptosis in HepG2 cells through Akt/p70S6K/bad signaling and mitochondrial apoptotic pathway. Anticancer Agents Med Chem. 13:1575–1581. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Maiorino MI, Bellastella G and Esposito K: Diabetes and sexual dysfunction: Current perspectives. Diabetes Metab Syndr Obes. 7:95–105. 2014.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gan D, Zhang P, Zhang J, Ding S, Fang J and Liu Y: KISS1/KISS1R mediates Sertoli cell apoptosis via the PI3K/AKT signalling pathway in a high‑glucose environment. Mol Med Rep 23: 477, 2021.
APA
Gan, D., Zhang, P., Zhang, J., Ding, S., Fang, J., & Liu, Y. (2021). KISS1/KISS1R mediates Sertoli cell apoptosis via the PI3K/AKT signalling pathway in a high‑glucose environment. Molecular Medicine Reports, 23, 477. https://doi.org/10.3892/mmr.2021.12116
MLA
Gan, D., Zhang, P., Zhang, J., Ding, S., Fang, J., Liu, Y."KISS1/KISS1R mediates Sertoli cell apoptosis via the PI3K/AKT signalling pathway in a high‑glucose environment". Molecular Medicine Reports 23.6 (2021): 477.
Chicago
Gan, D., Zhang, P., Zhang, J., Ding, S., Fang, J., Liu, Y."KISS1/KISS1R mediates Sertoli cell apoptosis via the PI3K/AKT signalling pathway in a high‑glucose environment". Molecular Medicine Reports 23, no. 6 (2021): 477. https://doi.org/10.3892/mmr.2021.12116
Copy and paste a formatted citation
x
Spandidos Publications style
Gan D, Zhang P, Zhang J, Ding S, Fang J and Liu Y: KISS1/KISS1R mediates Sertoli cell apoptosis via the PI3K/AKT signalling pathway in a high‑glucose environment. Mol Med Rep 23: 477, 2021.
APA
Gan, D., Zhang, P., Zhang, J., Ding, S., Fang, J., & Liu, Y. (2021). KISS1/KISS1R mediates Sertoli cell apoptosis via the PI3K/AKT signalling pathway in a high‑glucose environment. Molecular Medicine Reports, 23, 477. https://doi.org/10.3892/mmr.2021.12116
MLA
Gan, D., Zhang, P., Zhang, J., Ding, S., Fang, J., Liu, Y."KISS1/KISS1R mediates Sertoli cell apoptosis via the PI3K/AKT signalling pathway in a high‑glucose environment". Molecular Medicine Reports 23.6 (2021): 477.
Chicago
Gan, D., Zhang, P., Zhang, J., Ding, S., Fang, J., Liu, Y."KISS1/KISS1R mediates Sertoli cell apoptosis via the PI3K/AKT signalling pathway in a high‑glucose environment". Molecular Medicine Reports 23, no. 6 (2021): 477. https://doi.org/10.3892/mmr.2021.12116
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