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CDC20 promotes the progression of hepatocellular carcinoma by regulating epithelial‑mesenchymal transition

  • Authors:
    • Gang Yang
    • Guan Wang
    • Yongfu Xiong
    • Ji Sun
    • Weinan Li
    • Tao Tang
    • Jingdong Li
  • View Affiliations / Copyright

    Affiliations: Department of Hepatocellular Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637007, P.R. China, Physical Examination Center, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637007, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 483
    |
    Published online on: April 27, 2021
       https://doi.org/10.3892/mmr.2021.12122
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Abstract

Hepatocellular carcinoma (HCC) is a type of primary liver cancer, which is associated with high mortality. HCC is one of the most common malignant tumors worldwide. Cell division cycle 20 (CDC20) has been reported to be associated with the development of various malignant tumors and epithelial‑mesenchymal transition (EMT) has been reported to be involved in the malignant metastasis of HCC. Therefore, the present study hypothesized that CDC20 may participate in the malignant biological behavior of HCC via EMT. The present study analyzed the expression levels of CDC20 in HCC and the association between CDC20 and poor prognosis. Furthermore, the effects of CDC20 on the proliferation, invasion and migration of HCC cells were examined using proliferation, migration and invasion assays. Finally, alterations in EMT were analyzed. The results revealed that CDC20 was highly expressed in HCC and HCC cell lines (P<0.05), and its high expression level was significantly associated with poor prognosis in patients with HCC (P<0.05). CDC20 silencing inhibited the proliferation, migration and invasion of HCC cells. Furthermore, CDC20 silencing increased the expression levels of E‑cadherin, and decreased the expression levels of N‑cadherin, vimentin and Ki‑67. In conclusion, the present study reported that CDC20 may be a novel therapeutic target in HCC and CDC20 could promote the progression of HCC by regulating EMT.
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Copy and paste a formatted citation
Spandidos Publications style
Yang G, Wang G, Xiong Y, Sun J, Li W, Tang T and Li J: CDC20 promotes the progression of hepatocellular carcinoma by regulating epithelial‑mesenchymal transition. Mol Med Rep 24: 483, 2021.
APA
Yang, G., Wang, G., Xiong, Y., Sun, J., Li, W., Tang, T., & Li, J. (2021). CDC20 promotes the progression of hepatocellular carcinoma by regulating epithelial‑mesenchymal transition. Molecular Medicine Reports, 24, 483. https://doi.org/10.3892/mmr.2021.12122
MLA
Yang, G., Wang, G., Xiong, Y., Sun, J., Li, W., Tang, T., Li, J."CDC20 promotes the progression of hepatocellular carcinoma by regulating epithelial‑mesenchymal transition". Molecular Medicine Reports 24.1 (2021): 483.
Chicago
Yang, G., Wang, G., Xiong, Y., Sun, J., Li, W., Tang, T., Li, J."CDC20 promotes the progression of hepatocellular carcinoma by regulating epithelial‑mesenchymal transition". Molecular Medicine Reports 24, no. 1 (2021): 483. https://doi.org/10.3892/mmr.2021.12122
Copy and paste a formatted citation
x
Spandidos Publications style
Yang G, Wang G, Xiong Y, Sun J, Li W, Tang T and Li J: CDC20 promotes the progression of hepatocellular carcinoma by regulating epithelial‑mesenchymal transition. Mol Med Rep 24: 483, 2021.
APA
Yang, G., Wang, G., Xiong, Y., Sun, J., Li, W., Tang, T., & Li, J. (2021). CDC20 promotes the progression of hepatocellular carcinoma by regulating epithelial‑mesenchymal transition. Molecular Medicine Reports, 24, 483. https://doi.org/10.3892/mmr.2021.12122
MLA
Yang, G., Wang, G., Xiong, Y., Sun, J., Li, W., Tang, T., Li, J."CDC20 promotes the progression of hepatocellular carcinoma by regulating epithelial‑mesenchymal transition". Molecular Medicine Reports 24.1 (2021): 483.
Chicago
Yang, G., Wang, G., Xiong, Y., Sun, J., Li, W., Tang, T., Li, J."CDC20 promotes the progression of hepatocellular carcinoma by regulating epithelial‑mesenchymal transition". Molecular Medicine Reports 24, no. 1 (2021): 483. https://doi.org/10.3892/mmr.2021.12122
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