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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
July-2021 Volume 24 Issue 1

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

CXCR3 alleviates renal ischemia‑reperfusion injury via increase of Tregs

Wenjing Xian, Jiali Wu, Qingshu Li, Xunsong Du, Na Wang, Daiyu Chen, Wuxi Gao, Jun Cao
Article Number: 541
Published online on: 28 May 2021

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circSAMD4A participates in the apoptosis and autophagy of dopaminergic neurons via the miR‑29c‑3p‑mediated AMPK/mTOR pathway in Parkinson's disease

Wensheng Wang, Rongxiang Lv, Jingjing Zhang, Yu Liu
Article Number: 540
Published online on: 27 May 2021

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Correction Open Access

[Corrigendum] NORAD regulates epithelial‑mesenchymal transition of non‑small cell lung cancer cells via miR‑422a

Zhikun Chen, Qin Che, Chunxue Xie
Article Number: 539
Published online on: 27 May 2021

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Downregulation of miR‑483‑5p inhibits TGF‑β1‑induced EMT by targeting RhoGDI1 in pulmonary fibrosis

Guichuan Huang, Jing Zhang, Gang Qing, Daishun Liu, Xin Wang, Yi Chen, Yongchang Wu, Yishi Li, Shuliang Guo
Article Number: 538
Published online on: 26 May 2021

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Ginkgolide B‑mediated therapeutic effects on perioperative neurocognitive dysfunction are associated with the inhibition of iNOS‑mediated production of NO

Ting Luo, Dandan Lin, Yanan Hao, Rong Shi, Changwei Wei, Wenzhen Shen, Anshi Wu, Peili Huang
Article Number: 537
Published online on: 26 May 2021

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Article Open Access

Low‑calorie sweetener D‑psicose promotes hydrogen peroxide‑mediated apoptosis in C2C12 myogenic cells favoring skeletal muscle cell injury

Zhen-Jie Wei, Lu Sun, Yu-Lin Li, Jibran Sualeh Muhammad, Ying Wang, Qian-Wen Feng, Yan-Zhuo Zhang, Hidekuni Inadera, Zheng-Guo Cui, Cheng-Ai Wu
Article Number: 536
Published online on: 26 May 2021

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Tannic acid alleviates lipopolysaccharide‑induced H9C2 cell apoptosis by suppressing reactive oxygen species‑mediated endoplasmic reticulum stress

Yan-Ping Yang, Jie-Qiong Zhao, Hai-Bo Gao, Jin-Jing Li, Xiao-Li  Li, Xiao-Lin Niu, Yong-Hong Lei, Xue Li
Article Number: 535
Published online on: 26 May 2021

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Ophiopogonin B induces reactive oxygen species‑dependent apoptosis through the Hippo pathway in nasopharyngeal carcinoma

Wenhui Dong, Qing Dong, Hairui Ding
Article Number: 534
Published online on: 26 May 2021

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lncRNA TUG1 inhibits the cancer stem cell‑like properties of temozolomide‑resistant glioma cells by interacting with EZH2

Yiqiang Cao, Wenying Chai, Yonggang Wang, Dang Tang, Dongchuan Shao, Hai Song, Jiang Long
Article Number: 533
Published online on: 25 May 2021

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Anti‑inflammatory effect of Chrysanthemum zawadskii, peppermint, Glycyrrhiza glabra herbal mixture in lipopolysaccharide‑stimulated RAW264.7 macrophages

Byoung Ok Cho, Jae Young Shin, Hyun Ju Kang, Ji Hyeon Park, Suping Hao, Feng Wang, Seon Il Jang
Article Number: 532
Published online on: 25 May 2021

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Guan Xin Dan Shen formulation protects db/db mice against diabetic cardiomyopathy via activation of Nrf2 signaling

Bin Zhang, Chen-Yang Zhang, Xue-Lian Zhang, Gui-Bo Sun, Xiao-Bo Sun
Article Number: 531
Published online on: 25 May 2021

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Article Open Access

CDCA2 promotes tumorigenesis and induces radioresistance in oesophageal squamous cell carcinoma cells

Bing Xu, Hui Chen, Zhipeng Xu, Xijuan Yao, Xinchen Sun, Hongyan Cheng
Article Number: 530
Published online on: 25 May 2021

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κ‑opioid receptor agonist, U50488H, inhibits pyroptosis through NLRP3 via the Ca2+/CaMKII/CREB signaling pathway and improves synaptic plasticity in APP/PS1 mice

Xiaofu Song, Zhiqiang Cui, Jiahuan He, Tuo Yang, Xiaohong Sun
Article Number: 529
Published online on: 25 May 2021

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miR‑135a‑5p inhibits tumor invasion by targeting ANGPT2 in gallbladder cancer

Haiyan Diao, Xing Xu, Bin Zhao, Guanghua Yang
Article Number: 528
Published online on: 25 May 2021

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Article

MicroRNA‑421 attenuates macrophage‑mediated inflammation by inhibiting PDCD4 in vitro

Huifang Liu, Junzhi Sun, Li Gao, Lingling Fan, Dongmei Chen, Lifang Wu
Article Number: 527
Published online on: 25 May 2021

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LDL‑induced NLRC3 inflammasome activation in cardiac fibroblasts contributes to cardiomyocytic dysfunction

Peng Wang, Wenbo Zhang, Zhen Feng, Jian Zhang, Ying Sun, Wei Zhang
Article Number: 526
Published online on: 25 May 2021

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Endoplasmic reticulum stress promotes epithelial‑mesenchymal transition via the PERK signaling pathway in paraquat‑induced pulmonary fibrosis

Xiaoxiao Meng, Kan Liu, Hui Xie, Yong Zhu, Wei Jin, Jian Lu, Ruilan Wang
Article Number: 525
Published online on: 25 May 2021

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Effects of Txk‑mediated activation of NF‑κB signaling pathway on neurological deficit and oxidative stress after ischemia‑reperfusion in rats

Qian-Lan Xu, Jie Wu
Article Number: 524
Published online on: 21 May 2021

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Knockdown of GBAS regulates esophageal cancer cell viability and apoptosis

Jun Peng, Ke Ma, Hao Rong, Bo Xiao, Jiang Zhu, Jin-Tao He
Article Number: 523
Published online on: 21 May 2021

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Retraction Open Access

[Retracted] Decreased microRNA‑132 and its function in human non‑small cell lung cancer

Xiyu Liu, Song Yan, Changyan Pei, Youbin Cui
Article Number: 522
Published online on: 20 May 2021

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Role of P2X7R in eosinophilic and non‑eosinophilic chronic rhinosinusitis with nasal polyps

Yan Wang, Shan Chen, Wenwen Wang, Jianjun Chen, Weijia Kong, Yanjun Wang
Article Number: 521
Published online on: 20 May 2021

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Article Open Access

Carbenoxolone has the potential to ameliorate acute incision pain in rats

Shuzhen Dong, Kai Zhang, Yisa Shi
Article Number: 520
Published online on: 18 May 2021

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Correction Open Access

[Corrigendum] miR‑126 overexpression attenuates oxygen‑glucose deprivation/reperfusion injury by inhibiting oxidative stress and inflammatory response via the activation of SIRT1/Nrf2 signaling pathway in human umbilical vein endothelial cells

Jixin Li, Caili Yang, Yan Wang
Article Number: 519
Published online on: 18 May 2021

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Hydrogen sulfide attenuates renal I/R‑induced activation of the inflammatory response and apoptosis via regulating Nrf2‑mediated NLRP3 signaling pathway inhibition

Yonghong Su, Yaoqi Wang, Min Liu, Hongguang Chen
Article Number: 518
Published online on: 17 May 2021

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Phenylethanol glycosides from Herba Cistanche improve the hypoxic tumor microenvironment and enhance the effects of oxaliplatin via the HIF‑1α signaling pathway

Limei Wen, Junping Hu, Jiawei Zhang, Jianhua Yang
Article Number: 517
Published online on: 17 May 2021

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Article Open Access

KIF4A knockdown suppresses ovarian cancer cell proliferation and induces apoptosis by downregulating BUB1 expression

Wumin Jin, Lianmin Ye
Article Number: 516
Published online on: 17 May 2021

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Article Open Access

Selective inhibition of JNK mitochondrial location is protective against seawater inhalation‑induced ALI/ARDS

Liyan Bo, Yanyan Li, Wei Liu, Faguang Jin, Congcong Li
Article Number: 515
Published online on: 14 May 2021

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Review

NLRP3 inflammasome in sepsis (Review)

Xueyan Shi, Sichuang Tan, Sipin Tan
Article Number: 514
Published online on: 13 May 2021

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Correction Open Access

[Corrigendum] Beneficial effects of sulfonamide‑based gallates on osteoblasts in vitro

Li Huang, Pan Jin, Xiao Lin, Cuiwu Lin, Li Zheng, Jinmin Zhao
Article Number: 513
Published online on: 13 May 2021

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Review

Clinical Genomic, phenotype and epigenetic insights into the pathology, autoimmunity and weight management of patients with Myasthenia Gravis (Review)

Rebecca Golfinopoulou, Louis Papageorgiou, Aspasia Efthimiadou, Flora Bacopoulou, George P. Chrousos, Elias Eliopoulos, Dimitrios Vlachakis
Article Number: 512
Published online on: 12 May 2021

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Article Open Access

Long non‑coding RNA‑DUXAP8 regulates TOP2A in the growth and metastasis of osteosarcoma via microRNA‑635

Ting Yang, Jian Ping Guo, Fan Li, Chao Xiu, Hua Wang, Xian Liang Duan
Article Number: 511
Published online on: 12 May 2021

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lncRNA GAS5‑mediated miR‑23a‑3p promotes inflammation and cell apoptosis by targeting TLR4 in a cell model of sepsis

Zhenping Gao, Dan Huang
Article Number: 510
Published online on: 11 May 2021

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3,4,5‑Trihydroxycinnamic acid exerts anti‑inflammatory effects on TNF‑α/IFN‑γ‑stimulated HaCaT cells

Ji-Won Park, Jae-Hoon Oh, Daseul Hwang, Seong-Man Kim, Jae-Hong Min, Ji-Yun Seo, Wanjoo Chun, Hee Jae Lee, Sei-Ryang Oh, Jae-Won Lee, Kyung-Seop Ahn
Article Number: 509
Published online on: 11 May 2021

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Article Open Access

LY‑294002 enhances the chemosensitivity of liver cancer to oxaliplatin by blocking the PI3K/AKT/HIF‑1α pathway

Ruyue Xu, Yinci Zhang, Amin Li, Yongfang Ma, Wenpeng Cai, Li  Song, Yinghai Xie, Shuping Zhou, Weiya Cao, Xiaolong Tang
Article Number: 508
Published online on: 11 May 2021

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Overexpression of hsa_circ_0001445 reverses oxLDL‑induced inhibition of HUVEC proliferation via SRSF1

Guiying Liang, Sihua Chen, Sha Xin, Liang Dong
Article Number: 507
Published online on: 10 May 2021

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Review Open Access

Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells (Review) Erratum in /10.3892/mmr.2021.12265

Ying Li, Jinming Wang, Weiliang Zhong
Article Number: 506
Published online on: 10 May 2021

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Correction Open Access

[Corrigendum] TLR4 mediates inflammation and hepatic fibrosis induced by chronic intermittent hypoxia in rats

Zhi-Peng Lin, Hui-Li Lin, Xue-Ping Yu, Yi-Juan Zheng, Si-Yu Cheng
Article Number: 505
Published online on: 10 May 2021

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Correction Open Access

[Corrigendum] HK2 is associated with the Warburg effect and proliferation in liver cancer: Targets for effective therapy with glycyrrhizin

Zengpeng Sun, Zhiguo Tan, Chuang Peng, Weimin Yi
Article Number: 504
Published online on: 10 May 2021

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lncRNA NEAT1 regulates gastric carcinoma cell proliferation, invasion and apoptosis via the miR‑500a‑3p/XBP‑1 axis

Yun Zhou, Zhenghong Sha, Yong Yang, Shuimei Wu, Hong Chen
Article Number: 503
Published online on: 09 May 2021

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Article Open Access

Silencing a disintegrin and metalloproteinase‑33 attenuates the proliferation of vascular smooth muscle cells via PI3K/AKT pathway: Implications in the pathogenesis of airway vascular remodeling

Fang Yan, Yanyan Hao, Xinji Gong, Hu Sun, Jianbing Ding, Jing Wang
Article Number: 502
Published online on: 09 May 2021

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Article Open Access

Polygonatum sibiricum F. Delaroche polysaccharide ameliorates HFD‑induced mouse obesity via regulation of lipid metabolism and inflammatory response

Bo Liu, Yuan Tang, Zhenyan Song, Jinwen Ge
Article Number: 501
Published online on: 09 May 2021

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Review Open Access

Oral peroxidases: From antimicrobial agents to ecological actors (Review)

Philippe Courtois
Article Number: 500
Published online on: 06 May 2021

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Article Open Access

Transforming growth factor‑β1 functions as a competitive endogenous RNA that ameliorates intracranial hemorrhage injury by sponging microRNA‑93‑5p

Han Wang, Xianming Cao, Xiaoqing Wen, Dongling Li, Yetong Ouyang, Bing Bao, Yuqin Zhong, Zhengfang Qin, Min Yin, Zhiying Chen, Xiaoping Yin
Article Number: 499
Published online on: 06 May 2021

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Article Open Access

Circulating microRNA‑135a‑3p in serum extracellular vesicles as a potential biological marker of non‑alcoholic fatty liver disease

Hemin Jiang, Yu Qian, Ziyang Shen, Yuwei Liu, Yunqiang He, Rui Gao, Min Shen, Shu Chen, Qi Fu, Tao Yang
Article Number: 498
Published online on: 06 May 2021

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Article Open Access

Downregulation of microRNA‑221 facilitates H1N1 influenza A virus replication through suppression of type‑IFN response by targeting the SOCS1/NF‑κB pathway

Nali Zhang, Yuan Ma, Yuheng Tian, Yafei Zhou, Yuhua Tang, Shaobo Hu
Article Number: 497
Published online on: 06 May 2021

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Article Open Access

Human epididymis protein 4 promotes P‑glycoprotein‑mediated chemoresistance in ovarian cancer cells through interactions with Annexin II

Qing Liu, Da-Wo Liu, Ming-Jun Zheng, Lu Deng, Hui-Min Wang, Shan Jin, Juan-Juan Liu, Ying-Ying Hao, Lian-Cheng Zhu, Bei Lin
Article Number: 496
Published online on: 05 May 2021

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Article Open Access

Rapamycin protects against aristolochic acid nephropathy in mice by potentiating mammalian target of rapamycin‑mediated autophagy

Fan Lin, Yunqi Liu, Lili Tang, Xiaohui Xu, Xueli Zhang, Yifan Song, Bicheng Chen, Yeping Ren, Xiangdong Yang
Article Number: 495
Published online on: 05 May 2021

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Case Report Open Access

Further phenotypic features and two novel POC1A variants in a patient with SOFT syndrome: A case report

Songting Li, Yan Zhong, Yongjia Yang, Siping He, Wenjuan He
Article Number: 494
Published online on: 05 May 2021

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Review Open Access

Inflammatory response in epilepsy is mediated by glial cell gap junction pathway (Review)

Guangliang Wang, Jiangtao Wang, Cuijuan Xin, Jinyu Xiao, Jianmin Liang, Xuemei Wu
Article Number: 493
Published online on: 05 May 2021

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Article Open Access

Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis Expression of Concern in /10.3892/mmr.2026.13870 Corrigendum in /10.3892/mmr.2026.13930

Ruiqiao Guan, Zhihao Li, Xiaohong Dai, Wei Zou, Xueping Yu, Hao Liu, Qiuxin Chen, Wei Teng, Peng Liu, Xiaoying Liu, Shanshan Dong
Article Number: 492
Published online on: 05 May 2021

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Review

Roles of Cl‑/HCO3‑ anion exchanger 2 in the physiology and pathophysiology of the digestive system (Review)

Hui Wang, Jiaxing An, Hai Jin, Suyu He, Chengcheng Liao, Juan Wang, Biguang Tuo
Article Number: 491
Published online on: 05 May 2021

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Retraction Open Access

[Retracted] In vitro antitumor activity of the ethyl acetate extract Potentilla chinensis in osteosarcoma cancer cells

Guang Wan, Jin-Gang Tao, Guo-Dong Wang, Shen-Peng Liu, Hong-Xing Zhao, Qiu-Dong Liang
Article Number: 490
Published online on: 05 May 2021

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Correction Open Access

[Corrigendum] Role of adenosine deaminase 2 gene variants in pediatric deficiency of adenosine deaminase 2: A structural biological approach

Maria I. Zervou, George N. Goulielmos, Michail Matalliotakis, Charoula Matalliotaki, Demetrios A. Spandidos, Elias Eliopoulos
Article Number: 489
Published online on: 05 May 2021

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Article

Ivermectin inhibits cell proliferation and the expression levels of type I collagen, α‑SMA and CCN2 in hypertrophic scar fibroblasts

Song Tian, Yongjun Zheng, Shichu Xiao, Pengfei Luo, Rongju Sun, Jun Liu, Zhaofan Xia
Article Number: 488
Published online on: 29 April 2021

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Article Open Access

Parthenolide plays a protective role in the liver of mice with metabolic dysfunction‑associated fatty liver disease through the activation of the HIPPO pathway

Weihong Wang, Yukai He, Qiuli Liu
Article Number: 487
Published online on: 29 April 2021

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Article Open Access

Pyropia yezoensis protein protects against TNF‑α‑induced myotube atrophy in C2C12 myotubes via the NF‑κB signaling pathway

Min-Kyeong Lee, Youn Hee Choi, Taek-Jeong Nam
Article Number: 486
Published online on: 28 April 2021

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Article Open Access

Non-toxic sulfur inhibits LPS-induced inflammation by regulating TLR-4 and JAK2/STAT3 through IL-6 signaling

Dong Young Kang, Nipin Sp, Eun Seong Jo, Alexis Rugamba, Hyoung Do Kim, Il Ho Kim, Jong-Chan Park, Se Won Bae, Kyoung-Jin Jang, Young Mok Yang
Article Number: 485
Published online on: 27 April 2021

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Article Open Access

Oleic acid induces A7r5 cell proliferation and migration associated with increased expression of HGF and p‑p38

Jingjing Li, Ting Chu, Maosheng Yang
Article Number: 484
Published online on: 27 April 2021

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Article Open Access

CDC20 promotes the progression of hepatocellular carcinoma by regulating epithelial‑mesenchymal transition

Gang Yang, Guan Wang, Yongfu Xiong, Ji Sun, Weinan Li, Tao Tang, Jingdong Li
Article Number: 483
Published online on: 27 April 2021

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Article Open Access

The natural product lapiferin inhibits cell proliferation and promotes cell apoptosis in gingival squamous cell carcinoma via P21 regulation

Lin Liu, Cheng Peng, Yan Ruan, Qian Zhang
Article Number: 482
Published online on: 26 April 2021

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Retraction Open Access

[Retracted] Antitumor‑ and apoptosis‑inducing effects of pomolic acid against SK‑MEL‑2 human malignant melanoma cells are mediated via inhibition of cell migration and sub‑G1 cell cycle arrest

Tian-Hang Li, Hong-Xia Yan
Article Number: 481
Published online on: 26 April 2021

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Journal Cover
August-2026 Volume 34 Issue 2

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Regulatory function of ten‑eleven translocation‑2 in transcriptional mechanisms of demethylated myeloma cells

Lenka Slavickova, Michaela Nemcova, Dominika Svehlova, Veronika Frybortova, Jirina Manakova, Eva Kriegova, Jiri Minarik, Katerina Smesny Trtkova
Article Number: 237
Published online on: 25 June 2026

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Mulberroside A attenuates H2O2‑induced oxidative stress and barrier dysfunction in Caco‑2 cells through Nrf2/HO‑1‑associated antioxidant signaling

Jianxin Chen, Xiufeng Huang, Xi Chen, Wenhai Jin, Dawei Lin
Article Number: 236
Published online on: 25 June 2026

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[Retracted] Puerarin promotes DUSP1 expression by regulating miR‑133a‑3p in breast cancer

Zhifeng Li, Weiwei Xu, Xiaoyan Ren, Jinhua Xu, Jianxin Chen
Article Number: 235
Published online on: 23 June 2026

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Sulforaphane attenuates cisplatin‑induced acute kidney injury by inhibiting oxidative stress, inflammation and apoptosis via regulation of NRF2

Zeyu Wu, Mengting Lu, Lei Xu, Ming Luo, Limei Shan, Hongxia Xing, Wenwen Li, Junling Qian
Article Number: 234
Published online on: 19 June 2026

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Effects of β‑hydroxybutyrate on restoring autophagic flux and mitochondrial function in macrophages exposed to oxidized low‑density lipoprotein

Weiguang Luo, Mei He, Huiling Wang
Article Number: 233
Published online on: 19 June 2026

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Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review)

Xiaokang Wang, Qiwen Tan, Jingcheng Xu, Yunlin Yang, Haoyue Huang, Xiaomei Teng, Weihua Wu
Article Number: 232
Published online on: 18 June 2026

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Degraded sulfated galactan derived from Gracilaria fisheri induces immunogenic cell death in MDA‑MB‑231 cells

Tawut Rudtanatip, Yada Polsan, Waraporn Sakaew, Somsuda Somintara, Jenjiralai Phanphak, Jamal El‑Abid, Kanokpan Wongprasert, Choowadee Pariwatthanakun
Article Number: 231
Published online on: 17 June 2026

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Irbesartan ameliorates high‑glucose‑induced epithelial‑mesenchymal transition by downregulating the expression of NLRP3 in HK‑2 cells

Qing Deng, Xiujuan Liu, Dan Wen, Yuhua Cheng, Qing Zhao, Yu Wang, Yu Xiang, Qinkai Chen, Jinlei Lv
Article Number: 230
Published online on: 17 June 2026

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A β‑1,3‑1,6‑glucan from Aureobasidium pullulans enhances apoptotic and autophagic pathways in colorectal cancer cells

Ji-Won Park, Gyeong Mim Mun, Tae Min Jo, Ji A Shin, Takao Kuge, Hisashi Kimoto, Jin-Kyung Kim
Article Number: 229
Published online on: 16 June 2026

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Growth pattern and molecular biological analysis of primary meningioma cell cultures under different conditions

Stefan Linsler, Anna-Lena Moroldo, Walter Schulz‑Schaeffer, Ralf Ketter, Joachim Oertel, Steffi Urbschat
Article Number: 228
Published online on: 12 June 2026

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Melatonin alleviates mitochondrial damage by regulating SIRT3‑mediated mitochondrial dynamics in granulosa cells under PCOS‑like conditions

Congcong Xie, Zehao Liu, Tong Chen, Hui Lu, Xiujia Zhang, Wenbo Yu, Jiaxin Zhang, Dandan Shang, Xueying Wang
Article Number: 227
Published online on: 11 June 2026

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Strontium‑based metal‑organic framework/alendronate‑silk fibroin hydrogels promote tendon‑bone interface healing

Tao Yang, Hanji Zhang, Mingjun Li, Yiming Ren, Yunbo Sun, Weiyu Hou, Mengqiang Tian
Article Number: 226
Published online on: 11 June 2026

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[Retracted] Tripterygium glycoside suppresses epithelial‑to‑­­ mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway

Mei Tao, Danna Zheng, Xudong Liang, Diandian Wu, Kang Hu, Juan Jin, Qiang He
Article Number: 225
Published online on: 08 June 2026

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Gut microbiota‑derived metabolites in cardiovascular disease: Focus on trimethylamine N‑oxide, short‑chain fatty acids and bile acids (Review)

Meizhu Gao, Zhenming Hao, Yiling Li, Weixue Liu, Fubao Zhang
Article Number: 224
Published online on: 08 June 2026

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Fucoxanthin alleviates chondrocyte inflammation and osteoarthritis by modulating the JAK2/STAT3 signaling pathway

Miradj Siddick Adam, Huangming Zhuang, Xunshan Ren, Yuelong Zhang, Panghu Zhou
Article Number: 223
Published online on: 08 June 2026

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Prediction of molecular targets for zedoary turmeric oil in inhibiting proliferation and inducing apoptosis in non‑small cell lung cancer

Huaiyong Li, Lili Liu, Qingzhu Yang, Yao Li, Yongli Song, Jing Jiang, Zhenzhong Wu, Weiwei Zhang, Baisong Lou
Article Number: 222
Published online on: 08 June 2026

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Molecular mechanisms of iron metabolism and ferroptosis in cardiovascular diseases and intervention strategies targeting natural products (Review)

Liangqing Ge, Tianqing Zhang, Jiangbiao Yu, Sijie Xiao, Yu Zhou, Li Luo
Article Number: 221
Published online on: 05 June 2026

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[Corrigendum] Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis

Ruiqiao Guan, Zhihao Li, Xiaohong Dai, Wei Zou, Xueping Yu, Hao Liu, Qiuxin Chen, Wei Teng, Peng Liu, Xiaoying Liu, Shanshan Dong
Article Number: 220
Published online on: 03 June 2026

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LINC01117 promotes the malignant proliferation of lung adenocarcinoma by increasing HOXD8 mRNA stability

Lizhong Zeng, Jie Shi, Cai Zhang, Yujiao Dong, Yang Chen, Qiuhong Zhang, Long Zhang, Shuanying Yang
Article Number: 219
Published online on: 03 June 2026

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Targeting regulatory T cells in the prostate cancer microenvironment: From mechanisms to therapeutics (Review)

Hua Luo
Article Number: 218
Published online on: 03 June 2026

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Dapagliflozin alleviates heart failure with preserved ejection fraction potentially by regulating the AIM2/caspase‑1/GSDMD pathway and attenuating pyroptosis

Sailiang Ding, Hao Yang, Ting Lu, Yibin Luo, Liang Xu, Xianghui Zeng
Article Number: 217
Published online on: 03 June 2026

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[Retracted] Carnosic acid alleviates brain injury through NF‑κB‑regulated inflammation and Caspase‑3‑associated apoptosis in high fat‑induced mouse models

Yong Liu, Yan Zhang, Ming Hu, Yu-Hu Li, Xing-Hua Cao
Article Number: 216
Published online on: 02 June 2026

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SIRT1/AMPK/PGC1α pathway in ischemic stroke: Elucidating neuroprotective strategies (Review)

Irum Naz Abbasi, Nashwa Amin, Qiaolu Xu, Azhar Badry Hussain, Fei Wu, Xia Yuan, Yang Yang, Suhong Ye, Marong Fang, Yihua Jiang
Article Number: 215
Published online on: 02 June 2026

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Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review)

Yinhuan Wang, Jiefang Guan
Article Number: 214
Published online on: 29 May 2026

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September-2026 Volume 34 Issue 3

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Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Sedanolide alleviates LPS‑induced depressive‑like behaviors by modulating the C3a/C3aR signaling axis and microglial glycolysis

Shaocong Lu, Fangla Luo, Niqi Chen, Gongde Shi, Yeru Chen
Article Number: 257
Published online on: 16 July 2026

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Expression of Concern Open Access

[Expression of Concern] Chrysophanol inhibits proliferation and induces apoptosis through NF‑κB/cyclin D1 and NF‑κB/Bcl‑2 signaling cascade in breast cancer cell lines

Li Ren, Zhouping Li, Chunmei Dai, Danyu Zhao, Yanjie Wang, Chunyu Ma, Chun Liu
Article Number: 256
Published online on: 15 July 2026

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Article Open Access

PCSK9 alleviates doxorubicin‑induced pyroptosis of cardiomyocytes

Chaochu Cui, Jinyu Zhao, Xiaoqian Li, Shengming Huang, Gang Liu, Xinhui Xu, Can Guo, Tiesuo Zhao, Jiang Du, Shipeng Li, Xianwei Wang, Jianbo Yang
Article Number: 255
Published online on: 14 July 2026

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From cell to disease: Regulatory networks and mechanisms of super‑enhancers in aging (Review)

Xiaodan Wang, Weiqian Deng, Shuangxi Tu, Haojun Tang, Kai Yin, Xiao Zhu
Article Number: 254
Published online on: 14 July 2026

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[Retracted] Matrine‑induced apoptosis in Hep3B cells via the inhibition of MDM2

Ning Zhou, Jiequn Li, Ting Li, Guangshun Chen, Zhongqiang Zhang, Zhongzhou Si
Article Number: 253
Published online on: 13 July 2026

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Role of PANoptosis in the development of gastric immunity and related gastric mucosal disease (Review)

Lan Wang, Zhiyuan Ma, Bei Ji, Shuhui Liu, Shuji Terai, Biguang Tuo, Taolang Li, Xuemei Liu
Article Number: 252
Published online on: 09 July 2026

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Leonurine inhibits the proliferation and metastasis of liver cancer cells by regulating the PI3K/AKT signaling pathway via epithelial‑mesenchymal transition

Bowen Hu, Maher Al Hussan, Jiakai Zhang, Peihao Wen, Changjun Huang, Yang Chen, Huanfei Ding
Article Number: 251
Published online on: 08 July 2026

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[Corrigendum] Resistin aggravates the expression of proinflammatory cytokines in cerulein‑stimulated AR42J pancreatic acinar cells

Chong-Yi Jiang, Wei Wang
Article Number: 250
Published online on: 08 July 2026

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A‑Raf: A serine/threonine protein kinase with important biological functions (Review)

Muhan Yang, Mengying Chen, Jinmei Wei, Yanling Li, Chen Long, Yan Lei, Yanhong Zhou
Article Number: 249
Published online on: 07 July 2026

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Gut dysbiosis‑derived butyrate loss predicts feeding intolerance: Multiomics evidence guiding nurse‑driven microbiota‑supportive interventions (Review)

Ling Wei, Xiaohua Kong, Yuying Li, Huixia Wu, Yirong Gan, Fang Sun
Article Number: 248
Published online on: 07 July 2026

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[Retracted] Network pharmacology combined with experimental validation to investigate the effect of Rongjin Niantong Fang on chondrocyte apoptosis in knee osteoarthritis

Jun Chen, Ting Zhang, Qingqing Luo, Ruyi Wang, Yuting Dai, Zhenyuan Chen, Chutian Zhang, Xuzheng Chen, Guangwen Wu
Article Number: 247
Published online on: 06 July 2026

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Laggera alata attenuates LPS‑induced systemic inflammation and hepatic‑pulmonary injury by regulating PINK1/Parkin-associated mitophagy and macrophage polarization

Jiangcun Wei, Wen Zhong, Guangyun Zhou, Mingtao Huang, Xiaodong Huang, Jing Liang
Article Number: 246
Published online on: 02 July 2026

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Proteolysis‑targeting chimeras in oral squamous cell carcinoma: Current evidence, translational challenges and future directions (Review)

Yun Bai, Danhua Ma, Xi Yang, Min Wang
Article Number: 245
Published online on: 02 July 2026

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Evolving role of biomarkers beyond prostate‑specific antigen in refining prostate cancer screening: From blood‑based tests to urinary and genetic markers (Review)

Luxi Li, Linyue Zhang, Zehong Li, Keqiang Chai, Weidong Ren
Article Number: 244
Published online on: 02 July 2026

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Nanocurcumin attenuates brain injury in rats with desert dry‑heat‑induced exertional heat stroke by suppressing TLR4/MyD88/NF‑κB signaling

Lisong Su, Jinquan Qu, Jiajia Li, Wenhui Shi, Laiyang Song, Feixing Liang, Jiangwei Liu
Article Number: 243
Published online on: 02 July 2026

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TREM2 in glioma: Reprogramming the immune microenvironment from mechanistic understanding to clinical translation (Review)

Junqi Fan, Hongyan Shen, Dan Liu, Songbai Luo, Qingqing Huang, Yi Wen, Libang Yuan
Article Number: 242
Published online on: 02 July 2026

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Human parvovirus B19 VP1u‑induced osteoclastogenesis is enhanced by RANKL in RAW264.7 macrophage cells

Chun-Yu Lin, Bor-Show Tzang, Yi-Hsuan Lin, Chih-Chen Tzang, Tsai-Ching Hsu
Article Number: 241
Published online on: 30 June 2026

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Retraction Open Access

[Retracted] Anti‑tumor peptide AP25 decreases cyclin D1 expression and inhibits MGC‑803 proliferation via phospho­extracellular signal‑regulated kinase‑, Src‑, c‑Jun N‑terminal kinase‑ and phosphoinositide 3­-kinase‑associated pathways  

Jialiang Hu, Tao Cheng, Lijun Zhang, Beicheng Sun, Lei Deng, Hanmei Xu
Article Number: 240
Published online on: 29 June 2026

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Aspirin prevents postoperative peritoneal adhesions by inhibiting the TGF‑β1/Smad signaling pathway in rats

Siqi Yan, Yuan Ren, Bingyan Liu, Pai Xiong, Yimin Sun
Article Number: 239
Published online on: 29 June 2026

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Morinda officinalis oligosaccharides ameliorate corticosterone‑induced depression‑like behaviour in mice by modulating the BDNF signalling pathway and gut microbiota

Mengjie He, Zixuan Liu, Yuxin Chen, Xiaoru Wu, Xueling Dai, Qian Liu, Shuo Wang, Zeping Zuo, Yaxuan Sun
Article Number: 238
Published online on: 29 June 2026

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