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Pyropia yezoensis protein protects against TNF‑α‑induced myotube atrophy in C2C12 myotubes via the NF‑κB signaling pathway

  • Authors:
    • Min-Kyeong Lee
    • Youn Hee Choi
    • Taek-Jeong Nam
  • View Affiliations / Copyright

    Affiliations: Institute of Fisheries Sciences, Pukyong National University, Busan 46041, Republic of Korea
    Copyright: © Lee et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 486
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    Published online on: April 28, 2021
       https://doi.org/10.3892/mmr.2021.12125
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Abstract

The protein extracted from red algae Pyropia yezoensis has various biological activities, including anti‑inflammatory, anticancer, antioxidant, and antiobesity properties. However, the effects of P. yezoensis protein (PYCP) on tumor necrosis factor‑α (TNF‑α)‑induced muscle atrophy are unknown. Therefore, the present study investigated the protective effects and related mechanisms of PYCP against TNF‑α‑induced myotube atrophy in C2C12 myotubes. Treatment with TNF‑α (20 ng/ml) for 48 h significantly reduced myotube viability and diameter and increased intracellular reactive oxygen species levels; these effects were significantly reversed in a dose‑dependent manner following treatment with 25‑100 µg/ml PYCP. PYCP inhibited the expression of TNF receptor‑1 in TNF‑α‑induced myotubes. In addition, PYCP markedly downregulated the nuclear translocation of nuclear factor‑κB (NF‑κB) by inhibiting the phosphorylation of inhibitor of κB. Furthermore, PYCP treatment suppressed 20S proteasome activity, IL‑6 production, and the expression of the E3 ubiquitin ligases, atrogin‑1/muscle atrophy F‑box and muscle RING‑finger protein‑1. Finally, PYCP treatment increased the protein expression levels of myoblast determination protein 1 and myogenin in TNF‑α‑induced myotubes. The present findings indicate that PYCP may protect against TNF‑α‑induced myotube atrophy by inhibiting the proinflammatory NF‑κB pathway.
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View References

1 

Tolosa L, Morla M, Iglesias A, Busquets X, Llado J and Olmos G: IFN-gamma prevents TNF-alpha-induced apoptosis in C2C12 myotubes through down-regulation of TNF-R2 and increased NF-kappaB activity. Cell Signal. 17:1333–1342. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Lecker SH, Solomon V, Mitch WE and Goldberg AL: Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states. J Nutr. 129 (1S Suppl):227S–237S. 1999. View Article : Google Scholar : PubMed/NCBI

3 

Schiaffino S, Dyar KA, Ciciliot S, Blaauw B and Sandri M: Mechanisms regulating skeletal muscle growth and atrophy. FEBS J. 208:4294–4314. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Kandarian SC and Jackman RW: Intracellular signaling during skeletal muscle atrophy. Muscle Nerve. 33:155–165. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Egerman MA and Glass DJ: Signaling pathways controlling skeletal muscle mass. Crit Rev Biochem Mol Biol. 49:59–68. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Kirillova I, Chaisson M and Fausto N: Tumor necrosis factor induces DNA replication in hepatic cells through nuclear factor kappaB activation. Cell Growth Differ. 10:819–828. 1999.PubMed/NCBI

7 

Schutze S, Machleidt T and Kronke M: Mechanisms of tumor necrosis factor action. Semin Oncol. 19 (2 Suppl 4):S16–S24. 1992.PubMed/NCBI

8 

Basu A, Johnson DE and Woolard MD: Potentiation of tumor necrosis factor-alpha-induced cell death by rottlerin through a cytochrome-C-dependent pathway. Exp Cell Res. 278:209–214. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Li YP: TNF-alpha is a mitogen in skeletal muscle. Am J Physiol Cell Physiol. 285:C370–C376. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Li YP, Schwarts RJ, Waddell ID, Holloway BR and Reid MB: Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-kappaB activation in response to tumor necrosis factor alpha. FASEB J. 12:871–880. 1998. View Article : Google Scholar : PubMed/NCBI

11 

Cai D, Frantz JD, Tawa NE Jr, Melendez PA, Oh BC, Lidov HG, Hasselgren PO, Frontera WR, Lee J, Glass DJ and Shoelson SE: IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. Cell. 119:285–298. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Mourkioti F, Kratsios P, Luedde T, Song YH, Delafontaine P, Adami R, Parente V, Bottinelli R, Pasparakis M and Rosenthal N: Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration. J Clin Invest. 116:2945–2954. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Kumar A, Takada Y, Boriek AM and Aggarwasl BB: Nuclear factor-kappaB: Its role in health and disease. J Mol Med (Berl). 82:434–448. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Guttridge DC, Albanese C, Reuther JY, Pestell RG and Baldwin AS Jr: NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol Cell Biol. 19:5785–5799. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Mitin N, Kudla AJ, Konieczny SF and Taparowsky EJ: Differential effects of Ras signaling through NFkappaB on skeletal myogenesis. Oncogene. 20:1276–1286. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Berkes CA and Tapscott SJ: MyoD and the transcriptional control of myogenesis. Semin Cell Dev Biol. 16:585–595. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Wang Y, Hwang JY, Park HB, Yadav D, Oda T and Jin JO: Porphyran isolated from Pyropia yezoensis inhibits lipopolysaccharide-induced activation of dendritic cells in mice. Carbohydr Polym. 229:1154572020. View Article : Google Scholar : PubMed/NCBI

18 

Lee MK, Choi JW, Choi YH and Nam TJ: Pyropia yezoensis protein prevents dexamethasone-induced myotube atrophy in C2C12 myotubes. Mar Drugs. 16:4972018. View Article : Google Scholar : PubMed/NCBI

19 

Kim IH, Kwon MJ, Jung JH and Nam TJ: Protein extracted porphyra yezoensis prevents cisplatin-induced nephrotoxicity by downregulating the MAPK and NF-κB pathways. Int J Mol Med. 41:511–520. 2018.PubMed/NCBI

20 

Park SJ, Ryu J, Kim IH, Choi YH and Nam TJ: Activation of the mTOR signaling pathway in breast cancer MCF-7 cells by a peptide derived from porphyra yezoensis. Oncol Rep. 33:19–24. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Choi JW, Kwon MJ, Kim IH, Kim YM, Lee MK and Nam TJ: Pyropia yezoensis glycoprotein promotes the M1 to M2 macrophage phenotypic switch via the STAT3 and STAT6 transcription factors. Int J Mol Med. 38:666–674. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Kim CR, Kim YM, Lee MK, Kim IH, Choi YH and Nam TJ: Pyropia yezoensis peptide promotes collagen synthesis by activating the TGF-β/Smad signaling pathway in the human dermal fibroblast cell line HS27. Int J Mol Med. 39:31–38. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Choi JW, Kim IH, Kim YM, Lee MK, Choi YH and Nam TJ: Protective effect of Pyropia yezoensis glycoprotein on chronic ethanol consumption-induced hepatotoxicity in rats. Mol Med Rep. 14:4881–4886. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Castillero E, Alamdari N, Lecker SH and Hasselgren PO: Suppression of atrogin-1 and MuRF1 prevents dexamethasone-induced atrophy of cultured myotubes. Metabolism. 62:1495–1502. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Menconi M, Gonnella P, Petkova V, Lecker S and Hasselgren PO: Dexamethasone and corticosterone induce similar, but not identical, muscle wasting responses in cultured L6 and C2C12 myotubes. J Cell Biochem. 105:353–364. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Malafarina V, Uriz-Otano F, Iniesta R and Gil-Guerrero L: Sarcopenia in the elderly: Diagnosis, physiopathology and treatment. Maturitas. 71:109–114. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Kob R, Bollheimer LC, Bertsch T, Fellner C, Djukic M, Sieber CC and Fischer BE: Sarcopenic obesity: Molecular clues to a better understanding of its pathogenesis? Biogerontology. 16:15–29. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Jensen GL: Inflammation: Roles in aging and sarcopenia. JPEN J Parenter Enteral Nutr. 32:656–659. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Wing SS, Lecker SH and Jagoe RT: Proteolysis in illness-associated skeletal muscle atrophy: From pathways to networks. Crit Rev Clin Lab Sci. 48:49–70. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Ventadour S and Attaix D: Mechanisms of skeletal muscle atrophy. Curr Opin Rheumatol. 18:631–635. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Chen G and David V: TNF-R1 signaling: A beautiful pathway. Science. 296:1634–1635. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Li YP, Atkins CM, Sweatt JD and Reid MB: Mitochondria mediate tumor necrosis factor-alpha/NF-kappaB signaling in skeletal muscle myotubes. Antioxid Redox Signal. 1:97–104. 1999. View Article : Google Scholar : PubMed/NCBI

33 

Thoma A and Lightfoot AP: NF-κB and inflammatory cytokine signaling: Role in skeletal muscle atrophy. Adv Exp Med Biol. 1088:267–279. 2018. View Article : Google Scholar : PubMed/NCBI

34 

Li YP and Reid MB: NF-kappaB mediates the protein loss induced by TNF-alpha in differentiated skeletal muscle myotubes. Am J Physiol Regul Integr Comp Physiol. 279:R1165–R1170. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Thaloor D, Miller KJ, Gephart J, Mitchell PO and Pavlath GK: Systemic administration of the NF-kappaB inhibitor curcumin stimulates muscle regeneration after traumatic injury. Am J Physiol. 277:C320–C329. 1999. View Article : Google Scholar : PubMed/NCBI

36 

Nisr RB, Shah DS, Ganley IG and Hundal HS: Proinflammatory NFκB signaling promotes mitochondrial dysfunction in skeletal muscle in response to cellular fuel overloading. Cell Mol Life Sci. 76:4887–4904. 2019. View Article : Google Scholar : PubMed/NCBI

37 

McKinnell IW and Rudnicki MA: Molecular mechanisms of muscle atrophy. Cell. 119:907–910. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Legard GE and Pedersen BK: Muscle as an endocrine organ. Muscle Exerc Physiol. 25:258–307. 2019.

39 

Bhatnagar S, Panguluri SK, Gupta SK, Dahiya S, Lundy RF and Kumar A: Tumor necrosis factor-α regulates distinct molecular pathway and gene networks in cultured skeletal muscle cells. PLoS One. 5:e132622010. View Article : Google Scholar : PubMed/NCBI

40 

Lightfoot AP, Sakellariou GK, Nye GA, McArdle F, Jackson MJ, Griffiths RD and McArdle A: SS-31 attenuates TNF-α induced cytokine release from C2C12 myotubes. Redox Biol. 6:253–259. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Kaliman P, Canicio J, Testar X, Palacin M and Zorzano A: Insulin-like growth factor-II, phosphatidylinositol 3-kinase, nuclear factor-kappaB and inducible nitric-oxide synthase define a common myogenic signaling pathway. J Biol Chem. 274:17437–17444. 1999. View Article : Google Scholar : PubMed/NCBI

42 

Langen RC, Schols AM, Kelders MC, Wouters EF and Janssen-Heininger YM: Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor-kappaB. FASEB J. 15:1169–1180. 2001. View Article : Google Scholar : PubMed/NCBI

43 

Dogra C, Changotra H, Mohan S and Kumar A: Tumor necrosis factor-like weak inducer of apoptosis inhibits skeletal myogenesis through sustained activation of nuclear factor-kappaB and degradation of MyoD protein. J Biol Chem. 281:10327–10336. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Guttridge DC, Mayo MW, Madrid LV, Wang CY and Baldwin AS Jr: NF-kappaB-induced loss of MyoD messenger RNA: Possible role in muscle decay and cachexia. Science. 289:2363–2366. 2000. View Article : Google Scholar : PubMed/NCBI

45 

Sitcheran R, Cogswell PC and Baldwin AS Jr: NF-kappaB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism. Genes Dev. 17:2368–2373. 2003. View Article : Google Scholar : PubMed/NCBI

46 

Di Marco S, Mazroui R, Dallaire P, Chittur S, Tenenbaum SA, Radzioch D, Marette A and Gallouzi IE: NF-kappB-mediated MyoD decay during muscle wasting requires nitric oxide synthase mRNA stabilization, HuR protein, and nitric oxide release. Mol Cell Biol. 25:6533–6545. 2005. View Article : Google Scholar : PubMed/NCBI

47 

Roose JL, Wegener KM and Pakrasi HB: The extrinsic proteins of photosystem II. Photosynth Res. 92:369–387. 2007. View Article : Google Scholar : PubMed/NCBI

48 

Balint I, Bhattacharya J, Perelman A, Schatz D, Moskovitz Y, Keren N and Schwarz R: Inactivation of the extrinsic subunit of photosystem II, PsbU, in Synechococcus PCC 7942 results in elevated resistance to oxidative stress. FEBS Lett. 580:2117–2122. 2006. View Article : Google Scholar : PubMed/NCBI

49 

Abasova L, Deak Z, Schwarz R and Vass I: The role of the PsbU subunit in the light sensitivity of PSII in the cyanobacterium Synechococcus 7942. J Photochem Photobiol B. 105:149–156. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lee M, Choi Y and Nam T: <em>Pyropia yezoensis</em> protein protects against TNF‑α‑induced myotube atrophy in C2C12 myotubes via the NF‑κB signaling pathway. Mol Med Rep 24: 486, 2021.
APA
Lee, M., Choi, Y., & Nam, T. (2021). <em>Pyropia yezoensis</em> protein protects against TNF‑α‑induced myotube atrophy in C2C12 myotubes via the NF‑κB signaling pathway. Molecular Medicine Reports, 24, 486. https://doi.org/10.3892/mmr.2021.12125
MLA
Lee, M., Choi, Y., Nam, T."<em>Pyropia yezoensis</em> protein protects against TNF‑α‑induced myotube atrophy in C2C12 myotubes via the NF‑κB signaling pathway". Molecular Medicine Reports 24.1 (2021): 486.
Chicago
Lee, M., Choi, Y., Nam, T."<em>Pyropia yezoensis</em> protein protects against TNF‑α‑induced myotube atrophy in C2C12 myotubes via the NF‑κB signaling pathway". Molecular Medicine Reports 24, no. 1 (2021): 486. https://doi.org/10.3892/mmr.2021.12125
Copy and paste a formatted citation
x
Spandidos Publications style
Lee M, Choi Y and Nam T: <em>Pyropia yezoensis</em> protein protects against TNF‑α‑induced myotube atrophy in C2C12 myotubes via the NF‑κB signaling pathway. Mol Med Rep 24: 486, 2021.
APA
Lee, M., Choi, Y., & Nam, T. (2021). <em>Pyropia yezoensis</em> protein protects against TNF‑α‑induced myotube atrophy in C2C12 myotubes via the NF‑κB signaling pathway. Molecular Medicine Reports, 24, 486. https://doi.org/10.3892/mmr.2021.12125
MLA
Lee, M., Choi, Y., Nam, T."<em>Pyropia yezoensis</em> protein protects against TNF‑α‑induced myotube atrophy in C2C12 myotubes via the NF‑κB signaling pathway". Molecular Medicine Reports 24.1 (2021): 486.
Chicago
Lee, M., Choi, Y., Nam, T."<em>Pyropia yezoensis</em> protein protects against TNF‑α‑induced myotube atrophy in C2C12 myotubes via the NF‑κB signaling pathway". Molecular Medicine Reports 24, no. 1 (2021): 486. https://doi.org/10.3892/mmr.2021.12125
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