|
1
|
Valdivieso ÁG and Santa-Coloma TA: The
chloride anion as a signalling effector. Biol Rev Camb Philos Soc.
94:1839–1856. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Trampert DC, van de Graaf SFJ, Jongejan A,
Oude Elferink RPJ and Beuers U: Hepatobiliary acid-base
homeostasis: Insights from analogous secretory epithelia. J
Hepatol. 74:428–441. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Jun I, Cheng MH, Sim E, Jung J, Suh BL,
Kim Y, Son H, Park K, Kim CH, Yoon JH, et al: Pore dilatation
increases the bicarbonate permeability of CFTR, ANO1 and glycine
receptor anion channels. J Physiol. 594:2929–2955. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Shin DH, Kim M, Kim Y, Jun I, Jung J, Nam
JH, Cheng MH and Lee MG: Bicarbonate permeation through anion
channels: Its role in health and disease. Pflugers Arch.
472:1003–1018. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Parker MD and Boron WF: The divergence,
actions, roles, and relatives of sodium-coupled bicarbonate
transporters. Physiol Rev. 93:803–959. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Bertocchio JP, Genetet S, Da Costa L,
Walsh SB, Knebelmann B, Galimand J, Bessenay L, Guitton C, De
Lafaille R, Vargas-Poussou R, et al: Red blood cell AE1/band 3
transports in dominant distal renal tubular acidosis patients.
Kidney Int Rep. 5:348–357. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Casey JR, Sly WS, Shah GN and Alvarez BV:
Bicarbonate homeostasis in excitable tissues: Role of AE3
Cl−/HCO3− exchanger and carbonic
anhydrase XIV interaction. Am J Physiol Cell Physiol.
297:C1091–C1102. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Sowah D, Brown BF, Quon A, Alvarez BV and
Casey JR: Resistance to cardiomyocyte hypertrophy in
ae3−/− mice, deficient in the AE3
Cl−/HCO3− exchanger. BMC
Cardiovasc Disord. 14:892014. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Kopito RR, Lee BS, Simmons DM, Lindsey AE,
Morgans CW and Schneider K: Regulation of intracellular pH by a
neuronal homolog of the erythrocyte anion exchanger. Cell.
59:927–937. 1989. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Linn SC, Kudrycki KE and Shull GE: The
predicted translation product of a cardiac AE3 mRNA contains an N
terminus distinct from that of the brain AE3
Cl−/HCO3− exchanger. Cloning of a
cardiac AE3 cDNA, organization of the AE3 gene, and identification
of an alternative transcription initiation site. J Biol Chem.
267:7927–7935. 1992. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Bronckers AL, Jalali R and Lytton J:
Reduced protein expression of the
Na+/Ca2++K+-exchanger (SLC24A4) in
apical plasma membranes of maturation ameloblasts of fluorotic
mice. Calcif Tissue Int. 100:80–86. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Celay J, Lozano T, Concepcion AR, Beltrán
E, Rudilla F, García-Barchino MJ, Robles EF, Rabal O, de Miguel I,
Panizo C, et al: Targeting the anion exchanger 2 with specific
peptides as a new therapeutic approach in B lymphoid neoplasms.
Haematologica. 103:1065–1072. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Vigliarolo T, Zocchi E, Fresia C, Booz V
and Guida L: Abscisic acid influx into human nucleated cells occurs
through the anion exchanger AE2. Int J Biochem Cell Biol.
75:99–103. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Wu C, Liu X, Sun R, Sun R, Qin Y, Liu Z,
Yang S, Tang T, Zhu Z, Yu D and Liu F: Targeting anion exchange of
osteoclast, a new strategy for preventing wear particles
induced-osteolysis. Front Pharmacol. 9:12912018. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Gawenis LR, Ledoussal C, Judd LM, Prasad
V, Alper SL, Stuart-Tilley A, Woo AL, Grisham C, Sanford LP,
Doetschman T, et al: Mice with a targeted disruption of the AE2
Cl−/HCO3− exchanger are
achlorhydric. J Biol Chem. 279:30531–30539. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Yang Y, Wu PP, Wu J, Shen WW, Wu YL, Fu
AF, Zheng L, Jin XL and Fu GH: Expression of anion exchanger 2 in
human gastric cancer. Exp Oncol. 30:81–87. 2008.PubMed/NCBI
|
|
17
|
Sasaki M, Sato Y and Nakanuma Y: An
impaired biliary bicarbonate umbrella may be involved in
dysregulated autophagy in primary biliary cholangitis. Lab Invest.
98:745–754. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Alper SL: Molecular physiology and
genetics of Na+-independent SLC4 anion exchangers. J Exp
Biol. 212:1672–1683. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Romero MF: Molecular pathophysiology of
SLC4 bicarbonate transporters. Curr Opin Nephrol Hypertens.
14:495–501. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Cordat E and Reithmeier RA: Structure,
function, and trafficking of SLC4 and SLC26 anion transporters.
Curr Top Membr. 73:1–67. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Liu Y, Yang J and Chen LM: Structure and
function of SLC4 Family [Formula: See text] Transporters. Front
Physiol. 6:3552015. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Stewart AK, Kurschat CE, Vaughan-Jones RD
and Alper SL: Putative re-entrant loop 1 of AE2 transmembrane
domain has a major role in acute regulation of anion exchange by
pH. J Biol Chem. 284:6126–6139. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Stewart AK, Kerr N, Chernova MN, Alper SL
and Vaughan-Jones RD: Acute pH-dependent regulation of AE2-mediated
anion exchange involves discrete local surfaces of the NH2-terminal
cytoplasmic domain. J Biol Chem. 279:52664–52676. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Layden TJ, Schmidt L, Agnone L, Lisitza P,
Brewer J and Goldstein JL: Rabbit esophageal cell cytoplasmic pH
regulation: Role of Na+-H+ antiport and
H+-dependent HCO3− transport
systems. Am J Physiol. 263:G407–G413. 1992.PubMed/NCBI
|
|
25
|
Tobey NA, Reddy SP, Khalbuss WE, Silvers
SM, Cragoe EJ Jr and Orlando RC: Na(+)-dependent and -independent
Cl−/HCO3− exchangers in cultured
rabbit esophageal epithelial cells. Gastroenterology. 104:185–195.
1993. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Laczkó D, Rosztóczy A, Birkás K, Katona M,
Rakonczay Z Jr, Tiszlavicz L, Róka R, Wittmann T, Hegyi P and
Venglovecz V: Role of ion transporters in the bile acid-induced
esophageal injury. Am J Physiol Gastrointest Liver Physiol.
311:G16–G31. 2016. View Article : Google Scholar
|
|
27
|
Abdulnour-Nakhoul S, Nakhoul HN, Kalliny
MI, Kalliny MI, Gyftopoulos A, Rabon E, Doetjes R, Brown K and
Nakhoul NL: Ion transport mechanisms linked to bicarbonate
secretion in the esophageal submucosal glands. Am J Physiol Regul
Integr Comp Physiol. 301:R83–R96. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Shiozaki A, Hikami S, Ichikawa D, Kosuga
T, Shimizu H, Kudou M, Yamazato Y, Kobayashi T, Shoda K, Arita T,
et al: Anion exchanger 2 suppresses cellular movement and has
prognostic significance in esophageal squamous cell carcinoma.
Oncotarget. 9:25993–26006. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Persi E, Duran-Frigola M, Damaghi M, Roush
WR, Aloy P, Cleveland JL, Gillies RJ and Ruppin E: Systems analysis
of intracellular pH vulnerabilities for cancer therapy. Nat Commun.
9:29972018. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Seidler U, Song P, Xiao F, Riederer B,
Bachmann O and Chen M: Recent advances in the molecular and
functional characterization of acid/base and electrolyte
transporters in the basolateral membranes of gastric and duodenal
epithelial cells. Acta Physiol (Oxf). 201:3–20. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Humphreys BD, Jiang L, Chernova MN and
Alper SL: Hypertonic activation of AE2 anion exchanger in Xenopus
oocytes via NHE-mediated intracellular alkalinization. Am J
Physiol. 268:C201–C209. 1995. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Rossmann H, Bachmann O, Wang Z, Shull GE,
Obermaier B, Stuart-Tilley A, Alper SL and Seidler U: Differential
expression and regulation of AE2 anion exchanger subtypes in rabbit
parietal and mucous cells. J Physiol. 534:837–848. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Alper SL: Molecular physiology of SLC4
anion exchangers. Exp Physiol. 91:153–161. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Recalde S, Muruzábal F, Looije N, Kunne C,
Burrell MA, Sáez E, Martínez-Ansó E, Salas JT, Mardones P, Prieto
J, et al: Inefficient chronic activation of parietal cells in
Ae2a,b(−/-) mice. Am J Pathol. 169:165–176. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Kurschat CE, Shmukler BE, Jiang L, Wihelm
S, Kim EH, Chernova MN, Kinne RK, Stewart AK and Alper SL:
Alkaline-shifted pHo sensitivity of AE2c1-mediated anion exchange
reveals novel regulatory determinants in the AE2 N-terminal
cytoplasmic domain. J Biol Chem. 281:1885–1896. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Huang QR, Li Q, Chen YH, Li L, Liu LL, Lei
SH, Chen HP, Peng WJ and He M: Involvement of anion exchanger-2 in
apoptosis of endothelial cells induced by high glucose through an
mPTP-ROS-Caspase-3 dependent pathway. Apoptosis. 15:693–704. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Wang T, Fei HJ, Yang Y, Jiang XS, Yan M,
Zeng Z, Wu J, Song LJ, Tian H and Fu GH: Expression of AE1/p16
promoted degradation of AE2 in gastric cancer cells. BMC Cancer.
16:7162016. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Wang T, Zhao L, Yang Y, Tian H, Suo WH,
Yan M and Fu GH: EGR1 is critical for gastrin-dependent
upregulation of anion exchanger 2 in gastric cancer cells. FEBS J.
280:174–183. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Cui Y, Li SB, Peng XC, Wu J and Fu GH:
Trastuzumab inhibits growth of HER2-negative gastric cancer cells
through gastrin-initialized CCKBR signaling. Dig Dis Sci.
60:3631–3641. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Walker NM, Flagella M, Gawenis LR, Shull
GE and Clarke LL: An alternate pathway of cAMP-stimulated Cl
secretion across the NKCC1-null murine duodenum. Gastroenterology.
123:531–541. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Murek M, Kopic S and Geibel J: Evidence
for intestinal chloride secretion. Exp Physiol. 95:471–478. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Zhu JX, Xue H, Ji T and Xing Y: Cellular
localization of NKCC2 and its possible role in the Cl- absorption
in the rat and human distal colonic epithelia. Transl Res.
158:146–154. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Hashemian F, Ghorbanian MA, Hashemian F,
Mortazavi SA, Sheikhi M, Jahanshahi J and Poorolajal J: Effect of
topical furosemide on rhinosinusal polyposis relapse after
endoscopic sinus surgery: A randomized clinical trial. JAMA
Otolaryngol Head Neck Surg. 142:1045–1049. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Walker NM, Liu J, Stein SR, Stefanski CD,
Strubberg AM and Clarke LL: Cellular chloride and bicarbonate
retention alters intracellular pH regulation in Cftr KO crypt
epithelium. Am J Physiol Gastrointest Liver Physiol. 310:G70–G80.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Peña-Münzenmayer G, Catalán MA, Kondo Y,
Jaramillo Y, Liu F, Shull GE and Melvin JE: Ae4 (Slc4a9) anion
exchanger drives Cl- uptake-dependent fluid secretion by mouse
submandibular gland acinar cells. J Biol Chem. 290:10677–10688.
2015. View Article : Google Scholar
|
|
46
|
Kaji I and Kaunitz JD: Luminal
chemosensing in the gastroduodenal mucosa. Curr Opin Gastroenterol.
33:439–445. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Takeuchi K, Kita K, Hayashi S and Aihara
E: Regulatory mechanism of duodenal bicarbonate secretion: Roles of
endogenous prostaglandins and nitric oxide. Pharmacol Ther.
130:59–70. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Tuo B, Wen G, Wei J, Liu X, Wang X, Zhang
Y, Wu H, Dong X, Chow JY, Vallon V and Dong H: Estrogen regulation
of duodenal bicarbonate secretion and sex-specific protection of
human duodenum. Gastroenterology. 141:854–863. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Alrefai WA, Tyagi S, Nazir TM, Barakat J,
Anwar SS, Hadjiagapiou C, Bavishi D, Sahi J, Malik P, Goldstein J,
et al: Human intestinal anion exchanger isoforms: Expression,
distribution, and membrane localization. Biochim Biophys Acta.
1511:17–27. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Alper SL, Rossmann H, Wilhelm S,
Stuart-Tilley AK, Shmukler BE and Seidler U: Expression of AE2
anion exchanger in mouse intestine. Am J Physiol. 277:G321–G332.
1999.PubMed/NCBI
|
|
51
|
Bachmann O and Seidler U: News from the
end of the gut-how the highly segmental pattern of colonic
HCO3− transport relates to absorptive
function and mucosal integrity. Biol Pharm Bull. 34:794–802. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Ikuma M, Geibel J, Binder HJ and Rajendran
VM: Characterization of Cl-HCO3 exchange in basolateral
membrane of rat distal colon. Am J Physiol Cell Physiol.
285:C912–C921. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Gawenis LR, Bradford EM, Alper SL, Prasad
V and Shull GE: AE2 Cl−/HCO3−
exchanger is required for normal cAMP-stimulated anion secretion in
murine proximal colon. Am J Physiol Gastrointest Liver Physiol.
298:G493–G503. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Jeong YS and Hong JH: Governing effect of
regulatory proteins for Cl(−)/HCO3(−) exchanger 2
activity. Channels (Austin). 10:214–224. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
O'Mahony F and Harvey BJ: Sex and estrous
cycle-dependent rapid protein kinase signaling actions of estrogen
in distal colonic cells. Steroids. 73:889–894. 2008. View Article : Google Scholar
|
|
56
|
Song LJ, Liu RJ, Zeng Z, Alper SL, Cui HJ,
Lu Y, Zheng L, Yan ZW and Fu GH: Gastrin inhibits a novel,
pathological colon cancer signaling pathway involving EGR1, AE2,
and P-ERK. J Mol Med (Berl). 90:707–718. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Hulikova A, Black N, Hsia LT, Wilding J,
Bodmer WF and Swietach P: Stromal uptake and transmission of acid
is a pathway for venting cancer cell-generated acid. Proc Natl Acad
Sci USA. 113:E5344–E5353. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Roussa E, Alper SL and Thévenod F:
Immunolocalization of anion exchanger AE2, Na(+)/H(+) exchangers
NHE1 and NHE4, and vacuolar type H(+)-ATPase in rat pancreas. J
Histochem Cytochem. 49:463–474. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Rakonczay Z Jr, Fearn A, Hegyi P, Boros I,
Gray MA and Argent BE: Characterization of H+ and
HCO3− transporters in CFPAC-1 human
pancreatic duct cells. World J Gastroenterol. 12:885–895. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Rakonczay Z Jr, Hegyi P, Hasegawa M, Inoue
M, You J, Lida A, Lgnáth I, Alton EWFWA, Griesenbach U, Ovári G, et
al: CFTR gene transfer to human cystic fibrosis pancreatic duct
cells using a Sendai virus vector. J Cell Physiol. 214:442–455.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Park HW, Nam JH, Kim JY, Namkung W, Yoon
JS, Lee JS, Kim KS, Venglovecz V, Gray MA, Kim KH and Lee MG:
Dynamic regulation of CFTR bicarbonate permeability by [Cl-]i and
its role in pancreatic bicarbonate secretion. Gastroenterology.
139:620–631. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Yamaguchi M, Steward MC, Smallbone K,
Sohma Y, Yamamoto A, Ko SB, Kondo T and Ishiguro H:
Bicarbonate-rich fluid secretion predicted by a computational model
of guinea-pig pancreatic duct epithelium. J Physiol. 595:1947–1972.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Hong JH, Muhammad E, Zheng C, Hershkovitz
E, Alkrinawi S, Loewenthal N, Parvari R and Muallem S: Essential
role of carbonic anhydrase XII in secretory gland fluid and
HCO3(−) secretion revealed by disease causing human
mutation. J Physiol. 593:5299–5312. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Venter J, Francis H, Meng F, DeMorrow S,
Kennedy L, Standeford H, Hargrove L, Wu N, Wan Y, Frampton G, et
al: Development and functional characterization of extrahepatic
cholangiocyte lines from normal rats. Dig Liver Dis. 47:964–972.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Tietz PS, Marinelli RA, Chen XM, Huang B,
Cohn J, Kole J, McNiven MA, Alper S and LaRusso NF: Agonist-induced
coordinated trafficking of functionally related transport proteins
for water and ions in cholangiocytes. J Biol Chem. 278:20413–20419.
2003. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Aranda V, Martínez I, Melero S, Lecanda J,
Banales JM, Prieto J and Medina JF: Shared apical sorting of anion
exchanger isoforms AE2a, AE2b1, and AE2b2 in primary hepatocytes.
Biochem Biophys Res Commun. 319:1040–1046. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
García C, Montuenga LM, Medina JF and
Prieto J: In situ detection of AE2 anion-exchanger mRNA in the
human liver. Cell Tissue Res. 291:481–488. 1998. View Article : Google Scholar
|
|
68
|
Beuers U, Maroni L and Elferink RO: The
biliary HCO(3)(−) umbrella: Experimental evidence revisited. Curr
Opin Gastroenterol. 28:253–257. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Rodrigues PM, Perugorria MJ, Santos-Laso
A, Bujanda L, Beuers U and Banales JM: Primary biliary cholangitis:
A tale of epigenetically-induced secretory failure? J Hepatol.
69:1371–1383. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Hohenester S, Wenniger LM, Paulusma CC,
van Vliet SJ, Jefferson DM, Elferink RP and Beuers U: A biliary
HCO3- umbrella constitutes a protective mechanism
against bile acid-induced injury in human cholangiocytes.
Hepatology. 55:173–183. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Chang JC, Go S, de Waart DR, Munoz-Garrido
P, Beuers U, Paulusma CC and Oude Elferink R: Soluble adenylyl
cyclase regulates bile salt-induced apoptosis in human
cholangiocytes. Hepatology. 64:522–534. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Maillette de Buy Wenniger LJ, Hohenester
S, Maroni L, van Vliet SJ, Oude Elferink RP and Beuers U: The
cholangiocyte glycocalyx stabilizes the ‘Biliary HCO3
umbrella’: An integrated line of defense against toxic bile acids.
Dig Dis. 33:397–407. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Miszczuk GS, Banales JM, Zucchetti AE,
Pisani GB, Boaglio AC, Saez E, Medina JF, Roma MG and Crocenzi FA:
Adaptive downregulation of
Cl−/HCO3− exchange activity in rat
hepatocytes under experimental obstructive cholestasis. PLoS One.
14:e02122152019. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Uriarte I, Banales JM, Sáez E, Arenas F,
Oude Elferink RP, Prieto J and Medina JF: Bicarbonate secretion of
mouse cholangiocytes involves Na(+)-HCO(3)(−) cotransport in
addition to Na(+)-independent Cl(−)/HCO(3)(−) exchange. Hepatology.
51:891–902. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Erice O, Munoz-Garrido P, Vaquero J,
Perugorria MJ, Fernandez-Barrena MG, Saez E, Santos-Laso A,
Arbelaiz A, Jimenez-Agüero R, Fernandez-Irigoyen J, et al:
MicroRNA-506 promotes primary biliary cholangitis-like features in
cholangiocytes and immune activation. Hepatology. 67:1420–1440.
2018. View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Banales JM, Prieto J and Medina JF:
Cholangiocyte anion exchange and biliary bicarbonate excretion.
World J Gastroenterol. 12:3496–3511. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Renzi A, DeMorrow S, Onori P, Carpino G,
Mancinelli R, Meng F, Venter J, White M, Franchitto A, Francis H,
et al: Modulation of the biliary expression of arylalkylamine
N-acetyltransferase alters the autocrine proliferative responses of
cholangiocytes in rats. Hepatology. 57:1130–1141. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
78
|
Banales JM, Sáez E, Uriz M, Sarvide S,
Urribarri AD, Splinter P, Tietz Bogert PS, Bujanda L, Prieto J,
Medina JF and LaRusso NF: Up-regulation of microRNA 506 leads to
decreased Cl−/HCO3− anion
exchanger 2 expression in biliary epithelium of patients with
primary biliary cirrhosis. Hepatology. 56:687–697. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Brooks WH and Renaudineau Y: Epigenetics
and autoimmune diseases: The X chromosome-nucleolus nexus. Front
Genet. 6:222015. View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Wang W, Ren X, Cai Y, Chen L, Zhang W and
Xu J: Rifampicin induces bicarbonate-rich choleresis in rats:
Involvement of anion exchanger 2. Dig Dis Sci. 61:126–136. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Medina JF: Role of the anion exchanger 2
in the pathogenesis and treatment of primary biliary cirrhosis. Dig
Dis. 29:103–112. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Tian L, Ye Z, Kafka K, Stewart D, Anders
R, Schwarz KB and Jang YY: Biliary atresia relevant human induced
pluripotent stem cells recapitulate key disease features in a dish.
J Pediatr Gastroenterol Nutr. 68:56–63. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Arenas F, Hervías I, Sáez E, Melero S,
Prieto J, Parés A and Medina JF: Promoter hypermethylation of the
AE2/SLC4A2 gene in PBC. JHEP Rep. 1:145–153. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Melero S, Spirlì C, Zsembery A, Medina JF,
Joplin RE, Duner E, Zuin M, Neuberger JM, Prieto J and Strazzabosco
M: Defective regulation of cholangiocyte
Cl−/HCO3(−) and Na+/H+
exchanger activities in primary biliary cirrhosis. Hepatology.
35:1513–1521. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Hisamoto S, Shimoda S, Harada K, Iwasaka
S, Onohara S, Chong Y, Nakamura M, Bekki Y, Yoshizumi T, Ikegami T,
et al: Hydrophobic bile acids suppress expression of AE2 in biliary
epithelial cells and induce bile duct inflammation in primary
biliary cholangitis. J Autoimmun. 75:150–160. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
86
|
Prieto J, Qian C, García N, Díez J and
Medina JF: Abnormal expression of anion exchanger genes in primary
biliary cirrhosis. Gastroenterology. 105:572–578. 1993. View Article : Google Scholar : PubMed/NCBI
|
|
87
|
Concepcion AR, Salas JT, Sáez E, Sarvide
S, Ferrer A, Portu A, Uriarte I, Hervás-Stubbs S, Oude Elferink RP,
et al: CD8+ T cells undergo activation and programmed death-1
repression in the liver of aged Ae2a,b−/− mice favoring
autoimmune cholangitis. Oncotarget. 6:28588–28606. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Salas JT, Banales JM, Sarvide S, Recalde
S, Ferrer A, Uriarte I, Oude Elferink RP, Prieto J and Medina JF:
Ae2a,b-deficient mice develop antimitochondrial antibodies and
other features resembling primary biliary cirrhosis.
Gastroenterology. 134:1482–1493. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Concepcion AR, Salas JT, Sarvide S, Sáez
E, Ferrer A, López M, Portu A, Banales JM, Hervás-Stubbs S, Oude
Elferink RP, et al: Anion exchanger 2 is critical for CD8(+) T
cells to maintain pHi homeostasis and modulate immune responses.
Eur J Immunol. 44:1341–1351. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
90
|
Poupon R, Ping C, Chrétien Y, Corpechot C,
Chazoillères O, Simon T, Heath SC, Matsuda F, Poupon RE, Housset C
and Barbu V: Genetic factors of susceptibility and of severity in
primary biliary cirrhosis. J Hepatol. 49:1038–1045. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Zhang L, Su H, Li Y, Fan YJ, Wang Q, Jiang
J, Hu Y, Chen G, Tan B and Qiu F: Different effects of
ursodeoxycholic acid on intrahepatic cholestasis in acute and
recovery stages induced by alpha-naphthylisothiocyanate in mice.
Toxicol Appl Pharmacol. 342:69–78. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Úriz M, Sáez E, Prieto J, Medina JF and
Banales JM: Ursodeoxycholic acid is conjugated with taurine to
promote secretin-stimulated biliary hydrocholeresis in the normal
rat. PLoS One. 6:e287172011. View Article : Google Scholar
|
|
93
|
Wu TT, Hsieh YH, Wu CC, Tsai JH, Hsieh YS,
Huang CY and Liu JY: Overexpression of anion exchanger 2 in human
hepatocellular carcinoma. Chin J Physiol. 49:192–198.
2006.PubMed/NCBI
|
|
94
|
Liu CJ, Hwang JM, Wu TT, Hsieh YH, Wu CC,
Hsieh YS, Tsai CH, Wu HC, Huang CY and Liu JY: Anion exchanger
inhibitor DIDS induces human poorly-differentiated malignant
hepatocellular carcinoma HA22T cell apoptosis. Mol Cell Biochem.
308:117–125. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
95
|
Hwang JM, Kao SH, Hsieh YH, Li KL, Wang
PH, Hsu LS and Liu JY: Reduction of anion exchanger 2 expression
induces apoptosis of human hepatocellular carcinoma cells. Mol Cell
Biochem. 327:135–144. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
96
|
Svastova E, Witarski W, Csaderova L, Kosik
I, Skvarkova L, Hulikova A, Zatovicova M, Barathova M, Kopacek J,
Pastorek J and Pastorekova S: Carbonic anhydrase IX interacts with
bicarbonate transporters in lamellipodia and increases cell
migration via its catalytic domain. J Biol Chem. 287:3392–3402.
2012. View Article : Google Scholar : PubMed/NCBI
|