Roles of Cl‑/HCO3‑ anion exchanger 2 in the physiology and pathophysiology of the digestive system (Review)

Wang,Hui; An,Jiaxing; Jin,Hai; He,Suyu; Liao,Chengcheng; Wang,Juan; Tuo,Biguang

doi:10.3892/mmr.2021.12130

Roles of Cl^‑/HCO₃^‑ anion exchanger 2 in the physiology and pathophysiology of the digestive system (Review)

Authors:
- Hui Wang
- Jiaxing An
- Hai Jin
- Suyu He
- Chengcheng Liao
- Juan Wang
- Biguang Tuo
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Affiliations: Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China, The Fourth Department of the Digestive Disease Center, Suining Central Hospital, Suining, Sichuan 629000, P.R. China, Special Key Laboratory of Oral Disease Research, Higher Education Institution in Guizhou Province, School of Stomatology, Zunyi Medical University, Zunyi, Guizhou 563006, P.R. China
Published online on: May 5, 2021 https://doi.org/10.3892/mmr.2021.12130
Article Number: 491

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Abstract

Cl^‑/HCO₃^‑ anion exchangers (AEs), which are members of the solute carrier 4 family, contribute to the exchange of one intracellular HCO₃^‑ for one extracellular Cl^‑. AE2, a vital subtype of the Cl^‑/HCO₃^‑ exchangers, is expressed widely in various cells and tissues in mammals and serves essential roles in the pathophysiological processes of the cardiovascular system and renal tubular reabsorption. Recently, research on the function of AE2 in the digestive system shed new light on its roles in the regulation of cellular and organ physiology. AE2 not only participates in gastric acid secretion, but also mediates bile secretion and digestive cancer development. The aim of the present review was to describe the role of AE2 in the physiology and pathophysiology of the digestive system, with the aim of guiding clinical diagnosis and treatment.

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