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Oral peroxidases: From antimicrobial agents to ecological actors (Review)

  • Authors:
    • Philippe Courtois
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    Affiliations: Faculty of Medicine, Université Libre de Bruxelles, B‑1070 Brussels, Belgium
    Copyright: © Courtois et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 500
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    Published online on: May 6, 2021
       https://doi.org/10.3892/mmr.2021.12139
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Abstract

Sialoperoxidase and myeloperoxidase are the two main peroxidase enzymes found in the oral cavity. Sialoperoxidase is present in salivary secretions and in the biofilms that line the oral surfaces, while myeloperoxidase is abundant in the dento‑gingival sulcus area. In the presence of hydrogen peroxide (H2O2), oral peroxidases catalyze the oxidation of the pseudohalide anion thiocyanate (SCN‑) to hypothiocyanite (OSCN‑), a strong oxidant that serves an antimicrobial role. Furthermore, oral peroxidases consume bacteria‑produced H2O2 and could help inactivate toxic carcinogenic and genotoxic substances. Numerous in vitro studies have reported the antibacterial, antimycotic and antiviral role of peroxidases, suggesting possible applications in oral therapy. However, the use of oral hygiene products incorporating peroxidase systems has not yet been shown to be beneficial for the treatment or prevention of oral infections. This paradox reflects our incomplete knowledge of the physiological role of peroxidases in a complex environment, such as the oral region. While hygiene is crucial for restoring oral microbiota to a symbiotic state, there are no data to suggest that the addition of a peroxidase per se can create a dysbiotic state. Recent investigations have associated the presence of peroxidase activity with gram‑positive cocci microbial flora, and its insufficiency with dysbiosis has been linked to pathologies, such as caries, periodontitis or infections of the oral mucosa. Therefore, oxidants generated by oral peroxidases appear to be an essential ecological determinant for oral health through the selection of a symbiotic microbiota capable of resisting oxidative stress. The objective of the present review was to update the current knowledge of the physiological aspects and applications of oral peroxidases in clinical practice.
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1 

Pruitt KM and Reiter B: Biochemistry of peroxidase system: Antimicrobial effects. The lactoperoxidase system: Chemistry and Biological Significance. Pruitt KM and Tenovuo JO: Marcel Dekker; New York: pp. 143–178. 1985

2 

Bafort F, Parisi O, Perraudin JP and Jijakli MH: Mode of action of lactoperoxidase as related to its antimicrobial activity: A review. Enzyme Res. 2014:5171642014. View Article : Google Scholar : PubMed/NCBI

3 

Thomas EL, Jefferson MM, Joyner RE, Cook GS and King CC: Leukocyte myeloperoxidase and salivary lactoperoxidase: Identification and quantitation in human mixed saliva. J Dent Res. 73:544–555. 1994. View Article : Google Scholar : PubMed/NCBI

4 

Ihalin R, Loimaranta V and Tenovuo J: Origin, structure, and biological activities of peroxidases in human saliva. Arch Biochem Biophys. 445:261–268. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Morrison M, Allen PZ, Bright J and Jayasinghe W: Lactoperoxidase. V. Identification and isolation of lactoperoxidase from salivary gland. Arch Biochem Biophys. 111:126–133. 1965. View Article : Google Scholar : PubMed/NCBI

6 

Slowey RR, Eidelman S and Klebanoff SJ: Antibacterial activity of the purified peroxidase from human parotid saliva. J Bacteriol. 96:575–579. 1968. View Article : Google Scholar : PubMed/NCBI

7 

Mansson-Rahemtulla B, Rahemtulla F, Baldone DC, Pruitt KM and Hjerpe A: Purification and characterization of human salivary peroxidase. Biochemistry. 27:233–239. 1988. View Article : Google Scholar : PubMed/NCBI

8 

Mansson-Rahemtulla B, Rahemtulla F and Humphreys-Beher MG: Human salivary peroxidase and bovine lactoperoxidase are cross-reactive. J Dent Res. 69:1839–1846. 1990. View Article : Google Scholar : PubMed/NCBI

9 

Gothefors L and Marklund S: Lactoperoxidase activity in human milk and in saliva of newborn infants. Infect Immun. 11:1210–1215. 1975. View Article : Google Scholar : PubMed/NCBI

10 

Tenovuo J, Lehtonen OP, Aaltonen AS, Vilja P and Tuohimaa P: Antimicrobial factors in whole saliva of human infants. Infect Immun. 51:49–53. 1986. View Article : Google Scholar : PubMed/NCBI

11 

Tenovuo J: The peroxidase system in human secretions. The lactoperoxidase system: Chemistry and Biological Significance. Pruitt KM and Tenovuo J: Marcel Dekker; New York: pp. 101–122. 1985

12 

Tenovuo J: Nonimmunoglobulin defense factors in human saliva. Human saliva: Clinical chemistry and microbiology. 2. Tenovuo J: Boca Raton, FL: CRC Press; pp. 55–91. 1989

13 

Mäkinen KK and Tenovuo J: Chromatographic separation of human salivary peroxidases. Acta Odontol Scand. 34:141–150. 1976. View Article : Google Scholar

14 

Tenovuo J: Different molecular forms of human salivary lactoperoxidase. Arch Oral Biol. 26:1051–1055. 1981. View Article : Google Scholar : PubMed/NCBI

15 

Pruitt KM and Adamson M: Enzyme activity of salivary lactoperoxidase adsorbed to human enamel. Infect Immun. 17:112–116. 1977. View Article : Google Scholar : PubMed/NCBI

16 

Tenovuo J, Valtakoski J and Knuuttila ML: Antibacterial activity of lactoperoxidase adsorbed by human salivary sediment and hydroxyapatite. Caries Res. 11:257–262. 1977. View Article : Google Scholar : PubMed/NCBI

17 

Pruitt KM, Adamson M and Arnold R: Lactoperoxidase binding to streptococci. Infect Immun. 25:304–309. 1979. View Article : Google Scholar : PubMed/NCBI

18 

Cole MF, Hsu SD, Baum BJ, Bowen WH, Sierra Ll, Aquirre M and Gillepsie G: Specific and nonspecific immune factors in dental plaque fluid and saliva from young and old populations. Infect Immun. 31:998–1002. 1981. View Article : Google Scholar : PubMed/NCBI

19 

Wright DE: The differential leucocyte count of human saliva. Arch Oral Biol. 13:1159–1161. 1968. View Article : Google Scholar : PubMed/NCBI

20 

Raeste AM: The differential count of oral leukocytes. Scand J Dent Res. 80:63–67. 1972.PubMed/NCBI

21 

Skapski H and Lehner T: A crevicular washing method for investigating immune components of crevicular fluid in man. J Periodontal Res. 11:19–24. 1976. View Article : Google Scholar : PubMed/NCBI

22 

Kowolik MJ and Grant M: Myeloperoxidase activity in human gingival crevicular neutrophils. Arch Oral Biol. 28:293–295. 1983. View Article : Google Scholar : PubMed/NCBI

23 

Smith QT and Yang CH: Salivary myeloperoxidase of young adult humans. Proc Soc Exp Biol Med. 175:468–475. 1984. View Article : Google Scholar : PubMed/NCBI

24 

Vidović A, Vidović Juras D, Vučićević Boras V, Lukač J, Grubišić-Ilić M, Rak D and Sabioncello A: Determination of leucocyte subsets in human saliva by flow cytometry. Arch Oral Biol. 57:577–583. 2012. View Article : Google Scholar

25 

Calonius PE: The leukocyte count in saliva. Oral Surg Oral Med Oral Pathol. 11:43–46. 1958. View Article : Google Scholar : PubMed/NCBI

26 

Woolweaver DA, Koch GG, Crawford JJ and Lundblad RL: Relation of the orogranulocytic migratory rate to periodontal disease and blood leukocyte count: A clinical study. J Dent Res. 51:929–939. 1972. View Article : Google Scholar : PubMed/NCBI

27 

Cao CF and Smith QT: Crevicular fluid myeloperoxidase at healthy, gingivitis and periodontitis sites. J Clin Periodontol. 16:17–20. 1989. View Article : Google Scholar : PubMed/NCBI

28 

Aune TM and Thomas EL: Accumulation of hypothiocyanite ion during peroxidase-catalysed oxidation of thiocyanate ion. Eur J Biochem. 80:209–214. 1977. View Article : Google Scholar : PubMed/NCBI

29 

Aune TM and Thomas EL: Oxidation of protein sulfhydryls by products of peroxidase-catalyzed oxidation of thiocyanate ion. Biochemistry. 17:1005–1010. 1978. View Article : Google Scholar : PubMed/NCBI

30 

Thomas EL, Milligan TW, Joyner RE and Jefferson MM: Antibacterial activity of hydrogen peroxide and the lactoperoxidase-hydrogen peroxide-thiocyanate system against oral streptococci. Infect Immun. 62:529–535. 1994. View Article : Google Scholar : PubMed/NCBI

31 

Clem WH and Klebanoff SJ: Inhibitory effect of saliva on glutamic acid accumulation by Lactobacillus acidophilus and the role of the lactoperoxidase-thiocyanate system. J Bacteriol. 91:1848–1853. 1966. View Article : Google Scholar : PubMed/NCBI

32 

Courtois P, Majerus P, Labbé M, Vanden Abbeele A, Yourassowsky E and Pourtois M: Susceptibility of anaerobic microorganisms to hypothiocyanite produced by lactoperoxidase. Acta Stomatol Belg. 89:155–162. 1992.PubMed/NCBI

33 

Ahariz M, Mouhyi J, Louette P, Van Reck J, Malevez C and Courtois P: Adsorption of peroxidase on titanium surfaces: A pilot study. J Biomed Mater Res. 52:567–571. 2000. View Article : Google Scholar : PubMed/NCBI

34 

Sarr D, Tóth E, Gingerich A and Rada B: Antimicrobial actions of dual oxidases and lactoperoxidase. J Microbiol. 56:373–386. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Winterbourn CC, Kettle AJ and Hampton MB: Reactive oxygen species and neutrophil function. Annu Rev Biochem. 85:765–792. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Redanz S, Cheng X, Giacaman RA, Pfeifer CS, Merritt J and Kreth J: Live and let die: Hydrogen peroxide production by the commensal flora and its role in maintaining a symbiotic microbiome. Mol Oral Microbiol. 33:337–352. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Kraus FW, Nickerson JF, Perry WI and Walker AP: Peroxide and peroxidogenic bacteria in human saliva. J Bacteriol. 73:727–735. 1957. View Article : Google Scholar : PubMed/NCBI

38 

Carlsson J, Iwami Y and Yamada T: Hydrogen peroxide excretion by oral streptococci and effect of lactoperoxidase-thiocyanate-hydrogen peroxide. Infect Immun. 40:70–80. 1983. View Article : Google Scholar : PubMed/NCBI

39 

Ryan CS and Kleinberg I: Bacteria in human mouths involved in the production and utilization of hydrogen peroxide. Arch Oral Biol. 40:753–763. 1995. View Article : Google Scholar : PubMed/NCBI

40 

Amano A, Tamagawa H, Takagaki M, Murakami Y, Shizukuishi S and Tsunemitsu A: Relationship between enzyme activities involved in oxygen metabolism and oxygen tolerance in black-pigmented bacteroides. J Dent Res. 67:1196–1199. 1988. View Article : Google Scholar : PubMed/NCBI

41 

Sheng J, Nguyen PT and Marquis RE: Multi-target antimicrobial actions of zinc against oral anaerobes. Arch Oral Biol. 50:747–757. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Pruitt KM, Tenovuo J, Mansson-Rahemtulla B, Harrington P and Baldone DC: Is thiocyanate peroxidation at equilibrium in vivo? Biochim Biophys Acta. 870:385–391. 1986. View Article : Google Scholar : PubMed/NCBI

43 

Hänström L, Johansson A and Carlsson J: Lactoperoxidase and thiocyanate protect cultured mammalian cells against hydrogen peroxide toxicity. Med Biol. 61:268–274. 1983.

44 

Tenovuo J and Larjava H: The protective effect of peroxidase and thiocyanate against hydrogen peroxide toxicity assessed by the uptake of (3H)-thymidine by human gingival fibroblasts cultured in vitro. Arch Oral Biol. 29:445–451. 1984. View Article : Google Scholar : PubMed/NCBI

45 

Jakubovics NS, Yassin SA and Rickard AH: Community interactions of oral streptococci. Adv Appl Microbiol. 87:43–110. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Sies H: Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress. Redox Biol. 11:613–619. 2017. View Article : Google Scholar : PubMed/NCBI

47 

Duan D, Scoffield JA, Zhou X and Wu H: Fine-tuned production of hydrogen peroxide promotes biofilm formation of Streptococcus parasanguinis by a pathogenic cohabitant aggregatibacter actinomycetemcomitans. Environ Microbiol. 18:4023–4036. 2016. View Article : Google Scholar : PubMed/NCBI

48 

Logothetopoulos JH and Myant NB: Concentration of radio-iodide and 35-S-thiocyanate by the salivary glands. J Physiol. 134:189–194. 1956. View Article : Google Scholar : PubMed/NCBI

49 

Stephen KW, Robertson JW, Harden RM and Chisholm DM: Concentration of iodide, pertechnetate thiocyanate, and bromide in saliva from parotid, submandibular, and minor salivary glands in man. J Lab Clin Med. 81:219–229. 1973.PubMed/NCBI

50 

Felker P, Bunch R and Leung AM: Concentrations of thiocyanate and goitrin in human plasma, their precursor concentrations in brassica vegetables, and associated potential risk for hypothyroidism. Nutr Rev. 74:248–258. 2016. View Article : Google Scholar : PubMed/NCBI

51 

Narkowicz S, Jaszczak E, Polkowska Ż, Kielbratowska B, Kotłowska A and Namieśnik J: Determination of thiocyanate as a biomarker of tobacco smoke constituents in selected biological materials of human origin. Biomed Chromatogr. 32:e41112018. View Article : Google Scholar : PubMed/NCBI

52 

Bourdoux P, Delange F, Gerard M, Mafuta M, Hanson A and Ermans AM: Evidence that cassava ingestion increases thiocyanate formation: A possible etiologic factor in endemic goiter. J Clin Endocrinol Metab. 46:613–621. 1978. View Article : Google Scholar : PubMed/NCBI

53 

Tenovuo J and Mäkinen KK: Concentration of thiocyanate and ionizable iodine in saliva of smokers and non-smokers. J Dent Res. 55:661–663. 1976. View Article : Google Scholar : PubMed/NCBI

54 

Chandler JD and Day BJ: Biochemical mechanisms and therapeutic potential of the pseudohalide thiocyanate in human health. Free Radic Res. 49:695–710. 2015. View Article : Google Scholar : PubMed/NCBI

55 

Schiff L, Stevens CD, Molle WE, Steinberg H, Kumpe CW and Stewart P: Gastric (and salivary) excretion of radioiodine in man: Preliminary report. J Natl Cancer Inst. 7:349–354. 1947.PubMed/NCBI

56 

Venturi S and Venturi M: Iodine in evolution of salivary glands and in oral health. Nutr Health. 20:119–134. 2009. View Article : Google Scholar : PubMed/NCBI

57 

Gulaboglu M, Akgül HM, Akgül N and Cetin M: Urine and saliva iodine levels in patients with dental caries and normal healthy volunteers. Trace Elem Electroly. 29:28–33. 2012. View Article : Google Scholar

58 

Ross GR, Fabersani E, Russo M, Gómez A, Japaze H, González SN and Gauffin Cano P: Effect of excess iodide intake on salivary glands in a Swiss Albino mice model. Biomed Res Int. 2017:63028692017. View Article : Google Scholar : PubMed/NCBI

59 

Ren H, Qiu H, Liang X, Wang X and Jiang S: Determination of inorganic anions in saliva by electroosmotic flow controlled counterflow isotachophoretic stacking under field-amplified sample injection. J Chromatogr B Analyt Technol Biomed Life Sci. 935:75–79. 2013. View Article : Google Scholar : PubMed/NCBI

60 

Novo DR, Mello JE, Rondan FS, Henn AS, Mello PA and Mesko MF: Bromine and iodine determination in human saliva: Challenges in the development of an accurate method. Talanta. 191:415–421. 2019. View Article : Google Scholar : PubMed/NCBI

61 

Moss BR, Hall RF, Miller JK and Swanson EW: Effect of thiocyanate on iodide concentrating systems of the calf. Proc Soc Exp Biol Med. 129:153–155. 1968. View Article : Google Scholar : PubMed/NCBI

62 

Tenovuo J: Lactoperoxidase-catalyzed iodine metabolism in human saliva. Arch Oral Biol. 23:253–258. 1978. View Article : Google Scholar : PubMed/NCBI

63 

Sarimo SS and Tenovuo J: Enzymically iodinated human salivary proteins. Fractionation and characterization by column chromatography and electrofocusing. Biochem J. 167:23–29. 1977. View Article : Google Scholar : PubMed/NCBI

64 

Bosch EH, van Doorne H and de Vries S: The lactoperoxidase system: The influence of iodide and the chemical and antimicrobial stability over the period of about 18 months. J Appl Microbiol. 89:215–224. 2000. View Article : Google Scholar : PubMed/NCBI

65 

Schlorke D, Flemmig J, Birkemeyer C and Arnhold J: Formation of cyanogen iodide by lactoperoxidase. J Inorg Biochem. 154:35–41. 2016. View Article : Google Scholar : PubMed/NCBI

66 

Bafort F, Damblon C, Smargiasso N, De Pauw E, Perraudin JP and Jijakli MH: Reaction product variability and biological activity of the lactoperoxidase system depending on medium ionic strength and pH, and on substrate relative concentration. Chem Biodivers. 15:e17004972018. View Article : Google Scholar : PubMed/NCBI

67 

Sebaa S, Faltot M, De Breucker S, Boucherit-Otmani Z, Bafort F, Perraudin JP and Courtois Ph: Ex vivo decontamination of yeast-colonized dentures by iodine-thiocyanate complexes. Clin Cosmet Investig Dent. 10:149–158. 2018. View Article : Google Scholar : PubMed/NCBI

68 

Tonoyan L, Boyd A, Fleming GTA, Friel R, Gately CM, Mc Cay PH and O'Flaherty V: In vitro comparative cytotoxicity study of a novel biocidal iodo-thiocyanate complex. Toxicol In Vitro. 50:264–273. 2018. View Article : Google Scholar : PubMed/NCBI

69 

Pruitt KM, Mansson-Rahemtulla B, Baldone DC and Rahemtulla F: Steady-state kinetics of thiocyanate oxidation catalyzed by human salivary peroxidase. Biochemistry. 27:240–245. 1988. View Article : Google Scholar : PubMed/NCBI

70 

Ashby MT: Inorganic chemistry of defensive peroxidases in the human oral cavity. J Dent Res. 87:900–914. 2008. View Article : Google Scholar : PubMed/NCBI

71 

Pruitt KM, Mansson-Rahemtulla B and Tenovuo J: Detection of the hypothiocyanite (OSCN-) ion in human parotid saliva and the effect of pH on OSCN- generation in the salivary peroxidase antimicrobial system. Arch Oral Biol. 28:517–525. 1983. View Article : Google Scholar : PubMed/NCBI

72 

Thomas EL, Bates KP and Jefferson MM: Hypothiocyanite ions: Detection of the antimicrobial agent in human saliva. J Dent Res. 59:1446–1472. 1980. View Article : Google Scholar : PubMed/NCBI

73 

Pruitt KM, Kamau DN, Miller K, Månsson-Rahemtulla B and Rahemtulla F: Quantitative, standardized assays for determining the concentrations of bovine lactoperoxidase, human salivary peroxidase, and human myeloperoxidase. Anal Biochem. 191:278–286. 1990. View Article : Google Scholar : PubMed/NCBI

74 

Bafort F, Barthelemy JP, Parisi O, Perraudin JP and Jijakli HM: Development of a colorimetric method for the dosage of OI- anions and I2 in aqueous media. Commun Agric Appl Biol Sci. 79:155–160. 2014.PubMed/NCBI

75 

Thibodeau EA, Bowen WH and Marquis RE: pH-dependent fluoride inhibition of peroxidase activity. J Dent Res. 64:1211–1213. 1985. View Article : Google Scholar : PubMed/NCBI

76 

Mansson-Rahemtulla B, Baldone DC, Pruitt KM and Rahemtulla F: Specific assays for peroxidases in human saliva. Arch Oral Biol. 31:661–668. 1986. View Article : Google Scholar : PubMed/NCBI

77 

White WE Jr, Pruitt KM and Mansson-Rahemtulla B: Peroxidase-thiocyanate-peroxide antibacterial system does not damage DNA. Antimicrob Agents Chemother. 23:267–272. 1983. View Article : Google Scholar : PubMed/NCBI

78 

Altman LC, Baker C, Fleckman P, Luchtel D and Oda D: Neutrophil-mediated damage to human gingival epithelial cells. J Periodontal Res. 27:70–79. 1992. View Article : Google Scholar : PubMed/NCBI

79 

Ahariz M and Courtois P: Candida albicans susceptibility to lactoperoxidase-generated hypoiodite. Clin Cosmet Investig Dent. 2:69–78. 2010. View Article : Google Scholar : PubMed/NCBI

80 

Molloy C, Shepherd MG and Sullivan PA: Identification of envelope proteins of Candida albicans by vectorial iodination. Microbios. 57:73–83. 1989.PubMed/NCBI

81 

Fischer AJ, Lennemann NJ, Krishnamurthy S, Pócza P, Durairaj L, Launspach JL, Rhein BA, Wohlford-Lenane C, Lorentzen D, Bánfi B and McCray PB Jr: Enhancement of respiratory mucosal antiviral defenses by the oxidation of iodide. Am J Respir Cell Mol Biol. 45:874–881. 2011. View Article : Google Scholar : PubMed/NCBI

82 

Derscheid RJ, van Geelen A, Berkebile AR, Gallup JM, Hostetter SJ, Banfi B, McCray PB Jr and Ackermann MR: Increased concentration of iodide in airway secretions is associated with reduced respiratory syncytial virus disease severity. Am J Respir Cell Mol Biol. 50:389–397. 2014.PubMed/NCBI

83 

Shoemake BM, Vander Ley BL, Newcomer BW and Heller MC: Efficacy of oral administration of sodium iodide to prevent bovine respiratory disease complex. J Vet Intern Med. 32:516–524. 2018. View Article : Google Scholar : PubMed/NCBI

84 

Kumlien A, Carlsöö B and Bloom GD: Iodide accumulation and peroxidase activity in the submandibular salivary gland of the normal and castrated male hamster. Arch Oral Biol. 19:577–582. 1974. View Article : Google Scholar : PubMed/NCBI

85 

Tsuda S, Soutome S, Hayashida S, Funahara M, Yanamoto S and Umeda M: Topical povidone iodine inhibits bacterial growth in the oral cavity of patients on mechanical ventilation: A randomized controlled study. BMC Oral Health. 20:622020. View Article : Google Scholar : PubMed/NCBI

86 

Bafort F, Parisi O, Perraudin JP and Jijakli H: The lactoperoxidase system: A natural biochemical biocontrol agent for pre- and post-harvest applications. J Phytopathol. 165:22–34. 2017. View Article : Google Scholar : PubMed/NCBI

87 

Lewis C and Skoog DA: Spectrophotometric study of a thiocyanate complex of iodine. J Am Chem Soc. 84:1101–1106. 1962. View Article : Google Scholar

88 

Long C and Skoog DA: A thiocyanate complex of Iodine (I). Inorg Chem. 5:206–210. 1966. View Article : Google Scholar

89 

Országh I, Bazsa G and Beck MT: Spectrophotometric study of the reversible iodine-thiocyanate interaction. Inorganica Chim Acta. 6:271–274. 1972. View Article : Google Scholar

90 

Scott McIndoe J and Tuck DG: Studies of polyhalide ions in aqueous and non-aqueous solution by electrospray mass spectrometry. Dalt Trans. 2003:244–248. 2003. View Article : Google Scholar

91 

Courtois PH and Pourtois M: Purification of NADH: Hypothiocyanite oxidoreductase in Streptococcus sanguis. Biochem Mol Med. 57:134–138. 1996. View Article : Google Scholar : PubMed/NCBI

92 

Tonoyan L, Fleming GTA, Mc Cay PH, Friel R and O'Flaherty V: Antibacterial potential of an antimicrobial agent inspired by peroxidase-catalyzed systems. Front Microbiol. 8:6802017. View Article : Google Scholar : PubMed/NCBI

93 

Tenovuo J and Pruitt KM: Relationship of the human salivary peroxidase system to oral health. J Oral Pathol. 13:573–584. 1984. View Article : Google Scholar : PubMed/NCBI

94 

Hogg DM and Jago GR: The oxidation of reduced nicotinamide nucleotides by hydrogen peroxide in the presence of lactoperoxidase and thiocyanate, iodide or bromide. Biochem J. 117:791–797. 1970. View Article : Google Scholar : PubMed/NCBI

95 

Tenovuo J, Mansson-Rahemtulla B, Pruitt KM and Arnold R: Inhibition of dental plaque acid production by the salivary lactoperoxidase antimicrobial system. Infect Immun. 34:208–214. 1981. View Article : Google Scholar : PubMed/NCBI

96 

Ihalin R, Loimaranta V, Lenander-Lumikari M and Tenovuo J: The effects of different (pseudo)halide substrates on peroxidase-mediated killing of Actinobacillus actinomycetemcomitans. J Periodontal Res. 33:421–427. 1998. View Article : Google Scholar : PubMed/NCBI

97 

Fadel M and Courtois P: Effect of peroxidase-generated hypothiocyanite on the survival rate of Porphyromonas gingivalis NCTC 11834. Med Sci Res. 27:667–669. 1999.

98 

Fadel M and Courtois P: Inhibitory effect of lactoperoxidase-generated hypothiocyanite upon black pigmented anaerobe growth. Int J Mol Med. 8:59–62. 2001.PubMed/NCBI

99 

Majerus PM and Courtois PA: Susceptibility of Candida albicans to peroxidase-catalyzed oxidation products of thiocyanate, iodide and bromide. J Biol Buccale. 20:241–245. 1992.PubMed/NCBI

100 

Courtois P, van Beers D, de Foor M, Mandelbaum IM and Pourtois M: Abolition of herpes simplex cytopathic effect after treatment with peroxidase generated hypothiocyanite. J Biol Buccale. 18:71–74. 1990.PubMed/NCBI

101 

Pourtois M, Binet C, Van Tieghem N, Courtois P, Vandenabbeele A and Thiry L: Saliva can contribute in quick inhibition of HIV infectivity. AIDS. 5:598–600. 1991. View Article : Google Scholar : PubMed/NCBI

102 

Cegolon L, Salata C, Piccoli E, Juarez V, Palu' G, Mastrangelo G and Calistri A: In vitro antiviral activity of hypothiocyanite against A/H1N1/2009 pandemic influenza virus. Int J Hyg Environ Health. 217:17–22. 2014. View Article : Google Scholar : PubMed/NCBI

103 

Patel U, Gingerich A, Widman L, Sarr D, Tripp RA and Rada B: Susceptibility of influenza viruses to hypothiocyanite and hypoiodite produced by lactoperoxidase in a cell-free system. PLoS One. 13:e01991672018. View Article : Google Scholar : PubMed/NCBI

104 

Cegolon L, Javanbakht M and Mastrangelo G: Nasal disinfection for the prevention and control of COVID-19: A scoping review on potential chemo-preventive agents. Int J Hyg Environ Health. 230:1136052020. View Article : Google Scholar : PubMed/NCBI

105 

Nguyen GT, Green ER and Mecsas J: Neutrophils to the ROScue: Mechanisms of NADPH oxidase activation and bacterial resistance. Front Cell Infect Microbiol. 7:3732017. View Article : Google Scholar : PubMed/NCBI

106 

Carlsson J: Salivary peroxidase: An important part of our defense against oxygen toxicity. J Oral Pathol. 16:412–416. 1987. View Article : Google Scholar : PubMed/NCBI

107 

Cáp M, Váchová L and Palková Z: Reactive oxygen species in the signaling and adaptation of multicellular microbial communities. Oxid Med Cell Longev. 2012:9767532012. View Article : Google Scholar

108 

van Steenberghe D, Van den Eynde E, Jacobs R and Quirynen M: Effect of a lactoperoxidase containing toothpaste in radiation-induced xerostomia. Int Dent J. 44:133–138. 1994.PubMed/NCBI

109 

Lenander-Lumikari M, Månsson-Rahemtulla B and Rahemthulla F: Lysozyme enhances the inhibitory effects of the peroxidase system on glucose metabolism of Streptococcus mutans. J Dent Res. 71:484–490. 1992. View Article : Google Scholar : PubMed/NCBI

110 

Sardaro N, Della Vella F, Incalza MA, DI Stasio D, Lucchese A, Contaldo M, Laudadio C and Petruzzi M: Oxidative stress and oral mucosal diseases: An overview. In Vivo. 33:289–296. 2019. View Article : Google Scholar : PubMed/NCBI

111 

Magacz M, Kędziora K, Sapa J and Krzyściak W: The significance of lactoperoxidase system in oral health: Application and efficacy in oral hygiene products. Int J Mol Sci. 20:14432019. View Article : Google Scholar : PubMed/NCBI

112 

Mansson-Rahemtulla B, Pruitt KM, Tenovuo J and Le TM: A mouthrinse which optimizes in vivo generation of hypothiocyanite. J Dent Res. 62:1062–1066. 1983. View Article : Google Scholar : PubMed/NCBI

113 

FAO/WHO report, . Benefits and potential risks of the lactoperoxidase system of raw milk preservation. Report of an FAO/WHO technical meeting. FAO Headquarters; Rome, Italy: 28 November-2 December 2005. 2006

114 

Artym J and Zimecki M: Milk-derived proteins and peptides in clinical trials. Postepy Hig Med Dosw (Online). 67:800–816. 2013. View Article : Google Scholar : PubMed/NCBI

115 

Welk A, Meller CH, Schubert R, Schwahn CH, Kramer A and Below H: Effect of lactoperoxidase on the antimicrobial effectiveness of the thiocyanate hydrogen peroxide combination in a quantitative suspension test. BMC Microbiol. 9:1342009. View Article : Google Scholar : PubMed/NCBI

116 

Modesto A, Lima KC and de Uzeda M: Effects of three different infant dentifrices on biofilms and oral microorganisms. J Clin Pediatr Dent. 24:237–243. 2000.PubMed/NCBI

117 

Tenovuo J: Clinical applications of antimicrobial host proteins lactoperoxidase, lysozyme and lactoferrin in xerostomia: Efficacy and safety. Oral Dis. 8:23–29. 2002. View Article : Google Scholar : PubMed/NCBI

118 

Vanden Abbeele A, De Meel H, Courtois P and Pourtois M: Influence of a hypoiodite mouth-wash on dental plaque formation in vivo. Bull Group Int Rech Sci Stomatol Odontol. 39:57–61. 1996.PubMed/NCBI

119 

Nakano M, Wakabayashi H, Sugahara H, Odamaki T, Yamauchi K, Abe F, Xiao JZ, Murakami K, Ishikawa K and Hironaka S: Effects of lactoferrin and lactoperoxidase-containing food on the oral microbiota of older individuals. Microbiol Immunol. 61:416–426. 2017. View Article : Google Scholar : PubMed/NCBI

120 

Lenander-Lumikari M, Tenovuo J and Mikola H: Effects of a lactoperoxidase system-containing toothpaste on levels of hypothiocyanite and bacteria in saliva. Caries Res. 27:285–291. 1993. View Article : Google Scholar : PubMed/NCBI

121 

Koch G, Edlund K and Hoogendoorn H: Lactoperoxidase in the prevention of plaque accumulation, gingivitis and dental caries. II. Effect of mouthrinses with amyloglucosidase and glucoseoxidase on plaque accumulation on teeth in individuals on a sucrose diet. Odontol Revy. 24:367–372. 1973.PubMed/NCBI

122 

Hugoson A, Koch G, Thilander H and Hoogendoorn H: Lactoperoxidase in the prevention of plaque accumulation, gingivitis and dental caries. 3. Effect of mouthrinses with amyloglucosidase and glucoseoxidase in the model system of experimental gingivitis and caries in man. Odontol Revy. 25:69–80. 1974.PubMed/NCBI

123 

Koch G and Strand G: Effect of an enzyme dentifrice on caries. A two-year clinical pilot study. Swed Dent J. 3:9–13. 1979.PubMed/NCBI

124 

Rotgans J and Hoogendoorn H: The effect of brushing with a toothpaste containing amyloglucosidase and glucose oxidase on dental caries in rats. Caries Res. 13:150–153. 1979. View Article : Google Scholar : PubMed/NCBI

125 

Afseth J and Rølla G: Clinical experiments with a toothpaste containing amyloglucosidase and glucose oxidase. Caries Res. 17:472–475. 1983. View Article : Google Scholar : PubMed/NCBI

126 

Midda M and Cooksey MW: Clinical uses of an enzyme-containing dentifrice. J Clin Periodontol. 13:950–956. 1986. View Article : Google Scholar : PubMed/NCBI

127 

Bánóczy J, Dombi C, Czegledly A and Sari K: A clinical study with lactoperoxidase-containing gel and toothpaste in patients with dry mouth syndrome. J Clin Dent. 5:65–69. 1994.

128 

Toljanic JA, Siddiqui AA, Patterson GL and Irwin ME: An evaluation of a dentifrice containing salivary peroxidase elements for the control of gingival disease in patients with irradiated head and neck cancer. J Prosthet Dent. 76:292–296. 1996. View Article : Google Scholar : PubMed/NCBI

129 

Epstein JB, Emerton S, Le ND and Stevenson-Moore P: A double-blind crossover trial of Οral Βalance gel and Biotene® toothpaste versus placebo in patients with xerostomia following radiation therapy. Oral Oncol. 35:132–137. 1999. View Article : Google Scholar : PubMed/NCBI

130 

Warde P, Kroll B, O'Sullivan B, Aslanidis J, Tew-George E, Waldron J, Maxymiw W, Liu FF, Payne D and Cummings B: A phase II study of Biotene in the treatment of postradiation xerostomia in patients with head and neck cancer. Support Care Cancer. 8:203–208. 2000. View Article : Google Scholar : PubMed/NCBI

131 

Kirstilä V, Lenander-Lumikari M, Söderling E and Tenovuo J: Effects of oral hygiene products containing lactoperoxidase, lysozyme, and lactoferrin on the composition of whole saliva and on subjective oral symptoms in patients with xerostomia. Acta Odontol Scand. 54:391–397. 1996. View Article : Google Scholar

132 

Matear DW and Barbaro J: Effectiveness of saliva substitute products in the treatment of dry mouth in the elderly: A pilot study. J R Soc Promot Health. 125:35–41. 2005. View Article : Google Scholar : PubMed/NCBI

133 

Hatti S, Ravindra S, Satpathy A, Kulkarni RD and Parande MV: Biofilm inhibition and antimicrobial activity of a dentifrice containing salivary substitutes. Int J Dent Hyg. 5:218–224. 2007. View Article : Google Scholar : PubMed/NCBI

134 

Gil-Montoya JA, Guardia-López I and González-Moles MA: Evaluation of the clinical efficacy of a mouthwash and oral gel containing the antimicrobial proteins lactoperoxidase, lysozyme and lactoferrin in elderly patients with dry mouth-a pilot study. Gerodontology. 25:3–9. 2008. View Article : Google Scholar : PubMed/NCBI

135 

Shin K, Yaegaki K, Murata T, Ii H, Tanaka T, Aoyama I, Yamauchi K, Toida T and Iwatsuki K: Effects of a composition containing lactoferrin and lactoperoxidase on oral malodor and salivary bacteria: A randomized, double-blind, crossover, placebo-controlled clinical trial. Clin Oral Investig. 15:485–493. 2011. View Article : Google Scholar : PubMed/NCBI

136 

Jose A, Siddiqi M, Cronin M, DiLauro TS and Bosma ML: A randomized clinical trial in subjects with dry mouth evaluating subjective perceptions of an experimental oral gel, an oral rinse and a mouth spray compared to water. Am J Dent. 29:58–64. 2016.PubMed/NCBI

137 

Nakano M, Shimizu E, Wakabayashi H, Yamauchi K and Abe F: A randomized, double-blind, crossover, placebo-controlled clinical trial to assess effects of the single ingestion of a tablet containing lactoferrin, lactoperoxidase, and glucose oxidase on oral malodor. BMC Oral Health. 16:372016. View Article : Google Scholar : PubMed/NCBI

138 

Morita Y, Ishikawa K, Nakano M, Wakabayashi H, Yamauchi K, Abe F, Ooka T and Hironaka S: Effects of lactoferrin and lactoperoxidase-containing food on the oral hygiene status of older individuals: A randomized, double blinded, placebo-controlled clinical trial. Geriatr Gerontol Int. 17:714–721. 2017. View Article : Google Scholar : PubMed/NCBI

139 

Barbe AG, Schmidt-Park Y, Hamacher S, Derman SHM and Noack MJ: Efficacy of GUM® Hydral versus Biotène® Oralbalance mouthwashes plus gels on symptoms of medication-induced xerostomia: A randomized, double-blind, crossover study. Clin Oral Investig. 22:169–180. 2018. View Article : Google Scholar : PubMed/NCBI

140 

Nakano M, Yoshida A, Wakabayashi H, Tanaka M, Yamauchi K, Abe F and Masuda Y: Effect of tablets containing lactoferrin and lactoperoxidase on gingival health in adults: A randomized, double-blind, placebo-controlled clinical trial. J Periodontal Res. 54:702–708. 2019. View Article : Google Scholar : PubMed/NCBI

141 

Pruitt KM, Tenovuo J, Fleming W and Adamson M: Limiting factors for the generation of hypothiocyanite ion, an antimicrobial agent, in human saliva. Caries Res. 16:315–323. 1982. View Article : Google Scholar : PubMed/NCBI

142 

Sebaa S, Lybaert P, Boucherit-Otmani Z, Courtois PH and Ahariz M: Ex vivo yeast-decontamination of denture by H2O2/Iodide/Lactoperoxidase system: Need to overpass the microbial H2O2 catabolism. Oral Health Dent Manag. 14:62–69. 2015.

143 

Herlofson BB and Barkvoll P: Sodium lauryl sulfate and recurrent aphthous ulcers. A preliminary study. Acta Odontol Scand. 52:257–259. 1994. View Article : Google Scholar : PubMed/NCBI

144 

Cawley A, Golding S, Goulsbra A, Hoptroff M, Kumaran S and Marriott R: Microbiology insights into boosting salivary defences through the use of enzymes and proteins. J Dent. 80 (Suppl 1):S19–S25. 2019. View Article : Google Scholar : PubMed/NCBI

145 

Adams SE, Arnold D, Murphy B, Carroll P, Green AK, Smith AM, Marsh PD, Chen T, Marriott RE and Brading MG: A randomised clinical study to determine the effect of a toothpaste containing enzymes and proteins on plaque oral microbiome ecology. Sci Rep. 7:433442017. View Article : Google Scholar : PubMed/NCBI

146 

Memarzadeh Zahedani M, Schwahn C, Baguhl R, Kocher T, Below H and Welk A: Association of salivary peroxidase activity and concentration with periodontal health: A validity study. J Clin Periodontol. 44:803–812. 2017. View Article : Google Scholar : PubMed/NCBI

147 

Herrero ER, Boon N, Bernaerts K, Slomka V, Verspecht T, Quirynen M and Teughels W: Clinical concentrations of peroxidases cause dysbiosis in in vitro oral biofilms. J Periodontal Res. 53:457–466. 2018. View Article : Google Scholar : PubMed/NCBI

148 

Miller DP, Fitzsimonds ZR and Lamont RJ: Metabolic signaling and spatial interactions in the oral polymicrobial community. J Dent Res. 98:1308–1314. 2019. View Article : Google Scholar : PubMed/NCBI

149 

Diaz PI and Valm AM: Microbial interactions in oral communities mediate emergent biofilm properties. J Dent Res. 99:18–25. 2020. View Article : Google Scholar : PubMed/NCBI

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Courtois P: Oral peroxidases: From antimicrobial agents to ecological actors (Review). Mol Med Rep 24: 500, 2021.
APA
Courtois, P. (2021). Oral peroxidases: From antimicrobial agents to ecological actors (Review). Molecular Medicine Reports, 24, 500. https://doi.org/10.3892/mmr.2021.12139
MLA
Courtois, P."Oral peroxidases: From antimicrobial agents to ecological actors (Review)". Molecular Medicine Reports 24.1 (2021): 500.
Chicago
Courtois, P."Oral peroxidases: From antimicrobial agents to ecological actors (Review)". Molecular Medicine Reports 24, no. 1 (2021): 500. https://doi.org/10.3892/mmr.2021.12139
Copy and paste a formatted citation
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Spandidos Publications style
Courtois P: Oral peroxidases: From antimicrobial agents to ecological actors (Review). Mol Med Rep 24: 500, 2021.
APA
Courtois, P. (2021). Oral peroxidases: From antimicrobial agents to ecological actors (Review). Molecular Medicine Reports, 24, 500. https://doi.org/10.3892/mmr.2021.12139
MLA
Courtois, P."Oral peroxidases: From antimicrobial agents to ecological actors (Review)". Molecular Medicine Reports 24.1 (2021): 500.
Chicago
Courtois, P."Oral peroxidases: From antimicrobial agents to ecological actors (Review)". Molecular Medicine Reports 24, no. 1 (2021): 500. https://doi.org/10.3892/mmr.2021.12139
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