Open Access

Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells (Review)

  • Authors:
    • Ying Li
    • Jinming Wang
    • Weiliang Zhong
  • View Affiliations

  • Published online on: May 10, 2021     https://doi.org/10.3892/mmr.2021.12145
  • Article Number: 506
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Stem cells receive cues from their physical and mechanical microenvironment via mechanosensing and mechanotransduction. These cues affect proliferation, self‑renewal and differentiation into specific cell fates. A growing body of evidence suggests that yes‑associated protein (YAP) and transcriptional coactivator with PDZ‑binding motif (TAZ) mechanotransduction is key for driving stem cell behavior and regeneration via the Hippo and other signaling pathways. YAP/TAZ receive a range of physical cues, including extracellular matrix stiffness, cell geometry, flow shear stress and mechanical forces in the cytoskeleton, and translate them into cell‑specific transcriptional programs. However, the mechanism by which mechanical signals regulate YAP/TAZ activity in stem cells is not fully understand. The present review summarizes the current knowledge of the mechanisms involved in YAP/TAZ regulation on the physical and mechanical microenvironment, as well as its potential effects on stem cell differentiation.
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July-2021
Volume 24 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Li Y, Wang J and Zhong W: Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells (Review). Mol Med Rep 24: 506, 2021
APA
Li, Y., Wang, J., & Zhong, W. (2021). Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells (Review). Molecular Medicine Reports, 24, 506. https://doi.org/10.3892/mmr.2021.12145
MLA
Li, Y., Wang, J., Zhong, W."Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells (Review)". Molecular Medicine Reports 24.1 (2021): 506.
Chicago
Li, Y., Wang, J., Zhong, W."Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells (Review)". Molecular Medicine Reports 24, no. 1 (2021): 506. https://doi.org/10.3892/mmr.2021.12145