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Review Open Access

Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells (Review)

Erratum in: /10.3892/mmr.2021.12265
  • Authors:
    • Ying Li
    • Jinming Wang
    • Weiliang Zhong
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics Surgery, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 506
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    Published online on: May 10, 2021
       https://doi.org/10.3892/mmr.2021.12145
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Abstract

Stem cells receive cues from their physical and mechanical microenvironment via mechanosensing and mechanotransduction. These cues affect proliferation, self‑renewal and differentiation into specific cell fates. A growing body of evidence suggests that yes‑associated protein (YAP) and transcriptional coactivator with PDZ‑binding motif (TAZ) mechanotransduction is key for driving stem cell behavior and regeneration via the Hippo and other signaling pathways. YAP/TAZ receive a range of physical cues, including extracellular matrix stiffness, cell geometry, flow shear stress and mechanical forces in the cytoskeleton, and translate them into cell‑specific transcriptional programs. However, the mechanism by which mechanical signals regulate YAP/TAZ activity in stem cells is not fully understand. The present review summarizes the current knowledge of the mechanisms involved in YAP/TAZ regulation on the physical and mechanical microenvironment, as well as its potential effects on stem cell differentiation.
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1 

Vining KH and Mooney DJ: Mechanical forces direct stem cell behaviour in development and regeneration. Nat Rev Mol Cell Biol. 18:728–742. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Demehri S and Kopan R: Notch signaling in bulge stem cells is not required for selection of hair follicle fate. Development. 136:891–896. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Dupont S, Morsut L, Aragona M, Enzo E, Giulitti S, Cordenonsi M, Zanconato F, Le Digabel J, Forcato M, Bicciato S, et al: Role of YAP/TAZ in mechanotransduction. Nature. 474:179–183. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Lee JH, Park HK and Kim KS: Intrinsic and extrinsic mechanical properties related to the differentiation of mesenchymal stem cells. Biochem Biophys Res Commun. 473:752–757. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Engler AJ, Sen S, Sweeney HL and Discher DE: Matrix elasticity directs stem cell lineage specification. Cell. 126:677–689. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Li D, Zhou J, Chowdhury F, Cheng J, Wang N and Wang F: Role of mechanical factors in fate decisions of stem cells. Regen Med. 6:229–240. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Oh S, Brammer KS, Li YS, Teng D, Engler AJ, Chien S and Jin S: Stem cell fate dictated solely by altered nanotube dimension. Proc Natl Acad Sci USA. 106:2130–2135. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Zhong W, Tian K, Zheng X, Li L, Zhang W, Wang S and Qin J: Mesenchymal stem cell and chondrocyte fates in a multishear microdevice are regulated by Yes-associated protein. Stem Cells Deve. 22:2083–2093. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Ishihara E and Nishina H: Role of Hippo-YAP/TAZ signaling pathway in mechanotransduction. Clin Calcium. 26:1751–1756. 2016.(In Japanese). PubMed/NCBI

10 

McBeath R, Pirone DM, Nelson CM, Bhadriraju K and Chen CS: Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell. 6:483–495. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Dupont S: Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction. Exp Cell Res. 343:42–53. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Pocaterra A, Romani P and Dupont S: YAP/TAZ functions and their regulation at a glance. J Cell Sci. 133:jcs2304252020. View Article : Google Scholar : PubMed/NCBI

13 

Pan JX, Xiong L, Zhao K, Zeng P, Wang B, Tang FL, Sun D, Guo HH, Yang X, Cui S, et al: YAP promotes osteogenesis and suppresses adipogenic differentiation by regulating β-catenin signaling. Bone Res. 6:182018. View Article : Google Scholar : PubMed/NCBI

14 

Oliver-De La Cruz J, Nardone G, Vrbsky J, Pompeiano A, Perestrelo AR, Capradossi F, Melajová K, Filipensky P and Forte G: Substrate mechanics controls adipogenesis through YAP phosphorylation by dictating cell spreading. Biomaterials. 205:64–80. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Yang Y, Wang BK, Chang ML, Wan ZQ and Han GL: Cyclic stretch enhances osteogenic differentiation of human periodontal ligament cells via YAP activation. BioMed Res Int. 2018:21748242018. View Article : Google Scholar : PubMed/NCBI

16 

Kim NG, Koh E, Chen X and Gumbiner BM: E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components. Proc Natl Acad Sci USA. 108:11930–11935. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Xue X, Hong X, Li Z, Deng CX and Fu J: Acoustic tweezing cytometry enhances osteogenesis of human mesenchymal stem cells through cytoskeletal contractility and YAP activation. Biomaterials. 134:22–30. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Hu JK, Du W, Shelton SJ, Oldham MC, DiPersio CM and Klein OD: An FAK-YAP-mTOR signaling axis regulates stem cell-based tissue renewal in mice. Cell Stem Cell. 21:91–106.e6. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Lecarpentier E, Bhatt M, Bertin GI, Deloison B, Salomon LJ, Deloron P, Fournier T, Barakat AI and Tsatsaris V: Computational fluid dynamic simulations of maternal circulation: Wall shear stress in the human placenta and its biological implications. PLoS One. 11:e01472622016. View Article : Google Scholar : PubMed/NCBI

20 

Adamo L and Garcia-Cardeña G: Directed stem cell differentiation by fluid mechanical forces. Antioxid Redox Signal. 15:1463–1473. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Kaneko K, Ito M, Naoe Y, Lacy-Hulbert A and Ikeda K: Integrin alphav in the mechanical response of osteoblast lineage cells. Biochem Biophys Res Commun. 447:352–357. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Zhong W, Zhang W, Wang S and Qin J: Regulation of fibrochondrogenesis of mesenchymal stem cells in an integrated microfluidic platform embedded with biomimetic nanofibrous scaffolds. PLoS One. 8:e612832013. View Article : Google Scholar : PubMed/NCBI

23 

Wang KC, Yeh YT, Nguyen P, Limqueco E, Lopez J, Thorossian S, Guan KL, Li YJ and Chien S: Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis. Proc Natl Acad Sci USA. 113:11525–11530. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Halder G, Dupont S and Piccolo S: Transduction of mechanical and cytoskeletal cues by YAP and TAZ. Nat Rev Mol Cell Biol. 13:591–600. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Wang Y, Wang G, Luo X, Qiu J and Tang C: Substrate stiffness regulates the proliferation, migration, and differentiation of epidermal cells. Burns. 38:414–420. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, Gefen A, Reinhart-King CA, Margulies SS, Dembo M, Boettiger D, et al: Tensional homeostasis and the malignant phenotype. Cancer Cell. 8:241–254. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Discher DE, Janmey P and Wang YL: Tissue cells feel and respond to the stiffness of their substrate. Science. 310:1139–1143. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Connelly JT, Gautrot JE, Trappmann B, Tan DW, Donati G, Huck WT and Watt FM: Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions. Nat Cell Biol. 12:711–718. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Li Z, Gong Y, Sun S, Du Y, Lü D, Liu X and Long M: Differential regulation of stiffness, topography, and dimension of substrates in rat mesenchymal stem cells. Biomaterials. 34:7616–7625. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Hadden WJ, Young JL, Holle AW, McFetridge ML, Kim DY, Wijesinghe P, Taylor-Weiner H, Wen JH, Lee AR, Bieback K, et al: Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels. Proc Natl Acad Sci USA. 114:5647–5652. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Nelson CM and Bissell MJ: Modeling dynamic reciprocity: Engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation. Semin Cancer Biol. 15:342–352. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Witkowska-Zimny M, Walenko K, Wrobel E, Mrowka P, Mikulska A and Przybylski J: Effect of substrate stiffness on the osteogenic differentiation of bone marrow stem cells and bone-derived cells. Cell Biol Int. 37:608–616. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Brusatin G, Panciera T, Gandin A, Citron A and Piccolo S: Biomaterials and engineered microenvironments to control YAP/TAZ-dependent cell behaviour. Nat Mater. 17:1063–1075. 2018. View Article : Google Scholar : PubMed/NCBI

34 

Singhvi R, Kumar A, Lopez GP, Stephanopoulos GN, Wang DI, Whitesides GM and Ingber DE: Engineering cell shape and function. Science. 264:696–698. 1994. View Article : Google Scholar : PubMed/NCBI

35 

Kuroda M, Wada H, Kimura Y, Ueda K and Kioka N: Vinculin promotes nuclear localization of TAZ to inhibit ECM stiffness-dependent differentiation into adipocytes. J Cell Sci. 130:989–1002. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Musah S, Morin SA, Wrighton PJ, Zwick DB, Jin S and Kiessling LL: Glycosaminoglycan-binding hydrogels enable mechanical control of human pluripotent stem cell self-renewal. ACS Nano. 6:10168–10177. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Caliari SR, Vega SL, Kwon M, Soulas EM and Burdick JA: Dimensionality and spreading influence MSC YAP/TAZ signaling in hydrogel environments. Biomaterials. 103:314–323. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Wang N, Butler JP and Ingber DE: Mechanotransduction across the cell surface and through the cytoskeleton. Science. 260:1124–1127. 1993. View Article : Google Scholar : PubMed/NCBI

39 

Eyckmans J, Boudou T, Yu X and Chen CS: A hitchhiker's guide to mechanobiology. Deve Cell. 21:35–47. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Dogterom M, Kerssemakers JW, Romet-Lemonne G and Janson ME: Force generation by dynamic microtubules. Curr Opin Cell Biol. 17:67–74. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Vogel V and Sheetz M: Local force and geometry sensing regulate cell functions. Nat Rev Mol Cell Biol. 7:265–275. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Schwartz MA: Integrins and extracellular matrix in mechanotransduction. Cold Spring Harb Perspect Biol. 2:a0050662010. View Article : Google Scholar : PubMed/NCBI

43 

Fernandez BG, Gaspar P, Bras-Pereira C, Jezowska B, Rebelo SR and Janody F: Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. Development. 138:2337–2346. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Sansores-Garcia L, Bossuyt W, Wada K, Yonemura S, Tao C, Sasaki H and Halder G: Modulating F-actin organization induces organ growth by affecting the Hippo pathway. EMBO J. 30:2325–2335. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Chakraborty S, Njah K, Pobbati AV, Lim YB, Raju A, Lakshmanan M, Tergaonkar V, Lim CT and Hong W: Agrin as a Mechanotransduction signal regulating YAP through the hippo pathway. Cell Rep. 18:2464–2479. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Elosegui-Artola A, Andreu I, Beedle AEM, Lezamiz A, Uroz M, Kosmalska AJ, Oria R, Kechagia JZ, Rico-Lastres P, Le Roux AL, et al: Force triggers YAP nuclear entry by regulating transport across nuclear pores. Cell. 171:1397–1410.e14. 2017. View Article : Google Scholar : PubMed/NCBI

47 

Dasgupta I and McCollum D: Control of cellular responses to mechanical cues through YAP/TAZ regulation. J Biol Chem. 294:17693–17706. 2019. View Article : Google Scholar : PubMed/NCBI

48 

Cawthorn WP, Scheller EL and MacDougald OA: Adipose tissue stem cells meet preadipocyte commitment: Going back to the future. J Lipid Res. 53:227–246. 2012. View Article : Google Scholar : PubMed/NCBI

49 

Fu J, Wang YK, Yang MT, Desai RA, Yu X, Liu Z and Chen CS: Mechanical regulation of cell function with geometrically modulated elastomeric substrates. Nat Methods. 7:733–736. 2010. View Article : Google Scholar : PubMed/NCBI

50 

Geng Y and Wang Z: Review of cellular mechanotransduction on micropost substrates. Med Biol Eng Comput. 54:249–271. 2016. View Article : Google Scholar : PubMed/NCBI

51 

Sero JE and Bakal C: Multiparametric analysis of cell shape demonstrates that beta-PIX directly couples YAP activation to extracellular matrix adhesion. Cell Syst. 4:84–96.e86. 2017. View Article : Google Scholar : PubMed/NCBI

52 

Tang Y, Rowe RG, Botvinick EL, Kurup A, Putnam AJ, Seiki M, Weaver VM, Keller ET, Goldstein S, Dai J, et al: MT1-MMP-dependent control of skeletal stem cell commitment via a β1-integrin/YAP/TAZ signaling axis. Dev Cell. 25:402–416. 2013. View Article : Google Scholar : PubMed/NCBI

53 

Gattazzo F, Urciuolo A and Bonaldo P: Extracellular matrix: A dynamic microenvironment for stem cell niche. Biochim Biophys Acta. 1840:2506–2519. 2014. View Article : Google Scholar : PubMed/NCBI

54 

Lu D, Luo C, Zhang C, Li Z and Long M: Differential regulation of morphology and stemness of mouse embryonic stem cells by substrate stiffness and topography. Biomaterials. 35:3945–3955. 2014. View Article : Google Scholar : PubMed/NCBI

55 

Pucci B, Kasten M and Giordano A: Cell cycle and apoptosis. Neoplasia. 2:291–299. 2000. View Article : Google Scholar : PubMed/NCBI

56 

Pittenger MF, Discher DE, Peault BM, Phinney DG, Hare JM and Caplan AI: Mesenchymal stem cell perspective: Cell biology to clinical progress. NPJ Regen Med. 4:222019. View Article : Google Scholar : PubMed/NCBI

57 

Chen CS, Mrksich M, Huang S, Whitesides GM and Ingber DE: Geometric control of cell life and death. Science. 276:1425–1428. 1997. View Article : Google Scholar : PubMed/NCBI

58 

Wada K, Itoga K, Okano T, Yonemura S and Sasaki H: Hippo pathway regulation by cell morphology and stress fibers. Development. 138:3907–3914. 2011. View Article : Google Scholar : PubMed/NCBI

59 

Pek YS, Wan AC and Ying JY: The effect of matrix stiffness on mesenchymal stem cell differentiation in a 3D thixotropic gel. Biomaterials. 31:385–391. 2010. View Article : Google Scholar : PubMed/NCBI

60 

Burke DP and Kelly DJ: Substrate stiffness and oxygen as regulators of stem cell differentiation during skeletal tissue regeneration: A mechanobiological model. PLoS One. 7:e407372012. View Article : Google Scholar : PubMed/NCBI

61 

Tse JR and Engler AJ: Stiffness gradients mimicking in vivo tissue variation regulate mesenchymal stem cell fate. PLoS One. 6:e159782011. View Article : Google Scholar : PubMed/NCBI

62 

Panciera T, Azzolin L, Cordenonsi M and Piccolo S: Mechanobiology of YAP and TAZ in physiology and disease. Nat Rev Mol Cell Biol. 18:758–770. 2017. View Article : Google Scholar : PubMed/NCBI

63 

Hansen CG, Moroishi T and Guan KL: YAP and TAZ: A nexus for Hippo signaling and beyond. Trends Cell Biol. 25:499–513. 2015. View Article : Google Scholar : PubMed/NCBI

64 

Bejoy J, Song L and Li Y: Wnt-YAP interactions in the neural fate of human pluripotent stem cells and the implications for neural organoid formation. Organogenesis. 12:1–15. 2016. View Article : Google Scholar : PubMed/NCBI

65 

Tang Y, Feinberg T, Keller ET, Li XY and Weiss SJ: Snail/Slug binding interactions with YAP/TAZ control skeletal stem cell self-renewal and differentiation. Nat Cell Biol. 18:917–929. 2016. View Article : Google Scholar : PubMed/NCBI

66 

Szeto SG, Narimatsu M, Lu M, He X, Sidiqi AM, Tolosa MF, Chan L, De Freitas K, Bialik JF, Majumder S, et al: YAP/TAZ Are mechanoregulators of TGF-β-Smad signaling and renal fibrogenesis. J Am Soc Nephrol. 27:3117–3128. 2016. View Article : Google Scholar : PubMed/NCBI

67 

Plouffe SW, Meng Z, Lin KC, Lin B, Hong AW, Chun JV and Guan KL: Characterization of hippo pathway components by gene inactivation. Mol Cell. 64:993–1008. 2016. View Article : Google Scholar : PubMed/NCBI

68 

Zhao B, Wei X, Li W, Udan RS, Yang Q, Kim J, Xie J, Ikenoue T, Yu J, Li L, et al: Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev. 21:2747–2761. 2007. View Article : Google Scholar : PubMed/NCBI

69 

Bae JS, Kim SM and Lee H: The Hippo signaling pathway provides novel anti-cancer drug targets. Oncotarget. 8:16084–16098. 2016. View Article : Google Scholar : PubMed/NCBI

70 

Wang C, Gu C, Jeong KJ, Zhang D, Guo W, Lu Y, Ju Z, Panupinthu N, Yang JY, Gagea MM, et al: YAP/TAZ-mediated upregulation of GAB2 leads to increased sensitivity to growth factor-induced activation of the PI3K pathway. Cancer Res. 77:1637–1648. 2017. View Article : Google Scholar : PubMed/NCBI

71 

Wang L, Luo JY, Li B, Tian XY, Chen LJ, Huang Y, Liu J, Deng D, Lau CW, Wan S, et al: Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow. Nature. 540:579–582. 2016. View Article : Google Scholar : PubMed/NCBI

72 

Sukumaran SK, Stumpf M, Salamon S, Ahmad I, Bhattacharya K, Fischer S, Müller R, Altmüller J, Budde B, Thiele H, et al: CDK5RAP2 interaction with components of the Hippo signaling pathway may play a role in primary microcephaly. Mol Genet Genomics. 292:365–383. 2016. View Article : Google Scholar : PubMed/NCBI

73 

Schlegelmilch K, Mohseni M, Kirak O, Pruszak J, Rodriguez JR, Zhou D, Kreger BT, Vasioukhin V, Avruch J, Brummelkamp TR and Camargo FD: Yap1 acts downstream of α-catenin to control epidermal proliferation. Cell. 144:782–795. 2011. View Article : Google Scholar : PubMed/NCBI

74 

Wang P, Bai Y, Song B, Wang Y, Liu D, Lai Y, Bi X and Yuan Z: PP1A-mediated dephosphorylation positively regulates YAP2 activity. PLoS One. 6:e242882011. View Article : Google Scholar : PubMed/NCBI

75 

Denis D, Rouleau C and Schaffhausen BS: A transformation-defective polyomavirus middle T antigen with a novel defect in PI3 kinase signaling. J Virol. 91:e01774–16. 2017. View Article : Google Scholar : PubMed/NCBI

76 

Meng Z, Qiu Y, Lin KC, Kumar A, Placone JK, Fang C, Wang KC, Lu S, Pan M, Hong AW, et al: RAP2 mediates mechanoresponses of the Hippo pathway. Nature. 560:655–660. 2018. View Article : Google Scholar : PubMed/NCBI

77 

Chang L, Azzolin L, Di Biagio D, Zanconato F, Battilana G, Lucon Xiccato R, Aragona M, Giulitti S, Panciera T, Gandin A, et al: The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ. Nature. 563:265–269. 2018. View Article : Google Scholar : PubMed/NCBI

78 

Singh A, Brito I and Lammerding J: Beyond tissue stiffness and bioadhesivity: Advanced biomaterials to model tumor microenvironments and drug resistance. Trends Cancer. 4:281–291. 2018. View Article : Google Scholar : PubMed/NCBI

79 

Lopez JI, Mouw JK and Weaver VM: Biomechanical regulation of cell orientation and fate. Oncogene. 27:6981–6993. 2008. View Article : Google Scholar : PubMed/NCBI

80 

Hoon JL, Tan MH and Koh CG: The regulation of cellular responses to mechanical cues by Rho GTPases. Cells. 5:172016. View Article : Google Scholar : PubMed/NCBI

81 

Spector AA and Grayson WL: Stem cell fate decision making: Modeling approaches. ACS Biomater Sci Eng. 3:2702–2711. 2017. View Article : Google Scholar : PubMed/NCBI

82 

Wu RX, Yin Y, He XT, Li X and Chen FM: Engineering a cell home for stem cell homing and accommodation. Adv Biosyst. 1:e17000042017. View Article : Google Scholar : PubMed/NCBI

83 

Costanza B, Umelo IA, Bellier J, Castronovo V and Turtoi A: Stromal modulators of TGF-β in cancer. J Clin Med. 6:72017. View Article : Google Scholar : PubMed/NCBI

84 

Janmey PA, Wells RG, Assoian RK and McCulloch CA: From tissue mechanics to transcription factors. Differentiation. 86:112–120. 2013. View Article : Google Scholar : PubMed/NCBI

85 

Muehlich S, Rehm M, Ebenau A and Goppelt-Struebe M: Synergistic induction of CTGF by cytochalasin D and TGFbeta-1 in primary human renal epithelial cells: Role of transcriptional regulators MKL1, YAP/TAZ and Smad2/3. Cell Signal. 29:31–40. 2017. View Article : Google Scholar : PubMed/NCBI

86 

Rana MK, Aloisio FM, Choi C and Barber DL: Formin-dependent TGF-β signaling for epithelial to mesenchymal transition. Mol Biol Cell. 29:1465–1475. 2018. View Article : Google Scholar : PubMed/NCBI

87 

Ng LF, Kaur P, Bunnag N, Suresh J, Sung ICH, Tan QH, Gruber J and Tolwinski NS: WNT signaling in disease. Cells. 8:8262019. View Article : Google Scholar : PubMed/NCBI

88 

Mezzacappa C, Komiya Y and Habas R: Activation and function of small GTPases Rho, Rac, and Cdc42 during gastrulation. Methods Mol Biol. 839:119–131. 2012. View Article : Google Scholar : PubMed/NCBI

89 

Maeda T, Sakabe T, Sunaga A, Sakai K, Rivera AL, Keene DR, Sasaki T, Stavnezer E, Iannotti J, Schweitzer R, et al: Conversion of mechanical force into TGF-β-mediated biochemical signals. Curr Biol. 21:933–941. 2011. View Article : Google Scholar : PubMed/NCBI

90 

Varelas X, Sakuma R, Samavarchi-Tehrani P, Peerani R, Rao BM, Dembowy J, Yaffe MB, Zandstra PW and Wrana JL: TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nat Cell Biol. 10:837–848. 2008. View Article : Google Scholar : PubMed/NCBI

91 

Varelas X, Samavarchi-Tehrani P, Narimatsu M, Weiss A, Cockburn K, Larsen BG, Rossant J and Wrana JL: The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Dev Cell. 19:831–844. 2010. View Article : Google Scholar : PubMed/NCBI

92 

Narimatsu M, Samavarchi-Tehrani P, Varelas X and Wrana JL: Distinct polarity cues direct Taz/Yap and TGFβ receptor localization to differentially control TGFβ-induced Smad signaling. Dev Cell. 32:652–656. 2015. View Article : Google Scholar : PubMed/NCBI

93 

Alarcon C, Zaromytidou AI, Xi Q, Gao S, Yu J, Fujisawa S, Barlas A, Miller AN, Manova-Todorova K, Macias MJ, et al: Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell. 139:757–769. 2009. View Article : Google Scholar : PubMed/NCBI

94 

Qin Z, Xia W, Fisher GJ, Voorhees JJ and Quan T: YAP/TAZ regulates TGF-β/Smad3 signaling by induction of Smad7 via AP-1 in human skin dermal fibroblasts. Cell Commun Signal. 16:182018. View Article : Google Scholar : PubMed/NCBI

95 

Serowoky MA, Arata CE, Crump JG and Mariani FV: Skeletal stem cells: Insights into maintaining and regenerating the skeleton. Development. 147:dev1793252020. View Article : Google Scholar : PubMed/NCBI

96 

Tang Y and Weiss SJ: Snail/Slug-YAP/TAZ complexes cooperatively regulate mesenchymal stem cell function and bone formation. Cell Cycle. 16:399–405. 2017. View Article : Google Scholar : PubMed/NCBI

97 

Kovar H, Bierbaumer L and Radic-Sarikas B: The YAP/TAZ pathway in osteogenesis and bone sarcoma pathogenesis. Cells. 9:9722020. View Article : Google Scholar : PubMed/NCBI

98 

Fernandez LA, Northcott PA, Dalton J, Fraga C, Ellison D, Angers S, Taylor MD and Kenney AM: YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. Genes Dev. 23:2729–2741. 2009. View Article : Google Scholar : PubMed/NCBI

99 

Lin YT, Ding JY, Li MY, Yeh TS, Wang TW and Yu JY: YAP regulates neuronal differentiation through Sonic hedgehog signaling pathway. Exp Cell Res. 318:1877–1888. 2012. View Article : Google Scholar : PubMed/NCBI

100 

Hayashi S, Tamura K and Yokoyama H: Yap1, transcription regulator in the Hippo signaling pathway, is required for Xenopus limb bud regeneration. Dev Biol. 388:57–67. 2014. View Article : Google Scholar : PubMed/NCBI

101 

Hsu TH, Yang CY, Yeh TH, Huang YC, Wang TW and Yu JY: The Hippo pathway acts downstream of the Hedgehog signaling to regulate follicle stem cell maintenance in the Drosophila ovary. Sci Rep. 7:44802017. View Article : Google Scholar : PubMed/NCBI

102 

Machado MV, Michelotti GA, Pereira TA, Xie G, Premont R, Cortez-Pinto H and Diehl AM: Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease. J Hepatol. 63:962–970. 2015. View Article : Google Scholar : PubMed/NCBI

103 

Yimlamai D, Christodoulou C, Galli GG, Yanger K, Pepe-Mooney B, Gurung B, Shrestha K, Cahan P, Stanger BZ and Camargo FD: Hippo pathway activity influences liver cell fate. Cell. 157:1324–1338. 2014. View Article : Google Scholar : PubMed/NCBI

104 

Cotton JL, Li Q, Ma L, Park JS, Wang J, Ou J, Zhu LJ, Ip YT, Johnson RL and Mao J: YAP/TAZ and hedgehog coordinate growth and patterning in gastrointestinal mesenchyme. Dev Cell. 43:35–47.e4. 2017. View Article : Google Scholar : PubMed/NCBI

105 

Heng BC, Zhang X, Aubel D, Bai Y, Li X, Wei Y, Fussenegger M and Deng X: Role of YAP/TAZ in cell lineage fate determination and related signaling pathways. Front Cell Dev Biol. 8:7352020. View Article : Google Scholar : PubMed/NCBI

106 

Blanpain C and Fuchs E: Epidermal homeostasis: A balancing act of stem cells in the skin. Nat Rev Mol Cell Biol. 10:207–217. 2009. View Article : Google Scholar : PubMed/NCBI

107 

Simpson CL, Patel DM and Green KJ: Deconstructing the skin: Cytoarchitectural determinants of epidermal morphogenesis. Nat Rev Mol Cell Biol. 12:565–580. 2011. View Article : Google Scholar : PubMed/NCBI

108 

Watt FM, Estrach S and Ambler CA: Epidermal Notch signalling: Differentiation, cancer and adhesion. Curr Opin Cell Biol. 20:171–179. 2008. View Article : Google Scholar : PubMed/NCBI

109 

Totaro A, Castellan M, Battilana G, Zanconato F, Azzolin L, Giulitti S, Cordenonsi M and Piccolo S: YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate. Nat Commun. 8:152062017. View Article : Google Scholar : PubMed/NCBI

110 

Low BC, Pan CQ, Shivashankar GV, Bershadsky A, Sudol M and Sheetz M: YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth. FEBS Lett. 588:2663–2670. 2014. View Article : Google Scholar : PubMed/NCBI

111 

Piccolo S, Cordenonsi M and Dupont S: Molecular pathways: YAP and TAZ take center stage in organ growth and tumorigenesis. Clin Cancer Res. 19:4925–4930. 2013. View Article : Google Scholar : PubMed/NCBI

112 

Hayashi S, Yokoyama H and Tamura K: Roles of Hippo signaling pathway in size control of organ regeneration. Dev Growth Differ. 57:341–351. 2015. View Article : Google Scholar : PubMed/NCBI

113 

Ramos A and Camargo FD: The Hippo signaling pathway and stem cell biology. Trends Cell Biol. 22:339–346. 2012. View Article : Google Scholar : PubMed/NCBI

114 

Mo JS, Park HW and Guan KL: The Hippo signaling pathway in stem cell biology and cancer. EMBO Rep. 15:642–656. 2014. View Article : Google Scholar : PubMed/NCBI

115 

Hans C: Wnt/beta-catenin signaling in development and disease. Cell. 127:469–480. 2006. View Article : Google Scholar : PubMed/NCBI

116 

Niehrs C and Acebron SP: Mitotic and mitogenic Wnt signalling. EMBO J. 31:2705–2713. 2012. View Article : Google Scholar : PubMed/NCBI

117 

Piccolo S, Dupont S and Cordenonsi M: The biology of YAP/TAZ: Hippo signaling and beyond. Physiol Rev. 94:1287–1312. 2014. View Article : Google Scholar : PubMed/NCBI

118 

Azzolin L, Panciera T, Soligo S, Enzo E, Bicciato S, Dupont S, Bresolin S, Frasson C, Basso G, Guzzardo V, et al: YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response. Cell. 158:157–170. 2014. View Article : Google Scholar : PubMed/NCBI

119 

Park HW, Kim YC, Yu B, Moroishi T, Mo JS, Plouffe SW, Meng Z, Lin KC, Yu FX, Alexander CM, et al: Alternative Wnt signaling activates YAP/TAZ. Cell. 162:780–794. 2015. View Article : Google Scholar : PubMed/NCBI

120 

Chen X, Yuan W, Li Y, Luo J and Hou N: Role of Hippo-YAP1/TAZ pathway and its crosstalk in cardiac biology. Int J Biol Sci. 16:2454–2463. 2020. View Article : Google Scholar : PubMed/NCBI

121 

Sato N, Meijer L, Skaltsounis L, Greengard P and Brivanlou AH: Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med. 10:55–63. 2004. View Article : Google Scholar : PubMed/NCBI

122 

Weston CR and Davis RJ: The JNK signal transduction pathway. Curr Opin Cell Biol. 19:142–149. 2007. View Article : Google Scholar : PubMed/NCBI

123 

Chen F: JNK-induced apoptosis, compensatory growth, and cancer stem cells. Cancer Res. 72:379–386. 2012. View Article : Google Scholar : PubMed/NCBI

124 

Bogoyevitch MA and Kobe B: Uses for JNK: The many and varied substrates of the c-Jun N-terminal kinases. Microbiol Mol Biol Rev. 70:1061–1095. 2006. View Article : Google Scholar : PubMed/NCBI

125 

Kaunas R, Usami S and Chien S: Regulation of stretch-induced JNK activation by stress fiber orientation. Cell Signal. 18:1924–1931. 2006. View Article : Google Scholar : PubMed/NCBI

126 

Codelia VA, Sun G and Irvine KD: Regulation of YAP by mechanical strain through Jnk and Hippo signaling. Curr Biol. 24:2012–2017. 2014. View Article : Google Scholar : PubMed/NCBI

127 

Wang L, Luo JY, Li B, Tian XY, Chen LJ, Huang Y, Liu J, Deng D, Lau CW, Wan S, et al: Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow. Nature. 540:579–582. 2016. View Article : Google Scholar : PubMed/NCBI

128 

Plouffe SW, Hong AW and Guan KL: Disease implications of the Hippo/YAP pathway. Trends Mol Med. 21:212–222. 2015. View Article : Google Scholar : PubMed/NCBI

129 

Martinez B, Yang Y, Harker DMR, Farrar C, Mukundan H, Nath P and Mascareñas D: YAP/TAZ related BioMechano signal transduction and cancer metastasis. Front Cell Dev Biol. 7:1992019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Wang J and Zhong W: Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells (Review) Erratum in /10.3892/mmr.2021.12265. Mol Med Rep 24: 506, 2021.
APA
Li, Y., Wang, J., & Zhong, W. (2021). Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells (Review) Erratum in /10.3892/mmr.2021.12265. Molecular Medicine Reports, 24, 506. https://doi.org/10.3892/mmr.2021.12145
MLA
Li, Y., Wang, J., Zhong, W."Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells (Review) Erratum in /10.3892/mmr.2021.12265". Molecular Medicine Reports 24.1 (2021): 506.
Chicago
Li, Y., Wang, J., Zhong, W."Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells (Review) Erratum in /10.3892/mmr.2021.12265". Molecular Medicine Reports 24, no. 1 (2021): 506. https://doi.org/10.3892/mmr.2021.12145
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Wang J and Zhong W: Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells (Review) Erratum in /10.3892/mmr.2021.12265. Mol Med Rep 24: 506, 2021.
APA
Li, Y., Wang, J., & Zhong, W. (2021). Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells (Review) Erratum in /10.3892/mmr.2021.12265. Molecular Medicine Reports, 24, 506. https://doi.org/10.3892/mmr.2021.12145
MLA
Li, Y., Wang, J., Zhong, W."Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells (Review) Erratum in /10.3892/mmr.2021.12265". Molecular Medicine Reports 24.1 (2021): 506.
Chicago
Li, Y., Wang, J., Zhong, W."Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells (Review) Erratum in /10.3892/mmr.2021.12265". Molecular Medicine Reports 24, no. 1 (2021): 506. https://doi.org/10.3892/mmr.2021.12145
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