Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
July-2021 Volume 24 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2021 Volume 24 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

3,4,5‑Trihydroxycinnamic acid exerts anti‑inflammatory effects on TNF‑α/IFN‑γ‑stimulated HaCaT cells

  • Authors:
    • Ji-Won Park
    • Jae-Hoon Oh
    • Daseul Hwang
    • Seong-Man Kim
    • Jae-Hong Min
    • Ji-Yun Seo
    • Wanjoo Chun
    • Hee Jae Lee
    • Sei-Ryang Oh
    • Jae-Won Lee
    • Kyung-Seop Ahn
  • View Affiliations / Copyright

    Affiliations: Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Chungcheongbuk‑do 28116, Republic of Korea, Department of Pharmacology, College of Medicine, Kangwon National University, Chuncheon, Gangwon‑do 24341, Republic of Korea
    Copyright: © Park et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 509
    |
    Published online on: May 11, 2021
       https://doi.org/10.3892/mmr.2021.12148
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

3,4,5‑Trihydroxycinnamic acid (THCA) exhibits anti‑inflammatory activity in acute or chronic inflammatory disorders, such as acute lung injury and asthma. The present study investigated the anti‑inflammatory activity of THCA in a tumor necrosis factor‑α/interferon‑γ (TI) mixture‑stimulated human keratinocyte cell line. The results of ELISA and reverse transcription‑quantitative PCR revealed that THCA reduced the secretion and mRNA expression levels of interleukin (IL)‑6; IL‑8; thymus and activation‑regulated chemokine; macrophage‑derived chemokine; regulated upon activation, normal T cell expressed and secreted; and monocyte chemoattractant protein‑1 in TI mixture‑stimulated HaCaT cells. In addition, the results of western blot analysis demonstrated that THCA exerted inhibitory activity on the activation of AKT, ERK and nuclear factor‑κB in TI mixture‑stimulated HaCaT cells. Furthermore, THCA upregulated the expression levels of heme oxygenase‑1 and NAD(P)H:quinone oxidoreductase 1, and the activation of nuclear factor erythroid 2‑related factor 2 in HaCaT cells. These results demonstrated that THCA may exhibit anti‑inflammatory activity in activated HaCaT cells.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Park JW, Lee HS, Lim Y, Paik JH, Kwon OK, Kim JH, Paryanto I, Yunianto P, Choi S, Oh SR and Ahn KS: Rhododendron album Blume extract inhibits TNF-α/IFN-γ-induced chemokine production via blockade of NF-κB and JAK/STAT activation in human epidermal keratinocytes. Int J Mol Med. 41:3642–3652. 2018.PubMed/NCBI

2 

Huang WC, Dai YW, Peng HL, Kang CW, Kuo CY and Liou CJ: Phloretin ameliorates chemokines and ICAM-1 expression via blocking of the NF-κB pathway in the TNF-α-induced HaCaT human keratinocytes. Int Immunopharmacol. 27:32–37. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Kwon DJ, Bae YS, Ju SM, Goh AR, Choi SY and Park J: Casuarinin suppresses TNF-α-induced ICAM-1 expression via blockade of NF-κB activation in HaCaT cells. Biochem Biophys Res Commun. 409:780–785. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Xiong X, Huang C, Wang F, Dong J, Zhang D, Jiang J, Feng Y, Wu B, Xie T and Cheng L: Qingxue jiedu formulation ameliorated DNFB-induced atopic dermatitis by inhibiting STAT3/MAPK/NF-κB signaling pathways. J Ethnopharmacol. 270:1137732020. View Article : Google Scholar : PubMed/NCBI

5 

Kong L, Liu J, Wang J, Luo Q, Zhang H, Liu B, Xu F, Pang Q, Liu Y and Dong J: Icariin inhibits TNF-α/IFN-γ induced inflammatory response via inhibition of the substance P and p38-MAPK signaling pathway in human keratinocytes. Int Immunopharmacol. 29:401–407. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Lee HS, Park JW, Kwon OK, Lim Y, Kim JH, Kim SY, Zamora N, Rosales K, Choi S, Oh SR and Ahn KS: Anti-inflammatory effects of ethanol extract from the leaves and shoots of Cedrela odorata L. in cytokine-stimulated keratinocytes. Exp Ther Med. 18:833–840. 2019.PubMed/NCBI

7 

Lee da H and Lee CS: Flavonoid myricetin inhibits TNF-α-stimulated production of inflammatory mediators by suppressing the Akt, mTOR and NF-κB pathways in human keratinocytes. Eur J Pharmacol. 784:164–172. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Yang JH, Yoo JM, Lee E, Lee B, Cho WK, Park KI and Yeul Ma J: Anti-inflammatory effects of Perillae herba ethanolic extract against TNF-α/IFN-γ-stimulated human keratinocyte HaCaT cells. J Ethnopharmacol. 211:217–223. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Lee KS, Chun SY, Lee MG, Kim S, Jang TJ and Nam KS: The prevention of TNF-α/IFN-γ mixture-induced inflammation in human keratinocyte and atopic dermatitis-like skin lesions in Nc/Nga mice by mineral-balanced deep sea water. Biomed Pharmacother. 97:1331–1340. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Aye A, Song YJ, Jeon YD and Jin JS: Xanthone suppresses allergic contact dermatitis in vitro and in vivo. Int Immunopharmacol. 78:1060612020. View Article : Google Scholar : PubMed/NCBI

11 

Armutcu F, Akyol S, Ustunsoy S and Turan FF: Therapeutic potential of caffeic acid phenethyl ester and its anti-inflammatory and immunomodulatory effects (Review). Exp Ther Med. 9:1582–1588. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Choi HG, Tran PT, Lee JH, Min BS and Kim JA: Anti-inflammatory activity of caffeic acid derivatives isolated from the roots of Salvia miltiorrhiza bunge. Arch Pharm Res. 41:64–70. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Lee JW, Choi YJ, Park JH, Sim JY, Kwon YS, Lee HJ, Kim SS and Chun W: 3,4,5-Trihydroxycinnamic acid inhibits lipopolysaccharide-induced inflammatory response through the activation of Nrf2 pathway in BV2 microglial cells. Biomol Ther (Seoul). 21:60–65. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Lee JW, Bae CJ, Choi YJ, Kim SI, Kwon YS, Lee HJ, Kim SS and Chun W: 3,4,5-Trihydroxycinnamic acid inhibits lipopolysaccharide (LPS)-induced inflammation by Nrf2 activation in vitro and improves survival of mice in LPS-induced endotoxemia model in vivo. Mol Cell Biochem. 390:143–153. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Park JW, Kim SM, Min JH, Kim MG, Kwon OK, Hwang D, Oh JH, Park MW, Chun W, Lee HJ, et al: 3,4,5-Trihydroxycinnamic acid exerts anti-asthmatic effects in vitro and in vivo. Int Immunopharmacol. 88:1070022020. View Article : Google Scholar : PubMed/NCBI

16 

Min JH, Kim MG, Kim SM, Park JW, Chun W, Lee HJ, Oh SR, Ahn KS and Lee JW: 3,4,5-Trihydroxycinnamic acid exerts a protective effect on pulmonary inflammation in an experimental animal model of COPD. Int Immunopharmacol. 85:1066562020. View Article : Google Scholar : PubMed/NCBI

17 

Sawamura D, Meng X, Ina S, Sato M, Tamai K, Hanada K and Hashimoto I: Induction of keratinocyte proliferation and lymphocytic infiltration by in vivo introduction of the IL-6 gene into keratinocytes and possibility of keratinocyte gene therapy for inflammatory skin diseases using IL-6 mutant genes. J Immunol. 161:5633–5639. 1998.PubMed/NCBI

18 

Gallucci RM, Sloan DK, Heck JM, Murray AR and O'Dell SJ: Interleukin 6 indirectly induces keratinocyte migration. J Invest Dermatol. 122:764–772. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Lim HS, Jin SE, Kim OS, Shin HK and Jeong SJ: Alantolactone from saussurea lappa exerts antiinflammatory effects by inhibiting chemokine production and STAT1 phosphorylation in TNF-α and IFN-γ-induced in HaCaT cells. Phytother Res. 29:1088–1096. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Gros E, Bussmann C, Bieber T, Förster I and Novak N: Expression of chemokines and chemokine receptors in lesional and nonlesional upper skin of patients with atopic dermatitis. J Allergy Clin Immunol. 124:753–760.e1. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Kim HH, Bae Y and Kim SH: Galangin attenuates mast cell-mediated allergic inflammation. Food Chem Toxicol. 57:209–216. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Pivarcsi A and Homey B: Chemokine networks in atopic dermatitis: Traffic signals of disease. Curr Allergy Asthma Rep. 5:284–290. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Huang CH, Chang LC, Hu S, Hsiao CY and Wu SJ: Spilanthol inhibits TNF-α-induced ICAM-1 expression and pro-inflammatory responses by inducing heme oxygenase-1 expression and suppressing pJNK in HaCaT keratinocytes. Mol Med Rep. 18:2987–2994. 2018.PubMed/NCBI

24 

Kleszczyński K, Ernst IMA, Wagner AE, Kruse N, Zillikens D, Rimbach G and Fischer TW: Sulforaphane and phenylethyl isothiocyanate protect human skin against UVR-induced oxidative stress and apoptosis: Role of Nrf2-dependent gene expression and antioxidant enzymes. Pharmacol Res. 78:28–40. 2013. View Article : Google Scholar

25 

Kim H, Youn GS, An SY, Kwon HY, Choi SY and Park J: 2,3-Dimethoxy-2′-hydroxychalcone ameliorates TNF-α-induced ICAM-1 expression and subsequent monocyte adhesiveness via NF-kappaB inhibition and HO-1 induction in HaCaT cells. BMB Rep. 49:57–62. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Jeong SI, Choi BM and Jang SI: Sulforaphane suppresses TARC/CCL17 and MDC/CCL22 expression through heme oxygenase-1 and NF-κB in human keratinocytes. Arch Pharm Res. 33:1867–1876. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Hseu YC, Chen XZ, Vudhya Gowrisankar Y, Yen HR, Chuang JY and Yang HL: The skin-whitening effects of Ectoine via the suppression of α-MSH-stimulated melanogenesis and the activation of antioxidant Nrf2 pathways in UVA-irradiated keratinocytes. Antioxidants (Basel). 9:632020. View Article : Google Scholar : PubMed/NCBI

28 

Chen L and Zhong JL: MicroRNA and heme oxygenase-1 in allergic disease. Int Immunopharmacol. 80:1061322020. View Article : Google Scholar : PubMed/NCBI

29 

Choi M, Park M, Lee S, Lee JW, Choi WJ and Lee C: Establishment of Nrf2-deficient HaCaT and immortalized primary human foreskin keratinocytes and characterization of their responses to ROS-induced cytotoxicity. Toxicol In Vitro. 61:1046022019. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Park J, Oh J, Hwang D, Kim S, Min J, Seo J, Chun W, Lee HJ, Oh S, Lee J, Lee J, et al: 3,4,5‑Trihydroxycinnamic acid exerts anti‑inflammatory effects on TNF‑α/IFN‑γ‑stimulated HaCaT cells. Mol Med Rep 24: 509, 2021.
APA
Park, J., Oh, J., Hwang, D., Kim, S., Min, J., Seo, J. ... Ahn, K. (2021). 3,4,5‑Trihydroxycinnamic acid exerts anti‑inflammatory effects on TNF‑α/IFN‑γ‑stimulated HaCaT cells. Molecular Medicine Reports, 24, 509. https://doi.org/10.3892/mmr.2021.12148
MLA
Park, J., Oh, J., Hwang, D., Kim, S., Min, J., Seo, J., Chun, W., Lee, H. J., Oh, S., Lee, J., Ahn, K."3,4,5‑Trihydroxycinnamic acid exerts anti‑inflammatory effects on TNF‑α/IFN‑γ‑stimulated HaCaT cells". Molecular Medicine Reports 24.1 (2021): 509.
Chicago
Park, J., Oh, J., Hwang, D., Kim, S., Min, J., Seo, J., Chun, W., Lee, H. J., Oh, S., Lee, J., Ahn, K."3,4,5‑Trihydroxycinnamic acid exerts anti‑inflammatory effects on TNF‑α/IFN‑γ‑stimulated HaCaT cells". Molecular Medicine Reports 24, no. 1 (2021): 509. https://doi.org/10.3892/mmr.2021.12148
Copy and paste a formatted citation
x
Spandidos Publications style
Park J, Oh J, Hwang D, Kim S, Min J, Seo J, Chun W, Lee HJ, Oh S, Lee J, Lee J, et al: 3,4,5‑Trihydroxycinnamic acid exerts anti‑inflammatory effects on TNF‑α/IFN‑γ‑stimulated HaCaT cells. Mol Med Rep 24: 509, 2021.
APA
Park, J., Oh, J., Hwang, D., Kim, S., Min, J., Seo, J. ... Ahn, K. (2021). 3,4,5‑Trihydroxycinnamic acid exerts anti‑inflammatory effects on TNF‑α/IFN‑γ‑stimulated HaCaT cells. Molecular Medicine Reports, 24, 509. https://doi.org/10.3892/mmr.2021.12148
MLA
Park, J., Oh, J., Hwang, D., Kim, S., Min, J., Seo, J., Chun, W., Lee, H. J., Oh, S., Lee, J., Ahn, K."3,4,5‑Trihydroxycinnamic acid exerts anti‑inflammatory effects on TNF‑α/IFN‑γ‑stimulated HaCaT cells". Molecular Medicine Reports 24.1 (2021): 509.
Chicago
Park, J., Oh, J., Hwang, D., Kim, S., Min, J., Seo, J., Chun, W., Lee, H. J., Oh, S., Lee, J., Ahn, K."3,4,5‑Trihydroxycinnamic acid exerts anti‑inflammatory effects on TNF‑α/IFN‑γ‑stimulated HaCaT cells". Molecular Medicine Reports 24, no. 1 (2021): 509. https://doi.org/10.3892/mmr.2021.12148
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team