Clinical Genomic, phenotype and epigenetic insights into the pathology, autoimmunity and weight management of patients with Myasthenia Gravis (Review)

  • Authors:
    • Rebecca Golfinopoulou
    • Louis Papageorgiou
    • Aspasia Efthimiadou
    • Flora Bacopoulou
    • George P. Chrousos
    • Elias Eliopoulos
    • Dimitrios Vlachakis
  • View Affiliations

  • Published online on: May 12, 2021     https://doi.org/10.3892/mmr.2021.12151
  • Article Number: 512
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Abstract

Myasthenia Gravis (MG) is an autoimmune disease that affects neuromuscular junctions and is characterized by muscle weakness as a result of autoantibodies against certain proteins. As a heterogeneous disorder, MG presents with different types, including neonatal, ocular and generalized in both juveniles and adults. Different types of antibodies serve a role in how MG presents. The main biological characteristic of MG is the production of antibodies against the muscular acetylcholine receptor; however, other types of antibody have been associated with the disorder. The role of the thymus gland has been established and thymectomy is a possible treatment of the disease, along with traditional medication such as pyridostigmine bromide (Mestinon) and immunosuppresants. In recent years, steps have been made towards developing more sensitive diagnostic methods. Additionally, novel treatments have demonstrated promising results. Developing new assays may lead to an increased understanding of the disease and to unravelling the genetic pathway that leads to the development of neuromuscular diseases.
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July-2021
Volume 24 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Golfinopoulou R, Papageorgiou L, Efthimiadou A, Bacopoulou F, Chrousos GP, Eliopoulos E and Vlachakis D: Clinical Genomic, phenotype and epigenetic insights into the pathology, autoimmunity and weight management of patients with Myasthenia Gravis (Review). Mol Med Rep 24: 512, 2021
APA
Golfinopoulou, R., Papageorgiou, L., Efthimiadou, A., Bacopoulou, F., Chrousos, G.P., Eliopoulos, E., & Vlachakis, D. (2021). Clinical Genomic, phenotype and epigenetic insights into the pathology, autoimmunity and weight management of patients with Myasthenia Gravis (Review). Molecular Medicine Reports, 24, 512. https://doi.org/10.3892/mmr.2021.12151
MLA
Golfinopoulou, R., Papageorgiou, L., Efthimiadou, A., Bacopoulou, F., Chrousos, G. P., Eliopoulos, E., Vlachakis, D."Clinical Genomic, phenotype and epigenetic insights into the pathology, autoimmunity and weight management of patients with Myasthenia Gravis (Review)". Molecular Medicine Reports 24.1 (2021): 512.
Chicago
Golfinopoulou, R., Papageorgiou, L., Efthimiadou, A., Bacopoulou, F., Chrousos, G. P., Eliopoulos, E., Vlachakis, D."Clinical Genomic, phenotype and epigenetic insights into the pathology, autoimmunity and weight management of patients with Myasthenia Gravis (Review)". Molecular Medicine Reports 24, no. 1 (2021): 512. https://doi.org/10.3892/mmr.2021.12151