Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
August-2021 Volume 24 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2021 Volume 24 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

An increase in elastogenic components in the placental villi of women with chronic venous disease during pregnancy is associated with decreased EGFL7 expression level

  • Authors:
    • Miguel A. Ortega
    • Ángel Asúnsolo
    • Oscar Fraile‑Martínez
    • Felipe Sainz
    • Miguel A. Saez
    • Coral Bravo
    • Juan A. De León‑Luis
    • Miguel A. Alvarez‑Mon
    • Santiago Coca
    • Melchor Álvarez‑Mon
    • Julia Buján
    • Natalio García‑Honduvilla
  • View Affiliations / Copyright

    Affiliations: Department of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, 28801 Madrid, Spain, Ramón y Cajal Institute of Healthcare Research, 28034 Madrid, Spain, University Center for The Defense of Madrid, 28047 Madrid, Spain, Service of Gynecology and Obstetrics, Section of Fetal Maternal Medicine, Central University Hospital of Defence‑University of Alcalá, 28047 Madrid, Spain
    Copyright: © Ortega et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 556
    |
    Published online on: June 2, 2021
       https://doi.org/10.3892/mmr.2021.12195
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Chronic venous disease (CVD) is the response to a series of hemodynamic changes in the venous system and the onset of this disease is often triggered by pregnancy. Placental tissue is particularly sensitive to the characteristic changes which occurs in venous hypertension. In this regard, changes in the extracellular matrix (ECM), that occur to adapt to this situation, are fundamental to controlling elastogenesis. Therefore, the aim of the present study was to analyze the changes that occur in the mRNA and protein expression level of proteins related to elastogenesis in the placental villi of women diagnosed with CVD, in the third trimester of pregnancy. An observational, analytical and prospective cohort study was conducted, in which the placenta from 62 women with CVD were compared with that in placenta from 52 women without a diagnosis of CVD. Gene and protein expression levels were analyzed using reverse transcription‑quantitative PCR and immunohistochemistry, respectively. The results showed a significant decrease in the gene and protein expression level of EGFL7 in the placental villi of women with CVD. By contrast, significant increases in the gene and protein expression level of ECM‑related proteins, such as tropoelastin, fibulin 4, fibrillin 1 and members of the lysyl oxidase family (LOX and LOXL‑1) were also found in the placental villi of women with CVD. To the best of our knowledge, the results from the present study showed for the first time that CVD during pregnancy was associated with changes in the mRNA and protein expression level in essential components of the EGFL7‑modulated elastogenesis process in placental villi.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Ouzounian JG and Elkayam U: Physiologic changes during normal pregnancy and delivery. Cardiol Clin. 30:317–329. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Troiano NH: Physiologic and hemodynamic changes during pregnancy. AACN Adv Crit Care. 29:273–283. 2018. View Article : Google Scholar : PubMed/NCBI

3 

García-Honduvilla N, Ortega MA, Asúnsolo Á, Álvarez-Rocha MJ, Romero B, De León-Luis J, Álvarez-Mon M and Buján J: Placentas from women with pregnancy-associated venous insufficiency show villi damage with evidence of hypoxic cellular stress. Hum Pathol. 77:45–53. 2018. View Article : Google Scholar

4 

Saliba Júnior OA, Rollo HA, Saliba O and Sobreira ML: Graduated compression stockings effects on chronic venous disease signs and symptoms during pregnancy. Phlebology. 35:46–55. 2020. View Article : Google Scholar

5 

Ropacka-Lesiak M, Jarosław K and Bręborowicz G: Pregnancy-dependent blood flow velocity changes in lower extremities veins in venous insufficiency. Ginekol Pol. 86:659–665. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Iupatov EI, Ignat'ev IM and Fomina EE: Ultrasonographic examination of major veins of lower limbs and pelvic veins in pregnant women. Angiol Sosud Khir. 24:70–75. 2018.(In Russian). PubMed/NCBI

7 

Asbeutah AM, Al-Azemi M, Al-Sarhan S, Almajran A and Asfar SK: Changes in the diameter and valve closure time of leg veins in primigravida women during pregnancy. J Vasc Surg Venous Lymphat Disord. 3:147–153. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Fanfera FJ and Palmer LH: Pregnancy and varicose veins. Arch Surg. 96:33–35. 1968. View Article : Google Scholar : PubMed/NCBI

9 

Davies AH: The seriousness of chronic venous disease: A review of Real-World evidence. Adv Ther. 36 (Suppl 1):S5–S12. 2019. View Article : Google Scholar

10 

El-Sayed AAF: Preeclampsia: A review of the pathogenesis and possible management strategies based on its pathophysiological derangements. Taiwan J Obstet Gynecol. 56:593–598. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Ortega MA, Romero B, Asúnsolo Á, Martínez-Vivero C, Sainz F, Bravo C, De León-Luis J, Álvarez-Mon M, Buján J and García-Honduvilla N: Pregnancy-associated venous insufficiency course with placental and systemic oxidative stress. J Cell Mol Med. 24:4157–4170. 2020. View Article : Google Scholar : PubMed/NCBI

12 

Smith SD, Choudhury RH, Matos P, Horn JA, Lye SJ, Dunk CE, Aplin JD, Jones RL and Harris LK: Changes in vascular extracellular matrix composition during decidual spiral arteriole remodeling in early human pregnancy. Histol Histopathol. 31:557–571. 2016.PubMed/NCBI

13 

Gauster M, Berghold VM, Moser G, Orendi K, Siwetz M and Huppertz B: Fibulin-5 expression in the human placenta. Histochem Cell Biol. 135:203–213. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Schmidt M, De Mazière A, Smyczek T, Gray A, Parker L, Filvaroff E, French D, van Dijk S, Klumperman J and Ye W: The role of Egfl7 in vascular morphogenesis. Novartis Found Symp. 283:18–28. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Lelièvre E, Hinek A, Lupu F, Buquet C, Soncin F and Mattot V: VE-statin/egfl7 regulates vascular elastogenesis by interacting with lysyl oxidases. EMBO J. 27:1658–1670. 2008. View Article : Google Scholar

16 

Rahat B, Sharma R, Bagga R, Hamid A and Kaur J: Imbalance between matrix metalloproteinases and their tissue inhibitors in preeclampsia and gestational trophoblastic diseases. Reproduction. 152:11–22. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Ortega MA, Asúnsolo Á, Álvarez-Rocha MJ, Romero B, De León-Luis J, Álvarez-Mon M, Buján J and García-Honduvilla N: Remodelling of collagen fibres in the placentas of women with venous insufficiency during pregnancy. Histol Histopathol. 33:567–576. 2018.PubMed/NCBI

18 

Ortega MA, Saez MÁ, Asúnsolo Á, Romero B, Bravo C, Coca S, Sainz F, Álvarez-Mon M, Buján J and García-Honduvilla N: Upregulation of VEGF and PEDF in placentas of women with lower extremity venous insufficiency during pregnancy and its implication in villous calcification. Biomed Res Int. 2019:53209022019. View Article : Google Scholar : PubMed/NCBI

19 

Ortega MA, Saez MA, Fraile-Martínez O, Asúnsolo Á, Pekarek L, Bravo C, Coca S, Sainz F, Mon MÁ, Buján J and García-Honduvilla N: Increased angiogenesis and lymphangiogenesis in the placental villi of women with chronic venous disease during pregnancy. Int J Mol Sci. 21:24872020. View Article : Google Scholar : PubMed/NCBI

20 

Lurie F, Passman M, Meisner M, Dalsing M, Masuda E, Welch H, Bush RL, Blebea J, Carpentier PH, De Maeseneer M, et al: The 2020 update of the CEAP classification system and reporting standards. J Vasc Surg Venous Lymphat Disord. 8:342–352. 2020. View Article : Google Scholar : PubMed/NCBI

21 

Ortega MA, Asúnsolo Á, Leal J, Romero B, Alvarez-Rocha MJ, Sainz F, Álvarez-Mon M, Buján J and García-Honduvilla N: Implication of the PI3K/Akt/mTOR Pathway in the process of incompetent valves in patients with chronic venous insufficiency and the relationship with aging. Oxid Med Cell Longev. 2018:14951702018. View Article : Google Scholar : PubMed/NCBI

22 

Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, Kubista M, Mueller R, Nolan T, Pfaffl MW, Shipley GL, et al: The MIQE Guidelines: Minimum information for publication of quantitative real-time PCR experiments. Clin Chem. 55:611–622. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Ye J, Coulouris G, Zaretskaya I, Cutcutache I, Rozen S and Madden TL: Primer-BLAST: A tool to design target-specific primers for polymerase chain reaction. BMC Bioinformatics. 13:1342012. View Article : Google Scholar : PubMed/NCBI

24 

Vallone PM and Butler JM: AutoDimer: A screening tool for primer-dimer and hairpin structures. Biotechniques. 37:226–231. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Ortega MA, Romero B, Asúnsolo Á, Sola M, Álavrez-Rocha MJ, Sainz F, Álavrez-Mon M, Buján J and García-Honduvilla N: Patients with incompetent valves in chronic venous insufficiency show increased systematic lipid peroxidation and cellular oxidative stress markers. Oxid Med Cell Longev. 2019:51645762019. View Article : Google Scholar : PubMed/NCBI

27 

Remmele W and Schicketanz KH: Immunohistochemical determination of estrogen and progesterone receptor content in human breast cancer: Computer-assisted image analysis (QIC score) vs. subjective grading (IRS). Pathol Res Pract. 189:862–866. 1993. View Article : Google Scholar : PubMed/NCBI

28 

Cristóbal L, Ortega MA, Asúnsolo Á, Romero B, Álvarez-Mon M, Buján J, Maldonado AA and García-Honduvilla N: Human skin model for mimic dermal studies in pathology with a clinical implication in pressure ulcers. Histol Histopathol. 33:959–970. 2018.

29 

Macura B and Śliwa L: Epigenetics in the placenta, the current knowledge and future clinical perspectives. Przegl Lek. 72:673–676. 2015.PubMed/NCBI

30 

Chen Y, Peng W, Raffetto JD and Khalil RA: Matrix metalloproteinases in remodeling of lower extremity veins and chronic venous disease. Prog Mol Biol Transl Sci. 147:267–299. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Chabbert-Buffet N, Meduri G, Bouchard P and Spitz IM: Selective progesterone receptor modulators and progesterone antagonists: Mechanisms of action and clinical applications. Hum Reprod Update. 11:293–307. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Franczyk M, Lopucki M, Stachowicz N, Morawska D and Kankofer M: Extracellular matrix proteins in healthy and retained placentas, comparing hemochorial and synepitheliochorial placentas. Placenta. 50:19–24. 2017. View Article : Google Scholar : PubMed/NCBI

33 

García-Honduvilla N, Asúnsolo Á, Ortega MA, Sainz F, Leal J, Lopez-Hervas P, Pascual G and Buján J: Increase and redistribution of sex hormone receptors in premenopausal women are associated with varicose vein remodelling. Oxid Med Cell Longev. 2018:39740262018. View Article : Google Scholar

34 

Ortega MA, Asúnsolo Á, Romero B, Álvarez-Rocha MJ, Sainz F, Leal J, Álvarez-Mon M, Buján J and García-Honduvilla N: Unravelling the role of MAPKs (ERK1/2) in venous reflux in patients with chronic venous disorder. Cells Tissues Organs. 206:272–282. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Ren Z, Cui N, Zhu M and Khalil RA: Placental growth factor reverses decreased vascular and uteroplacental MMP-2 and MMP-9 and increased MMP-1 and MMP-7 and collagen types I and IV in hypertensive pregnancy. Am J Physiol Heart Circ Physiol. 315:H33–H47. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Handorf AM, Zhou Y, Halanski MA and Li WJ: Tissue stiffness dictates development, homeostasis, and disease progression. Organogenesis. 11:1–15. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Baldwin AK, Simpson A, Steer R, Cain SA and Kielty CM: Elastic fibres in health and disease. Expert Rev Mol Med. 15:e82013. View Article : Google Scholar : PubMed/NCBI

38 

Ortega MA, Romero B, Asúnsolo Á, Sainz F, Martinez-Vivero C, Álvarez-Mon M, Buján J and García-Honduvilla N: Behavior of smooth muscle cells under hypoxic conditions: Possible implications on the varicose vein endothelium. Biomed Res Int. 2018:71561502018. View Article : Google Scholar : PubMed/NCBI

39 

Simon EG, Callé S, Perrotin F and Remenieras JP: Measurement of shear wave speed dispersion in the placenta by transient elastography: A preliminary ex vivo study. PLoS One. 13:e01943092018. View Article : Google Scholar : PubMed/NCBI

40 

Hein S, Yamamoto SY, Okazaki K, Jourdan-LeSaux C, Csiszar K and Bryant-Greenwood GD: Lysyl oxidases: Expression in the fetal membranes and placenta. Placenta. 22:49–57. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Polettini J, Silva MG, Kacerovsky M, Syed TA, Saade GR and Menon R: Screening of lysyl oxidase (LOX) and lysyl oxidase like (LOXL) enzyme expression and activity in preterm prelabor rupture of fetal membranes. J Perinat Med. 44:99–109. 2016.PubMed/NCBI

42 

Liu X, Zhao Y, Gao J, Pawlyk B, Starcher B, Spencer JA, Yanagisawa H, Zuo J and Li T: Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. Nat Genet. 36:178–182. 2004. View Article : Google Scholar : PubMed/NCBI

43 

Saw SN, Tay JJH, Poh YW, Yang L, Tan WC, Tan LK, Clark A, Biswas A, Mattar CNZ and Yap CH: Altered placental chorionic arterial biomechanical properties during intrauterine growth restriction. Sci Rep. 8:165262018. View Article : Google Scholar : PubMed/NCBI

44 

Thomassin L, Werneck CC, Broekelmann TJ, Gleyzal C, Hornstra IK, Mecham RP and Sommer P: The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers. J Biol Chem. 280:42848–42855. 2005. View Article : Google Scholar : PubMed/NCBI

45 

Hieber AD, Corcino D, Motosue J, Sandberg LB, Roos PJ, Yu SY, Csiszar K, Kagan HM, Boyd CD and Bryant-Greenwood GD: Detection of elastin in the human fetal membranes: Proposed molecular basis for elasticity. Placenta. 18:301–312. 1997. View Article : Google Scholar : PubMed/NCBI

46 

Baldock C, Oberhauser AF, Ma L, Lammie D, Siegler V, Mithieux SM, Tu Y, Chow JY, Suleman F, Malfois M, et al: Shape of tropoelastin, the highly extensible protein that controls human tissue elasticity. Proc Natl Acad Sci USA. 108:4322–4327. 2011. View Article : Google Scholar : PubMed/NCBI

47 

Jacobson SL, Kimberly D, Thornburg K and Maslen C: Localization of fibrillin-1 in the human term placenta. J Soc Gynecol Investig. 2:686–690. 1995. View Article : Google Scholar : PubMed/NCBI

48 

Fleming S and Bell SC: Localization of fibrillin-1 in human endometrium and decidua during the menstrual cycle and pregnancy. Hum Reprod. 12:2051–2056. 1997. View Article : Google Scholar : PubMed/NCBI

49 

Sherratt MJ, Baldock C, Louise Haston JL, Holmes DF, Jones CJ, Shuttleworth CA, Wess TJ and Kielty CM: Fibrillin microfibrils are stiff reinforcing fibres in compliant tissues. J Mol Biol. 332:183–193. 2003. View Article : Google Scholar : PubMed/NCBI

50 

Costa AM, Maximiano EB, Avvad-Portari E, Jésus NR, Levy RA and Porto LC: Contractile cells and fibrillin-1 distribution is disturbed in terminal villi of placentae from patients with preeclampsia and systemic lupus erythematosus. Placenta. 27:234–243. 2006. View Article : Google Scholar : PubMed/NCBI

51 

Abbas Y, Carnicer-Lombarte A, Gardner L, Thomas J, Brosens JJ, Moffett A, Sharkey AM, Franze K, Burton GJ and Oyen ML: Tissue stiffness at the human maternal-fetal interface. Hum Reprod. 34:1999–2008. 2019. View Article : Google Scholar : PubMed/NCBI

52 

Handford PA: Fibrillin-1, a calcium binding protein of extracellular matrix. Biochim Biophys Acta. 1498:84–90. 2000. View Article : Google Scholar : PubMed/NCBI

53 

Papke CL and Yanagisawa H: Fibulin-4 and fibulin-5 in elastogenesis and beyond: Insights from mouse and human studies. Matrix Biol. 37:142–149. 2014. View Article : Google Scholar : PubMed/NCBI

54 

Kumra H, Nelea V, Hakami H, Pagliuzza A, Djokic J, Xu J, Yanagisawa H and Reinhardt DP: Fibulin-4 exerts a dual role in LTBP-4L-mediated matrix assembly and function. Proc Natl Acad Sci USA. 116:20428–20437. 2019. View Article : Google Scholar : PubMed/NCBI

55 

Burger J, van Vliet N, van Heijningen P, Kumra H, Kremers GJ, Alves M, van Cappellen G, Yanagisawa H, Reinhardt DP, Kanaar R, et al: Fibulin-4 deficiency differentially affects cytoskeleton structure and dynamics as well as TGFβ signaling. Cell Signal. 58:65–78. 2019. View Article : Google Scholar : PubMed/NCBI

56 

d'Audigier C, Susen S, Blandinieres A, Mattot V, Saubamea B, Rossi E, Nevo N, Lecourt S, Guerin CL, Dizier B, et al: Egfl7 represses the vasculogenic potential of human endothelial progenitor cells. Stem Cell Rev Rep. 14:82–91. 2018. View Article : Google Scholar

57 

Lacko LA, Massimiani M, Sones JL, Hurtado R, Salvi S, Ferrazzani S, Davisson RL, Campagnolo L and Stuhlmann H: Novel expression of EGFL7 in placental trophoblast and endothelial cells and its implication in preeclampsia. Mech Dev. 133:163–176. 2014. View Article : Google Scholar : PubMed/NCBI

58 

Massimiani M, Vecchione L, Piccirilli D, Spitalieri P, Amati F, Salvi S, Ferrazzani S, Stuhlmann H and Campagnolo L: Epidermal growth factor-like domain 7 promotes migration and invasion of human trophoblast cells through activation of MAPK, PI3K and NOTCH signaling pathways. Mol Hum Reprod. 21:435–451. 2015. View Article : Google Scholar : PubMed/NCBI

59 

Lacko LA, Hurtado R, Hinds S, Poulos MG, Butler JM and Stuhlmann H: Altered feto-placental vascularization, feto-placental malperfusion and fetal growth restriction in mice with Egfl7 loss of function. Development. 144:2469–2479. 2017.PubMed/NCBI

60 

Shrestha D, Ouidir M, Workalemahu T, Zeng X and Tekola-Ayele F: Placental DNA methylation changes associated with maternal prepregnancy BMI and gestational weight gain. Int J Obes (Lond). 44:1406–1416. 2020. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ortega MA, Asúnsolo Á, Fraile‑Martínez O, Sainz F, Saez MA, Bravo C, De León‑Luis JA, Alvarez‑Mon MA, Coca S, Álvarez‑Mon M, Álvarez‑Mon M, et al: An increase in elastogenic components in the placental villi of women with chronic venous disease during pregnancy is associated with decreased EGFL7 expression level. Mol Med Rep 24: 556, 2021.
APA
Ortega, M.A., Asúnsolo, Á., Fraile‑Martínez, O., Sainz, F., Saez, M.A., Bravo, C. ... García‑Honduvilla, N. (2021). An increase in elastogenic components in the placental villi of women with chronic venous disease during pregnancy is associated with decreased EGFL7 expression level. Molecular Medicine Reports, 24, 556. https://doi.org/10.3892/mmr.2021.12195
MLA
Ortega, M. A., Asúnsolo, Á., Fraile‑Martínez, O., Sainz, F., Saez, M. A., Bravo, C., De León‑Luis, J. A., Alvarez‑Mon, M. A., Coca, S., Álvarez‑Mon, M., Buján, J., García‑Honduvilla, N."An increase in elastogenic components in the placental villi of women with chronic venous disease during pregnancy is associated with decreased EGFL7 expression level". Molecular Medicine Reports 24.2 (2021): 556.
Chicago
Ortega, M. A., Asúnsolo, Á., Fraile‑Martínez, O., Sainz, F., Saez, M. A., Bravo, C., De León‑Luis, J. A., Alvarez‑Mon, M. A., Coca, S., Álvarez‑Mon, M., Buján, J., García‑Honduvilla, N."An increase in elastogenic components in the placental villi of women with chronic venous disease during pregnancy is associated with decreased EGFL7 expression level". Molecular Medicine Reports 24, no. 2 (2021): 556. https://doi.org/10.3892/mmr.2021.12195
Copy and paste a formatted citation
x
Spandidos Publications style
Ortega MA, Asúnsolo Á, Fraile‑Martínez O, Sainz F, Saez MA, Bravo C, De León‑Luis JA, Alvarez‑Mon MA, Coca S, Álvarez‑Mon M, Álvarez‑Mon M, et al: An increase in elastogenic components in the placental villi of women with chronic venous disease during pregnancy is associated with decreased EGFL7 expression level. Mol Med Rep 24: 556, 2021.
APA
Ortega, M.A., Asúnsolo, Á., Fraile‑Martínez, O., Sainz, F., Saez, M.A., Bravo, C. ... García‑Honduvilla, N. (2021). An increase in elastogenic components in the placental villi of women with chronic venous disease during pregnancy is associated with decreased EGFL7 expression level. Molecular Medicine Reports, 24, 556. https://doi.org/10.3892/mmr.2021.12195
MLA
Ortega, M. A., Asúnsolo, Á., Fraile‑Martínez, O., Sainz, F., Saez, M. A., Bravo, C., De León‑Luis, J. A., Alvarez‑Mon, M. A., Coca, S., Álvarez‑Mon, M., Buján, J., García‑Honduvilla, N."An increase in elastogenic components in the placental villi of women with chronic venous disease during pregnancy is associated with decreased EGFL7 expression level". Molecular Medicine Reports 24.2 (2021): 556.
Chicago
Ortega, M. A., Asúnsolo, Á., Fraile‑Martínez, O., Sainz, F., Saez, M. A., Bravo, C., De León‑Luis, J. A., Alvarez‑Mon, M. A., Coca, S., Álvarez‑Mon, M., Buján, J., García‑Honduvilla, N."An increase in elastogenic components in the placental villi of women with chronic venous disease during pregnancy is associated with decreased EGFL7 expression level". Molecular Medicine Reports 24, no. 2 (2021): 556. https://doi.org/10.3892/mmr.2021.12195
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team