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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
August-2021 Volume 24 Issue 2

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Expression levels of specific microRNAs are increased after exercise and are associated with cognitive improvement in Parkinson's disease

Franciele Cascaes Da Silva, Michele Patrícia Rode, Giovanna Grunewald Vietta, Rodrigo Da Rosa Iop, Tânia Beatriz Creczynski‑Pasa, Alessandra Swarowsky Martin, Rudney Da Silva
Article Number: 618
Published online on: 29 June 2021

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Article Open Access

circPTPN22 as a novel biomarker and ceRNA in peripheral blood mononuclear cells of rheumatoid arthritis

Zhuyan Jiang, Zhiting Zhong, Qingqing Miao, Yue Zhang, Bing Ni, Mengjie Zhang, Jun Tang
Article Number: 617
Published online on: 29 June 2021

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Article

H3K9me2 regulates early transcription factors to promote mesenchymal stem‑cell differentiation into cardiomyocytes

Xiaolin Sun, Xiang Gu, Hongxiao Li, Pei Xu, Mengting Li, Ye Zhu, Qisheng Zuo, Bichun Li
Article Number: 616
Published online on: 29 June 2021

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Article

Anti‑angiogenic effect of mountain ginseng in vitro and in vivo: Comparison with farm‑cultivated ginseng

Jin Soo Kim, Jae-Myung Yoo, Jong Eel Park, Jungeun Kim, Sun-Gun Kim, Young Mi Seok, Jun-Ho Son, Hyo Jung Kim
Article Number: 615
Published online on: 29 June 2021

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Article Open Access

Nuclear PKR in retinal neurons in the early stage of diabetic retinopathy in streptozotocin‑induced diabetic rats

Viviane Aline Oliveira Silva, Nayara Delgado André, Thaís Amaral E Sousa, Vâni Maria Alves, Isis Do Carmo Kettelhut, Fernando Luiz De Lucca
Article Number: 614
Published online on: 28 June 2021

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Article Open Access

PI3K/AKT phosphorylation activates ERRα by upregulating PGC‑1α and PGC‑1β in gallbladder cancer

Lei Wang, Mengmeng Yang, Huihan Jin
Article Number: 613
Published online on: 28 June 2021

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Article Open Access

Sulforaphane protects against oxidative stress‑induced apoptosis via activating SIRT1 in mouse osteoarthritis

Mangmang Chen, Lipeng Huang, Yangxun Lv, Liubing Li, Qirong Dong
Article Number: 612
Published online on: 28 June 2021

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Review Open Access

Dysregulated inflammation may predispose patients with serious mental illnesses to severe COVID‑19 (Review)

Sergej Nadalin, Hrvoje Jakovac, Vjekoslav Peitl, Dalibor Karlović, Alena Buretić‑Tomljanović
Article Number: 611
Published online on: 28 June 2021

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Article Open Access

Effects of Melandrium firmum Rohrbach on RANKL‑induced osteoclast differentiation and OVX rats

Minsun Kim, Jae-Hyun Kim, Sooyeon Hong, Boguen Kwon, Eun-Young Kim, Hyuk-Sang Jung, Youngjoo Sohn
Article Number: 610
Published online on: 25 June 2021

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Article Open Access

Interference with circRNA DOCK1 inhibits hepatocellular carcinoma cell proliferation, invasion and migration by regulating the miR-654-5p/SMAD2 axis

Yujuan Lu, Jingzhi Zhang, Yanhui Wu
Article Number: 609
Published online on: 25 June 2021

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Article Open Access

Humanized anti‑TLR4 monoclonal antibody ameliorates lipopolysaccharide‑related acute kidney injury by inhibiting TLR4/NF‑κB signaling

Qiuhua Zhang, Liang Wang, Mian Wu, Xiaobin Liu, Yushan Zhu, Jin Zhu, Changying Xing
Article Number: 608
Published online on: 25 June 2021

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Article Open Access

Solanum nigrum Line inhibits osteoclast differentiation and suppresses bone mineral density reduction in the ovariectomy‑induced osteoporosis model

Jae-Hyun Kim, Hwajeong Shin, Minsun Kim, Sangwoo Kim, Kwangchan Song, Hyuk-Sang Jung, Youngjoo Sohn
Article Number: 607
Published online on: 25 June 2021

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Article

Telomere shortening and expression of TRF1 and TRF2 in uterine leiomyoma

Bong-Kyeong Oh, Yoojung Choi, Joong Sub Choi
Article Number: 606
Published online on: 24 June 2021

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Review Open Access

Protective role of taurine against oxidative stress (Review)

Stella Baliou, Maria Adamaki, Petros Ioannou, Aglaia Pappa, Mihalis I. Panayiotidis, Demetrios A. Spandidos, Ioannis Christodoulou, Anthony M. Kyriakopoulos, Vassilis Zoumpourlis
Article Number: 605
Published online on: 24 June 2021

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Article Open Access

M2‑like tumour‑associated macrophage‑secreted IGF promotes thyroid cancer stemness and metastasis by activating the PI3K/AKT/mTOR pathway

Juan Lv, Chao Liu, Fu-Kun Chen, Zhi-Ping Feng, Li Jia, Peng-Jie Liu, Zhi-Xian Yang, Fei Hou, Zhi-Yong Deng
Article Number: 604
Published online on: 28 June 2021

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Article Open Access

Circular RNA profiling reveals a potential role of hsa_circ_IPCEF1 in papillary thyroid carcinoma

Min Guo, Yushuang Sun, Junzhu Ding, Yong Li, Sihan Yang, Yanna Zhao, Xin Jin, Shan-Shan Li
Article Number: 603
Published online on: 24 June 2021

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Review Open Access

Circular RNA: A novel type of biomarker for glioma (Review)

Wei Sun, Huandi Zhou, Xuetao Han, Liubing Hou, Xiaoying Xue
Article Number: 602
Published online on: 24 June 2021

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Article Open Access

Pulmonary coagulation and fibrinolysis abnormalities that favor fibrin deposition in the lungs of mouse antibody-mediated transfusion-related acute lung injury

Yunhong Yu, Peng Jiang, Pan Sun, Na Su, Fangzhao Lin
Article Number: 601
Published online on: 23 June 2021

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Correction Open Access

[Corrigendum] Traditional Chinese medicine, Fuzheng Kang‑Ai decoction, inhibits metastasis of lung cancer cells through the STAT3/MMP9 pathway

Longmei Li, Sumei Wang, Xiaobin Yang, Shunqin Long, Shujing Xiao, Wanyin Wu, Swei Sunny Hann
Article Number: 600
Published online on: 25 June 2021

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Retraction Open Access

[Retracted] Antitumor effect of resveratrol on chondrosarcoma cells via phosphoinositide 3‑kinase/AKT and p38 mitogen‑activated protein kinase pathways

Zixun Dai, Pengfei Lei, Jie Xie, Yihe Hu
Article Number: 599
Published online on: 23 June 2021

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Article Open Access

Effects of sterol derivatives in cationic liposomes on biodistribution and gene-knockdown in the lungs of mice systemically injected with siRNA lipoplexes

Yoshiyuki Hattori, Hiromu Saito, Teruaki Oku, Kei-Ichi Ozaki
Article Number: 598
Published online on: 23 June 2021

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Article Open Access

Inhibition of lncRNA SNHG8 plays a protective role in hypoxia-ischemia-reoxygenation-induced myocardial injury by regulating miR-335 and RASA1 expression

Yanfeng Liu, Ping Zhou, Fengxiao Wang, Xuehong Zhang, Dongmei Yang, Lang Hong, Dongyun Ruan
Article Number: 597
Published online on: 22 June 2021

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Article Open Access

Identification of differentially expressed proteins involved in fetal scarless wound healing using a rat model of cleft lip

Yu Yan, Hong Liu, Jiarong Yi, Zizi Chen, Jia Chen, Jianfei Zhang, Kewa Gao, Siqi He, Aijun Wang, Ping Jin, Feng Hu, Jianda Zhou
Article Number: 596
Published online on: 22 June 2021

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Article Open Access

Targeted silencing of TEM8 suppresses non‑small cell lung cancer tumor growth via the ERK/Bcl‑2 signaling pathway

Quan Gong, Jing Deng, Lijuan Zhang, Chunyan Zhou, Chaojiang Fu, Xicai Wang, Li Zhuang
Article Number: 595
Published online on: 22 June 2021

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Article

Lycopene prevents oxygen-glucose deprivation-induced autophagic death in SH-SY5Y cells via inhibition of the oxidative stress-activated AMPK/mTOR pathway

Tan Li, Yang Zhang, Yi Qi, He Liu
Article Number: 594
Published online on: 22 June 2021

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Article Open Access

Excessive mechanical stretch‑mediated osteoblasts promote the catabolism and apoptosis of chondrocytes via the Wnt/β‑catenin signaling pathway

Cheng-Xian Song, Sheng-Yao Liu, Wen-Ting Zhu, Shao-Yong Xu, Guo-Xin Ni
Article Number: 593
Published online on: 17 June 2021

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Article Open Access

Tripterygium glycoside suppresses epithelial‑to‑mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway Retraction in /10.3892/mmr.2026.13935

Mei Tao, Danna Zheng, Xudong Liang, Diandian Wu, Kang Hu, Juan Jin, Qiang He
Article Number: 592
Published online on: 17 June 2021

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Article

Downregulation of VDR in benign paroxysmal positional vertigo patients inhibits otolith‑associated protein expression levels

Shu Zhang, Juanli Xing, Yulin Gong, Ping Li, Boqian Wang, Ling Xu
Article Number: 591
Published online on: 17 June 2021

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Article Open Access

Dendrobium mixture attenuates renal damage in rats with diabetic nephropathy by inhibiting the PI3K/Akt/mTOR pathway

Yong Chen, Yan Fang Zheng, Xiao Hui Lin, Jie Ping Zhang, Fan Lin, Hong Shi
Article Number: 590
Published online on: 17 June 2021

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Article Open Access

DNAJC2 is reversely regulated by miR‑627‑3p, promoting the proliferation of colorectal cancer

Hongfu Liu, Juan Li, Huali Zhao, Xiaohui Liu, Xinying Ye
Article Number: 589
Published online on: 16 June 2021

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Article Open Access

miR‑205‑3p promotes lung cancer progression by targeting APBB2

Ling-Bin Xu, Jie Xiong, Ya-Hui Zhang, Yun Dai, Xiao-Ping Ren, Ya-Juan Ren, Dong Han, Sheng-Hong Wei, Min Qi
Article Number: 588
Published online on: 16 June 2021

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Retraction Open Access

[Retracted] Additive effects of eukaryotic co‑expression plasmid carrying GRIM‑19 and LKB1 genes on breast cancer in vitro and in vivo

Wei Zhang, Ying Shao, Ye Du, Wei Geng, Tong Jiang, Haipeng Liu, Duo Zhang
Article Number: 587
Published online on: 16 June 2021

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Retraction Open Access

[Retracted] Upregulation of GRIM‑19 inhibits the growth and invasion of human breast cancer cells

Wei Zhang, Ye Du, Tong Jiang, Wei Geng, Jiuli Yuan, Duo Zhang
Article Number: 586
Published online on: 16 June 2021

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Article Open Access

Serum long non‑coding RNA NNT‑AS1 protected by exosome is a potential biomarker and functions as an oncogene via the miR‑496/RAP2C axis in colorectal cancer

Hua Yin, Jingjing Hu, Zhiying Ye, Saijun Chen, Yunwen Chen
Article Number: 585
Published online on: 15 June 2021

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Article

SARS‑CoV‑2 spike protein‑induced host inflammatory response signature in human corneal epithelial cells

Guoqiang Zhu, Leyu Lyu, Hua Yang, Guibo Liu, Shuo Yang, Chuankai  Gu, Limei Wang, Haijing Yan, Ming Hu, Chengye Che
Article Number: 584
Published online on: 15 June 2021

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Article Open Access

Regulation of angiogenesis by microRNAs in cancer

Qi Zheng, Wei Hou
Article Number: 583
Published online on: 15 June 2021

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Article Open Access

MicroRNA‑193a‑5p exerts a tumor suppressive role in epithelial ovarian cancer by modulating RBBP6

Shuangli Zhang, Jun Liu, Jie He, Nuo Yi
Article Number: 582
Published online on: 15 June 2021

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Article Open Access

Anti‑inflammatory role of microRNA‑429 in human gingival epithelial cells‑inhibition of IL‑8 production through direct binding to IKKβ mRNA

Hiromichi Kawasaki, Hirotaka Amano
Article Number: 581
Published online on: 14 June 2021

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Article Open Access

Aggravation of hepatic ischemia‑reperfusion injury with increased inflammatory cell infiltration is associated with the TGF‑β/Smad3 signaling pathway

Haixia Li, Xiaoyun Shen, Yifan Tong, Tong Ji, Yan Feng, Yanping Tang, Rongyun Mai, Jiaxiang Ye, Ting Que, Xiaoling Luo
Article Number: 580
Published online on: 14 June 2021

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Retraction Open Access

[Retracted] miR‑200b inhibits migration and invasion in non‑small cell lung cancer cells via targeting FSCN1

Peng Xiao, Wenliang Liu, Hui Zhou
Article Number: 579
Published online on: 14 June 2021

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Article Open Access

COVID‑19 vaccination and IgG and IgA antibody dynamics in healthcare workers

Sabina Zurac, Luciana Nichita, Bogdan Mateescu, Cristian Mogodici, Alexandra Bastian, Cristiana Popp, Mirela Cioplea, Claudiu Socoliuc, Carolina Constantin, Monica Neagu
Article Number: 578
Published online on: 13 June 2021

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Article Open Access

High fluid shear stress prevents atherosclerotic plaque formation by promoting endothelium denudation and synthetic phenotype of vascular smooth muscle cells

Juan Wang, Yan Wang, Lin Sheng, Tian He, Xiang Nin, Aiying Xue, Hua Zhang, Zhendong Liu
Article Number: 577
Published online on: 13 June 2021

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Article Open Access

MicroRNA‑16‑5p/BIMP1/NF‑κB axis regulates autophagy to exert a tumor‑suppressive effect on bladder cancer

Jiani He, Zhongkai Qiu, Hao Zhang, Zhipeng Gao, Yuanjun Jiang, Zhenhua Li, Chuize Kong, Xiaojun Man
Article Number: 576
Published online on: 13 June 2021

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Article Open Access

Green tea protects against hippocampal neuronal apoptosis in diabetic encephalopathy by inhibiting JNK/MLCK signaling

Yongjie Xu, Shengju Liu, Liying Zhu, Longguang Dai, Wen Qian, Jingzhi Zhang, Xing Li, Wei Pan
Article Number: 575
Published online on: 10 June 2021

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Article Open Access

Dexmedetomidine attenuates neuronal injury induced by cerebral ischemia‑reperfusion by regulating miR‑199a

Yulin Zhu, Huatang Zhao, Wenshan Zhang, Xingang Ma, Ye Liu
Article Number: 574
Published online on: 09 June 2021

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Retraction Open Access

[Retracted] MicroRNA-200c inhibits the metastasis of non-small cell lung cancer cells by targeting ZEB2, an epithelial-mesenchymal transition regulator

Aihong Jiao, Minghua Sui, Liangming Zhang, Ping Sun, Dongmei Geng, Weiwei Zhang, Xiuwen Wang, Junxia Li
Article Number: 573
Published online on: 08 June 2021

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Article Open Access

A report of two cases of bulbospinal form Alexander disease and preliminary exploration of the disease

Xiaoxuan Song, Jingwen Jiang, Wotu Tian, Feixia Zhan, Zeyu Zhu, Binyin Li, Huidong Tang, Li Cao
Article Number: 572
Published online on: 08 June 2021

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Article Open Access

Baicalin relieves Mycoplasma pneumoniae infection‑induced lung injury through regulating microRNA‑221 to inhibit the TLR4/NF‑κB signaling pathway

Han Zhang, Xiang Li, Juan Wang, Qi Cheng, Yunxiao Shang, Guizhen Wang
Article Number: 571
Published online on: 08 June 2021

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Retraction Open Access

[Retracted] MicroRNA‑138 inhibits migration and invasion of non‑small cell lung cancer cells by targeting LIMK1

Yanjuan Tan, Huaidong Hu, Wuyuan Tan, Longyu Jin, Jianxin Liu, Hui Zhou
Article Number: 570
Published online on: 08 June 2021

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Retraction Open Access

[Retracted] MicroRNA‑10b suppresses the migration and invasion of chondrosarcoma cells by targeting brain‑derived neurotrophic factor

Abudunaibi Aili, Yong Chen, Hongqi Zhang
Article Number: 569
Published online on: 08 June 2021

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Article Open Access

MicroRNA‑142‑3p suppresses cell proliferation, invasion and epithelial‑to‑mesenchymal transition via RAC1‑ERK1/2 signaling in colorectal cancer

Na Xie, Qiuping Meng, Yixin Zhang, Zhifei Luo, Fenggui  Xue, Sisi Liu, Ying Li, Yousheng Huang
Article Number: 568
Published online on: 07 June 2021

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Article

miR‑483 promotes the development of colorectal cancer by inhibiting the expression level of EI24

Wei Zhou, Wanli Yang, Jing Yang, Haijun Zhu, Lili Duan, Xiaoqian Wang, Yiding Li, Liaoran Niu, Shuao Xiao, Rui Zhang, Jianjun Yang, Liu Hong
Article Number: 567
Published online on: 07 June 2021

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Article Open Access

Long non‑coding RNA XIST promotes cerebral ischemia/reperfusion injury by modulating miR‑27a‑3p/FOXO3 signaling

Hua Zhang, Junyong Xia, Qiushan Hu, Liqin Xu, Hongyan Cao, Xu Wang, Min Cao
Article Number: 566
Published online on: 07 June 2021

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Article Open Access

Curcumin induces apoptosis by inhibiting BCAT1 expression and mTOR signaling in cytarabine‑resistant myeloid leukemia cells

Yu-Hsin Tseng, Rei-Cheng Yang, Shyh-Shin Chiou, Tzong-Ming Shieh, Yin-Hwa Shih, Pei-Chin Lin
Article Number: 565
Published online on: 07 June 2021

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Article Open Access

Resveratrol affects the expression of uric acid transporter by improving inflammation

Xuemei Zhang, Qian Nie, Zhimei Zhang, Jing Zhao, Fengxiao Zhang, Chao Wang, Xing Wang, Guangyao Song
Article Number: 564
Published online on: 07 June 2021

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Article Open Access

Effects of miR‑210‑3p on the erythroid differentiation of K562 cells under hypoxia

Caiyan Hu, Yupeng Yan, Chengbing Fu, Jin Ding, Tiantian Li, Shuqiong Wang, Liu Fang
Article Number: 563
Published online on: 07 June 2021

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Article Open Access

miR‑200b upregulation promotes migration of BEAS‑2B cells following long‑term exposure to cigarette smoke by targeting ETS1

Jin Wang, Ruixin Yao, Qiulin Luo, Lirong Tan, Beibei Jia, Nan Ouyang, Yezhou Li, Jian Tong, Jianxiang Li
Article Number: 562
Published online on: 06 June 2021

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Article Open Access

Next‑generation sequencing of miRNAs and lncRNAs from rat femur and tibia under mechanical stress

Yiyan Qiu, Guozheng Zhu, Canjun Zeng, Song Yuan, Yuepeng Qian, Zelin Ye, Shanwen Zhao, Runguang Li
Article Number: 561
Published online on: 04 June 2021

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Article Open Access

Shikonin inhibits the Warburg effect, cell proliferation, invasion and migration by downregulating PFKFB2 expression in lung cancer

Liying Sha, Zhiqiang Lv, Yujun Liu, Yun Zhang, Xin Sui, Teng Wang, Hui Zhang
Article Number: 560
Published online on: 04 June 2021

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Article Open Access

Soluble fibrinogen‑like protein 2 levels are decreased in patients with ischemic heart failure and associated with cardiac function

Ya You, Shiyuan Huang, Hui Liu, Cheng Fan, Kun Liu, Zhaohui Wang
Article Number: 559
Published online on: 03 June 2021

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Article Open Access

DHA ameliorates MeHg‑induced PC12 cell apoptosis by inhibiting the ROS/JNK signaling pathway

Hong Zhang, Susu Wang, Yaqian Wang, Anxin Lu, Chunping Hu, Chonghuai Yan
Article Number: 558
Published online on: 03 June 2021

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Article Open Access

miR‑451 suppresses the malignant characteristics of colorectal cancer via targeting SAMD4B

Chunrong Wu, Xiaohu Liu, Bo Li, Guiying Sun, Chunfang Peng, Debing Xiang
Article Number: 557
Published online on: 03 June 2021

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An increase in elastogenic components in the placental villi of women with chronic venous disease during pregnancy is associated with decreased EGFL7 expression level

Miguel A. Ortega, Ángel Asúnsolo, Oscar Fraile‑Martínez, Felipe Sainz, Miguel A. Saez, Coral Bravo, Juan A. De León‑Luis, Miguel A. Alvarez‑Mon, Santiago Coca, Melchor Álvarez‑Mon, Julia Buján, Natalio García‑Honduvilla
Article Number: 556
Published online on: 02 June 2021

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Ginkgolide J protects human synovial cells SW982 via suppression of p38‑dependent production of pro‑inflammatory mediators

Yujie Zhao, Yuan Chen, Jiayi Wang, Xue Zhu, Ke Wang, Yue Li, Fanfan Zhou
Article Number: 555
Published online on: 02 June 2021

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Mechanism underlying long non‑coding RNA ILF3‑AS1‑mediated inhibition of cervical cancer cell proliferation, invasion and migration, and promotion of apoptosis

Linmei Zhu, Ruixia Chen, Chunlin Jiang, Qingsheng Xie, Wenshuai Zhao, Xiaohong Gao, Haiming Huang
Article Number: 554
Published online on: 02 June 2021

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lncRNA TUG1 regulates angiogenesis via the miR‑204‑5p/JAK2/STAT3 axis in hepatoblastoma

Miao-Xian Yuan, Chun-Yi Ji, Hong-Qiang Gao, Xin-Yi Sheng, Wei-Xin Xie, Qiang Yin
Article Number: 553
Published online on: 02 June 2021

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Long non‑coding RNA HCG11 suppresses the malignant phenotype of non‑small cell lung cancer cells by targeting a miR‑875/SATB2 axis

Zhou Su, Mi Chen, Ruilin Ding, Lian Shui, Qingmei Zhao, Wenjuan Luo
Article Number: 552
Published online on: 02 June 2021

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SMARCC2 combined with c‑Myc inhibits the migration and invasion of glioma cells via modulation of the Wnt/β‑catenin signaling pathway

Chiyang Li, Chengshuo Fei, Junjie Li, Hang Wu, Lei Chen, Ramzi Roshani, Hong Li, Linyong Shi, Chong Song, Junwei Gu, Yuntao Lu, Qiang Zhou
Article Number: 551
Published online on: 02 June 2021

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Porcupine inhibitor LGK‑974 inhibits Wnt/β‑catenin signaling and modifies tumor‑associated macrophages resulting in inhibition of the malignant behaviors of non‑small cell lung cancer cells

Yang Tang, Maoyan Jiang, Anping Chen, Wendong Qu, Xu Han, Jiebin Zuo, Gang Xu, Yongxiang Song, Cheng Chen, Xixian Ke
Article Number: 550
Published online on: 02 June 2021

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HIGD‑1B inhibits hypoxia‑induced mitochondrial fragmentation by regulating OPA1 cleavage in cardiomyocytes

Yan Pang, Zhide Zhu, Zhihao Wen, Junshen Lu, Hao Lin, Meiling Tang, Zhiliang Xu, Jianqi Lu
Article Number: 549
Published online on: 02 June 2021

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MAPK4 silencing together with a PARP1 inhibitor as a combination therapy in triple‑negative breast cancer cells

Xiaoqi Zeng, Shanshan Jiang, Simin Ruan, Zhaoze Guo, Jingyun Guo, Minfeng Liu, Changsheng Ye, Jianyu Dong
Article Number: 548
Published online on: 02 June 2021

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Critical role of SIRT1 upregulation on the protective effect of lncRNA ANRIL against hypoxia/reoxygenation injury in H9c2 cardiomyocytes

Binghui Song, Dongmei Wei, Gang Yin, Xiaoguang Song, Shuqing Wang, Shanshan Jia, Jidong Zhang, Longhu Li, Xiaofei Wu
Article Number: 547
Published online on: 02 June 2021

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[Retracted] MicroRNA‑133a inhibits proliferation and invasion, and induces apoptosis in gastric carcinoma cells via targeting fascin actin‑bundling protein 1

Chen Lai, Zihua Chen, Ruixin Li
Article Number: 546
Published online on: 01 June 2021

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[Retracted] Knockdown of PREX2a inhibits the malignant phenotype of glioma cells

Liang Liu, Zhixiong Liu, Hao Wang, Long Chen, Fuqiang Ruan, Jihui Zhang, Yi Hu, Hengshan Luo, Shuai Wen
Article Number: 545
Published online on: 01 June 2021

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Perampanel, an AMPAR antagonist, alleviates experimental intracerebral hemorrhage‑induced brain injury via necroptosis and neuroinflammation

Lixiang Yang, Yue Wang, Can Zhang, Huilin Cheng
Article Number: 544
Published online on: 29 May 2021

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Long non‑coding RNA SNHG20 promotes cell proliferation, migration and invasion in retinoblastoma via the miR‑335‑5p/E2F3 axis

Jing Song, Ziping Zhang
Article Number: 543
Published online on: 29 May 2021

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Total saponins from Rhizoma Panacis Majoris inhibit proliferation, induce cell cycle arrest and apoptosis and influence MAPK signalling pathways on the colorectal cancer cell

Lu Chang, Rui Zhou, Yihan He, Mei Meng, Jinhang Hu, Yanru Liu, Yalei Pan, Zhishu Tang, Zhenggang Yue
Article Number: 542
Published online on: 29 May 2021

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Journal Cover
August-2026 Volume 34 Issue 2

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Regulatory function of ten‑eleven translocation‑2 in transcriptional mechanisms of demethylated myeloma cells

Lenka Slavickova, Michaela Nemcova, Dominika Svehlova, Veronika Frybortova, Jirina Manakova, Eva Kriegova, Jiri Minarik, Katerina Smesny Trtkova
Article Number: 237
Published online on: 25 June 2026

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Mulberroside A attenuates H2O2‑induced oxidative stress and barrier dysfunction in Caco‑2 cells through Nrf2/HO‑1‑associated antioxidant signaling

Jianxin Chen, Xiufeng Huang, Xi Chen, Wenhai Jin, Dawei Lin
Article Number: 236
Published online on: 25 June 2026

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[Retracted] Puerarin promotes DUSP1 expression by regulating miR‑133a‑3p in breast cancer

Zhifeng Li, Weiwei Xu, Xiaoyan Ren, Jinhua Xu, Jianxin Chen
Article Number: 235
Published online on: 23 June 2026

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Sulforaphane attenuates cisplatin‑induced acute kidney injury by inhibiting oxidative stress, inflammation and apoptosis via regulation of NRF2

Zeyu Wu, Mengting Lu, Lei Xu, Ming Luo, Limei Shan, Hongxia Xing, Wenwen Li, Junling Qian
Article Number: 234
Published online on: 19 June 2026

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Effects of β‑hydroxybutyrate on restoring autophagic flux and mitochondrial function in macrophages exposed to oxidized low‑density lipoprotein

Weiguang Luo, Mei He, Huiling Wang
Article Number: 233
Published online on: 19 June 2026

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Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review)

Xiaokang Wang, Qiwen Tan, Jingcheng Xu, Yunlin Yang, Haoyue Huang, Xiaomei Teng, Weihua Wu
Article Number: 232
Published online on: 18 June 2026

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Degraded sulfated galactan derived from Gracilaria fisheri induces immunogenic cell death in MDA‑MB‑231 cells

Tawut Rudtanatip, Yada Polsan, Waraporn Sakaew, Somsuda Somintara, Jenjiralai Phanphak, Jamal El‑Abid, Kanokpan Wongprasert, Choowadee Pariwatthanakun
Article Number: 231
Published online on: 17 June 2026

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Article

Irbesartan ameliorates high‑glucose‑induced epithelial‑mesenchymal transition by downregulating the expression of NLRP3 in HK‑2 cells

Qing Deng, Xiujuan Liu, Dan Wen, Yuhua Cheng, Qing Zhao, Yu Wang, Yu Xiang, Qinkai Chen, Jinlei Lv
Article Number: 230
Published online on: 17 June 2026

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A β‑1,3‑1,6‑glucan from Aureobasidium pullulans enhances apoptotic and autophagic pathways in colorectal cancer cells

Ji-Won Park, Gyeong Mim Mun, Tae Min Jo, Ji A Shin, Takao Kuge, Hisashi Kimoto, Jin-Kyung Kim
Article Number: 229
Published online on: 16 June 2026

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Growth pattern and molecular biological analysis of primary meningioma cell cultures under different conditions

Stefan Linsler, Anna-Lena Moroldo, Walter Schulz‑Schaeffer, Ralf Ketter, Joachim Oertel, Steffi Urbschat
Article Number: 228
Published online on: 12 June 2026

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Melatonin alleviates mitochondrial damage by regulating SIRT3‑mediated mitochondrial dynamics in granulosa cells under PCOS‑like conditions

Congcong Xie, Zehao Liu, Tong Chen, Hui Lu, Xiujia Zhang, Wenbo Yu, Jiaxin Zhang, Dandan Shang, Xueying Wang
Article Number: 227
Published online on: 11 June 2026

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Strontium‑based metal‑organic framework/alendronate‑silk fibroin hydrogels promote tendon‑bone interface healing

Tao Yang, Hanji Zhang, Mingjun Li, Yiming Ren, Yunbo Sun, Weiyu Hou, Mengqiang Tian
Article Number: 226
Published online on: 11 June 2026

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[Retracted] Tripterygium glycoside suppresses epithelial‑to‑­­ mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway

Mei Tao, Danna Zheng, Xudong Liang, Diandian Wu, Kang Hu, Juan Jin, Qiang He
Article Number: 225
Published online on: 08 June 2026

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Gut microbiota‑derived metabolites in cardiovascular disease: Focus on trimethylamine N‑oxide, short‑chain fatty acids and bile acids (Review)

Meizhu Gao, Zhenming Hao, Yiling Li, Weixue Liu, Fubao Zhang
Article Number: 224
Published online on: 08 June 2026

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Fucoxanthin alleviates chondrocyte inflammation and osteoarthritis by modulating the JAK2/STAT3 signaling pathway

Miradj Siddick Adam, Huangming Zhuang, Xunshan Ren, Yuelong Zhang, Panghu Zhou
Article Number: 223
Published online on: 08 June 2026

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Prediction of molecular targets for zedoary turmeric oil in inhibiting proliferation and inducing apoptosis in non‑small cell lung cancer

Huaiyong Li, Lili Liu, Qingzhu Yang, Yao Li, Yongli Song, Jing Jiang, Zhenzhong Wu, Weiwei Zhang, Baisong Lou
Article Number: 222
Published online on: 08 June 2026

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Molecular mechanisms of iron metabolism and ferroptosis in cardiovascular diseases and intervention strategies targeting natural products (Review)

Liangqing Ge, Tianqing Zhang, Jiangbiao Yu, Sijie Xiao, Yu Zhou, Li Luo
Article Number: 221
Published online on: 05 June 2026

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Correction Open Access

[Corrigendum] Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis

Ruiqiao Guan, Zhihao Li, Xiaohong Dai, Wei Zou, Xueping Yu, Hao Liu, Qiuxin Chen, Wei Teng, Peng Liu, Xiaoying Liu, Shanshan Dong
Article Number: 220
Published online on: 03 June 2026

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LINC01117 promotes the malignant proliferation of lung adenocarcinoma by increasing HOXD8 mRNA stability

Lizhong Zeng, Jie Shi, Cai Zhang, Yujiao Dong, Yang Chen, Qiuhong Zhang, Long Zhang, Shuanying Yang
Article Number: 219
Published online on: 03 June 2026

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Targeting regulatory T cells in the prostate cancer microenvironment: From mechanisms to therapeutics (Review)

Hua Luo
Article Number: 218
Published online on: 03 June 2026

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Dapagliflozin alleviates heart failure with preserved ejection fraction potentially by regulating the AIM2/caspase‑1/GSDMD pathway and attenuating pyroptosis

Sailiang Ding, Hao Yang, Ting Lu, Yibin Luo, Liang Xu, Xianghui Zeng
Article Number: 217
Published online on: 03 June 2026

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[Retracted] Carnosic acid alleviates brain injury through NF‑κB‑regulated inflammation and Caspase‑3‑associated apoptosis in high fat‑induced mouse models

Yong Liu, Yan Zhang, Ming Hu, Yu-Hu Li, Xing-Hua Cao
Article Number: 216
Published online on: 02 June 2026

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SIRT1/AMPK/PGC1α pathway in ischemic stroke: Elucidating neuroprotective strategies (Review)

Irum Naz Abbasi, Nashwa Amin, Qiaolu Xu, Azhar Badry Hussain, Fei Wu, Xia Yuan, Yang Yang, Suhong Ye, Marong Fang, Yihua Jiang
Article Number: 215
Published online on: 02 June 2026

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Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review)

Yinhuan Wang, Jiefang Guan
Article Number: 214
Published online on: 29 May 2026

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Journal Cover
September-2026 Volume 34 Issue 3

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Retraction Open Access

[Retracted] Anti‑tumor peptide AP25 decreases cyclin D1 expression and inhibits MGC‑803 proliferation via phospho­extracellular signal‑regulated kinase‑, Src‑, c‑Jun N‑terminal kinase‑ and phosphoinositide 3­-kinase‑associated pathways  

Jialiang Hu, Tao Cheng, Lijun Zhang, Beicheng Sun, Lei Deng, Hanmei Xu
Article Number: 240
Published online on: 29 June 2026

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Aspirin prevents postoperative peritoneal adhesions by inhibiting the TGF‑β1/Smad signaling pathway in rats

Siqi Yan, Yuan Ren, Bingyan Liu, Pai Xiong, Yimin Sun
Article Number: 239
Published online on: 29 June 2026

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Morinda officinalis oligosaccharides ameliorate corticosterone‑induced depression‑like behaviour in mice by modulating the BDNF signalling pathway and gut microbiota

Mengjie He, Zixuan Liu, Yuxin Chen, Xiaoru Wu, Xueling Dai, Qian Liu, Shuo Wang, Zeping Zuo, Yaxuan Sun
Article Number: 238
Published online on: 29 June 2026

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