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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August-2021 Volume 24 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Expression levels of specific microRNAs are increased after exercise and are associated with cognitive improvement in Parkinson's disease

Franciele Cascaes Da Silva, Michele Patrícia Rode, Giovanna Grunewald Vietta, Rodrigo Da Rosa Iop, Tânia Beatriz Creczynski‑Pasa, Alessandra Swarowsky Martin, Rudney Da Silva
Article Number: 618
Published online on: 29 June 2021

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Article Open Access

circPTPN22 as a novel biomarker and ceRNA in peripheral blood mononuclear cells of rheumatoid arthritis

Zhuyan Jiang, Zhiting Zhong, Qingqing Miao, Yue Zhang, Bing Ni, Mengjie Zhang, Jun Tang
Article Number: 617
Published online on: 29 June 2021

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Article

H3K9me2 regulates early transcription factors to promote mesenchymal stem‑cell differentiation into cardiomyocytes

Xiaolin Sun, Xiang Gu, Hongxiao Li, Pei Xu, Mengting Li, Ye Zhu, Qisheng Zuo, Bichun Li
Article Number: 616
Published online on: 29 June 2021

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Article

Anti‑angiogenic effect of mountain ginseng in vitro and in vivo: Comparison with farm‑cultivated ginseng

Jin Soo Kim, Jae-Myung Yoo, Jong Eel Park, Jungeun Kim, Sun-Gun Kim, Young Mi Seok, Jun-Ho Son, Hyo Jung Kim
Article Number: 615
Published online on: 29 June 2021

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Article Open Access

Nuclear PKR in retinal neurons in the early stage of diabetic retinopathy in streptozotocin‑induced diabetic rats

Viviane Aline Oliveira Silva, Nayara Delgado André, Thaís Amaral E Sousa, Vâni Maria Alves, Isis Do Carmo Kettelhut, Fernando Luiz De Lucca
Article Number: 614
Published online on: 28 June 2021

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Article Open Access

PI3K/AKT phosphorylation activates ERRα by upregulating PGC‑1α and PGC‑1β in gallbladder cancer

Lei Wang, Mengmeng Yang, Huihan Jin
Article Number: 613
Published online on: 28 June 2021

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Article Open Access

Sulforaphane protects against oxidative stress‑induced apoptosis via activating SIRT1 in mouse osteoarthritis

Mangmang Chen, Lipeng Huang, Yangxun Lv, Liubing Li, Qirong Dong
Article Number: 612
Published online on: 28 June 2021

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Review Open Access

Dysregulated inflammation may predispose patients with serious mental illnesses to severe COVID‑19 (Review)

Sergej Nadalin, Hrvoje Jakovac, Vjekoslav Peitl, Dalibor Karlović, Alena Buretić‑Tomljanović
Article Number: 611
Published online on: 28 June 2021

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Article Open Access

Effects of Melandrium firmum Rohrbach on RANKL‑induced osteoclast differentiation and OVX rats

Minsun Kim, Jae-Hyun Kim, Sooyeon Hong, Boguen Kwon, Eun-Young Kim, Hyuk-Sang Jung, Youngjoo Sohn
Article Number: 610
Published online on: 25 June 2021

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Article Open Access

Interference with circRNA DOCK1 inhibits hepatocellular carcinoma cell proliferation, invasion and migration by regulating the miR-654-5p/SMAD2 axis

Yujuan Lu, Jingzhi Zhang, Yanhui Wu
Article Number: 609
Published online on: 25 June 2021

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Article Open Access

Humanized anti‑TLR4 monoclonal antibody ameliorates lipopolysaccharide‑related acute kidney injury by inhibiting TLR4/NF‑κB signaling

Qiuhua Zhang, Liang Wang, Mian Wu, Xiaobin Liu, Yushan Zhu, Jin Zhu, Changying Xing
Article Number: 608
Published online on: 25 June 2021

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Article Open Access

Solanum nigrum Line inhibits osteoclast differentiation and suppresses bone mineral density reduction in the ovariectomy‑induced osteoporosis model

Jae-Hyun Kim, Hwajeong Shin, Minsun Kim, Sangwoo Kim, Kwangchan Song, Hyuk-Sang Jung, Youngjoo Sohn
Article Number: 607
Published online on: 25 June 2021

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Article

Telomere shortening and expression of TRF1 and TRF2 in uterine leiomyoma

Bong-Kyeong Oh, Yoojung Choi, Joong Sub Choi
Article Number: 606
Published online on: 24 June 2021

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Review Open Access

Protective role of taurine against oxidative stress (Review)

Stella Baliou, Maria Adamaki, Petros Ioannou, Aglaia Pappa, Mihalis I. Panayiotidis, Demetrios A. Spandidos, Ioannis Christodoulou, Anthony M. Kyriakopoulos, Vassilis Zoumpourlis
Article Number: 605
Published online on: 24 June 2021

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Article Open Access

M2‑like tumour‑associated macrophage‑secreted IGF promotes thyroid cancer stemness and metastasis by activating the PI3K/AKT/mTOR pathway

Juan Lv, Chao Liu, Fu-Kun Chen, Zhi-Ping Feng, Li Jia, Peng-Jie Liu, Zhi-Xian Yang, Fei Hou, Zhi-Yong Deng
Article Number: 604
Published online on: 28 June 2021

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Article Open Access

Circular RNA profiling reveals a potential role of hsa_circ_IPCEF1 in papillary thyroid carcinoma

Min Guo, Yushuang Sun, Junzhu Ding, Yong Li, Sihan Yang, Yanna Zhao, Xin Jin, Shan-Shan Li
Article Number: 603
Published online on: 24 June 2021

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Review Open Access

Circular RNA: A novel type of biomarker for glioma (Review)

Wei Sun, Huandi Zhou, Xuetao Han, Liubing Hou, Xiaoying Xue
Article Number: 602
Published online on: 24 June 2021

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Article Open Access

Pulmonary coagulation and fibrinolysis abnormalities that favor fibrin deposition in the lungs of mouse antibody-mediated transfusion-related acute lung injury

Yunhong Yu, Peng Jiang, Pan Sun, Na Su, Fangzhao Lin
Article Number: 601
Published online on: 23 June 2021

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Correction Open Access

[Corrigendum] Traditional Chinese medicine, Fuzheng Kang‑Ai decoction, inhibits metastasis of lung cancer cells through the STAT3/MMP9 pathway

Longmei Li, Sumei Wang, Xiaobin Yang, Shunqin Long, Shujing Xiao, Wanyin Wu, Swei Sunny Hann
Article Number: 600
Published online on: 25 June 2021

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Retraction Open Access

[Retracted] Antitumor effect of resveratrol on chondrosarcoma cells via phosphoinositide 3‑kinase/AKT and p38 mitogen‑activated protein kinase pathways

Zixun Dai, Pengfei Lei, Jie Xie, Yihe Hu
Article Number: 599
Published online on: 23 June 2021

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Article Open Access

Effects of sterol derivatives in cationic liposomes on biodistribution and gene-knockdown in the lungs of mice systemically injected with siRNA lipoplexes

Yoshiyuki Hattori, Hiromu Saito, Teruaki Oku, Kei-Ichi Ozaki
Article Number: 598
Published online on: 23 June 2021

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Article Open Access

Inhibition of lncRNA SNHG8 plays a protective role in hypoxia-ischemia-reoxygenation-induced myocardial injury by regulating miR-335 and RASA1 expression

Yanfeng Liu, Ping Zhou, Fengxiao Wang, Xuehong Zhang, Dongmei Yang, Lang Hong, Dongyun Ruan
Article Number: 597
Published online on: 22 June 2021

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Article Open Access

Identification of differentially expressed proteins involved in fetal scarless wound healing using a rat model of cleft lip

Yu Yan, Hong Liu, Jiarong Yi, Zizi Chen, Jia Chen, Jianfei Zhang, Kewa Gao, Siqi He, Aijun Wang, Ping Jin, Feng Hu, Jianda Zhou
Article Number: 596
Published online on: 22 June 2021

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Article Open Access

Targeted silencing of TEM8 suppresses non‑small cell lung cancer tumor growth via the ERK/Bcl‑2 signaling pathway

Quan Gong, Jing Deng, Lijuan Zhang, Chunyan Zhou, Chaojiang Fu, Xicai Wang, Li Zhuang
Article Number: 595
Published online on: 22 June 2021

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Article

Lycopene prevents oxygen-glucose deprivation-induced autophagic death in SH-SY5Y cells via inhibition of the oxidative stress-activated AMPK/mTOR pathway

Tan Li, Yang Zhang, Yi Qi, He Liu
Article Number: 594
Published online on: 22 June 2021

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Article Open Access

Excessive mechanical stretch‑mediated osteoblasts promote the catabolism and apoptosis of chondrocytes via the Wnt/β‑catenin signaling pathway

Cheng-Xian Song, Sheng-Yao Liu, Wen-Ting Zhu, Shao-Yong Xu, Guo-Xin Ni
Article Number: 593
Published online on: 17 June 2021

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Article Open Access

Tripterygium glycoside suppresses epithelial‑to‑mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway

Mei Tao, Danna Zheng, Xudong Liang, Diandian Wu, Kang Hu, Juan Jin, Qiang He
Article Number: 592
Published online on: 17 June 2021

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Article

Downregulation of VDR in benign paroxysmal positional vertigo patients inhibits otolith‑associated protein expression levels

Shu Zhang, Juanli Xing, Yulin Gong, Ping Li, Boqian Wang, Ling Xu
Article Number: 591
Published online on: 17 June 2021

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Article Open Access

Dendrobium mixture attenuates renal damage in rats with diabetic nephropathy by inhibiting the PI3K/Akt/mTOR pathway

Yong Chen, Yan Fang Zheng, Xiao Hui Lin, Jie Ping Zhang, Fan Lin, Hong Shi
Article Number: 590
Published online on: 17 June 2021

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Article Open Access

DNAJC2 is reversely regulated by miR‑627‑3p, promoting the proliferation of colorectal cancer

Hongfu Liu, Juan Li, Huali Zhao, Xiaohui Liu, Xinying Ye
Article Number: 589
Published online on: 16 June 2021

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Article Open Access

miR‑205‑3p promotes lung cancer progression by targeting APBB2

Ling-Bin Xu, Jie Xiong, Ya-Hui Zhang, Yun Dai, Xiao-Ping Ren, Ya-Juan Ren, Dong Han, Sheng-Hong Wei, Min Qi
Article Number: 588
Published online on: 16 June 2021

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Retraction Open Access

[Retracted] Additive effects of eukaryotic co‑expression plasmid carrying GRIM‑19 and LKB1 genes on breast cancer in vitro and in vivo

Wei Zhang, Ying Shao, Ye Du, Wei Geng, Tong Jiang, Haipeng Liu, Duo Zhang
Article Number: 587
Published online on: 16 June 2021

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Retraction Open Access

[Retracted] Upregulation of GRIM‑19 inhibits the growth and invasion of human breast cancer cells

Wei Zhang, Ye Du, Tong Jiang, Wei Geng, Jiuli Yuan, Duo Zhang
Article Number: 586
Published online on: 16 June 2021

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Article Open Access

Serum long non‑coding RNA NNT‑AS1 protected by exosome is a potential biomarker and functions as an oncogene via the miR‑496/RAP2C axis in colorectal cancer

Hua Yin, Jingjing Hu, Zhiying Ye, Saijun Chen, Yunwen Chen
Article Number: 585
Published online on: 15 June 2021

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Article

SARS‑CoV‑2 spike protein‑induced host inflammatory response signature in human corneal epithelial cells

Guoqiang Zhu, Leyu Lyu, Hua Yang, Guibo Liu, Shuo Yang, Chuankai  Gu, Limei Wang, Haijing Yan, Ming Hu, Chengye Che
Article Number: 584
Published online on: 15 June 2021

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Article Open Access

Regulation of angiogenesis by microRNAs in cancer

Qi Zheng, Wei Hou
Article Number: 583
Published online on: 15 June 2021

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Article Open Access

MicroRNA‑193a‑5p exerts a tumor suppressive role in epithelial ovarian cancer by modulating RBBP6

Shuangli Zhang, Jun Liu, Jie He, Nuo Yi
Article Number: 582
Published online on: 15 June 2021

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Article Open Access

Anti‑inflammatory role of microRNA‑429 in human gingival epithelial cells‑inhibition of IL‑8 production through direct binding to IKKβ mRNA

Hiromichi Kawasaki, Hirotaka Amano
Article Number: 581
Published online on: 14 June 2021

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Article Open Access

Aggravation of hepatic ischemia‑reperfusion injury with increased inflammatory cell infiltration is associated with the TGF‑β/Smad3 signaling pathway

Haixia Li, Xiaoyun Shen, Yifan Tong, Tong Ji, Yan Feng, Yanping Tang, Rongyun Mai, Jiaxiang Ye, Ting Que, Xiaoling Luo
Article Number: 580
Published online on: 14 June 2021

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Retraction Open Access

[Retracted] miR‑200b inhibits migration and invasion in non‑small cell lung cancer cells via targeting FSCN1

Peng Xiao, Wenliang Liu, Hui Zhou
Article Number: 579
Published online on: 14 June 2021

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Article Open Access

COVID‑19 vaccination and IgG and IgA antibody dynamics in healthcare workers

Sabina Zurac, Luciana Nichita, Bogdan Mateescu, Cristian Mogodici, Alexandra Bastian, Cristiana Popp, Mirela Cioplea, Claudiu Socoliuc, Carolina Constantin, Monica Neagu
Article Number: 578
Published online on: 13 June 2021

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Article Open Access

High fluid shear stress prevents atherosclerotic plaque formation by promoting endothelium denudation and synthetic phenotype of vascular smooth muscle cells

Juan Wang, Yan Wang, Lin Sheng, Tian He, Xiang Nin, Aiying Xue, Hua Zhang, Zhendong Liu
Article Number: 577
Published online on: 13 June 2021

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Article Open Access

MicroRNA‑16‑5p/BIMP1/NF‑κB axis regulates autophagy to exert a tumor‑suppressive effect on bladder cancer

Jiani He, Zhongkai Qiu, Hao Zhang, Zhipeng Gao, Yuanjun Jiang, Zhenhua Li, Chuize Kong, Xiaojun Man
Article Number: 576
Published online on: 13 June 2021

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Article Open Access

Green tea protects against hippocampal neuronal apoptosis in diabetic encephalopathy by inhibiting JNK/MLCK signaling

Yongjie Xu, Shengju Liu, Liying Zhu, Longguang Dai, Wen Qian, Jingzhi Zhang, Xing Li, Wei Pan
Article Number: 575
Published online on: 10 June 2021

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Article Open Access

Dexmedetomidine attenuates neuronal injury induced by cerebral ischemia‑reperfusion by regulating miR‑199a

Yulin Zhu, Huatang Zhao, Wenshan Zhang, Xingang Ma, Ye Liu
Article Number: 574
Published online on: 09 June 2021

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Retraction Open Access

[Retracted] MicroRNA-200c inhibits the metastasis of non-small cell lung cancer cells by targeting ZEB2, an epithelial-mesenchymal transition regulator

Aihong Jiao, Minghua Sui, Liangming Zhang, Ping Sun, Dongmei Geng, Weiwei Zhang, Xiuwen Wang, Junxia Li
Article Number: 573
Published online on: 08 June 2021

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Article Open Access

A report of two cases of bulbospinal form Alexander disease and preliminary exploration of the disease

Xiaoxuan Song, Jingwen Jiang, Wotu Tian, Feixia Zhan, Zeyu Zhu, Binyin Li, Huidong Tang, Li Cao
Article Number: 572
Published online on: 08 June 2021

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Article Open Access

Baicalin relieves Mycoplasma pneumoniae infection‑induced lung injury through regulating microRNA‑221 to inhibit the TLR4/NF‑κB signaling pathway

Han Zhang, Xiang Li, Juan Wang, Qi Cheng, Yunxiao Shang, Guizhen Wang
Article Number: 571
Published online on: 08 June 2021

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Retraction Open Access

[Retracted] MicroRNA‑138 inhibits migration and invasion of non‑small cell lung cancer cells by targeting LIMK1

Yanjuan Tan, Huaidong Hu, Wuyuan Tan, Longyu Jin, Jianxin Liu, Hui Zhou
Article Number: 570
Published online on: 08 June 2021

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Retraction Open Access

[Retracted] MicroRNA‑10b suppresses the migration and invasion of chondrosarcoma cells by targeting brain‑derived neurotrophic factor

Abudunaibi Aili, Yong Chen, Hongqi Zhang
Article Number: 569
Published online on: 08 June 2021

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Article Open Access

MicroRNA‑142‑3p suppresses cell proliferation, invasion and epithelial‑to‑mesenchymal transition via RAC1‑ERK1/2 signaling in colorectal cancer

Na Xie, Qiuping Meng, Yixin Zhang, Zhifei Luo, Fenggui  Xue, Sisi Liu, Ying Li, Yousheng Huang
Article Number: 568
Published online on: 07 June 2021

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Article

miR‑483 promotes the development of colorectal cancer by inhibiting the expression level of EI24

Wei Zhou, Wanli Yang, Jing Yang, Haijun Zhu, Lili Duan, Xiaoqian Wang, Yiding Li, Liaoran Niu, Shuao Xiao, Rui Zhang, Jianjun Yang, Liu Hong
Article Number: 567
Published online on: 07 June 2021

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Article Open Access

Long non‑coding RNA XIST promotes cerebral ischemia/reperfusion injury by modulating miR‑27a‑3p/FOXO3 signaling

Hua Zhang, Junyong Xia, Qiushan Hu, Liqin Xu, Hongyan Cao, Xu Wang, Min Cao
Article Number: 566
Published online on: 07 June 2021

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Article Open Access

Curcumin induces apoptosis by inhibiting BCAT1 expression and mTOR signaling in cytarabine‑resistant myeloid leukemia cells

Yu-Hsin Tseng, Rei-Cheng Yang, Shyh-Shin Chiou, Tzong-Ming Shieh, Yin-Hwa Shih, Pei-Chin Lin
Article Number: 565
Published online on: 07 June 2021

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Article Open Access

Resveratrol affects the expression of uric acid transporter by improving inflammation

Xuemei Zhang, Qian Nie, Zhimei Zhang, Jing Zhao, Fengxiao Zhang, Chao Wang, Xing Wang, Guangyao Song
Article Number: 564
Published online on: 07 June 2021

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Article Open Access

Effects of miR‑210‑3p on the erythroid differentiation of K562 cells under hypoxia

Caiyan Hu, Yupeng Yan, Chengbing Fu, Jin Ding, Tiantian Li, Shuqiong Wang, Liu Fang
Article Number: 563
Published online on: 07 June 2021

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Article Open Access

miR‑200b upregulation promotes migration of BEAS‑2B cells following long‑term exposure to cigarette smoke by targeting ETS1

Jin Wang, Ruixin Yao, Qiulin Luo, Lirong Tan, Beibei Jia, Nan Ouyang, Yezhou Li, Jian Tong, Jianxiang Li
Article Number: 562
Published online on: 06 June 2021

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Article Open Access

Next‑generation sequencing of miRNAs and lncRNAs from rat femur and tibia under mechanical stress

Yiyan Qiu, Guozheng Zhu, Canjun Zeng, Song Yuan, Yuepeng Qian, Zelin Ye, Shanwen Zhao, Runguang Li
Article Number: 561
Published online on: 04 June 2021

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Article Open Access

Shikonin inhibits the Warburg effect, cell proliferation, invasion and migration by downregulating PFKFB2 expression in lung cancer

Liying Sha, Zhiqiang Lv, Yujun Liu, Yun Zhang, Xin Sui, Teng Wang, Hui Zhang
Article Number: 560
Published online on: 04 June 2021

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Article Open Access

Soluble fibrinogen‑like protein 2 levels are decreased in patients with ischemic heart failure and associated with cardiac function

Ya You, Shiyuan Huang, Hui Liu, Cheng Fan, Kun Liu, Zhaohui Wang
Article Number: 559
Published online on: 03 June 2021

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Article Open Access

DHA ameliorates MeHg‑induced PC12 cell apoptosis by inhibiting the ROS/JNK signaling pathway

Hong Zhang, Susu Wang, Yaqian Wang, Anxin Lu, Chunping Hu, Chonghuai Yan
Article Number: 558
Published online on: 03 June 2021

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Article Open Access

miR‑451 suppresses the malignant characteristics of colorectal cancer via targeting SAMD4B

Chunrong Wu, Xiaohu Liu, Bo Li, Guiying Sun, Chunfang Peng, Debing Xiang
Article Number: 557
Published online on: 03 June 2021

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An increase in elastogenic components in the placental villi of women with chronic venous disease during pregnancy is associated with decreased EGFL7 expression level

Miguel A. Ortega, Ángel Asúnsolo, Oscar Fraile‑Martínez, Felipe Sainz, Miguel A. Saez, Coral Bravo, Juan A. De León‑Luis, Miguel A. Alvarez‑Mon, Santiago Coca, Melchor Álvarez‑Mon, Julia Buján, Natalio García‑Honduvilla
Article Number: 556
Published online on: 02 June 2021

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Ginkgolide J protects human synovial cells SW982 via suppression of p38‑dependent production of pro‑inflammatory mediators

Yujie Zhao, Yuan Chen, Jiayi Wang, Xue Zhu, Ke Wang, Yue Li, Fanfan Zhou
Article Number: 555
Published online on: 02 June 2021

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Mechanism underlying long non‑coding RNA ILF3‑AS1‑mediated inhibition of cervical cancer cell proliferation, invasion and migration, and promotion of apoptosis

Linmei Zhu, Ruixia Chen, Chunlin Jiang, Qingsheng Xie, Wenshuai Zhao, Xiaohong Gao, Haiming Huang
Article Number: 554
Published online on: 02 June 2021

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lncRNA TUG1 regulates angiogenesis via the miR‑204‑5p/JAK2/STAT3 axis in hepatoblastoma

Miao-Xian Yuan, Chun-Yi Ji, Hong-Qiang Gao, Xin-Yi Sheng, Wei-Xin Xie, Qiang Yin
Article Number: 553
Published online on: 02 June 2021

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Long non‑coding RNA HCG11 suppresses the malignant phenotype of non‑small cell lung cancer cells by targeting a miR‑875/SATB2 axis

Zhou Su, Mi Chen, Ruilin Ding, Lian Shui, Qingmei Zhao, Wenjuan Luo
Article Number: 552
Published online on: 02 June 2021

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SMARCC2 combined with c‑Myc inhibits the migration and invasion of glioma cells via modulation of the Wnt/β‑catenin signaling pathway

Chiyang Li, Chengshuo Fei, Junjie Li, Hang Wu, Lei Chen, Ramzi Roshani, Hong Li, Linyong Shi, Chong Song, Junwei Gu, Yuntao Lu, Qiang Zhou
Article Number: 551
Published online on: 02 June 2021

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Porcupine inhibitor LGK‑974 inhibits Wnt/β‑catenin signaling and modifies tumor‑associated macrophages resulting in inhibition of the malignant behaviors of non‑small cell lung cancer cells

Yang Tang, Maoyan Jiang, Anping Chen, Wendong Qu, Xu Han, Jiebin Zuo, Gang Xu, Yongxiang Song, Cheng Chen, Xixian Ke
Article Number: 550
Published online on: 02 June 2021

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HIGD‑1B inhibits hypoxia‑induced mitochondrial fragmentation by regulating OPA1 cleavage in cardiomyocytes

Yan Pang, Zhide Zhu, Zhihao Wen, Junshen Lu, Hao Lin, Meiling Tang, Zhiliang Xu, Jianqi Lu
Article Number: 549
Published online on: 02 June 2021

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MAPK4 silencing together with a PARP1 inhibitor as a combination therapy in triple‑negative breast cancer cells

Xiaoqi Zeng, Shanshan Jiang, Simin Ruan, Zhaoze Guo, Jingyun Guo, Minfeng Liu, Changsheng Ye, Jianyu Dong
Article Number: 548
Published online on: 02 June 2021

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Critical role of SIRT1 upregulation on the protective effect of lncRNA ANRIL against hypoxia/reoxygenation injury in H9c2 cardiomyocytes

Binghui Song, Dongmei Wei, Gang Yin, Xiaoguang Song, Shuqing Wang, Shanshan Jia, Jidong Zhang, Longhu Li, Xiaofei Wu
Article Number: 547
Published online on: 02 June 2021

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[Retracted] MicroRNA‑133a inhibits proliferation and invasion, and induces apoptosis in gastric carcinoma cells via targeting fascin actin‑bundling protein 1

Chen Lai, Zihua Chen, Ruixin Li
Article Number: 546
Published online on: 01 June 2021

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[Retracted] Knockdown of PREX2a inhibits the malignant phenotype of glioma cells

Liang Liu, Zhixiong Liu, Hao Wang, Long Chen, Fuqiang Ruan, Jihui Zhang, Yi Hu, Hengshan Luo, Shuai Wen
Article Number: 545
Published online on: 01 June 2021

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Perampanel, an AMPAR antagonist, alleviates experimental intracerebral hemorrhage‑induced brain injury via necroptosis and neuroinflammation

Lixiang Yang, Yue Wang, Can Zhang, Huilin Cheng
Article Number: 544
Published online on: 29 May 2021

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Long non‑coding RNA SNHG20 promotes cell proliferation, migration and invasion in retinoblastoma via the miR‑335‑5p/E2F3 axis

Jing Song, Ziping Zhang
Article Number: 543
Published online on: 29 May 2021

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Total saponins from Rhizoma Panacis Majoris inhibit proliferation, induce cell cycle arrest and apoptosis and influence MAPK signalling pathways on the colorectal cancer cell

Lu Chang, Rui Zhou, Yihan He, Mei Meng, Jinhang Hu, Yanru Liu, Yalei Pan, Zhishu Tang, Zhenggang Yue
Article Number: 542
Published online on: 29 May 2021

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January-2026 Volume 33 Issue 1

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Non‑coding RNAs in epithelial‑mesenchymal transition of renal cell carcinoma (Review)

Ziqiao Liu, Hanshen Zhou, Junxiao Shen, Yiming Qi, Xuke Gong, Cheng Zhang
Article Number: 51
Published online on: 24 November 2025

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FOXJ3 drives mesenchymal stem cell osteogenic differentiation via the Wnt/β‑catenin pathway: A novel regulator implicated in osteoporosis

Hongwei Xiao, Jianfeng Li, Wei Huang, Yi Qin
Article Number: 50
Published online on: 21 November 2025

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NEDD4 regulates VEGF signaling and mTOR to promote angiogenesis and the cell cycle in steroid‑induced osteonecrosis of the femoral head

Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
Article Number: 49
Published online on: 21 November 2025

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Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway

Chih-Hsuan Hsia, Chun-Ming Yang, Chao-Chien Chang, Ting-Lin Yen, Arief Gunawan Darmanto, Chi-Chang Huang, Joen-Rong Sheu
Article Number: 48
Published online on: 21 November 2025

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Research progress on molecular therapy for glaucoma (Review)

Weiwei Wang, Gangwei Cheng, Qi Zhou, Sheng Wang, Linyi Zhang
Article Number: 47
Published online on: 21 November 2025

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Natural compounds for the treatment of rheumatoid arthritis based on the ‘gut‑joint axis’ (Review)

Wenjie Hu, Rui Li, Zhongming Zhang
Article Number: 46
Published online on: 20 November 2025

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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

Pan Guo, Mengke Sun, Jingyu Zhang, Qianshu Yuan, Hong Cui, Junkai Huang, Jing Luo, Qianyu Zhu, Bingxin Zhang, Lizhi Hu
Article Number: 45
Published online on: 20 November 2025

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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

Banghao Sun, Zhenyu Zhao, Qingyu Meng, Luya Pu, Xingyu Jiang, Shuai Li, Fadi Cao, Fan Li
Article Number: 44
Published online on: 20 November 2025

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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
Published online on: 18 November 2025

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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
Published online on: 17 November 2025

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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
Article Number: 41
Published online on: 12 November 2025

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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
Article Number: 40
Published online on: 12 November 2025

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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
Published online on: 12 November 2025

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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
Published online on: 10 November 2025

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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
Article Number: 35
Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
Published online on: 10 November 2025

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Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
Article Number: 22
Published online on: 31 October 2025

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Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review)

Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Article

Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 33 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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