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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August-2021 Volume 24 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Expression levels of specific microRNAs are increased after exercise and are associated with cognitive improvement in Parkinson's disease

Franciele Cascaes Da Silva, Michele Patrícia Rode, Giovanna Grunewald Vietta, Rodrigo Da Rosa Iop, Tânia Beatriz Creczynski‑Pasa, Alessandra Swarowsky Martin, Rudney Da Silva
Article Number: 618
Published online on: 29 June 2021

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Article Open Access

circPTPN22 as a novel biomarker and ceRNA in peripheral blood mononuclear cells of rheumatoid arthritis

Zhuyan Jiang, Zhiting Zhong, Qingqing Miao, Yue Zhang, Bing Ni, Mengjie Zhang, Jun Tang
Article Number: 617
Published online on: 29 June 2021

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Article

H3K9me2 regulates early transcription factors to promote mesenchymal stem‑cell differentiation into cardiomyocytes

Xiaolin Sun, Xiang Gu, Hongxiao Li, Pei Xu, Mengting Li, Ye Zhu, Qisheng Zuo, Bichun Li
Article Number: 616
Published online on: 29 June 2021

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Article

Anti‑angiogenic effect of mountain ginseng in vitro and in vivo: Comparison with farm‑cultivated ginseng

Jin Soo Kim, Jae-Myung Yoo, Jong Eel Park, Jungeun Kim, Sun-Gun Kim, Young Mi Seok, Jun-Ho Son, Hyo Jung Kim
Article Number: 615
Published online on: 29 June 2021

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Article Open Access

Nuclear PKR in retinal neurons in the early stage of diabetic retinopathy in streptozotocin‑induced diabetic rats

Viviane Aline Oliveira Silva, Nayara Delgado André, Thaís Amaral E Sousa, Vâni Maria Alves, Isis Do Carmo Kettelhut, Fernando Luiz De Lucca
Article Number: 614
Published online on: 28 June 2021

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Article Open Access

PI3K/AKT phosphorylation activates ERRα by upregulating PGC‑1α and PGC‑1β in gallbladder cancer

Lei Wang, Mengmeng Yang, Huihan Jin
Article Number: 613
Published online on: 28 June 2021

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Article Open Access

Sulforaphane protects against oxidative stress‑induced apoptosis via activating SIRT1 in mouse osteoarthritis

Mangmang Chen, Lipeng Huang, Yangxun Lv, Liubing Li, Qirong Dong
Article Number: 612
Published online on: 28 June 2021

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Review Open Access

Dysregulated inflammation may predispose patients with serious mental illnesses to severe COVID‑19 (Review)

Sergej Nadalin, Hrvoje Jakovac, Vjekoslav Peitl, Dalibor Karlović, Alena Buretić‑Tomljanović
Article Number: 611
Published online on: 28 June 2021

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Article Open Access

Effects of Melandrium firmum Rohrbach on RANKL‑induced osteoclast differentiation and OVX rats

Minsun Kim, Jae-Hyun Kim, Sooyeon Hong, Boguen Kwon, Eun-Young Kim, Hyuk-Sang Jung, Youngjoo Sohn
Article Number: 610
Published online on: 25 June 2021

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Article Open Access

Interference with circRNA DOCK1 inhibits hepatocellular carcinoma cell proliferation, invasion and migration by regulating the miR-654-5p/SMAD2 axis

Yujuan Lu, Jingzhi Zhang, Yanhui Wu
Article Number: 609
Published online on: 25 June 2021

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Article Open Access

Humanized anti‑TLR4 monoclonal antibody ameliorates lipopolysaccharide‑related acute kidney injury by inhibiting TLR4/NF‑κB signaling

Qiuhua Zhang, Liang Wang, Mian Wu, Xiaobin Liu, Yushan Zhu, Jin Zhu, Changying Xing
Article Number: 608
Published online on: 25 June 2021

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Article Open Access

Solanum nigrum Line inhibits osteoclast differentiation and suppresses bone mineral density reduction in the ovariectomy‑induced osteoporosis model

Jae-Hyun Kim, Hwajeong Shin, Minsun Kim, Sangwoo Kim, Kwangchan Song, Hyuk-Sang Jung, Youngjoo Sohn
Article Number: 607
Published online on: 25 June 2021

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Article

Telomere shortening and expression of TRF1 and TRF2 in uterine leiomyoma

Bong-Kyeong Oh, Yoojung Choi, Joong Sub Choi
Article Number: 606
Published online on: 24 June 2021

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Review Open Access

Protective role of taurine against oxidative stress (Review)

Stella Baliou, Maria Adamaki, Petros Ioannou, Aglaia Pappa, Mihalis I. Panayiotidis, Demetrios A. Spandidos, Ioannis Christodoulou, Anthony M. Kyriakopoulos, Vassilis Zoumpourlis
Article Number: 605
Published online on: 24 June 2021

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Article Open Access

M2‑like tumour‑associated macrophage‑secreted IGF promotes thyroid cancer stemness and metastasis by activating the PI3K/AKT/mTOR pathway

Juan Lv, Chao Liu, Fu-Kun Chen, Zhi-Ping Feng, Li Jia, Peng-Jie Liu, Zhi-Xian Yang, Fei Hou, Zhi-Yong Deng
Article Number: 604
Published online on: 28 June 2021

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Article Open Access

Circular RNA profiling reveals a potential role of hsa_circ_IPCEF1 in papillary thyroid carcinoma

Min Guo, Yushuang Sun, Junzhu Ding, Yong Li, Sihan Yang, Yanna Zhao, Xin Jin, Shan-Shan Li
Article Number: 603
Published online on: 24 June 2021

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Review Open Access

Circular RNA: A novel type of biomarker for glioma (Review)

Wei Sun, Huandi Zhou, Xuetao Han, Liubing Hou, Xiaoying Xue
Article Number: 602
Published online on: 24 June 2021

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Article Open Access

Pulmonary coagulation and fibrinolysis abnormalities that favor fibrin deposition in the lungs of mouse antibody-mediated transfusion-related acute lung injury

Yunhong Yu, Peng Jiang, Pan Sun, Na Su, Fangzhao Lin
Article Number: 601
Published online on: 23 June 2021

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Correction Open Access

[Corrigendum] Traditional Chinese medicine, Fuzheng Kang‑Ai decoction, inhibits metastasis of lung cancer cells through the STAT3/MMP9 pathway

Longmei Li, Sumei Wang, Xiaobin Yang, Shunqin Long, Shujing Xiao, Wanyin Wu, Swei Sunny Hann
Article Number: 600
Published online on: 25 June 2021

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Retraction Open Access

[Retracted] Antitumor effect of resveratrol on chondrosarcoma cells via phosphoinositide 3‑kinase/AKT and p38 mitogen‑activated protein kinase pathways

Zixun Dai, Pengfei Lei, Jie Xie, Yihe Hu
Article Number: 599
Published online on: 23 June 2021

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Article Open Access

Effects of sterol derivatives in cationic liposomes on biodistribution and gene-knockdown in the lungs of mice systemically injected with siRNA lipoplexes

Yoshiyuki Hattori, Hiromu Saito, Teruaki Oku, Kei-Ichi Ozaki
Article Number: 598
Published online on: 23 June 2021

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Article Open Access

Inhibition of lncRNA SNHG8 plays a protective role in hypoxia-ischemia-reoxygenation-induced myocardial injury by regulating miR-335 and RASA1 expression

Yanfeng Liu, Ping Zhou, Fengxiao Wang, Xuehong Zhang, Dongmei Yang, Lang Hong, Dongyun Ruan
Article Number: 597
Published online on: 22 June 2021

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Article Open Access

Identification of differentially expressed proteins involved in fetal scarless wound healing using a rat model of cleft lip

Yu Yan, Hong Liu, Jiarong Yi, Zizi Chen, Jia Chen, Jianfei Zhang, Kewa Gao, Siqi He, Aijun Wang, Ping Jin, Feng Hu, Jianda Zhou
Article Number: 596
Published online on: 22 June 2021

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Article Open Access

Targeted silencing of TEM8 suppresses non‑small cell lung cancer tumor growth via the ERK/Bcl‑2 signaling pathway

Quan Gong, Jing Deng, Lijuan Zhang, Chunyan Zhou, Chaojiang Fu, Xicai Wang, Li Zhuang
Article Number: 595
Published online on: 22 June 2021

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Article

Lycopene prevents oxygen-glucose deprivation-induced autophagic death in SH-SY5Y cells via inhibition of the oxidative stress-activated AMPK/mTOR pathway

Tan Li, Yang Zhang, Yi Qi, He Liu
Article Number: 594
Published online on: 22 June 2021

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Article Open Access

Excessive mechanical stretch‑mediated osteoblasts promote the catabolism and apoptosis of chondrocytes via the Wnt/β‑catenin signaling pathway

Cheng-Xian Song, Sheng-Yao Liu, Wen-Ting Zhu, Shao-Yong Xu, Guo-Xin Ni
Article Number: 593
Published online on: 17 June 2021

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Article Open Access

Tripterygium glycoside suppresses epithelial‑to‑mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway

Mei Tao, Danna Zheng, Xudong Liang, Diandian Wu, Kang Hu, Juan Jin, Qiang He
Article Number: 592
Published online on: 17 June 2021

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Article

Downregulation of VDR in benign paroxysmal positional vertigo patients inhibits otolith‑associated protein expression levels

Shu Zhang, Juanli Xing, Yulin Gong, Ping Li, Boqian Wang, Ling Xu
Article Number: 591
Published online on: 17 June 2021

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Article Open Access

Dendrobium mixture attenuates renal damage in rats with diabetic nephropathy by inhibiting the PI3K/Akt/mTOR pathway

Yong Chen, Yan Fang Zheng, Xiao Hui Lin, Jie Ping Zhang, Fan Lin, Hong Shi
Article Number: 590
Published online on: 17 June 2021

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Article Open Access

DNAJC2 is reversely regulated by miR‑627‑3p, promoting the proliferation of colorectal cancer

Hongfu Liu, Juan Li, Huali Zhao, Xiaohui Liu, Xinying Ye
Article Number: 589
Published online on: 16 June 2021

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Article Open Access

miR‑205‑3p promotes lung cancer progression by targeting APBB2

Ling-Bin Xu, Jie Xiong, Ya-Hui Zhang, Yun Dai, Xiao-Ping Ren, Ya-Juan Ren, Dong Han, Sheng-Hong Wei, Min Qi
Article Number: 588
Published online on: 16 June 2021

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Retraction Open Access

[Retracted] Additive effects of eukaryotic co‑expression plasmid carrying GRIM‑19 and LKB1 genes on breast cancer in vitro and in vivo

Wei Zhang, Ying Shao, Ye Du, Wei Geng, Tong Jiang, Haipeng Liu, Duo Zhang
Article Number: 587
Published online on: 16 June 2021

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Retraction Open Access

[Retracted] Upregulation of GRIM‑19 inhibits the growth and invasion of human breast cancer cells

Wei Zhang, Ye Du, Tong Jiang, Wei Geng, Jiuli Yuan, Duo Zhang
Article Number: 586
Published online on: 16 June 2021

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Article Open Access

Serum long non‑coding RNA NNT‑AS1 protected by exosome is a potential biomarker and functions as an oncogene via the miR‑496/RAP2C axis in colorectal cancer

Hua Yin, Jingjing Hu, Zhiying Ye, Saijun Chen, Yunwen Chen
Article Number: 585
Published online on: 15 June 2021

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Article

SARS‑CoV‑2 spike protein‑induced host inflammatory response signature in human corneal epithelial cells

Guoqiang Zhu, Leyu Lyu, Hua Yang, Guibo Liu, Shuo Yang, Chuankai  Gu, Limei Wang, Haijing Yan, Ming Hu, Chengye Che
Article Number: 584
Published online on: 15 June 2021

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Article Open Access

Regulation of angiogenesis by microRNAs in cancer

Qi Zheng, Wei Hou
Article Number: 583
Published online on: 15 June 2021

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Article Open Access

MicroRNA‑193a‑5p exerts a tumor suppressive role in epithelial ovarian cancer by modulating RBBP6

Shuangli Zhang, Jun Liu, Jie He, Nuo Yi
Article Number: 582
Published online on: 15 June 2021

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Article Open Access

Anti‑inflammatory role of microRNA‑429 in human gingival epithelial cells‑inhibition of IL‑8 production through direct binding to IKKβ mRNA

Hiromichi Kawasaki, Hirotaka Amano
Article Number: 581
Published online on: 14 June 2021

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Article Open Access

Aggravation of hepatic ischemia‑reperfusion injury with increased inflammatory cell infiltration is associated with the TGF‑β/Smad3 signaling pathway

Haixia Li, Xiaoyun Shen, Yifan Tong, Tong Ji, Yan Feng, Yanping Tang, Rongyun Mai, Jiaxiang Ye, Ting Que, Xiaoling Luo
Article Number: 580
Published online on: 14 June 2021

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Retraction Open Access

[Retracted] miR‑200b inhibits migration and invasion in non‑small cell lung cancer cells via targeting FSCN1

Peng Xiao, Wenliang Liu, Hui Zhou
Article Number: 579
Published online on: 14 June 2021

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Article Open Access

COVID‑19 vaccination and IgG and IgA antibody dynamics in healthcare workers

Sabina Zurac, Luciana Nichita, Bogdan Mateescu, Cristian Mogodici, Alexandra Bastian, Cristiana Popp, Mirela Cioplea, Claudiu Socoliuc, Carolina Constantin, Monica Neagu
Article Number: 578
Published online on: 13 June 2021

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Article Open Access

High fluid shear stress prevents atherosclerotic plaque formation by promoting endothelium denudation and synthetic phenotype of vascular smooth muscle cells

Juan Wang, Yan Wang, Lin Sheng, Tian He, Xiang Nin, Aiying Xue, Hua Zhang, Zhendong Liu
Article Number: 577
Published online on: 13 June 2021

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Article Open Access

MicroRNA‑16‑5p/BIMP1/NF‑κB axis regulates autophagy to exert a tumor‑suppressive effect on bladder cancer

Jiani He, Zhongkai Qiu, Hao Zhang, Zhipeng Gao, Yuanjun Jiang, Zhenhua Li, Chuize Kong, Xiaojun Man
Article Number: 576
Published online on: 13 June 2021

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Article Open Access

Green tea protects against hippocampal neuronal apoptosis in diabetic encephalopathy by inhibiting JNK/MLCK signaling

Yongjie Xu, Shengju Liu, Liying Zhu, Longguang Dai, Wen Qian, Jingzhi Zhang, Xing Li, Wei Pan
Article Number: 575
Published online on: 10 June 2021

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Article Open Access

Dexmedetomidine attenuates neuronal injury induced by cerebral ischemia‑reperfusion by regulating miR‑199a

Yulin Zhu, Huatang Zhao, Wenshan Zhang, Xingang Ma, Ye Liu
Article Number: 574
Published online on: 09 June 2021

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Retraction Open Access

[Retracted] MicroRNA-200c inhibits the metastasis of non-small cell lung cancer cells by targeting ZEB2, an epithelial-mesenchymal transition regulator

Aihong Jiao, Minghua Sui, Liangming Zhang, Ping Sun, Dongmei Geng, Weiwei Zhang, Xiuwen Wang, Junxia Li
Article Number: 573
Published online on: 08 June 2021

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Article Open Access

A report of two cases of bulbospinal form Alexander disease and preliminary exploration of the disease

Xiaoxuan Song, Jingwen Jiang, Wotu Tian, Feixia Zhan, Zeyu Zhu, Binyin Li, Huidong Tang, Li Cao
Article Number: 572
Published online on: 08 June 2021

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Article Open Access

Baicalin relieves Mycoplasma pneumoniae infection‑induced lung injury through regulating microRNA‑221 to inhibit the TLR4/NF‑κB signaling pathway

Han Zhang, Xiang Li, Juan Wang, Qi Cheng, Yunxiao Shang, Guizhen Wang
Article Number: 571
Published online on: 08 June 2021

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Retraction Open Access

[Retracted] MicroRNA‑138 inhibits migration and invasion of non‑small cell lung cancer cells by targeting LIMK1

Yanjuan Tan, Huaidong Hu, Wuyuan Tan, Longyu Jin, Jianxin Liu, Hui Zhou
Article Number: 570
Published online on: 08 June 2021

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Retraction Open Access

[Retracted] MicroRNA‑10b suppresses the migration and invasion of chondrosarcoma cells by targeting brain‑derived neurotrophic factor

Abudunaibi Aili, Yong Chen, Hongqi Zhang
Article Number: 569
Published online on: 08 June 2021

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Article Open Access

MicroRNA‑142‑3p suppresses cell proliferation, invasion and epithelial‑to‑mesenchymal transition via RAC1‑ERK1/2 signaling in colorectal cancer

Na Xie, Qiuping Meng, Yixin Zhang, Zhifei Luo, Fenggui  Xue, Sisi Liu, Ying Li, Yousheng Huang
Article Number: 568
Published online on: 07 June 2021

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Article

miR‑483 promotes the development of colorectal cancer by inhibiting the expression level of EI24

Wei Zhou, Wanli Yang, Jing Yang, Haijun Zhu, Lili Duan, Xiaoqian Wang, Yiding Li, Liaoran Niu, Shuao Xiao, Rui Zhang, Jianjun Yang, Liu Hong
Article Number: 567
Published online on: 07 June 2021

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Article Open Access

Long non‑coding RNA XIST promotes cerebral ischemia/reperfusion injury by modulating miR‑27a‑3p/FOXO3 signaling

Hua Zhang, Junyong Xia, Qiushan Hu, Liqin Xu, Hongyan Cao, Xu Wang, Min Cao
Article Number: 566
Published online on: 07 June 2021

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Article Open Access

Curcumin induces apoptosis by inhibiting BCAT1 expression and mTOR signaling in cytarabine‑resistant myeloid leukemia cells

Yu-Hsin Tseng, Rei-Cheng Yang, Shyh-Shin Chiou, Tzong-Ming Shieh, Yin-Hwa Shih, Pei-Chin Lin
Article Number: 565
Published online on: 07 June 2021

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Article Open Access

Resveratrol affects the expression of uric acid transporter by improving inflammation

Xuemei Zhang, Qian Nie, Zhimei Zhang, Jing Zhao, Fengxiao Zhang, Chao Wang, Xing Wang, Guangyao Song
Article Number: 564
Published online on: 07 June 2021

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Article Open Access

Effects of miR‑210‑3p on the erythroid differentiation of K562 cells under hypoxia

Caiyan Hu, Yupeng Yan, Chengbing Fu, Jin Ding, Tiantian Li, Shuqiong Wang, Liu Fang
Article Number: 563
Published online on: 07 June 2021

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Article Open Access

miR‑200b upregulation promotes migration of BEAS‑2B cells following long‑term exposure to cigarette smoke by targeting ETS1

Jin Wang, Ruixin Yao, Qiulin Luo, Lirong Tan, Beibei Jia, Nan Ouyang, Yezhou Li, Jian Tong, Jianxiang Li
Article Number: 562
Published online on: 06 June 2021

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Article Open Access

Next‑generation sequencing of miRNAs and lncRNAs from rat femur and tibia under mechanical stress

Yiyan Qiu, Guozheng Zhu, Canjun Zeng, Song Yuan, Yuepeng Qian, Zelin Ye, Shanwen Zhao, Runguang Li
Article Number: 561
Published online on: 04 June 2021

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Article Open Access

Shikonin inhibits the Warburg effect, cell proliferation, invasion and migration by downregulating PFKFB2 expression in lung cancer

Liying Sha, Zhiqiang Lv, Yujun Liu, Yun Zhang, Xin Sui, Teng Wang, Hui Zhang
Article Number: 560
Published online on: 04 June 2021

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Article Open Access

Soluble fibrinogen‑like protein 2 levels are decreased in patients with ischemic heart failure and associated with cardiac function

Ya You, Shiyuan Huang, Hui Liu, Cheng Fan, Kun Liu, Zhaohui Wang
Article Number: 559
Published online on: 03 June 2021

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Article Open Access

DHA ameliorates MeHg‑induced PC12 cell apoptosis by inhibiting the ROS/JNK signaling pathway

Hong Zhang, Susu Wang, Yaqian Wang, Anxin Lu, Chunping Hu, Chonghuai Yan
Article Number: 558
Published online on: 03 June 2021

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Article Open Access

miR‑451 suppresses the malignant characteristics of colorectal cancer via targeting SAMD4B

Chunrong Wu, Xiaohu Liu, Bo Li, Guiying Sun, Chunfang Peng, Debing Xiang
Article Number: 557
Published online on: 03 June 2021

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An increase in elastogenic components in the placental villi of women with chronic venous disease during pregnancy is associated with decreased EGFL7 expression level

Miguel A. Ortega, Ángel Asúnsolo, Oscar Fraile‑Martínez, Felipe Sainz, Miguel A. Saez, Coral Bravo, Juan A. De León‑Luis, Miguel A. Alvarez‑Mon, Santiago Coca, Melchor Álvarez‑Mon, Julia Buján, Natalio García‑Honduvilla
Article Number: 556
Published online on: 02 June 2021

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Ginkgolide J protects human synovial cells SW982 via suppression of p38‑dependent production of pro‑inflammatory mediators

Yujie Zhao, Yuan Chen, Jiayi Wang, Xue Zhu, Ke Wang, Yue Li, Fanfan Zhou
Article Number: 555
Published online on: 02 June 2021

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Mechanism underlying long non‑coding RNA ILF3‑AS1‑mediated inhibition of cervical cancer cell proliferation, invasion and migration, and promotion of apoptosis

Linmei Zhu, Ruixia Chen, Chunlin Jiang, Qingsheng Xie, Wenshuai Zhao, Xiaohong Gao, Haiming Huang
Article Number: 554
Published online on: 02 June 2021

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lncRNA TUG1 regulates angiogenesis via the miR‑204‑5p/JAK2/STAT3 axis in hepatoblastoma

Miao-Xian Yuan, Chun-Yi Ji, Hong-Qiang Gao, Xin-Yi Sheng, Wei-Xin Xie, Qiang Yin
Article Number: 553
Published online on: 02 June 2021

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Long non‑coding RNA HCG11 suppresses the malignant phenotype of non‑small cell lung cancer cells by targeting a miR‑875/SATB2 axis

Zhou Su, Mi Chen, Ruilin Ding, Lian Shui, Qingmei Zhao, Wenjuan Luo
Article Number: 552
Published online on: 02 June 2021

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SMARCC2 combined with c‑Myc inhibits the migration and invasion of glioma cells via modulation of the Wnt/β‑catenin signaling pathway

Chiyang Li, Chengshuo Fei, Junjie Li, Hang Wu, Lei Chen, Ramzi Roshani, Hong Li, Linyong Shi, Chong Song, Junwei Gu, Yuntao Lu, Qiang Zhou
Article Number: 551
Published online on: 02 June 2021

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Porcupine inhibitor LGK‑974 inhibits Wnt/β‑catenin signaling and modifies tumor‑associated macrophages resulting in inhibition of the malignant behaviors of non‑small cell lung cancer cells

Yang Tang, Maoyan Jiang, Anping Chen, Wendong Qu, Xu Han, Jiebin Zuo, Gang Xu, Yongxiang Song, Cheng Chen, Xixian Ke
Article Number: 550
Published online on: 02 June 2021

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HIGD‑1B inhibits hypoxia‑induced mitochondrial fragmentation by regulating OPA1 cleavage in cardiomyocytes

Yan Pang, Zhide Zhu, Zhihao Wen, Junshen Lu, Hao Lin, Meiling Tang, Zhiliang Xu, Jianqi Lu
Article Number: 549
Published online on: 02 June 2021

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MAPK4 silencing together with a PARP1 inhibitor as a combination therapy in triple‑negative breast cancer cells

Xiaoqi Zeng, Shanshan Jiang, Simin Ruan, Zhaoze Guo, Jingyun Guo, Minfeng Liu, Changsheng Ye, Jianyu Dong
Article Number: 548
Published online on: 02 June 2021

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Critical role of SIRT1 upregulation on the protective effect of lncRNA ANRIL against hypoxia/reoxygenation injury in H9c2 cardiomyocytes

Binghui Song, Dongmei Wei, Gang Yin, Xiaoguang Song, Shuqing Wang, Shanshan Jia, Jidong Zhang, Longhu Li, Xiaofei Wu
Article Number: 547
Published online on: 02 June 2021

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Retraction Open Access

[Retracted] MicroRNA‑133a inhibits proliferation and invasion, and induces apoptosis in gastric carcinoma cells via targeting fascin actin‑bundling protein 1

Chen Lai, Zihua Chen, Ruixin Li
Article Number: 546
Published online on: 01 June 2021

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[Retracted] Knockdown of PREX2a inhibits the malignant phenotype of glioma cells

Liang Liu, Zhixiong Liu, Hao Wang, Long Chen, Fuqiang Ruan, Jihui Zhang, Yi Hu, Hengshan Luo, Shuai Wen
Article Number: 545
Published online on: 01 June 2021

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Perampanel, an AMPAR antagonist, alleviates experimental intracerebral hemorrhage‑induced brain injury via necroptosis and neuroinflammation

Lixiang Yang, Yue Wang, Can Zhang, Huilin Cheng
Article Number: 544
Published online on: 29 May 2021

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Long non‑coding RNA SNHG20 promotes cell proliferation, migration and invasion in retinoblastoma via the miR‑335‑5p/E2F3 axis

Jing Song, Ziping Zhang
Article Number: 543
Published online on: 29 May 2021

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Total saponins from Rhizoma Panacis Majoris inhibit proliferation, induce cell cycle arrest and apoptosis and influence MAPK signalling pathways on the colorectal cancer cell

Lu Chang, Rui Zhou, Yihan He, Mei Meng, Jinhang Hu, Yanru Liu, Yalei Pan, Zhishu Tang, Zhenggang Yue
Article Number: 542
Published online on: 29 May 2021

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Journal Cover
May-2026 Volume 33 Issue 5

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Identification of STMN1 as a lactylation‑related driver of lung cancer progression using Mendelian randomization

Yifan Cai, Yucheng Zhong, Honglin Wang, Shuang Zhu, Fang Huang, Qiuyue Zhang, Shaobo Hu
Article Number: 156
Published online on: 30 March 2026

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Advances in the mechanisms of extracellular vesicles and circulating tumor cells in hepatocellular carcinoma metastasis (Review)

Sitong Yi, Wenxin Liu, Zhaohui Wang
Article Number: 155
Published online on: 30 March 2026

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Diagnostic importance of serum markers in lung cancer

Qichen Liang, Jianmei Song, Haixiang Wei, Lu Ning, Baoyu He, Ziteng Zhang
Article Number: 154
Published online on: 30 March 2026

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VSNL1 attenuates hypoxia‑induced myocardial apoptosis by regulating the CNP/NPRB pathway

Xing Yang, Wenjuan Fang, Rui Chang, Linlin Ma, Xiaoyan Chen, Yanfei Li
Article Number: 153
Published online on: 30 March 2026

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Stabilin‑1: An immunoregulatory scavenger receptor in inflammation and tissue homeostasis (Review)

Xiao-Lei Xiang, Xin-Tong Ye, Yu-Tong Wu, Chen Chen, Chu-Ying Yu, Su-Ting Qian, Dan-Li Cai
Article Number: 152
Published online on: 26 March 2026

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Mechanism and therapeutic prospects of adipose tissue B lymphocytes in obesity and obesity‑associated metabolic diseases (Review)

Hong Wang, Hongyuan Lv, Xiaolin Zhang, Meifang Liu, Liyuan Wang
Article Number: 151
Published online on: 26 March 2026

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Tonsil‑derived mesenchymal stem cell‑derived extracellular vesicles suppress MAPK‑NF‑κB signaling and restore osteogenic differentiation in LPS‑stimulated periodontal ligament fibroblasts

Won-Jung Bae, Su Kang Kim, Han-Soo Kim, Sang Wook Kang, Ju Yeon Ban
Article Number: 150
Published online on: 26 March 2026

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Succinylation modification in diabetes and diabetic complications: Mechanisms and functions (Review)

Yeteng Xiong, Fei Luo, Bingnan Li, Qinfeng Yang
Article Number: 149
Published online on: 26 March 2026

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Polyphyllin II regulates ROS levels and promotes ferroptosis in bladder cancer cells

Quanlai Qiao, Ruifang Guo, Zhonghua Sun, Yaxin Shi, Yuning Xie, Zhiyong Liu
Article Number: 148
Published online on: 26 March 2026

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Veronicastrum sibiricum (L.) Pennell extract alleviates inflammation‑induced muscle atrophy through NLRP3 inflammasome regulation and mitochondrial function restoration

Eunhye Lee, Minjeong Kwon, Ju-Ock Nam
Article Number: 147
Published online on: 26 March 2026

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Role and clinical importance of lactylation in tumors (Review)

Chaowei Zhang, Xinyu Tang, Yuxuan Han, Weiyi Yao, Qing Hong, Yanan Zhu, Na Chen
Article Number: 146
Published online on: 26 March 2026

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Photodynamic therapy: A paradigm shift in overcoming drug‑resistant tuberculosis (Review)

Shuhao Cheng, Yuqing Wang, Jie Yao, Guodong Cheng, Gengzhi Ye, Fapeng Shi, Xiaolei Ma
Article Number: 145
Published online on: 26 March 2026

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Heterogeneous nuclear ribonucleoprotein K in cancer biology and its therapeutic applications (Review)

Yiyu Qin, Yang Zhou
Article Number: 144
Published online on: 26 March 2026

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Retraction Open Access

[Retracted] Na+/K+‑ATPase DR region‑specific antibody protects U251 cells against hypoxia reperfusion‑induced injury via the PI3K/AKT and ERK pathways

Huilin Gong, Pengbiao Lü, Jiangwei Zhang, Dandong Li, Jin Zheng, Jinning Song
Article Number: 143
Published online on: 23 March 2026

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Multi‑omics and their integration in psoriasis research (Review)

Hengyan Zhang, Danping Li, Lijuan Zhu, Heguo Yan, Licong Yang, Xuesong Yang, Ye Zhou
Article Number: 142
Published online on: 23 March 2026

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LDHA protects vascular endothelial cells from oxidative stress‑induced mitochondrial damage via HIF‑1α activation and glycolytic reprogramming

Beibei Dai, Lili Yang, Yu Zhang, Aiyong Yu
Article Number: 141
Published online on: 23 March 2026

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Article

Mechanism of BRCC36 affecting cardiac rupture after acute infarction through the Wnt‑JNK signaling pathway

Yongzhe Guo, Linyan Chen, Shumei Li, Xintao Zhang, Huizhong Lin
Article Number: 140
Published online on: 20 March 2026

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Correction Open Access

[Corrigendum] Puerarin alleviates the ototoxicity of gentamicin by inhibiting the mitochondria‑dependent apoptosis pathway

Ping Niu, Yuxuan Sun, Shiyi Wang, Guang Li, Xiaomin Tang, Jiaqiang Sun, Chunchen Pan, Jingwu Sun
Article Number: 139
Published online on: 19 March 2026

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Role of liver X receptors in the pathogenesis and treatment of chronic liver disease (Review)

Honghui You, Xiangjun Tang, Xiaoyan Fu, Jiaqi Zhou, Liyuan Wang, Hongxia Zhang, Xianhong Du, Shujuan Liang, Meifang Liu
Article Number: 138
Published online on: 19 March 2026

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Mechanistic insights and therapeutic potential of sphingosine‑1‑phosphate in the development of pulmonary fibrosis (Review)

Yanling Qin, Chenqi Tang, Sen Tan, Guangnan Liu
Article Number: 137
Published online on: 18 March 2026

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Advances in the biological functions of miR‑205 in various diseases (Review)

Dandan Chai, Hua Du, Yingxu Shi
Article Number: 136
Published online on: 18 March 2026

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Retraction Open Access

[Retracted] MicroRNA‑25‑3p regulates human nucleus pulposus cell proliferation and apoptosis in intervertebral disc degeneration by targeting Bim

Zhifang Zhao, Jie Zheng, Youchen Ye, Kefeng Zhao, Ruozhang Wang, Ran Wang
Article Number: 135
Published online on: 16 March 2026

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Precision medicine approach to coronary artery disease: Haptoglobin phenotype‑guided risk assessment

Zhengxin He, Hong Liu, Keran Jia, Daxin Lei, Liyun An, Jia Wang, Fukun Wang
Article Number: 134
Published online on: 12 March 2026

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Expression of Concern Open Access

[Expression of Concern] Dexmedetomidine protects against sepsis‑associated encephalopathy through Hsp90/AKT signaling

Lijun Yin, Xuejun Chen, Hongbo Ji, Shunli Gao
Article Number: 133
Published online on: 11 March 2026

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Glucose‑driven TRIB3 enhances the tumorigenic potential of colon cancer via the PI3K/AKT pathway

Yunting Bai, Xuying Huang, Guangyu An, Yang Ge, Rui Yan, Dan Yu
Article Number: 132
Published online on: 10 March 2026

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[Retracted] miR‑222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8

Yan-Yan Bai, Jun-Zhi Niu
Article Number: 131
Published online on: 09 March 2026

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Dexmedetomidine protects against myocardial ischemia reperfusion injury by inhibiting the TLR2‑NF‑κB pathway in diabetic mice

Zhengjie Chen, Liangyu Zheng, Gang Chen
Article Number: 130
Published online on: 06 March 2026

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Long non‑coding RNA NKILA regulates the JAK2/STAT3 pathway to exacerbate TGF‑β1‑mediated renal fibrosis

Yu Han, Siqi Yang, Jing Zhang, Yaoguang Wang, Xi Zhao, Huan Liu
Article Number: 129
Published online on: 05 March 2026

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Retraction Open Access

[Retracted] Combination of HSP90 and autophagy inhibitors promotes hepatocellular carcinoma apoptosis following incomplete thermal ablation

Fen Chen, Haiyang Xie, Haiwei Bao, Laurencia Violetta, Shusen Zheng
Article Number: 128
Published online on: 05 March 2026

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Review Open Access

Advances regarding physiological functions and mechanisms of theaflavin‑3,3'‑digallate (Review)

Teng Ma, Siwei Zhang, Miaomiao Xiao, Zhijian Ma, Junhong Guan
Article Number: 127
Published online on: 04 March 2026

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Mechanisms and therapeutic potential of glycyrrhizic acid: Insights into key signaling pathways and disease modulation (Review)

Jinjin Yu, Huiheng Qu, Weicheng Xu, Yiming Fang, Nan Wang, Wei Shi
Article Number: 126
Published online on: 04 March 2026

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Pyroptosis in cerebral ischemia‑reperfusion injury: Molecular mechanisms and therapeutic implications (Review)

Ze Li, Qiuli Ming, Tianyu Yang, Mengna Liu, Linpeng Fu, Jingshuang Yang, Zhaofeng Lu
Article Number: 125
Published online on: 04 March 2026

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Characteristics of chromosomal instability‑related lncRNAs associated with progression and prognosis in breast cancer

Qi Chen, Hui Chen, Hui Yang, Yin Tao, Xiaolan Zhu
Article Number: 124
Published online on: 04 March 2026

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Correction Open Access

[Corrigendum] Associations between Huwe1 and autophagy in rat cerebral neuron oxygen‑glucose deprivation and reperfusion injury 

Guo-Qian He, Yan Chen, Hui-Juan Liao, Wen-Ming Xu, Wei Zhang, Guo-Lin He
Article Number: 123
Published online on: 26 February 2026

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Journal Cover
June-2026 Volume 33 Issue 6

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Emerging roles of POLR2L of RNA polymerase II dynamics and disease mechanisms (Review)

Beomwoo Lee, Changgyu Son, Sunho Eom, Yuwen Li, Seon-Hwan Kim, Jongsun Park
Article Number: 159
Published online on: 30 March 2026

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Combining bioinformatics prediction with experimental validation to explore the ameliorative effect of Psoralea corylifolia on vitiligo

Chen Zhang, Zhanhong Cao, Mengyang Wei, Xuanxuan Zhu, Yan Yan, Zhenhua Wang, Meng Zhang
Article Number: 158
Published online on: 30 March 2026

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[Retracted] All‑trans‑retinoic acid inhibits chondrogenesis of rat embryo hindlimb bud mesenchymal cells by down­regulating p53 expression

Tao-Gen Zhang, Xue-Dong Li, Guo-Yong Yu, Peng Xie, Yun-Guo Wang, Zhao-Yong Liu, Quan Hong, De-Zhong Liu, Shi-Xin Du
Article Number: 157
Published online on: 30 March 2026

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