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Article

miR‑483 promotes the development of colorectal cancer by inhibiting the expression level of EI24

  • Authors:
    • Wei Zhou
    • Wanli Yang
    • Jing Yang
    • Haijun Zhu
    • Lili Duan
    • Xiaoqian Wang
    • Yiding Li
    • Liaoran Niu
    • Shuao Xiao
    • Rui Zhang
    • Jianjun Yang
    • Liu Hong
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China, Department of Emergency, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China, Department of General Surgery, Xi'an Central Hospital, Xi'an, Shaanxi 710003, P.R. China
  • Article Number: 567
    |
    Published online on: June 7, 2021
       https://doi.org/10.3892/mmr.2021.12206
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Abstract

MicroRNAs (miRs) serve an important role in cell differentiation, proliferation and apoptosis by negatively regulating gene expression at the transcriptional or post‑transcriptional level. EI24 autophagy associated transmembrane protein (EI24) is a tumor suppressor gene that serves an important role in the occurrence and development of digestive system tumors. However, little is known regarding the relationship between EI24 and the prognosis of patients with colorectal cancer (CRC). Our previous study confirmed EI24 as the target molecule of miR‑483, using reporter gene detection. Thus, the aim of the present study was to elucidate the effect of the abnormal expression of miR‑483 on the malignant phenotype of CRC through a series of cell function experiments and nude mice tumorigenicity experiments, and to determine the expression level of EI24, a downstream target gene of miR‑483, in CRC and its relationship with patient prognosis. In CRC tissues and cells, the expression level of miR‑483 was upregulated, while the expression level of EI24 was downregulated. Cell function tests such as MTT assay, cell cycle assay, colony formation assay, Migration and invasion assays and nude mice tumorigenicity experiments demonstrated that the overexpression of miR‑483 promoted the proliferation, invasion and metastasis of CRC. Moreover, the reverse transcription‑quantitative PCR results indicated that overexpression of miR‑483 inhibited the expression level of EI24. The relationship between the clinical data and immunohistochemical results from 183 patients with CRC and survival was examined. It was found that the expression level of EI24 was positively associated with the prognosis of patients. As a cancer‑promoting factor, miR‑483 enhances the proliferation, migration and invasion of CRC cells by reducing the expression level of EI24.
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View References

1 

Dekker E, Tanis PJ, Vleugels JLA, Kasi PM and Wallace MB: Colorectal cancer. Lancet. 394:1467–1480. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Yang Q, Hou C, Huang D, Zhuang C, Jiang W, Geng Z, Wang X and Hu L: miR-455-5p functions as a potential oncogene by targeting galectin-9 in colon cancer. Oncol Lett. 13:1958–1964. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Brenner H, Kloor M and Pox CP: Colorectal cancer. Lancet. 383:1490–1502. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Zhou W, Zhou X, Liu JQ, Zhang YJ and Hong L: High expression of miR-21 in tissue correlated with the poor survival of patients with esophageal cancer: A pilot study using the meta-analysis. J Prev Med Care. 1:9–15. 2016. View Article : Google Scholar

5 

Chen X, Zhang DH and You ZH: A heterogeneous label propagation approach to explore the potential associations between miRNA and disease. J Transl Med. 16:3482018. View Article : Google Scholar : PubMed/NCBI

6 

Ma J, Hong L, Chen Z, Nie Y and Fan D: Epigenetic regulation of microRNAs in gastric cancer. Dig Dis Sci. 59:716–723. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Chi SW, Zang JB, Mele A and Darnell RB: Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps. Nature. 460:479–486. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Zhou W, Yang W, Ma J, Zhang H, Li Z, Zhang L, Liu J, Han Z, Wang H and Hong L: Role of miR-483 in digestive tract cancers: From basic research to clinical value. J Cancer. 9:407–414. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Ferland-McCollough D, Fernandez-Twinn DS, Cannell IG, David H, Warner M, Vaag AA, Bork-Jensen J, Brøns C, Gant TW, Willis AE, et al: Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes. Cell Death Differ. 19:1003–1012. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Wang H, Zhang H, Sun Q, Wang Y, Yang J, Yang J, Zhang T, Luo S, Wang L, Jiang Y, et al: Intra-articular delivery of Antago-miR-483-5p inhibits osteoarthritis by modulating matrilin 3 and tissue inhibitor of metalloproteinase 2. Mol Ther. 25:715–727. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Qiao Y, Ma N, Wang X, Hui Y, Li F, Xiang Y, Zhou J, Zou C, Jin J, Lv G, et al: miR-483-5p controls angiogenesis in vitro and targets serum response factor. FEBS Lett. 585:3095–3100. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Shi L, Liu S, Zhao WQ and Shi JZ: miR-483-5p and miR-486-5p are down-regulated in cumulus cells of metaphase II oocytes from women with polycystic ovary syndrome. Reprod Biomed Online. 31:565–572. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Yu X, Li Z, Chan MT and Wu WK: The roles of microRNAs in Wilms' tumors. Tumour Biol. 37:1445–1450. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Song Q, Xu Y, Yang C, Chen Z, Jia C, Chen J, Zhang Y, Lai P, Fan X, Zhou X, et al: miR-483-5p promotes invasion and metastasis of lung adenocarcinoma by targeting RhoGDI1 and ALCAM. Cancer Res. 74:3031–3042. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Patterson EE, Holloway AK, Weng J, Fojo T and Kebebew E: MicroRNA profiling of adrenocortical tumors reveals miR-483 as a marker of malignancy. Cancer. 117:1630–1639. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Si Y, Zhang H, Ning T, Bai M, Wang Y, Yang H, Wang X, Li J, Ying G and Ba Y: miR-26a/b inhibit tumor growth and angiogenesis by targeting the HGF-VEGF axis in gastric carcinoma. Cell Physiol Biochem. 42:1670–1683. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Xue L, Nan J, Dong L, Zhang C, Li H, Na R, He H and Wang Y: Upregulated miR-483-5p expression as a prognostic biomarker for esophageal squamous cell carcinoma. Cancer Biomark. 19:193–197. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Zang Y, Zhu L, Li T, Wang Q, Li J, Qian Y, Wei L, Xie M, Tang WH, Liu X, et al: EI24 suppresses tumorigenesis in pancreatic cancer via regulating c-Myc. Gastroenterol Res Pract. 2018:26265452018. View Article : Google Scholar : PubMed/NCBI

19 

Li Z, Meng Q, Pan A, Wu X and Li L: MicroRNA-455-3p promotes invasion and migration in triple negative breast cancer by targeting tumor suppressor EI24. Oncotarget. 8:19455–19466. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Choi JM, Jang JY, Choi YR, Kim HR, Cho BC and Lee HW: Reduced expression of EI24 confers resistance to gefitinib through IGF-1R signaling in PC9 NSCLC cells. Lung Cancer. 90:175–181. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Nam TW, Park SY, Lee JH, Roh JI and Lee HW: Effect of EI24 expression on the tumorigenesis of ApcMin/+ colorectal cancer mouse model. Biochem Biophys Res Commun. 514:1087–1092. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Choi JM, Devkota S, Sung YH and Lee HW: EI24 regulates epithelial-to-mesenchymal transition and tumor progression by suppressing TRAF2-mediated NF-κB activity. Oncotarget. 4:2383–2396. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Mazumder Indra D, Mitra S, Singh RK, Dutta S, Roy A, Mondal RK, Basu PS, Roychoudhury S and Panda CK: Inactivation of CHEK1 and EI24 is associated with the development of invasive cervical carcinoma: Clinical and prognostic implications. Int J Cancer. 129:1859–1871. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Ma J, Hong L, Xu G, Hao J, Wang R, Guo H, Liu J, Zhang Y, Nie Y and Fan D: miR-483-3p plays an oncogenic role in esophageal squamous cell carcinoma by targeting tumor suppressor EI24. Cell Biol Int. 40:448–455. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Mentz RJ, Hernandez AF, Berdan LG, Rorick T, O'Brien EC, Ibarra JC, Curtis LH and Peterson ED: Good clinical practice guidance and pragmatic clinical trials: Balancing the best of both worlds. Circulation. 133:872–880. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

27 

MacArthur Clark JA and Sun D: Guidelines for the ethical review of laboratory animal welfare People's Republic of China National Standard GB/T 3589218 [Issued 6 February 2018 Effective from 1 September 2018]. Animal Model Exp Med. 3:103–113. 2020. View Article : Google Scholar : PubMed/NCBI

28 

Duan L, Ma J, Yang W, Cao L, Wang X, Niu L, Li Y, Zhou W, Zhang Y, Liu J, et al: EI24 inhibits cell proliferation and drug resistance of esophageal squamous cell carcinoma. Front Oncol. 10:15702020. View Article : Google Scholar : PubMed/NCBI

29 

Malki A, ElRuz RA, Gupta I, Allouch A, Vranic S and Al Moustafa AE: Molecular mechanisms of colon cancer progression and metastasis: Recent insights and advancements. Int J Mol Sci. 22:1302020. View Article : Google Scholar : PubMed/NCBI

30 

Leber MF and Efferth T: Molecular principles of cancer invasion and metastasis (review). Int J Oncol. 34:881–895. 2009.PubMed/NCBI

31 

Vu T and Datta PK: Regulation of EMT in colorectal cancer: A culprit in metastasis. Cancers (Basel). 9:1712017. View Article : Google Scholar : PubMed/NCBI

32 

Haase G, Gavert N, Brabletz T and Ben-Ze'ev A: The Wnt target gene L1 in colon cancer invasion and metastasis. Cancers (Basel). 8:482016. View Article : Google Scholar : PubMed/NCBI

33 

Weidle UH, Birzele F and Krüger A: Molecular targets and pathways involved in liver metastasis of colorectal cancer. Clin Exp Metastasis. 32:623–635. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Liu X, Ji Q, Fan Z and Li Q: Cellular signaling pathways implicated in metastasis of colorectal cancer and the associated targeted agents. Future Oncol. 11:2911–2922. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Huang D, Sun W, Zhou Y, Li P, Chen F, Chen H, Xia D, Xu E, Lai M, Wu Y and Zhang H: Mutations of key driver genes in colorectal cancer progression and metastasis. Cancer Metastasis Rev. 37:173–187. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Huang S, Tan X, Huang Z, Chen Z, Lin P and Fu SW: MicroRNA biomarkers in colorectal cancer liver metastasis. J Cancer. 9:3867–3873. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Niu L, Yang W, Duan L, Wang X, Li Y, Xu C, Liu C, Zhang Y, Zhou W, Liu J, et al: Biological implications and clinical potential of metastasis-related miRNA in colorectal cancer. Mol Ther Nucleic Acids. 23:42–54. 2020. View Article : Google Scholar : PubMed/NCBI

38 

Allgayer H, Leupold JH and Patil N: Defining the ‘Metastasome’: Perspectives from the genome and molecular landscape in colorectal cancer for metastasis evolution and clinical consequences. Semin Cancer Biol. 60:1–13. 2020. View Article : Google Scholar : PubMed/NCBI

39 

Zhou Y and Hong L: Prediction value of miR-483 and miR-214 in prognosis and multidrug resistance of esophageal squamous cell carcinoma. Genet Test Mol Biomarkers. 17:470–474. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Wang C, Wang X, Su Z, Fei H, Liu X and Pan Q: miR-25 promotes hepatocellular carcinoma cell growth, migration and invasion by inhibiting RhoGDI1. Oncotarget. 6:36231–36244. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Xiao Y, Guo Q, Jiang TJ, Yuan Y, Yang L, Wang GW and Xiao WF: miR-483-3p regulates osteogenic differentiation of bone marrow mesenchymal stem cells by targeting STAT1. Mol Med Rep. 20:4558–4566. 2019.PubMed/NCBI

42 

Cui H, Liu Y, Jiang J, Liu Y, Yang Z, Wu S, Cao W, Cui IH and Yu C: IGF2-derived miR-483 mediated oncofunction by suppressing DLC-1 and associated with colorectal cancer. Oncotarget. 7:48456–48466. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Løes IM, Immervoll H, Sorbye H, Angelsen JH, Horn A, Knappskog S and Lønning PE: Impact of KRAS, BRAF, PIK3CA, TP53 status and intraindividual mutation heterogeneity on outcome after liver resection for colorectal cancer metastases. Int J Cancer. 139:647–656. 2016. View Article : Google Scholar

44 

Kawaguchi Y, Kopetz S, Newhook TE, De Bellis M, Chun YS, Tzeng CD, Aloia TA and Vauthey JN: Mutation status of RAS, TP53, and SMAD4 is superior to mutation status of RAS alone for predicting prognosis after resection of colorectal liver metastases. Clin Cancer Res. 25:5843–5851. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhou W, Yang W, Yang J, Zhu H, Duan L, Wang X, Li Y, Niu L, Xiao S, Zhang R, Zhang R, et al: miR‑483 promotes the development of colorectal cancer by inhibiting the expression level of EI24. Mol Med Rep 24: 567, 2021.
APA
Zhou, W., Yang, W., Yang, J., Zhu, H., Duan, L., Wang, X. ... Hong, L. (2021). miR‑483 promotes the development of colorectal cancer by inhibiting the expression level of EI24. Molecular Medicine Reports, 24, 567. https://doi.org/10.3892/mmr.2021.12206
MLA
Zhou, W., Yang, W., Yang, J., Zhu, H., Duan, L., Wang, X., Li, Y., Niu, L., Xiao, S., Zhang, R., Yang, J., Hong, L."miR‑483 promotes the development of colorectal cancer by inhibiting the expression level of EI24". Molecular Medicine Reports 24.2 (2021): 567.
Chicago
Zhou, W., Yang, W., Yang, J., Zhu, H., Duan, L., Wang, X., Li, Y., Niu, L., Xiao, S., Zhang, R., Yang, J., Hong, L."miR‑483 promotes the development of colorectal cancer by inhibiting the expression level of EI24". Molecular Medicine Reports 24, no. 2 (2021): 567. https://doi.org/10.3892/mmr.2021.12206
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou W, Yang W, Yang J, Zhu H, Duan L, Wang X, Li Y, Niu L, Xiao S, Zhang R, Zhang R, et al: miR‑483 promotes the development of colorectal cancer by inhibiting the expression level of EI24. Mol Med Rep 24: 567, 2021.
APA
Zhou, W., Yang, W., Yang, J., Zhu, H., Duan, L., Wang, X. ... Hong, L. (2021). miR‑483 promotes the development of colorectal cancer by inhibiting the expression level of EI24. Molecular Medicine Reports, 24, 567. https://doi.org/10.3892/mmr.2021.12206
MLA
Zhou, W., Yang, W., Yang, J., Zhu, H., Duan, L., Wang, X., Li, Y., Niu, L., Xiao, S., Zhang, R., Yang, J., Hong, L."miR‑483 promotes the development of colorectal cancer by inhibiting the expression level of EI24". Molecular Medicine Reports 24.2 (2021): 567.
Chicago
Zhou, W., Yang, W., Yang, J., Zhu, H., Duan, L., Wang, X., Li, Y., Niu, L., Xiao, S., Zhang, R., Yang, J., Hong, L."miR‑483 promotes the development of colorectal cancer by inhibiting the expression level of EI24". Molecular Medicine Reports 24, no. 2 (2021): 567. https://doi.org/10.3892/mmr.2021.12206
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