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MicroRNA‑16‑5p/BIMP1/NF‑κB axis regulates autophagy to exert a tumor‑suppressive effect on bladder cancer

  • Authors:
    • Jiani He
    • Zhongkai Qiu
    • Hao Zhang
    • Zhipeng Gao
    • Yuanjun Jiang
    • Zhenhua Li
    • Chuize Kong
    • Xiaojun Man
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Urology, Benxi Central Hospital, Benxi, Liaoning 117000, P.R. China, Department of Urology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 576
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    Published online on: June 13, 2021
       https://doi.org/10.3892/mmr.2021.12215
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Abstract

Bladder cancer (BC) is the second most common urological disease worldwide. Previous studies have reported that microRNA (miR)‑16‑5p is associated with the development of BC, but whether miR‑16‑5p regulates BC cell autophagy remains unknown. Thus, the aim of the present study was to investigate this issue. miR‑16‑5p expression in BC cells was assessed by reverse transcription‑quantitative PCR. Cell viability and apoptosis were detected via Cell Counting Kit‑8 and flow cytometry assays, respectively. For cell autophagy detection, autophagic flux was detected using a mCherry‑green fluorescent protein‑microtubule‑associated proteins 1A/1B light chain 3B (LC3) puncta formation assay, followed by determination of autophagy‑related protein markers. The targeting relationship between miR‑16‑5p and caspase recruitment domain family member 10 (BIMP1) was confirmed using a dual‑luciferase reporter assay, followed by detection of the BIMP1/NF‑κB signaling pathway. The results showed that miR‑16‑5p overexpression inhibited cell viability, whereas miR‑16‑5p knockdown promoted cell viability in BC. Furthermore, miR‑16‑5p overexpression induced autophagy, which was accompanied by increased autophagic flux and expression of the autophagy‑related proteins LC3‑II and beclin 1, as well as decreased p62 expression, whereas miR‑16‑5p silencing led to an inhibition of autophagy in BC cells. Moreover, autophagy inhibitor 3‑methyladenine treatment inhibited cell autophagy and apoptosis in miR‑16‑5p‑overexpressing cells. Mechanistic studies demonstrated that miR‑16‑5p could inhibit the BIMP1/NF‑κB signaling pathway and this inhibition was achieved by directly targeting BIMP1. Furthermore, it was found that blockade of the BIMP1/NF‑κB signaling pathway inversed the inhibitory effects of miR‑16‑5p knockdown on autophagy in BC cells. In vivo experiments further verified the tumor‑suppressive effect on BC of the miR‑16‑5p/BIMP1/NF‑κB axis. Therefore, the results of the present study indicated that miR‑16‑5p promotes autophagy of BC cells via the BIMP1/NF‑κB signaling pathway, and an improved understanding of miR‑16‑5p function may provide therapeutic targets for clinical intervention in this disease.
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1 

Antoni S, Ferlay J, Soerjomataram I, Znaor A, Jemal A and Bray F: Bladder cancer incidence and mortality: A global overview and recent trends. Eur Urol. 71:96–108. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Benhamou S, Bonastre J, Groussard K, Radvanyi F, Allory Y and Lebret T: A prospective multicenter study on bladder cancer: The COBLAnCE cohort. BMC Cancer. 16:8372016. View Article : Google Scholar : PubMed/NCBI

3 

Racioppi M, D'Agostino D, Totaro A, Pinto F, Sacco E, D'Addessi A, Marangi F, Palermo G and Bassi PF: Value of current chemotherapy and surgery in advanced and metastatic bladder cancer. Urol Int. 88:249–258. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Blick C, Ramachandran A, McCormick R, Wigfield S, Cranston D, Catto J and Harris AL: Identification of a hypoxia-regulated miRNA signature in bladder cancer and a role for miR-145 in hypoxia-dependent apoptosis. Br J Cancer. 113:634–644. 2015. View Article : Google Scholar : PubMed/NCBI

5 

van Rhijn BW, Burger M, Lotan Y, Solsona E, Stief CG, Sylvester RJ, Witjes JA and Zlotta AR: Recurrence and progression of disease in non-muscle-invasive bladder cancer: From epidemiology to treatment strategy. Eur Urol. 56:430–442. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Mizushima N and Komatsu M: Autophagy: Renovation of cells and tissues. Cell. 147:728–741. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Cheng Y, Li Z, Xie J, Wang P, Zhu J, Li Y and Wang Y: MiRNA-224-5p inhibits autophagy in breast cancer cells via targeting Smad4. Biochem Biophys Res Commun. 506:793–798. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Bartel DP: MicroRNAs: Target recognition and regulatory functions. Cell. 136:215–233. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Vishnoi A and Rani S: MiRNA biogenesis and regulation of diseases: An overview. Methods Mol Biol. 1509:1–10. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Huang N, Wu J, Qiu W, Lyu Q, He J, Xie W, Xu N and Zhang Y: MiR-15a and miR-16 induce autophagy and enhance chemosensitivity of camptothecin. Cancer Biol Ther. 16:941–948. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Jiang QQ, Liu B and Yuan T: MicroRNA-16 inhibits bladder cancer proliferation by targeting Cyclin D1. Asian Pac J Cancer Prev. 14:4127–4130. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Wang H, Zhang Y, Wu Q, Wang YB and Wang W: miR-16 mimics inhibit TGF-β1-induced epithelial-to-mesenchymal transition via activation of autophagy in non-small cell lung carcinoma cells. Oncol Rep. 39:247–254. 2018.PubMed/NCBI

13 

Xia ZX, Li ZX, Zhang M, Sun LM, Zhang QF and Qiu XS: CARMA3 regulates the invasion, migration, and apoptosis of non-small cell lung cancer cells by activating NF-кB and suppressing the P38 MAPK signaling pathway. Exp Mol Pathol. 100:353–360. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Zhang S, Zhang C, Liu W, Zheng W, Zhang Y, Wang S, Huang D, Liu X and Bai Z: MicroRNA-24 upregulation inhibits proliferation, metastasis and induces apoptosis in bladder cancer cells by targeting CARMA3. Int J Oncol. 47:1351–1360. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Patel M, Horgan PG, McMillan DC and Edwards J: NF-κB pathways in the development and progression of colorectal cancer. Transl Res. 197:43–56. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Zhang J, Kuang Y, Wang Y, Xu Q and Ren Q: Notch-4 silencing inhibits prostate cancer growth and EMT via the NF-κB pathway. Apoptosis. 22:877–884. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Wang C, Li A, Yang S, Qiao R, Zhu X and Zhang J: CXCL5 promotes mitomycin C resistance in non-muscle invasive bladder cancer by activating EMT and NF-κB pathway. Biochem Biophys Res Commun. 498:862–868. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Xiao G: Autophagy and NF-kappaB: Fight for fate. Cytokine Growth Factor Rev. 18:233–243. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Hu W, Chen SS, Zhang JL, Lou XE and Zhou HJ: Dihydroartemisinin induces autophagy by suppressing NF-κB activation. Cancer Lett. 343:239–248. 2014. View Article : Google Scholar : PubMed/NCBI

20 

He HJ, Bing H and Liu G: TSR2 Induces laryngeal cancer cell apoptosis through inhibiting NF-κB signaling pathway. Laryngoscope. 128:E130–E134. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

22 

National Research Council, . Committee for the Update of the Guide for the Care and Use of Laboratory Animals. Guide for the Care and Use of Laboratory Animals. 8th edition. National Academies Press; Washington, DC: 2011, PubMed/NCBI

23 

Wang F, Wu H, Fan M, Yu R, Zhang Y, Liu J, Zhou X, Cai Y, Huang S, Hu Z and Jin X: Sodium butyrate inhibits migration and induces AMPK-mTOR pathway-dependent autophagy and ROS-mediated apoptosis via the miR-139-5p/Bmi-1 axis in human bladder cancer cells. FASEB J. 34:4266–4282. 2020. View Article : Google Scholar : PubMed/NCBI

24 

Liu X, Li S, Li Y, Cheng B, Tan B and Wang G: Puerarin inhibits proliferation and induces apoptosis by upregulation of miR-16 in bladder cancer cell line T24. Oncol Res. 26:1227–1234. 2018. View Article : Google Scholar : PubMed/NCBI

25 

White E, Mehnert JM and Chan CS: Autophagy, metabolism, and cancer. Clin Cancer Res. 21:5037–5046. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Levy JMM, Towers CG and Thorburn A: Targeting autophagy in cancer. Nat Rev Cancer. 17:528–542. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Won SJ, Yen CH, Liu HS, Wu SY, Lan SH, Jiang-Shieh YF, Lin CN and Su CL: Justicidin A-induced autophagy flux enhances apoptosis of human colorectal cancer cells via class III PI3K and Atg5 pathway. J Cell Physiol. 230:930–946. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Yan S, Yang X, Chen T, Xi Z and Jiang X: The PPARγ agonist Troglitazone induces autophagy, apoptosis and necroptosis in bladder cancer cells. Cancer Gene Ther. 21:188–193. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Maiuri MC, Le Toumelin G, Criollo A, Rain JC, Gautier F, Juin P, Tasdemir E, Pierron G, Troulinaki K, Tavernarakis N, et al: Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J. 26:2527–2539. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Galonek HL and Hardwick JM: Upgrading the BCL-2 network. Nat Cell Biol. 8:1317–1319. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Zhao T, Miao Z, Wang Z, Xu Y, Wu J, Liu X, You Y and Li J: CARMA3 overexpression accelerates cell proliferation and inhibits paclitaxel-induced apoptosis through NF-κB regulation in breast cancer cells. Tumour Biol. 34:3041–3047. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Man X, Liu T, Jiang Y, Zhang Z, Zhu Y, Li Z, Kong C and He J: Silencing of CARMA3 inhibits bladder cancer cell migration and invasion via deactivating β-catenin signaling pathway. Onco Targets Ther. 12:6309–6322. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Wang L, Qian L, Li X and Yan J: MicroRNA-195 inhibits colorectal cancer cell proliferation, colony-formation and invasion through targeting CARMA3. Mol Med Rep. 10:473–478. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Man X, He J, Kong C, Zhu Y and Zhang Z: Clinical significance and biological roles of CARMA3 in human bladder carcinoma. Tumour Biol. 35:4131–4136. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Xia Y, Shen S and Verma IM: NF-κB, an active player in human cancers. Cancer Immunol Res. 2:823–830. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Naugler WE and Karin M: NF-kappaB and cancer-identifying targets and mechanisms. Curr Opin Genet Dev. 18:19–26. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Yan W, Ma X, Zhao X and Zhang S: Baicalein induces apoptosis and autophagy of breast cancer cells via inhibiting PI3K/AKT pathway in vivo and vitro. Drug Des Devel Ther. 12:3961–3972. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Ruan L and Qian X: MiR-16-5p inhibits breast cancer by reducing AKT3 to restrain NF-κB pathway. Biosci Rep. Aug 23–2019.(Epub ahead of print). doi: 10.1042/BSR20191611. View Article : Google Scholar

39 

Paul-Samojedny M, Pudelko A, Kowalczyk M, Fila-Daniłow A, Suchanek-Raif R, Borkowska P and Kowalski J: Knockdown of AKT3 and PI3KCA by RNA interference changes the expression of the genes that are related to apoptosis and autophagy in T98G glioblastoma multiforme cells. Pharmacol Rep. 67:1115–1123. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
He J, Qiu Z, Zhang H, Gao Z, Jiang Y, Li Z, Kong C and Man X: MicroRNA‑16‑5p/BIMP1/NF‑κB axis regulates autophagy to exert a tumor‑suppressive effect on bladder cancer. Mol Med Rep 24: 576, 2021.
APA
He, J., Qiu, Z., Zhang, H., Gao, Z., Jiang, Y., Li, Z. ... Man, X. (2021). MicroRNA‑16‑5p/BIMP1/NF‑κB axis regulates autophagy to exert a tumor‑suppressive effect on bladder cancer. Molecular Medicine Reports, 24, 576. https://doi.org/10.3892/mmr.2021.12215
MLA
He, J., Qiu, Z., Zhang, H., Gao, Z., Jiang, Y., Li, Z., Kong, C., Man, X."MicroRNA‑16‑5p/BIMP1/NF‑κB axis regulates autophagy to exert a tumor‑suppressive effect on bladder cancer". Molecular Medicine Reports 24.2 (2021): 576.
Chicago
He, J., Qiu, Z., Zhang, H., Gao, Z., Jiang, Y., Li, Z., Kong, C., Man, X."MicroRNA‑16‑5p/BIMP1/NF‑κB axis regulates autophagy to exert a tumor‑suppressive effect on bladder cancer". Molecular Medicine Reports 24, no. 2 (2021): 576. https://doi.org/10.3892/mmr.2021.12215
Copy and paste a formatted citation
x
Spandidos Publications style
He J, Qiu Z, Zhang H, Gao Z, Jiang Y, Li Z, Kong C and Man X: MicroRNA‑16‑5p/BIMP1/NF‑κB axis regulates autophagy to exert a tumor‑suppressive effect on bladder cancer. Mol Med Rep 24: 576, 2021.
APA
He, J., Qiu, Z., Zhang, H., Gao, Z., Jiang, Y., Li, Z. ... Man, X. (2021). MicroRNA‑16‑5p/BIMP1/NF‑κB axis regulates autophagy to exert a tumor‑suppressive effect on bladder cancer. Molecular Medicine Reports, 24, 576. https://doi.org/10.3892/mmr.2021.12215
MLA
He, J., Qiu, Z., Zhang, H., Gao, Z., Jiang, Y., Li, Z., Kong, C., Man, X."MicroRNA‑16‑5p/BIMP1/NF‑κB axis regulates autophagy to exert a tumor‑suppressive effect on bladder cancer". Molecular Medicine Reports 24.2 (2021): 576.
Chicago
He, J., Qiu, Z., Zhang, H., Gao, Z., Jiang, Y., Li, Z., Kong, C., Man, X."MicroRNA‑16‑5p/BIMP1/NF‑κB axis regulates autophagy to exert a tumor‑suppressive effect on bladder cancer". Molecular Medicine Reports 24, no. 2 (2021): 576. https://doi.org/10.3892/mmr.2021.12215
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